The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Synovial fibroblasts: key players in rheumatoid arthritis
Open accessAbstract
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. The involvement of immune cells is a general hallmark of autoimmune-related disorders. In this regard, macrophages, T cells and their respective cytokines play a pivotal role in RA. However, the notion that RA is a primarily T-cell-dependent disease has been strongly challenged during recent years. Rather, it has been understood that resident, fibroblast-like cells contribute significantly to the perpetuation of disease, and that they may even play a role in its initiation. These rheumatoid arthritis synovial fibroblasts (RASFs) constitute a quite unique cell type that distinguishes RA from other inflammatory conditions of the joints. A number of studies have demonstrated that RASFs show alterations in morphology and behaviour, including molecular changes in signalling cascades, apoptosis responses and in the expression of adhesion molecules as well as matrix-degrading enzymes. These changes appear to reflect a stable activation of RASFs, which occurs independently of continuous exogenous stimulation. As a consequence, RASFs are no longer considered passive bystanders but active players in the complex intercellular network of RA.
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1 retracted
Lakka, S. S., Gondi, C. S., Yanamandra, N., Olivero, W. C., Dinh, D. H., Gujrati, M., & Rao, J. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207616 · Cited by 291
RetractedEfficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,514
Maini, R., St Clair, E. W., Breedveld, F., Furst, D., Kalden, J., Weisman, M., Smolen, J., Emery, P., Harriman, G., Feldmann, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)05246-0 · Cited by 2,345
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,660
Kremer, J. M., Westhovens, R., Leon, M., Di Giorgio, E., Alten, R., Steinfeld, S., Russell, A., Dougados, M., Emery, P., Nuamah, I. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035075 · Cited by 1,058
Epidemiology and genetics of rheumatoid arthritis.
Silman, A. J., & Pearson, J. E. (2002) · Arthritis Research · doi:10.1186/ar578 · Cited by 985
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Müller‐Ladner, U., Kriegsmann, J., Franklin, B. N., Matsumoto, S., Geiler, T., Gay, R. E., & Gay, S. (1996) · Europe PMC (PubMed Central) · Cited by 606
Self-citationChoy, E. H. S., Isenberg, D. A., Garrood, T., Farrow, S., Ioannou, Y., Bird, H., Cheung, N., Williams, B., Hazleman, B., Price, R., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10623 · Cited by 526
Cited by
Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 494
McGonagle, D., Lories, R. J. U., Tan, A. L., & Benjamin, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22758 · Cited by 398
Smoking and Rheumatoid Arthritis
Chang, K., Yang, S., Kim, S., Han, K., Park, S., & Shin, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151222279 · Cited by 337
Crum, R. J., Hall, K., Molina, C. P., Hussey, G. S., Graham, E., Li, H., & Badylak, S. F. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00208-9 · Cited by 50
Metadata
- Authors
- Huber, L. C., Distler, O., Tarner, I., Gay, R. E., Gay, S., & Pap, T.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-27
- Volume
- 45
- Issue
- 6
- Pages
- 669-675
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2025851689
- Cited by
- 607
- References
- 83
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huber, L. C., Distler, O., Tarner, I., Gay, R. E., Gay, S., & Pap, T. (2006). Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology. https://doi.org/10.1093/rheumatology/kel065
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
