The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies
Open accessAbstract
Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of onset in late adolescence. Late adolescence may reflect a critical period in brain development making it particularly vulnerable for the onset of psychopathology. Neuroimaging studies that focus on this age range may provide unique insights into the onset and course of psychosis. In this review, we examine the evidence from 2 unique longitudinal cohorts that span the ages from early childhood through young adulthood; a study of childhood-onset schizophrenia where patients and siblings are followed from ages 6 through to their early twenties, and an ultra-high risk study where subjects (mean age of 19 years) are studied before and after the onset of psychosis. From the available evidence, we make an argument that subtle, regionally specific, and genetically influenced alterations during developmental age windows influence the course of psychosis and the resultant brain phenotype. The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed.
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Cites
Dynamic mapping of human cortical development during childhood through early adulthood
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BackgroundSelf-citationBrain development during childhood and adolescence: a longitudinal MRI study
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Why do many psychiatric disorders emerge during adolescence?
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Self-citationNeurodevelopmental Trajectories of the Human Cerebral Cortex
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Cited by
Imaging structural co-variance between human brain regions
Alexander-Bloch, A., Giedd, J. N., & Bullmore, E. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3465 · Cited by 1,064
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Self-citationA review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis
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Self-citationBrain development and aging: Overlapping and unique patterns of change
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Metadata
- Authors
- Gogtay, N., Vyas, N. S., Testa, R., Wood, S. J., & Pantelis, C.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-19
- Volume
- 37
- Issue
- 3
- Pages
- 504-513
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2100371827
- Cited by
- 344
- References
- 137
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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