Oculomotor and pupillometric indices of pro- and antisaccade performance in youth-onset psychosis and attention deficit/hyperactivity disorder
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The goals of the study were to examine inhibitory deficits on the antisaccade task in 8- to 20-year olds with youth-onset psychosis or attention deficit/hyperactivity disorder (ADHD) and healthy controls and to examine if age-related changes in performance differed across groups. In addition to the conventional measures of performance, pupillary dilations were used to obtain estimates of phasic and tonic level of arousal. Results showed that the psychosis, but not the ADHD, group had elevated antisaccade error rates; however, variability of error rates was high in all groups. These inhibitory failures were accompanied by a lower level of momentary cognitive effort (as indexed by pupillary dilations). The largest differences between the control and clinical groups were found not in the expected indices of inhibition but in the probability of correcting inhibitory errors and in variability of antisaccade response times, which were correlated with each other. These findings did not appear to be attributable to a deficit in maintaining task instructions in mind in either disorder or lack of motivation in ADHD. Instead, results point to impairments in both clinical groups in sustaining attention on a trial-by-trial basis, resulting in deficits in self-monitoring. Thus, results show inhibitory deficits in the context of more general attentional impairments in both disorders.
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Karatekin et al. (2010) found that pupillary responses (i.e., pupil dilations to visual stimuli) were equivalent in children and adolescents with ADHD during a pro-and anti-saccade task compared to typically developing controls.
“In the other study (Karatekin et al., 2010), pupillary responses (i.e., pupil dilations to visual stimuli) were equivalent in children and adolescents with ADHD, during a pro-and anti-saccade task, compared to typically developing controls.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Karatekin et al., 2010
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Towards ADHD Identification in Children Through Eye Tracker Data Analysis
Le, N. T., Huynh, N. L. V., Phan, H. K., Le, C. D., & Tran, T. T. (2025) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-90194-2_22
- Authors
- Karatekin, C., Bingham, C., & White, T.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Karatekin, C.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-08
- Volume
- 36
- Issue
- 6
- Pages
- 1167-1186
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2963044
- OpenAlex
- W2147751145
- Cited by
- 47
- References
- 125
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08mh068540-05)
- National Institute of Mental Health (R03MH063150, K08-MH068540)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- antisaccade task
- MeSH terms
- Adolescent, Arousal, Attention Deficit Disorder with Hyperactivity, Child, Eye Movements, Female, Humans, Inhibition, Psychological, Male, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Psychotic Disorders, Pupil, Reaction Time, Reflex, Pupillary, Young Adult
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