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Elevated amygdala response to faces and gaze aversion in autism spectrum disorder
Open accessAbstract
Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an experimental eye-gaze manipulation on amygdala responses to faces. Individuals with ASD showed less gaze toward the eye region of faces relative to a control group. Among individuals with ASD, reduced eye gaze was associated with higher threat ratings of neutral faces. Amygdala signal was elevated in the ASD group relative to controls. This elevated response was further potentiated by experimentally manipulating gaze to the eye region. Potentiation by the gaze manipulation was largest for those individuals who exhibited the least amount of naturally occurring gaze toward the eye region and was associated with their subjective threat ratings. Effects were largest for neutral faces, highlighting the importance of examining neutral faces in the pathophysiology of autism and questioning their use as control stimuli with this population. Overall, our findings provide support for the notion that gaze direction modulates affective response to faces in ASD.
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“In humans, alterations in amygdala responses to positive and negative emotions have been reported in neuropsychiatric conditions, such as autism and schizophrenia [72,73], in association with OXTR genetic variants [41,102] or following intranasal OXT [33,36,38,103].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [72]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
(1970) · Cited by 24,983
Asymptotic Confidence Intervals for Indirect Effects in Structural Equation Models
Sobel, M. E. (1982) · Sociological Methodology · doi:10.2307/270723 · Cited by 12,810
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005653411471 · Cited by 6,450
Wechsler Abbreviated Scale of Intelligence
Dumont, R., Willis, J. O., Veizel, K., & Zibulsky, J. (2014) · Wiley eBooks · doi:10.1002/9781118660584.ese2519 · Cited by 5,546
Wechsler Abbreviated Scale of Intelligence
Wechsler, D. (1999) · PsycTESTS Dataset · doi:10.1037/t15170-000 · Cited by 4,681
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Items 101–144 of 144
The Strengths of Speech Divergence in Autistic People: Implications for Assessment and Support
Kapp, S. K., & Gudknecht, J. (2025) · Infant and Child Development · doi:10.1002/icd.70017 · Cited by 5
Impairment in reading negative social cues extends beyond the face in autism
Lott-Sandkamp, L. L., Spengler, F. B., & Heinrichs, M. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.06.032 · Cited by 7
Ibrahim, K., Iturmendi-Sabater, I., Vasishth, M., Barron, D. S., Guardavaccaro, M., Funaro, M. C., Holmes, A. J., McCarthy, G., Eickhoff, S. B., & Sukhodolsky, D. G. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2023.12.003 · Cited by 5
“Please Draw Me a Face…” Atypical Face Mental Concept in Autism
Meaux, E., Bakhos, D., Bonnet‐Brilhault, F., Gillet, P., Lescanne, E., Barthélémy, C., & Batty, M. (2014) · Psychology · doi:10.4236/psych.2014.511150 · Cited by 5
The Relationship Between Sensory Processing and Emotional Regulation : A Literature Review
작업치료과, 신., Hong, E., & Hong, S.-Y. (2016) · Journal of Korean Society of Sensory Integration Therapists · doi:10.18064/jkasi.2016.14.1.050 · Cited by 3
Khalulyan, A., Byrd, K. S., Tarbox, J., Little, A., & Moll, H. (2020) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2020.106075 · Cited by 3
Pupil contagion variation with gaze, arousal, and autistic traits
Galazka, M. A., Thorsson, M., Kleberg, J. L., Hadjikhani, N. K., & Johnels, J. Å. (2024) · Scientific Reports · doi:10.1038/s41598-024-68670-7 · Cited by 4
Young, L. R., Yu, W., Holloway, M., Rodgers, B. N., Chapman, S. B., & Krawczyk, D. C. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.08.026 · Cited by 4
Glaser, B. (2018) · Archives of Psychology · doi:10.31296/aop.v2i8.75 · Cited by 4
Understanding face processing in autism spectrum disorder: insights from cognitive neuroscience
Zhang, L., Guan, X., Wang, D., Wang, J., Liu, X., Liu, S., & Ming, D. (2025) · Cognitive Neurodynamics · doi:10.1007/s11571-025-10321-2 · Cited by 2
Adrenarche, social cognition, and the development and evolution of autism spectrum traits
Szakal, C., & Crespi, B. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1576392 · Cited by 2
Speranza, B. E., Do, M., Hill, A. T., Donaldson, P. H., Enticott, P. G., & Kirkovski, M. (2025) · BMC Psychology · doi:10.1186/s40359-024-02218-2 · Cited by 2
Neuropsychologie et remédiations des troubles du spectre de l’autisme
Kovarski, K., Meaux, E., & Batty, M. (2018) · De Boeck Supérieur eBooks · doi:10.3917/dbu.breti.2018.01.0137 · Cited by 2
The Strengths of Speech Delay: Getting a Grip on the Sensory-Motor Complexity of AutismPreprint
Kapp, S. K. (2023) · doi:10.22541/au.168428686.66533786/v1 · Cited by 2
Zimmermann, J. T., Ellison, T. M., Cangemi, F., Wehrle, S., Vogeley, K. T., & Grice, M. (2024) · Frontiers in Communication · doi:10.3389/fcomm.2024.1483135 · Cited by 1
The Specificity of Faces Processing in Children with Autism: Evidences from Eye Movement Study
刘, 妮. (2024) · Advances in Psychology · doi:10.12677/ap.2024.144234 · Cited by 1
DeStefani, S., Blain, S. D., Kraft, J. D., Locarno, L. R., Mathis, K., Lasagna, C. A., Colombi, C., Burton, C. Z., Turner, J. A., Thakkar, K. N., et al. (2026) · Research in Autism · doi:10.1016/j.reia.2026.202821 · Cited by 1
ICT Individualized Education Support System for Supporting Children with Developmental Disabilities
Ogoshi, Y., & Ogoshi, S. (2022) · Denshi Jouhou Tsuushin Gakkai Tsuushin Sosaieti magajin/B-plus/Denshi Jouhou Tsuushin Gakkai Tsuushin Sosaeti magajin · doi:10.1587/bplus.16.197 · Cited by 1
Torres‐Marín, J., Vizcaíno-Cuenca, R., & Carretero‐Dios, H. (2023) · Humor - International Journal of Humor Research · doi:10.1515/humor-2020-0058 · Cited by 1
Neural Mechanisms of Emotional Dysregulation
Ibrahim, K., McCarthy, G., & Sukhodolsky, D. G. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_102453 · Cited by 1
Ibrahim, K., Iturmendi-Sabater, I., Vasishth, M., Barron, D. S., Guardavaccaro, M., Funaro, M. C., Holmes, A. J., McCarthy, G., Eickhoff, S. B., & Sukhodolsky, D. G. (2022) · Research Square · doi:10.21203/rs.3.rs-2297758/v1 · Cited by 1
Speranza, B. E., Do, M., Hill, A. T., Donaldson, P. H., Enticott, P. G., & Kirkovski, M. (2024) · doi:10.31219/osf.io/8dxhs · Cited by 1
Sargent, K. (2022) · Digital Archive @ GSU · doi:10.57709/7282109
Murphy, E. R. (2013) · DigitalGeorgetown (Georgetown University Library)
Maddox, B. B. (2014) · VTechWorks (Virginia Tech)
Mechanisms of impairments in visual social attention in autism spectrum disorders
Hou, W., Li, J., Li, T., & Zhu, L. (2018) · Scientia Sinica Vitae · doi:10.1360/n052018-00151
Attention bias toward threatening emotional faces in individuals with high-functioning autism
Xiaozhuang, F. A. N., Xiaobin, B. I., Yu, X. I. E., & He, H. (2020) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2020.01172
An Exploratory Model for Face Recognition Problem in Autism: An Artificial Neural Network Approach
Nofallah, S., Bakouie, F., Memari, A. H., & Gharibzadeh, S. (2019) · Journal of Neurodevelopmental Cognition · doi:10.29252/jncog.1.2.42
Neural Mechanisms of Emotional Dysregulation
Ibrahim, K., McCarthy, G., & Sukhodolsky, D. G. (2019) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_102453-1
Face Processing in Autism: Active Avoidance of the Eyes Versus Passive Indifference
Tanaka, J. W., Dwyer, P. S. R., & Kyotani, H. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_102199
Face Processing in Autism: Active Avoidance of the Eyes Versus Passive Indifference
Tanaka, J. W., Dwyer, P. S. R., & Kyotani, H. (2017) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_102199-1
Altered interpersonal distance regulation in autism spectrum disorder
Farkas, K., Pesthy, O., Guttengéber, A., Weigl, A. S., Veres, A., Székely, A., Komoróczy, E., Szuromi, B., Janacsek, K., Réthelyi, J., et al. (2022) · European Psychiatry · doi:10.1192/j.eurpsy.2022.1892
Jung, S., & Lee, S. (2022) · Drug Targets and Therapeutics · doi:10.58502/dtt.22.008
An Exploratory Model for Face Recognition Problem in Autism: An Artificial Neural Network Approach
Nofallah, S., Bakouie, F., Memari, A. H., & Gharibzadeh, S. (2022) · Journal of Neurodevelopmental Cognition · doi:10.52547/jncog.2022.103439
Binocular rivalry in autistic and socially anxious adults
Kamhout, S., Olivier, J. M., Morris, J., Brimhall, H. R., Black, B. L., Gabrielsen, T. P., South, M., Lundwall, R. A., & Nielsen, J. A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1181797 · Cited by 1
Understanding the Neurobiological Components of Neurodevelopmental Disorders
Thompson, B. L. (2024) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-66932-3_6
TECHNIKA OKULOGRAFII W DIAGNOZIE I TERAPII DZIECI Z ZABURZENIAMI ZE SPEKTRUM AUTYZMU
Młynarczyk-Karabin, E. (2025) · Special School · doi:10.71358/ss.2376
Autistic traits modulate neural responses to social signals during natural vision
Ye, Q., Chen, J., Santavirta, S., Putkinen, V., Salmi, J., & Nummenmaa, L. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.122121
Nakamura, M., Sato, T., Kurotani, T., Sakai, K., Hadjiev, A. M., Sasai, S., Mimura, K., Kawai, N., Shimmura, T., & Ichinohe, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.17.688777
Javitt, D. C., Martı́nez, A., Sehatpour, P., Butler, P. D., Dias, E., Micceri, K., Breland, M. M., & Tobe, R. H. (2026) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2026.1771087
Yates, J. R. (2026) · Springer eBooks · doi:10.1007/978-3-032-15602-0_15
Gürcan, E., Watson, S., & Rutherford, M. D. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106768
Metadata
- Authors
- Tottenham, N., Hertzig, M. E., Gillespie-Lynch, K., Gilhooly, T., Millner, A. J., & Casey, B. J.
- Affiliations
- University of California, Los Angeles (US)
- St. John's University (US)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-16
- Volume
- 9
- Issue
- 1
- Pages
- 106-117
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC3871735
- OpenAlex
- W2133553417
- Cited by
- 144
- References
- 98
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 16 · 2021: 11 · 2020: 9 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 10 · 2013: 3
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- autism spectrum disorder, amygdala, face perception, gaze aversion, gaze, neutral faces, threat detection, gaze direction, social cognition
- MeSH terms
- Adolescent, Adult, Amygdala, Attention Deficit Disorder with Hyperactivity, Child, Child Development Disorders, Pervasive, Escape Reaction, Face, Facial Expression, Female, Fixation, Ocular, Humans, Image Processing, Computer-Assisted, Male, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Young Adult
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