Cited by 270Bone health and osteoporosis researchBone Metabolism and DiseasesBone Tissue Engineering Materials

Bone Biology and the Clinical Implications for Osteoporosis

Downey, Patricia A, Siegel, Michael I·2006·Physical Therapy

Abstract

Bone biology is a complex and vastly growing area of study. It brings together the traditional fields of anatomy, physiology, and biomechanics with the increasingly complex fields of developmental biology and molecular genetics. For clinicians who treat bone disorders such as osteoporosis, developing a working knowledge of this topic is essential. This article discusses bone from a structural, anatomical, and functional perspective. It reviews skeletogenesis as a developmental process and from a regulatory perspective and presents biomechanical principles and theories. Osteoporosis is reviewed, including recent literature related to the role of exercise in prevention and treatment of this disease. [Downey PA, Siegel MI. Bone biology and the clinical implications for osteoporosis.]

Integrity signals

Registry

Crossref · 10.1093/ptj/86.1.77

Cites

62 of 62 references verified0 citation errors · 0 not checkable

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  • Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts.

    “Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts [1, 2].”

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Authors
Downey, P. A., & Siegel, M. I.
Affiliations
  • Chatham University (US)
  • University of Pittsburgh (US)
Corresponding author
Downey, Patricia A
Venue
Physical Therapy
Published
2006-01-01
Volume
86
Issue
1
Pages
77-91
ISSN
  • 0031-9023 (ISSN-L)
  • 1538-6724
OpenAlex
W2122579890
Cited by
270
References
62
Citations by year
2026: 10 · 2025: 15 · 2024: 10 · 2023: 26 · 2022: 19 · 2021: 8 · 2020: 23 · 2019: 29 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 10
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Locations
  • Physical Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
bone biology, osteoporosis, skeletogenesis, skeletal development, bone biomechanics, bone anatomy, bone physiology, bone disease, physical activity, osteoporosis prevention, osteoporosis treatment
MeSH terms
Biomechanical Phenomena, Bone and Bones, Bone Development, Humans, Osteoporosis, Weight Lifting, Exercise, Bone Remodeling

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