Changes in serum TSH and free T4 during human sleep restriction
Open accessAbstract
STUDY OBJECTIVES: To examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function. DESIGN: Two-period crossover intervention study. SETTING: University clinical research center and sleep laboratory. PARTICIPANTS: 11 healthy volunteers (5F/6M) with a mean (+/- SD) age of 39 +/- 5 y and BMI 26.5 +/- 1.5 kg/m2. INTERVENTION: Randomized exposure to 14 days of sedentary living with ad libitum food intake and 5.5- vs. 8.5-h overnight sleep opportunity. MEASUREMENTS AND RESULTS: Serum thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured at the end of each intervention. Partial sleep restriction was accompanied by a modest but statistically significant reduction in TSH and free T4, seen mainly in the female participants of the study. CONCLUSIONS: Compared to the well-known rise in TSH and thyroid hormone concentrations during acute sleep loss, tests obtained after 14 days of partial sleep restriction did not show a similar activation of the human thyroid axis.
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Decreased peripheral thyroid hormone levels are likely secondary to suppression of the nocturnal TSH peak, possibly via decreased TRH drive in the PVN.
“Decreased peripheral thyroid hormone levels are likely secondary to suppression of the nocturnal TSH peak, possibly secondary to decreased drive from TRH neurons in the PVN.116”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [116]
Acute total sleep deprivation increases TSH and free T4; partial sleep deprivation decreases TSH and T4, suggesting a dose-related effect.
“Acute total sleep deprivation increased TSH and free T4 levels,88 whereas partial sleep deprivation of 5.5-h nights for two weeks or six 4-h nights decreased TSH and T4 levels, suggesting a dose-related effect104,116”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [116]
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Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
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- Authors
- Kessler, L., Nedeltcheva, A., Imperial, J., & Penev, P. D.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Penev, Plamen D.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08
- Volume
- 33
- Issue
- 8
- Pages
- 1115-1118
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2910542
- OpenAlex
- W1485322446
- Cited by
- 68
- References
- 15
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Chicago
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health (1s10rr004999-01)
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL089637)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK020595)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep restriction, thyroid-stimulating hormone, free thyroxine, thyroid function, hypothalamic-pituitary-thyroid axis, sleep deprivation, sex differences, chronic sleep loss
- MeSH terms
- Adult, Circadian Rhythm, Female, Humans, Male, Recurrence, Reference Values, Sleep Deprivation, Thyrotropin, Thyroxine
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