Serum osteocalcin concentrations in patients with rheumatoid arthritis.
Open accessAbstract
Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA) the serum osteocalcin concentrations and, in addition, the serum concentrations of 25-hydroxyvitamin D, parathyroid hormone, and calcitonin were measured in 29 patients with RA and in 30 control subjects. Whereas serum osteocalcin concentrations were similar in patients with RA and in control subjects, serum 25-hydroxyvitamin D concentrations were significantly decreased in patients with RA. Serum concentrations of parathyroid hormone and calcitonin in patients with RA and in control subjects were not statistically different. The normal osteocalcin concentrations in patients with RA suggest a normal rate of bone formation in these patients.
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In patients with chronic inflammatory diseases, serum levels of osteocalcin have been described as decreased, increased, or normal.
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [106]
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Cited by
Sorted by citations
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
Background
- Authors
- Pietschmann, P., Machold, K. P., Wolosczuk, W., & Smolen, J. S.
- Affiliations
- University of Vienna (AT)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 1989-08
- Volume
- 48
- Issue
- 8
- Pages
- 654-657
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC1003841
- OpenAlex
- W1986368903
- Cited by
- 28
- References
- 27
- Citations by year
- 2025: 1 · 2020: 1 · 2018: 2 · 2014: 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- osteocalcin, rheumatoid arthritis, bone formation, bone demineralization, 25-hydroxyvitamin D, parathyroid hormone, calcitonin, bone turnover markers
- MeSH terms
- Arthritis, Rheumatoid, Bone and Bones, Calcifediol, Calcitonin, Calcium-Binding Proteins, Female, Humans, Male, Middle Aged, Parathyroid Hormone, Osteocalcin
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