Bone Biology and the Clinical Implications for Osteoporosis
Abstract
Bone biology is a complex and vastly growing area of study. It brings together the traditional fields of anatomy, physiology, and biomechanics with the increasingly complex fields of developmental biology and molecular genetics. For clinicians who treat bone disorders such as osteoporosis, developing a working knowledge of this topic is essential. This article discusses bone from a structural, anatomical, and functional perspective. It reviews skeletogenesis as a developmental process and from a regulatory perspective and presents biomechanical principles and theories. Osteoporosis is reviewed, including recent literature related to the role of exercise in prevention and treatment of this disease. [Downey PA, Siegel MI. Bone biology and the clinical implications for osteoporosis.]
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Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts.
“Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts [1, 2].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [2]
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
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- Authors
- Downey, P. A., & Siegel, M. I.
- Affiliations
- Chatham University (US)
- University of Pittsburgh (US)
- Corresponding author
- Downey, Patricia A
- ORCID
- Siegel, Michael I
- Venue
- Physical Therapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01-01
- Volume
- 86
- Issue
- 1
- Pages
- 77-91
- ISSN
- 0031-9023 (ISSN-L)
- 1538-6724
- OpenAlex
- W2122579890
- Cited by
- 270
- References
- 62
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 10 · 2023: 26 · 2022: 19 · 2021: 8 · 2020: 23 · 2019: 29 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 10
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physical Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- bone biology, osteoporosis, skeletogenesis, skeletal development, bone biomechanics, bone anatomy, bone physiology, bone disease, physical activity, osteoporosis prevention, osteoporosis treatment
- MeSH terms
- Biomechanical Phenomena, Bone and Bones, Bone Development, Humans, Osteoporosis, Weight Lifting, Exercise, Bone Remodeling
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