The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Amygdala–frontal connectivity during emotion regulation
Open accessAbstract
Successful control of affect partly depends on the capacity to modulate negative emotional responses through the use of cognitive strategies (i.e., reappraisal). Recent studies suggest the involvement of frontal cortical regions in the modulation of amygdala reactivity and the mediation of effective emotion regulation. However, within-subject inter-regional connectivity between amygdala and prefrontal cortex in the context of affect regulation is unknown. Here, using psychophysiological interaction analyses of functional magnetic resonance imaging data, we show that activity in specific areas of the frontal cortex (dorsolateral, dorsal medial, anterior cingulate, orbital) covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task. Moreover, strength of amygdala coupling with orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal. These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.
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“Further, greater dmPFC activation and connectivity with the amygdala corresponded to reappraisal success in both healthy individuals (Banks, Eddy, Angstadt, Nathan, & Phan, 2007; Wager, Davidson, Hughes, Lindquist, & Ochsner, 2008) and patients with social anxiety disorder (Goldin et al., 2009).”
From Changes in functional connectivity with cognitive behavioral therapy for social anxiety disorder predict outcomes at follow-up (2020) · cites this paper as Banks, Eddy, Angstadt, Nathan, & Phan, 2007
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Alcohol disrupts functional connectivity between the amygdala and prefrontal areas—including the dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), ventrolateral PFC (VLPFC), and anterior cingulate cortex (ACC)—regions critical for emotion regulation, behavioral inhibition, and social cognition (Harenski And Hamann 2006; Banks et al. 2007; Goldin et al. 2008; Prater et al. 2013).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Banks et al. 2007
Experimental — accuracy not yet measuredIn the citing paper
“neuroimaging studies in humans show an inverse relationship between the amygdala and multiple PFC regions including vmPFC,45,46 vlPFC,32,47,48 dmPFC,23,34,49–54 and dlPFC.25,34”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [48]
In the citing paper
“Reciprocal connections between the BLA and mPFC are important for fear extinction, fear discrimination, and other processes requiring the resolution of conflicting information (47–50), and dendritic hypotrophy in mPFC neurons has been linked to stress and alcohol-related deficits in fear extinction (51,52).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [48]
In the citing paper
“specifically prefrontal down-regulation of amygdala activity has been associated with the attenuation of negative affect during emotion regulation (Banks et al., 2007).”
From Positive parenting predicts the development of adolescent brain structure: a longitudinal study (2014) · cites this paper as Banks et al., 2007
In the citing paper
“There is also evidence that the interaction between prefrontal structures and the amygdala is critical to emotion regulation”
From Positive parenting predicts the development of adolescent brain structure: a longitudinal study (2014) · cites this paper as Banks et al., 2007
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Citations
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · cited 1×
“This is broadly consistent with the role of these regions in cognitive inhibition/control and executive function (Cabeza and Nyberg, 2000; Miller and Cohen, 2001), processes that are relevant to reappraisal-based affect regulation.”
BackgroundLazarus, R. S. (1991) · doi:10.1093/oso/9780195069945.001.0001 · Cited by 12,691
Gross, J. J., & John, O. P. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.85.2.348 · Cited by 11,929
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Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · cited 4×
“Based on our experimental design (i.e., involving negatively valenced images) and to perform unbiased contrast analysis, we first performed a conjunction analysis with SPM2 (Price and Friston, 1997; Friston et al., 1999; Nichols et al., 2005) to identify amygdala activation that was present across both Maintain and Re…”
MethodInfluentialCognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · cited 1×
“For example, the ACC, VLPFC and DLPFC have been found to activate to response inhibition during the cognitive-emotion interference tasks (Whalen et al., 1998; Bush et al., 2000; Etkin et al., 2006).”
Emotion regulation: affective, cognitive, and social consequences.
Gross, J. J. (2002) · Psychophysiology · doi:10.1017/s0048577201393198 · Cited by 4,890
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583 · cited 1×
“…future studies driven by these findings and anatomical studies would develop an a priori mechanistic neural network model of how prefrontal cortex influences amygdala, and vice versa and pursue effective connectivity analyses in order to infer causal relationships (Friston et al., 2003).”
BackgroundThe cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · cited 7×
“Taken together, the data from animal and human studies point to a specific amygdala–frontal circuit of emotion generation and regulation (Davidson et al., 2000; Phan et al., 2002; Phillips et al., 2003a; Ochsner and Gross, 2005; Quirk and Beer, 2006).”
BackgroundMethodInfluentialImaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598 · cited 2×
“This is broadly consistent with the role of these regions in cognitive inhibition/control and executive function (Cabeza and Nyberg, 2000; Miller and Cohen, 2001), processes that are relevant to reappraisal-based affect regulation.”
Background
Research works printed but not linked: 2
- 10.1080/026999399379186 · DOI
- 10.1016/S0006-3223(02)01817-6 · DOI · Paper page
Cited by
Sorted by citations
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024
“When individuals regulate their emotions, the amygdala is thought to be down-regulated by the vmPFC and hippocampus (Banks et al., 2007; Davidson et al., 2000; Milad, Rauch, Pitman, & Quirk, 2006), both of which have extensive connections with the amygdala.”
The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889
Webb, T. L., Miles, E., & Sheeran, P. (2012) · Psychological Bulletin · doi:10.1037/a0027600 · Cited by 2,006
“…1 Anger R3 C1 39 42 0.74 0.66 Ayduk et al. (2002) 1 Negative affect R3 Cont1 88 100 0.44 Ayduk et al. (2002) 1 Negative affect C1 Cont1 85 100 0.02 Banks et al. (2007) 1 Negative affect R2 Cont5 14 1.83 Bates (2007) 1 Negative affect S4 Cont1 19 20 0.16 Bates (2007) 1 Negative affect D2 Cont1 19…”
InfluentialThe Evolution of the Cognitive Model of Depression and Its Neurobiological Correlates
Beck, A. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08050721 · Cited by 1,537
“Banks and colleagues (58) found that the reduced amygdala coupling with the orbitofrontal cortex and the dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal.”
BackgroundPhillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383
Metadata
- Authors
- Banks, S. J., Eddy, K. T., Angstadt, M., Nathan, P. J., & Phan, K. L.
- Affiliations
- University of Chicago (US)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07-21
- Volume
- 2
- Issue
- 4
- Pages
- 303-312
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC2566753
- OpenAlex
- W2146828510
- Cited by
- 1,187
- References
- 92
- Citations by year
- 2026: 39 · 2025: 61 · 2024: 44 · 2023: 57 · 2022: 69 · 2021: 100 · 2020: 92 · 2019: 104 · 2018: 87 · 2017: 78 · 2016: 98 · 2015: 75 · 2014: 76 · 2013: 49 · 2012: 44
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH076198, K23MH076198)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- amygdala, prefrontal cortex, emotion regulation, cognitive reappraisal, orbitofrontal cortex, dorsomedial prefrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex, negative affect, amygdala reactivity
- MeSH terms
- Adult, Affect, Amygdala, Facial Expression, Female, Frontal Lobe, Humans, Male, Nerve Net, Expressed Emotion, Young Adult
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