INCREASED LEVELS OF OSTEOCALCIN (SERUM BONE GLA-PROTEIN) IN RHEUMATOID ARTHRITIS
Abstract
Serum osteocalcin was measured by radio-immunoassay in 56 patients with rheumatoid arthritis (RA), and in 50 controls. Mean serum osteocalcin levels were significantly higher in patients with RA. There was a positive correlation between osteocalcin and fasting mucopolysaccharide/creatinine ratio in both sexes, and between osteocalcin and fasting hydroxyproline/creatinine ratio in women. Serum alkaline phosphatase activity, a less specific marker for bone formation, was also increased in RA, and there was a positive correlation with osteocalcin in both sexes. These data suggest that overall bone turnover is increased in RA and that serum osteocalcin may provide additional information for the evaluation of bone metabolism in this disease.
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In patients with chronic inflammatory diseases, serum levels of osteocalcin have been described as decreased, increased, or normal.
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [105]
Cited by
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BONE MASS MEASUREMENT AND BONE METABOLISM IN RHEUMATOID ARTHRITIS: A REVIEW
Deodhar, A. A., & Woolf, A. D. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.4.309 · Cited by 234 · see citing works
“To try and resolve these issues, bone turnover in RA has been studied by new biochemical assays of bone metabolism [23-27] and also by bone histomorphometry [28-31].”
BackgroundSolal, M. C., Sebert, J., Boudailliez, B., et al. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-3-516 · Cited by 157 · see citing works
Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis
Pepmueller, P. H., Cassidy, J. T., Allen, S. H., et al. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390506 · Cited by 146 · see citing works
Bone gla protein (osteocalcin) assay standardization report
Delmas, P. D., Christiansen, C., Mann, K. G., & Price, P. A. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050104 · Cited by 132 · see citing works
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
BackgroundSex- and age-related changes in bone and serum osteocalcin
Vanderschueren, D., Gevers, G., Raymaekers, G., Devos, P., & Dequeker, J. (1990) · Calcified Tissue International · doi:10.1007/bf02555041 · Cited by 104 · see citing works
Self-citationStolina, M., Adamu, S., Ominsky, M., Dwyer, D., Asuncion, F., Geng, Z., Middleton, S., Brown, H., Pretorius, J., Schett, G., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050601 · Cited by 99 · see citing works
Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases
Reed, A. M., Haugen, M., Pachman, L. M., et al. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81605-1 · Cited by 97 · see citing works
Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis
Hillman, L. S., Cassidy, J. T., Johnson, L., Lee, D., & Allen, S. H. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83179-8 · Cited by 72 · see citing works
“4) [26] 2.”
Biological markers in rheumatoid arthritis
Poole, A. R., & Dieppe, P. A. (1994) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(94)90081-7 · Cited by 69 · see citing works
Osteoporosis and Hip Fractures
Scott, J. C. (1990) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00897-8 · Cited by 61 · see citing works
Repair of osteopenia in children with juvenile rheumatoid arthritis
Reed, A. M., Haugen, M., Pachman, L. M., et al. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(06)80006-5 · Cited by 63 · see citing works
Saxne, T., Zunino, L., & Heinegård, D. K. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380113 · Cited by 62 · see citing works
Bone turnover in non-steroid treated rheumatoid arthritis.
Compston, J. E., Vedi, S., Croucher, P. I., Garrahan, N. J., & O’Sullivan, M. (1994) · Annals of the Rheumatic Diseases · doi:10.1136/ard.53.3.163 · Cited by 56 · see citing works
MacDonald, A. G., Birkinshaw, G., Durham, B., Rc, B., & Fraser, W. D. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.1.50 · Cited by 49 · see citing works
“This uncertainty again mirrors the position in RA, where osteocalcin has been reported as being decreased, normal or increased [19–21].”
BackgroundGevers, G., & Dequeker, J. (1987) · Collagen and Related Research · doi:10.1016/s0174-173x(87)80041-9 · Cited by 49 · see citing works
Self-citationHillman, L. S., Cassidy, J. T., Popescu, M. F., et al. (2008) · Pediatric Pulmonology · doi:10.1002/ppul.20863 · Cited by 48 · see citing works
Dequeker, J., & Geusens, P. P. M. M. (1990) · Annals of the Rheumatic Diseases · doi:10.1136/ard.49.5.276 · Cited by 46 · see citing works
Self-citationOsteoporosis in Rheumatoid Arthritis
Dequeker, J., Westhovens, R., & Ravelingien, I. (2000) · Springer eBooks · doi:10.1007/978-1-4471-3825-9_36 · Cited by 45 · see citing works
Self-citationIntranasal calcitonin for the prevention of bone erosion and bone loss in rheumatoid arthritis.
Sileghem, A., Geusens, P., & Dequeker, J. (1992) · Annals of the Rheumatic Diseases · doi:10.1136/ard.51.6.761 · Cited by 39 · see citing works
Self-citationAota, S., Nakamura, T., Suzuki, K., et al. (1996) · Calcified Tissue International · doi:10.1007/s002239900144 · Cited by 38 · see citing works
Geusens, P., Vanderschueren, D., Verstraeten, A., Dequeker, J., Devos, P., & Bouillon, R. (1991) · Calcified Tissue International · doi:10.1007/bf02556112 · Cited by 36 · see citing works
“The sensitivity of the assay was 0.13 ng of bovine osteocalcin/ml [ 35 ].”
MethodInfluentialSelf-citationPolito, C., Strano, C. G., Rea, L., et al. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.3.193 · Cited by 36 · see citing works
Raymaekers, G., Aerssens, J., den Eynde, R. V., et al. (1992) · Calcified Tissue International · doi:10.1007/bf00334486 · Cited by 36 · see citing works
Self-citationBiochemical markers of bone turnover:A review
Åkesson, K. (1995) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679508995567 · Cited by 34 · see citing works
Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis.
Kröger, H., Risteli, J., Risteli, L., Penttilä, I., & ALHAVA, E. M. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.5.338 · Cited by 33 · see citing works
Bone metabolism in patients with rheumatoid arthritis
Bijlsma, J. W. J. (1988) · Clinical Rheumatology · doi:10.1007/bf02284051 · Cited by 32 · see citing works
“Alkaline phosphatase: A significant increase in serum alkaline phosphatase activity is reported in all studies (9, 12-16 ).”
BackgroundResultVerdrengh, M., Carlsten, H., Ohlsson, C., & Tarkowski, A. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20317 · Cited by 30 · see citing works
Effect of calcitonin on bone histomorphometry and bone metabolism in rheumatoid arthritis
Kröger, H., Arnala, I., & Alhava, E. M. (1992) · Calcified Tissue International · doi:10.1007/bf00297290 · Cited by 30 · see citing works
“The studies of S-BGP, a proposed marker of bone formarion, have revealed discrepant findings in RA [23-25].”
ResultSalisbury, C., & Sharif, M. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.9.558 · Cited by 29 · see citing works
Serum osteocalcin concentrations in patients with rheumatoid arthritis.
Pietschmann, P., Machold, K. P., Wolosczuk, W., & Smolen, J. S. (1989) · Annals of the Rheumatic Diseases · doi:10.1136/ard.48.8.654 · Cited by 28 · see citing works
Hillman, L. S., Cassidy, J. T., Chanetsa, F. F., Hewett, J. E., Higgins, B. J., & Robertson, J. D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23809 · Cited by 28 · see citing works
Reduced bone formation in non-steroid treated patients with rheumatoid arthritis.
Compston, J. E., Vedi, S., Mellish, R. W. E., Croucher, P. I., & O’Sullivan, M. (1989) · Annals of the Rheumatic Diseases · doi:10.1136/ard.48.6.483 · Cited by 28 · see citing works
Osteoporosis in rheumatoid arthritis: Effect of disease activity
Çeliker, R., Gökçe-Kutsal, Y., Cindaş, A., et al. (1995) · Clinical Rheumatology · doi:10.1007/bf02207677 · Cited by 27 · see citing works
“Previous studies of the circulating concent ra t ion of osteocalcin in R A have found this to be increased(23,24), decreased (25) or normal(2,26,27).”
BackgroundVerbruggen, A., Clerck, L. S. D., Bridts, C. H., et al. (1999) · Cytokine · doi:10.1006/cyto.1998.0500 · Cited by 24 · see citing works
Alkaline phosphatase isoenzymes in rheumatic diseases
Siede, W. H., Seiffert, U. B., Merle, S., Goll, H.-G., & Oremek, G. M. (1989) · Clinical Biochemistry · doi:10.1016/s0009-9120(89)80009-8 · Cited by 23 · see citing works
Abnormal osteocalcin binding in rheumatoid arthritis.
Fairney, A., Patel, K. C., Hollings, N., & Seifert, M. (1990) · Annals of the Rheumatic Diseases · doi:10.1136/ard.49.4.229 · Cited by 21 · see citing works
Modifications of biochemical markers of bone and collagen turnover during corticosteroid therapy
Conti, A., Sartório, A., Ferrero, S., Ferrario, S., & Ambrosi, B. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349848 · Cited by 21 · see citing works
Montecucco, C., Baldi, F., Fortina, A. B., et al. (1988) · Clinical Rheumatology · doi:10.1007/bf02239194 · Cited by 21 · see citing works
“Recent investigations have shown that the noncollagenous bone protein osteocalcin (OC), also termed bone Gla-protein, is a good marker of new bone formation so that its concentration in serum can be used to evaluate osteoblast activity in health and disease ( 5-7 ).”
BackgroundOutcome in rheumatoid arthritis.
Healey, L. A. (1993) · PubMed · Cited by 21 · see citing works
Jm, M.-M., Dequeker, J., & Gevers, G. (1988) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(88)80005-0 · Cited by 19 · see citing works
Self-citationThe search for laboratory measures of outcome in rheumatoid arthritis
Wollheim, F. A., & Eberhardt, K. (1992) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80339-5 · Cited by 16 · see citing works
Jensen, T. S., Hansen, M., Madsen, J. C., Kollerup, G., Stoltenberg, M., Florescu, A., & Schwarz, P. (2001) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510152567130 · Cited by 14 · see citing works
Osteocalcin in canine joint diseases
Arican, M., Carter, S. D., & Bennett, D. (1996) · British Veterinary Journal · doi:10.1016/s0007-1935(96)80035-2 · Cited by 14 · see citing works
Bone loss of the radius in rheumatoid arthritis Comparison between 34 patients and 40 controls
Toyoda, T., Inokuchi, S., Saito, S., et al. (1996) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679608994686 · Cited by 14 · see citing works
“Several investigators (Als et al. 1985a, Gevers et al. 1986, Rico et al. 1990, Eggelmeijer et al. 1993) have reported a similar increase in bone turnover with the high levels of ALP.”
BackgroundBone densitometry measurements in early inflammatory disease
Bhalla, A., & Shenstone, B. (1992) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80182-7 · Cited by 13 · see citing works
Magarò, M., Altomonte, L., MIRONE, L., et al. (1989) · Clinical Rheumatology · doi:10.1007/bf02032102 · Cited by 12 · see citing works
“According to other authors ( 16 ), we think that increase in serum osteocalcin levels in active RA patients is an index of accelerated bone turnover in such patients, consistent with an impairment in whole bone metabolism.”
BackgroundMarkers of bone and collagen breakdown in early inflammatory arthritis
Peel, N. F. A., Eastell, R., & Russell, R. G. G. (1992) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80179-7 · Cited by 12 · see citing works
Osteocalcin and bone mineral content in rheumatoid arthritis
Peretz, A., Praet, J. P., Rozenberg, S., Bosson, D., Famaey, J. P., & Bourdoux, P. (1989) · Clinical Rheumatology · doi:10.1007/bf02031067 · Cited by 11 · see citing works
“In contrast with some authors(17, 18 ,19), but in agreement with others (20,21), mean blood BGP levels measured in RA patients were not statistically different from those of controls.”
ResultLocomotor side-effects of corticosteroids
Geusens, P. P. M. M., & Dequeker, J. (1991) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80298-5 · Cited by 9 · see citing works
Self-citationBaja densidad mineral ósea en artritis idiopática juvenil: prevalencia y factores relacionados
Zavala, R. G., Cuadros, E. N., Pedraz, L. M., et al. (2017) · Anales de Pediatría · doi:10.1016/j.anpedi.2016.12.005 · Cited by 8 · see citing works
“Diversos trabajos han intentado esclarecer a través del estudio aumento del turnover óseo o a 9,10 resultados contradictorios .”
Low bone mineral density in juvenile idiopathic arthritis: Prevalence and related factors
Zavala, R. G., Cuadros, E. N., Pedraz, L. M., et al. (2017) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2016.12.004 · Cited by 8 · see citing works
Franck, H., Ittel, T. H., Tasch, O., et al. (1992) · Rheumatology International · doi:10.1007/bf00302154 · Cited by 7 · see citing works
“Other authors [ 20 ] have found increased OC levels in patients with RA. However, they do not give information about anatomical stages of the patient group.”
BackgroundMethodInfluentialBone Alkaline Phosphatase in Rheumatic Diseases
Beyeler, C., Banks, R. E., Thompson, D., Forbes, M. A., Cooper, E. H., & Bird, H. A. (1995) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329503200405 · Cited by 7 · see citing works
Biomarks in secondary osteoporosis
Dias, A. A., Vaz, A. L., Hargreaves, M., Afonso, C., Araújo, D. D. S., & Bravo, T. (1989) · Clinical Rheumatology · doi:10.1007/bf02207241 · Cited by 7 · see citing works
Fatahi, S., Ghaedi, E., Mousavi, S. M., Bawadi, H., Rahmani, J., Pezeshki, M., & Varkaneh, H. K. (2019) · Hormone and Metabolic Research · doi:10.1055/a-0897-844 · Cited by 6 · see citing works
“In addition, studies on populations with inflammatory diseases such as rheumatoid arthritis reported a positive association between OC and CRP levels [70].”
BackgroundMasood, A., Benabdelkamel, H., Alfadda, A. A., Al-Arfaj, A. S., Fallata, A., Joy, S. S., Mogren, M. A., Rahman, A. M. A., & Siaj, M. (2025) · Proteomes · doi:10.3390/proteomes13030032 · Cited by 5 · see citing works
“Seriolo et al. found that serum osteocalcin concentrations in patients with active RA were found to be significantly lower than those in patients with remission of RA and in healthy controls [35], while other authors found the levels to be similar to those in controls [36] or increased [37].”
Plasma and bone osteocalcin levels in rats with type ii collagen—induced arthritis
TANAKA, H. L., Shirota, H., Kuwada, M., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780311111 · Cited by 5 · see citing works
The relationship between eggshell quality and bone biology in the laying hen
Darnell-Middleton, S. L. (1999) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.30935 · Cited by 4 · see citing works
Rheumatic Disorders and Glucocorticoid-Induced Osteoporosis
Dequeker, J., Westhovens, R., & Luyten, F. P. (2002) · KARGER eBooks · doi:10.1159/000061077 · Cited by 2 · see citing works
Self-citationFranck, H., Ittel, T. H., Tasch, O., Herborn, G., & Rau, R. (1992) · Springer eBooks · doi:10.1007/978-3-642-76766-1_89 · Cited by 1 · see citing works
Suryana, B. P. P., Will, R., Annie, L. I. M., et al. (2005) · APLAR Journal of Rheumatology · doi:10.1111/j.1479-8077.2005.00130.x
36 Osteoporosis in Rheumatoid Arthritis
Dequeker, J., Westhovens, R., & Ravelingien, I. (2000)
Self-citationDeodhar, A. A. (1996) · OpenGrey (Institut de l'Information Scientifique et Technique)
The usefulness of osteocalcin measurements in Malaysian patients with rheumatoid arthritis
Wong, T. H. (2018) · International e-Journal of Science Medicine & Education · doi:10.56026/imu.12.1.4
Marhoffer, W., Stracke, H. H. G., Schmidt, K. L., et al. (1994) · Springer eBooks · doi:10.1007/978-3-642-78676-1_41
- Authors
- GEVERS, G., DEVOS, P., DE ROO, M., & DEQUEKER, J.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- DEQUEKER, J.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 25
- Issue
- 3
- Pages
- 260-262
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2172277662
- Cited by
- 68
- References
- 0
- Citations by year
- 2025: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteocalcin, rheumatoid arthritis, bone turnover, bone metabolism, alkaline phosphatase, hydroxyproline/creatinine ratio, bone formation markers
- MeSH terms
- Adult, Aged, Alkaline Phosphatase, Arthritis, Rheumatoid, Calcium-Binding Proteins, Female, Humans, Male, Middle Aged, Osteocalcin
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