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Circadian and Wake-Dependent Influences on Subjective Sleepiness, Cognitive Throughput, and Reaction Time Performance in Older and Young Adults
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STUDY OBJECTIVES: To assess circadian and homeostatic influences on subjective sleepiness and cognitive performance in older adults when sleep and waking are scheduled at different times of day; to assess changes in subjective sleepiness and cognitive performance across several weeks of an inpatient study; and to compare these findings with results from younger adults. DESIGN: Three 24-h baseline days consisting of 16 h of wakefulness and an 8-h sleep opportunity followed by 3-beat cycles of a 20-h forced desynchrony (FD) condition; 18 20-h "days," each consisting of 13.33 h of scheduled wakefulness and 6.67 h of scheduled sleep opportunity. SETTING: Intensive Physiological Monitoring Unit of the Brigham and Women's Hospital General Clinical Research Center. PARTICIPANTS: 10 healthy older adults (age 64.00 +/- 5.98 y, 5 females) and 10 healthy younger adults (age 24.50 +/- 3.54 y, 5 females). INTERVENTIONS: Wake episodes during FD scheduled to begin 4 h earlier each day allowing for data collection at a full range of circadian phases. MEASUREMENTS AND RESULTS: Subjective sleepiness, cognitive throughput, and psychomotor vigilance assessed every 2 h throughout the study. Core body temperature (CBT) data collected throughout to assess circadian phase. Older subjects were less sleepy and performed significantly better on reaction time (RT) measures than younger subjects. Decrements among younger subjects increased in magnitude further into the experiment, while the performance of older subjects remained stable. CONCLUSIONS: Our findings demonstrate that the waking performance and alertness of healthy older subjects are less impacted by the cumulative effects of repeated exposure to adverse circadian phase than that of young adults. This suggests that there are age-related changes in the circadian promotion of alertness, in the wake-dependent decline of alertness, and/or in how these 2 regulatory systems interact in healthy aging.
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“Highly controlled in‐laboratory forced‐desynchrony studies provide further evidence for this relationship, demonstrating that these cognitive functions undergo changes in circadian rhythm and decline as wakefulness is prolonged [29, 30].”
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923
Cognitive Stimulation in Patients with Dementia: Randomized Controlled Trial
Mapelli, D., Rosa, E. D., Nocita, R., & Sava, D. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353457 · Cited by 3,477
Dinges, D. F., & Powell, J. W. (1985) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03200977 · Cited by 1,812
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
Self-citationSleep Disorders and Sleep Deprivation: An Unmet Public Health Problem
(2006) · PsycEXTRA Dataset · doi:10.1037/e719732007-001 · Cited by 1,333
Sleep disturbances and chronic disease in older adults
Foley, D., Ancoli-Israel, S., Britz, P., & Walsh, J. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.02.010 · Cited by 1,203
Sustained attention performance during sleep deprivation: evidence of state instability.
Doran, S. M., Dongen, H. P. A. V., & Dinges, D. F. (2001) · PubMed · Cited by 801
Carrier, J., Land, S., Buysse, D. J., Kupfer, D. J., & Monk, T. H. (2001) · Psychophysiology · doi:10.1111/1469-8986.3820232 · Cited by 494
Ultrashort sleep-waking schedule. III. ‘Gates’ and ‘Forbidden zones’ for sleep
Lavie, P. (1986) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(86)90123-9 · Cited by 480
Wyatt, J. K., Cecco, A. R.-D., Czeisler, C. A., & Dijk, D. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1152 · Cited by 477
Self-citationDijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467
Self-citationAssociation of sleep-wake habits in older people with changes in output of circadian pacemaker
Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., Sánchez, R., Ríos, C. D., & Ronda, J. M. (1992) · The Lancet · doi:10.1016/0140-6736(92)92817-y · Cited by 437
Self-citationRelations Between Performance and Subjective Ratings of Sleepiness During a Night Awake
Gillberg, M., Kecklund, G., & Åkerstedt, T. (1994) · Sleep · doi:10.1093/sleep/17.3.236 · Cited by 423
Alterations in Nocturnal Serum Melatonin Levels In Humans With Growth and Aging*
Waldhauser, F., Weiszenbacher, G., Tatzer, E., Gisinger, B., Waldhauser, M., SCHEMPER, M., & Frisch, H. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-3-648 · Cited by 407
Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects
Iguchi, H., Kato, K., & Ibayashi, H. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-1-27 · Cited by 381
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Weitzman, E. D., Moline, M. L., Czeisler, C. A., & Zimmerman, J. C. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90018-5 · Cited by 367
Later endogenous circadian temperature nadir relative to an earlier wake time in older people
Duffy, J. F., Dijk, D., Klerman, E. B., & Czeisler, C. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1478 · Cited by 318
Self-citationLearning as accumulation: A reexamination of the learning curve.
Mazur, J., & Hastie, R. (1978) · Psychological Bulletin · doi:10.1037/0033-2909.85.6.1256 · Cited by 298
JOHNSON, M. P., Duffy, J. F., Dijk, D., Ronda, J. M., DYAL, C. M., & Czeisler, C. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00004.x · Cited by 240
Self-citationBlatter, K., Graw, P., Münch, M. Y., Knoblauch, V., Wirz‐Justice, A., & Cajochen, C. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.018 · Cited by 235
Healthy Older Adults Better Tolerate Sleep Deprivation Than Young Adults
Duffy, J. F., Willson, H. J., Wang, W., & Czeisler, C. A. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02303.x · Cited by 209
Self-citationSleep and wakefulness out of phase with internal biological time impairs learning in humans
Wright, K. P., Hull, J. T., Hughes, R. J., Ronda, J. M., & Czeisler, C. A. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.4.508 · Cited by 191
Self-citationWyatt, J. K., Cajochen, C., Cecco, A. R.-D., Czeisler, C. A., & Dijk, D. (2004) · SLEEP · doi:10.1093/sleep/27.3.374 · Cited by 181
Self-citationSimulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process
Achermann, P., & Borbély, A. A. (1994) · Biological Cybernetics · doi:10.1007/bf00197314 · Cited by 180
Wyatt, J. K., Dijk, D., Cecco, A. R.-D., Ronda, J. M., & Czeisler, C. A. (2006) · SLEEP · doi:10.1093/sleep/29.5.609 · Cited by 177
Self-citationCircadian temperature rhythms in young adult and aged men
Vitiello, M. V., Smallwood, R. G., Avery, D., Pascualy, R. A., Martin, D. C., & Prinz, P. N. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90146-6 · Cited by 164
Age-Related Increase in Awakenings: Impaired Consolidation of NonREM Sleep at All Circadian Phases
Dijk, D., Duffy, J. F., & Czeisler, C. A. (2001) · SLEEP · doi:10.1093/sleep/24.5.565 · Cited by 159
Self-citationAge-related attenuation of the evening circadian arousal signal in humans
Münch, M. Y., Knoblauch, V., Blatter, K., Schroder, C. M., Schnitzler, C., Kräuchi, K., Wirz‐Justice, A., & Cajochen, C. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.004 · Cited by 158
Dijk, D., & Duffy, J. F. (1999) · Annals of Medicine · doi:10.3109/07853899908998789 · Cited by 155
Self-citationAge-Related Changes in the Time Course of Vigilant Attention During 40 Hours Without Sleep in Men
Adam, M., Rétey, J., Khatami, R., & Landolt, H. (2006) · SLEEP · doi:10.1093/sleep/29.1.55 · Cited by 154
The effect of sleep fragmentation on sleep and performance in younger and older subjects
Bonnet, M. H. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80006-5 · Cited by 129
The Minnesota Multiphasic Personality Inventory: VI. The K Scale.
McKinley, J., Hathaway, S. R., & Meehl, P. E. (1948) · Journal of Consulting Psychology · doi:10.1037/h0061377 · Cited by 122
Horowitz, T. S., Cade, B. E., Wolfe, J. M., & Czeisler, C. A. (2003) · Psychological Science · doi:10.1046/j.0956-7976.2003.psci_1464.x · Cited by 121
Performance and sleepiness following moderate sleep disruption and slow wave sleep deprivation
Bonnet, M. H. (1986) · Physiology & Behavior · doi:10.1016/s0031-9384(86)80012-9 · Cited by 108
Circadian Regulation Dominates Homeostatic Control of Sleep Length and Prior Wake Length in Humans
Strogatz, S. H., Kronauer, R. E., & Czeisler, C. A. (1986) · SLEEP · doi:10.1093/sleep/9.2.353 · Cited by 92
Age and individual variability in performance during sleep restriction
Bliese, P. D., Wesensten, N. J., & Balkin, T. J. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00557.x · Cited by 92
Haimov, I., & Lavie, P. (1997) · SLEEP · doi:10.1093/sleep/20.4.294 · Cited by 76
Sleep inertia varies with circadian phase and sleep stage in older adults.
Silva, E. J., & Duffy, J. F. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.4.928 · Cited by 68
Self-citationAmplitude Reduction of the Circadian Temperature and Sleep Rhythms in the Elderly
Carrier, J., Monk, T. H., Buysse, D. J., & Kupfer, D. J. (1996) · Chronobiology International · doi:10.3109/07420529609012661 · Cited by 64
Air operations and circadian performance rhythms
Klein, K. E., Wegmann, H. M., Athanassenas, G., Hohlweck, H., & Kuklinski, P. (1977) · Applied Ergonomics · doi:10.1016/0003-6870(77)90074-6 · Cited by 60
Sleep in normal and pathological aging
Blois, R., Feinberg, I., Gaillard, J. M., Kupfer, D. J., & Webb, W. B. (1983) · Cellular and Molecular Life Sciences · doi:10.1007/bf01971096 · Cited by 52
Circadian Variation in Human Performance Evaluated By the Walter Reed Performance
Battery, A., Gillooly, P. B., Smolensky, M. H., Albright, D. L., Hsi, B. P., & Thorne, D. R. (1990) · Chronobiology International · doi:10.3109/07420529009056966 · Cited by 47
Flagged first, then by citations
Research works printed but not linked: 2
- 1989, Minnesota Multiphasic Personality Inventory-2
- 1996, Manual for the Beck Depression Inventory-II
Cited by
Sorted by citations
Effects of sleep deprivation on cognition
Killgore, W. D. S. (2010) · Progress in Brain Research · doi:10.1016/b978-0-444-53702-7.00007-5 · Cited by 1,421
Sleep and Sleep Disorders in Older Adults
Crowley, K. E. (2011) · Neuropsychology Review · doi:10.1007/s11065-010-9154-6 · Cited by 655
Sex difference in the near-24-hour intrinsic period of the human circadian timing system
Duffy, J. F., Cain, S. W., Chang, A., Phillips, A. J. K., Münch, M. Y., Gronfier, C., Wyatt, J. K., Dijk, D., Wright, K. P., & Czeisler, C. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010666108 · Cited by 601
Self-citationCircadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease
Videnovic, A., Noble, C., Reid, K. J., Peng, J., Turek, F. W., Marconi, A., Rademaker, A. W., Simuni, T., Zadikoff, C., & Zee, P. C. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6239 · Cited by 390
Sleep, sleepiness, fatigue, and performance of 12-hour-shift nurses
Geiger-Brown, J., Rogers, V. E., Trinkoff, A. M., Kane, R. L., Bausell, R. B., & Scharf, S. M. (2012) · Chronobiology International · doi:10.3109/07420528.2011.645752 · Cited by 382
Metadata
- Authors
- Silva, E. J., Wang, W., Ronda, J. M., Wyatt, J. K., & Duffy, J. F.
- Affiliations
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Corresponding author
- Silva, Edward J.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04
- Volume
- 33
- Issue
- 4
- Pages
- 481-490
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2849787
- OpenAlex
- W1833552908
- Cited by
- 114
- References
- 49
- Citations by year
- 2025: 8 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 13
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01ag012642-04)
- National Institute on Aging (R01AG006072, AG09975, AG12642, AG06072, P01AG009975)
- National Center for Research Resources (RR02635, M01RR002635)
- NIH Clinical Center
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, subjective sleepiness, cognitive performance, reaction time, older adults, age differences, forced desynchrony, core body temperature, alertness, sleep homeostasis, psychomotor vigilance, healthy aging
- MeSH terms
- Adult, Age Factors, Aged, Aging, Arousal, Body Temperature, Circadian Rhythm, Cognition, Cognition Disorders, Female, Humans, Male, Middle Aged, Psychomotor Performance, Reaction Time, Sleep Wake Disorders, Wakefulness, Sleep Disorders, Circadian Rhythm, Young Adult
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