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Cited by 284Schizophrenia research and treatmentVisual perception and processing mechanismsHallucinations in medical conditions

Perceptual Organization Impairment in Schizophrenia and Associated Brain Mechanisms: Review of Research from 2005 to 2010

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Silverstein, S. M., Keane, B. P.·2011·Schizophrenia Bulletin
DOI 10.1093/schbul/sbr052PMC PMC3122298
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Abstract

Perceptual organization (PO) refers to the processes by which visual information is structured into coherent patterns such as groups, contours, perceptual wholes, and object representations. Impairments in PO have been demonstrated in schizophrenia since the 1960s and have been linked to several illness-related factors including poor premorbid functioning, poor prognosis, and disorganized symptoms. This literature was last reviewed in 2005. Since then, electrophysiological (electroencephalographic, event-related potential, and magnetoencephalographic) and fMRI studies in both patient and nonpatient samples have clarified brain mechanisms involved in the impairment, and additional behavioral studies in patients and nonpatients have clarified the computational mechanisms. In addition, data now exist on the functional consequences of PO impairments, in terms of secondary difficulties in face processing, selective attention, working memory, and social cognition. Preliminary data on drug effects on PO and on changes in response to treatment suggest that anomalies in PO may furnish a biomarker for the integrity of its associated biological mechanisms. All of this recent evidence allows for a clearer picture of the nature of the impairment and how it relates to broader aspects of brain and behavioral functioning in schizophrenia.

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  • The loss of precise top-down (empirical) priors can also be invoked to explain a resistance to illusions that depend upon prior beliefs.

    “The loss of precise top-down (empirical) priors can also be invoked to explain a resistance to illusions (Silverstein and Keane, 2011) that depend upon prior beliefs.”

    From The Computational Anatomy of Psychosis (2013) · cites this paper as Silverstein and Keane, 2011

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  1. Uhlhaas PJ, Silverstein SM. Perceptual organization in schizophrenia spectrum disorders: empirical research and the- oretical implications. Psychol Bull. 2005;131:618-632.
  2. Matussek P. Studies in delusional perception. Translated and condensed. In: Cutting J, Shepherd M, eds. Clinical Roots of the Schizophrenia Concept. Translations of Seminal European Contributions on Schizophrenia. Cambridge, UK: Cambridge University Press; 1987.
  3. Watt RJ, Phillips WA. The function of dynamic grouping in vision. Trends Cogn Sci. 2000;4:447-454.
  4. Phillips WA, Singer W. In search of common foundations for cortical computation. Behav Brain Sci. 1997;20:657-683 dis- cussion 83-722.
  5. Schenkel LS, Spaulding WD, Silverstein SM. Poor premorbid social functioning and theory of mind deficit in schizophre- nia: evidence of reduced context processing? J Psychiatr Res. 2005;39:499-508.
  6. Uhlhaas PJ, Phillips WA, Schenkel LS, Silverstein SM. The- ory of mind and perceptual context-processing in schizophre- nia. Cogn Neuropsychiatry. 2006;11:416-436.
  7. Uhlhaas PJ, Phillips WA, Mitchell G, Silverstein SM. Percep- tual grouping in disorganized schizophrenia. Psychiatry Res. 2006;145:105-117.
  8. Uhlhaas PJ, Phillips WA, Silverstein SM. The course and clinical correlates of dysfunctions in visual perceptual organi- zation in schizophrenia during the remission of psychotic symptoms. Schizophr Res. 2005;75:183-192.
  9. Silverstein SM, Hatashita-Wong M, Schenkel LS, et al. Re- duced top-down influences in contour detection in schizo- phrenia. Cogn Neuropsychiatry. 2006;11:112-132.
  10. Silverstein SM, Berten S, Essex B, Kovacs I, Susmaras T, Little DM. An fMRI examination of visual integration in schizophrenia. J Integr Neurosci. 2009;8:175-202.
  11. Sehatpour P, Dias EC, Butler PD, et al. Impaired visual ob- ject processing across an occipital-frontal-hippocampal brain network in schizophrenia: an integrated neuroimaging study. Arch Gen Psychiatry. 2010;67:772-782.
  12. Silverstein SM, Bakshi S, Nuernberger S, Carpinello K, Wilkniss S. Effects of stimulus structure and target-dis- tracter similarity on the development of visual memory rep- resentations in schizophrenia. Cogn Neuropsychiatry. 2005; 10:215-229.
  13. Silverstein SM, All SD, Kasi R, et al. Increased fusiform area activation in schizophrenia during processing of spatial fre- quency-degraded faces, as revealed by fMRI. Psychol Med. 2010;40:1159-1169.
  14. Joshua N, Rossell S. Configural face processing in schizo- phrenia. Schizophr Res. 2009;112:99-103.
  15. Shin YW, Na MH, Ha TH, Kang DH, Yoo SY, Kwon JS. Dysfunction in configural face processing in patients with schizophrenia. Schizophr Bull. 2008;34:538-543.
  16. Kim HS, Shin NY, Choi JS, et al. Processing of facial config- uration in individuals at ultra-high risk for schizophrenia. Schizophr Res. 2010;118:81-87.
  17. Tschacher W, Dubouloz P, Meier R, Junghan U. Altered per- ception of apparent motion in schizophrenia spectrum disor- der. Psychiatry Res. 2008;159:290-299.
  18. Kim J, Doop ML, Blake R, Park S. Impaired visual recogni- tion of biological motion in schizophrenia. Schizophr Res. 2005;77:299-307.
  19. Chen Y, Bidwell LC, Holzman PS. Visual motion integra- tion in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder. Schizophr Res. 2005; 74:271-281.
  20. Cocchi L, Schenk F, Volken H, Bovet P, Parnas J, Vianin P. Visuo-spatial processing in a dynamic and a static working memory paradigm in schizophrenia. Psychiatry Res. 2007; 152:129-142.
  21. van Assche M, Giersch A. Visual organization processes in schizophrenia. Schizophr Bull. 2011;37:394-404.
  22. Keri S, Kelemen O, Benedek G. Attentional modulation of perceptual organisation in schizophrenia. Cogn Neuropsychi- atry. 2009;14:77-86.
  23. Keri S, Kiss I, Kelemen O, Benedek G, Janka Z. Anomalous visual experiences, negative symptoms, perceptual organization and the magnocellular pathway in schizophrenia: a shared con- struct? Psychol Med. 2005;35:1445-1455.
  24. Elahipanah A, Christensen BK, Reingold EM. Visual selec- tive attention among persons with schizophrenia: the distrac- tor ratio effect. Schizophr Res. 2008;105:61-67.
  25. Knight RA, Silverstein SM. The role of cognitive psychology in guiding research on cognitive deficits in schizophrenia. In: Lenzenweger M, Dworkin RH, eds. Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. Washington, DC: APA Press; 1998:247-295.
  26. Silverstein SM, Berten S, Essex B, All SD, Kasi R, Little DM. Perceptual organization and visual search processes during target detection task performance in schizophrenia, as revealed by fMRI. Neuropsychologia. 2010;48:2886-2893.
  27. Beck DM, Palmer SE. Top-down influences on perceptual grouping. J Exp Psychol Hum Percept Perform. 2002;28: 1071-1084.
  28. Giersch A, Rhein V. Lack of flexibility in visual grouping in patients with schizophrenia. J Abnorm Psychol. 2008;117: 132-142.
  29. Horton HK, Silverstein SM. Visual context processing defi- cits in schizophrenia: effects of deafness and disorganization. Schizophr Bull. 2011;37:716-726.
  30. Kourtzi Z, Tolias AS, Altmann CF, Augath M, Logothetis NK. Integration of local features into global shapes: monkey and human FMRI studies. Neuron. 2003;37:333-346.
  31. Longevialle-Henin R, Bourdel MC, Willard D, et al. [Visuo- spatial context processing in untreated schizophrenic patients and relation to disorganization syndrome]. Encephale. 2005;31:323-329.
  32. Silverstein S, Uhlhaas PJ, Essex B, Halpin S, Schall U, Carr V. Perceptual organization in first episode schizophrenia and ultra-high-risk states. Schizophr Res. 2006;83:41-52.
  33. Uhlhaas PJ, Millard I, Muetzelfeldt L, Curran HV, Morgan CJ. Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later. J Psychopharmacol. 2007;21:347-352.
  34. Phillips WA, Silverstein SM. Convergence of biological and psychological perspectives on cognitive coordination in schizo- phrenia. Behav Brain Sci. 2003;26:65-82 discussion 82-137.
  35. Connor CE, Brincat SL, Pasupathy A. Transformation of shape information in the ventral pathway. Curr Opin Neuro- biol. 2007;17:140-147.
  36. Caplovitz GP, Barroso DJ, Hsieh PJ, Tse PU. fMRI reveals that non-local processing in ventral retinotopic cortex under- lies perceptual grouping by temporal synchrony. Hum Brain Mapp. 2008;29:651-661.
  37. Silverstein SM. Failures of dynamic coordination in disease states, and their implications for normal brain function. In: Singer W, von der Malsburg C, Phillips WA, eds. Dynamic Coordination in the Brain: From Molecules to Mind: Ernst Strungmann Forum Report #5. Cambridge, MA: MIT Press; 2010:245-265.
  38. Mitelman SA, Buchsbaum MS. Very poor outcome schizo- phrenia: clinical and neuroimaging aspects. Int Rev Psychia- try. 2007;19:345-357.
  39. McMains SA, Kastner S. Defining the units of competition: influences of perceptual organization on competitive interac- tions in human visual cortex. J Cogn Neurosci. 2010; 22:2417-2426.
  40. Foxe JJ, Murray MM, Javitt DC. Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investiga- tion of illusory contour processing. Cereb Cortex. 2005;15:1914- 1927.
  41. Johnson SC, Lowery N, Kohler C, Turetsky BI. Global- local visual processing in schizophrenia: evidence for an early visual processing deficit. Biol Psychiatry. 2005;58:937- 946.
  42. Uhlhaas PJ, Linden DE, Singer W, et al. Dysfunctional long- range coordination of neural activity during Gestalt percep- tion in schizophrenia. J Neurosci. 2006;26:8168-8175.
  43. Turetsky BI, Kohler CG, Indersmitten T, Bhati MT, Charbonnier D, Gur RC. Facial emotion recognition in schizophrenia: when and why does it go awry? Schizophr Res. 2007;94:253-263.
  44. Talamini LM, de Haan L, Nieman DH, Linszen DH, Meeter M. Reduced context effects on retrieval in first-episode schizophrenia. PLoS One. 2010;5:e10356.
  45. Dakin S, Frith U. Vagaries of visual perception in autism. Neuron. 2005;48:497-507.

Cited by

Sorted by citations

Authors
Silverstein, S. M., & Keane, B. P.
Affiliations
  • University of Medicine and Dentistry of New Jersey (US)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Silverstein, S. M.
ORCID
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
2011-06-22
Volume
37
Issue
4
Pages
690-699
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/sbr052
PMC
PMC3122298
OpenAlex
W2131918913
Cited by
284
References
7
Citations by year
2026: 16 · 2025: 9 · 2024: 11 · 2023: 15 · 2022: 15 · 2021: 16 · 2020: 18 · 2019: 19 · 2018: 23 · 2017: 22 · 2016: 14 · 2015: 35 · 2014: 17 · 2013: 38 · 2012: 12
FWCI
2.93
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
perceptual organization, schizophrenia
MeSH terms
Brain, Brain Mapping, Cognition Disorders, Discrimination Learning, Electroencephalography, Evoked Potentials, Form Perception, Humans, Judgment, Magnetic Resonance Imaging, Models, Theoretical, Neuropsychological Tests, Optical Illusions, Pattern Recognition, Visual, Perceptual Disorders, Prognosis, Recruitment, Neurophysiological, Schizophrenia, Schizophrenic Psychology, Visual Perception, Magnetoencephalography

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