The association between osteocalcin and C-reactive protein; A relation of bone with inflammation: A systematic review and meta-analysis
Abstract
Abstract A meta-analysis was performed to summarize the evidence from observational studies regarding the association between serum osteocalcin (OC) and C-reactive protein (CRP). A systemic research of the literature databases including PubMed, SCOPUS, and Google Scholar was performed to identify the relevant studies up to March 2018. We used the random-effects model by the method of DerSimonian and Laird to calculate the overall effect size. Q-test and I 2-statistics were used to assess between-study heterogeneity. In addition, we did subgroup analysis to detect possible sources of heterogeneity based on BMI range, gender, type of study population and age. We identified 21studies of association between serum osteocalcin and CRP eligible for the meta-analysis. The overall effect size showed a significant inverse association between OC and CRP (Fisher’s z=–0.127; 95% CI: –0.166, –0.088, p<0.0001). However, the significant chi-squared statistic result, indicates a heterogeneity of effect sizes (I 2=61.6, df=20, p<0.0001). The subgroup analysis found BMI range, type of study population, and age were the potential sources of heterogeneity. In addition, the strongest correlation was observed in the subgroup of obese subjects (Fisher’s z=–0.264, p=0.002), less than 40 years old (Fisher’s z=–0.115, p<0.0001) and healthy subjects (Fisher’s z=–0.115, p<0.0001). These findings suggest that there is a significant inverse association between serum OC and CRP levels in the adult population.
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Meta-analyses of clinical studies showed inverse correlations between OCN levels and BMI, insulin resistance, the inflammatory marker CRP, body fat mass, and specifically, visceral fat mass, determined with radiologic imaging studies.
“Meta-analyses of clinical studies showed inverse correlations between OCN levels and BMI [202], insulin resistance [203], the inflammatory marker CRP [204], body fat mass [205], and specifically, visceral fat mass, determined with radiologic imaging studies [206,207,208].”
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Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
- Authors
- Fatahi, S., Ghaedi, E., Mousavi, S. M., Bawadi, H., Rahmani, J., Pezeshki, M., & Varkaneh, H. K.
- Affiliations
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Qatar University (QA)
- Shahid Beheshti University (IR)
- Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2019-06
- Volume
- 51
- Issue
- 06
- Pages
- 353-361
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2949173291
- Cited by
- 6
- References
- 64
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Qatar University QSpace (Qatar University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- osteocalcin, C-reactive protein, bone, inflammation, obesity, body mass index, serum biomarkers, bone remodeling, healthy adults
- MeSH terms
- Bone Diseases, C-Reactive Protein, Humans, Inflammation, Prognosis, Biomarkers, Osteocalcin, Incidence
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