Effects of genistein exposure on sexually dimorphic behaviors in rats.
Abstract
The phytoestrogen genistein, the principal isoflavone in soybeans, has adverse effects on animal reproduction. As adult physiology and behavior are sensitive to perturbation by developmental estrogens, exposure to genistein during development may produce behavioral alterations as well. Pregnant rats were fed soy-free diets containing 0, 25, 250, or 1250 ppm genistein (approximately 0, 2, 20, or 100 mg/kg/day) beginning on gestational day 7, and offspring continued on these diets through postnatal day (PND) 77. Male and female offspring were assessed for levels of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. Consumption of the salt solution was affected by genistein, with animals in the 1250-ppm group drinking significantly more than controls; consumption of plain water was unaffected. Genistein treatment also significantly affected play behavior; although no treated group was significantly different from controls, and the effect was not sexually dimorphic. Running wheel activity and saccharin solution consumption showed significant sex differences, but no effects of genistein treatment. Gestational duration, total and live pups per litter, and total and live litter sex ratios were not significantly affected by genistein. However, average weight per live pup at birth and offspring body weights from PND 42-77 were significantly decreased in the 1250-ppm group. Body…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Phytoestrogens in chow can enhance sex differences in the brain and in behavior.
“Phytoestrogens in chow can enhance sex differences in the brain and in behavior [51], [52], [53], [54], [55].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [53]
Other manipulations such as prenatal protein deprivation, perinatal genistein exposure, prenatal PCB exposure, or maternal stress during gestation can also demasculinize play behavior.
“Other manipulations such as prenatal protein deprivation (Almeida et al. 1996), perinatal genistein exposure (Flynn et al. 2000), prenatal polychlorinated biphenyl (PCB) exposure (Vreugdenhil et al. 2002), or maternal stress during gestation can also demasculinize play behavior (Ward and Stehm 1991).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Flynn et al. 2000
Cites
Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442 · see citing works
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203 · see citing works
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., WATANABE, S.-I. I., Itoh, N., Shibuya, M., & Fukami, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45614-1 · Cited by 3,723 · see citing works
Developmental Effects of Endocrine-Disrupting Chemicals in Wildlife and Humans
Colborn, T., Saal, F. S. V., & Soto, A. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101378 · Cited by 3,570 · see citing works
Kavlock, R. J., Daston, G. P., DeRosa, C., Fenner-Crisp, P. A., Gray, L. E., Kaattari, S. L., Lucier, G. W., Luster, M. I., Mac, M. J., Maczka, C., et al. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s4715 · Cited by 1,171 · see citing works
Coward, L. U., Barnes, N. C., Setchell, K. D. R., & Barnes, S. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00035a027 · Cited by 883 · see citing works
Human behavioral sex differences: A role for gonadal hormones during early development?
Collaer, M. L., & Hines, M. (1995) · Psychological Bulletin · doi:10.1037/0033-2909.118.1.55 · Cited by 767 · see citing works
Beatty, W. W. (1979) · Hormones and Behavior · doi:10.1016/0018-506x(79)90017-5 · Cited by 631 · see citing works
Panksepp, J. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140405 · Cited by 537 · see citing works
Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life
Setchell, K. D. R., Zimmer-Nechemias, L., Cai, J., & Heubi, J. E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1453s · Cited by 388 · see citing works
Santell Ross, C., Chen, C. Y., Nair, M. G., & Helferich, W. G. (1997) · Journal of Nutrition · doi:10.1093/jn/127.2.263 · Cited by 355 · see citing works
Blizard, D. A., Lippman, H. R., & Chen, J. J. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90188-2 · Cited by 196 · see citing works
The Effect of Prenatal Exposure to the Phytoestrogen Genistein on Sexual Differentiation in Rats
Levy, J., Faber, K. A., Ayyash, L. A., & Hughes, C. L. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43832 · Cited by 190 · see citing works
Maternal and neonatal phytoestrogens in Japanese women during birth
Adlercreutz, H., Yamada, T., Wähälä, K., & Watanabe, S. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70281-4 · Cited by 164 · see citing works
Holder, C. L., Churchwell, M. I., & Doerge, D. R. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9902651 · Cited by 154 · see citing works
Isoflavones in human breast milk and other biological fluids
Franke, A. A., Custer, L. J., & Tanaka, Y. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1466s · Cited by 153 · see citing works
Hormonal organization of sex differences in play fighting and spatial behavior.
Beatty, W. W. (1984) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64444-1 · Cited by 147 · see citing works
Meaney, M. J., Stewart, J., Poulin, P., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000123524 · Cited by 144 · see citing works
Lamartiniere, C. A., Zhang, J.-X., & Cotroneo, M. S. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1400s · Cited by 132 · see citing works
Physiological effects of phyto-oestrogens in relation to cancer and other human health risks
Cassidy, A. (1996) · Proceedings of The Nutrition Society · doi:10.1079/pns19960038 · Cited by 131 · see citing works
Faber, K. A., & Hughes, C. L. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90007-t · Cited by 119 · see citing works
Tilson, H. A. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106807 · Cited by 106 · see citing works
Phytoestrogen Influences on the Development of Behavior and Gonadotropin Function
Whitten, P. L., Lewis, C., Russell, E., & Naftolin, F. N. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43836 · Cited by 82 · see citing works
Pellis, S. M., Pellis, V. C., & McKenna, M. M. (1994) · Journal of Comparative Psychology · doi:10.1037/0735-7036.108.1.68 · Cited by 76 · see citing works
Sex differences in the taste preference for a salt solution in the rat
Křeček, J., Nováková, V., & Stibral, K. (1972) · Physiology & Behavior · doi:10.1016/0031-9384(72)90358-7 · Cited by 75 · see citing works
Sex and sodium intake in the rat.
Chow, S. Y., Sakai, R. R., Witcher, J. A., Adler, N. T., & al, E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.172 · Cited by 69 · see citing works
Sj, R., Scully, R. E., Wr, W., & Herbst, A. L. (1977) · PubMed · Cited by 66 · see citing works
Sex differences in salt taste: The effect of testosterone
Křeček, J. (1973) · Physiology & Behavior · doi:10.1016/0031-9384(73)90144-3 · Cited by 65 · see citing works
Behavioral effects of methylazoxymethanol-induced micrencephaly.
Ferguson, S. A., Racey, F. D., Paule, M. G., & Holson, R. R. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.6.1067 · Cited by 46 · see citing works
Developmental neurotoxicity of endocrine disrupters: focus on estrogens.
Ferguson, S. A., Scallet, A. C., Flynn, K., Meredith, J. M., & Schwetz, B. A. (2000) · PubMed · Cited by 33 · see citing works
Self-citationMultigenerational exposure to dietary genistein has no severe effects on nursing behavior in rats.
Flynn, K., Ferguson, S. A., Delclos, K. B., & Newbold, R. R. (2000) · PubMed · Cited by 24 · see citing works
Self-citationEffects of early life undernutrition in artificially-reared rats 2. Subsequent behaviour
Tonkiss, J., Smart, J. L., & Massey, R. F. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90311-8 · Cited by 20 · see citing works
Lucion, A. B., De-Almeida, R. M. M., & Da-Silva, R. S. M. (1996) · PubMed · Cited by 14 · see citing works
Křeček, J. (1978) · PubMed · Cited by 14 · see citing works
Differential role of ovarian hormones for taste preferences in rats.
Mascarenhas, J. F., Borker, A. S., & Venkatesh, P. (1992) · PubMed · Cited by 7 · see citing works
Hormones, Development, and Sexual Dimorphic Behaviors
Schulkin, J. A. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9780511818738.002 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats
Delclos, K. B., Bucci, T. J., Lomax, L. G., Latendresse, J. R., Warbritton, A. R., Weis, C. C., & Newbold, R. R. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00177-0 · Cited by 208 · see citing works
Reproductive effects in male and female rats of neonatal exposure to genistein
Nagao, T., Yoshimura, S., Saito, Y., Nakagomi, M., Usumi, K., & Ono, H. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00141-1 · Cited by 195 · see citing works
Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
Wolstenholme, J. T., Taylor, J. A., Shetty, S. R. J., Edwards, M., Connelly, J. J., & Rissman, E. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025448 · Cited by 168 · see citing works
“Phytoestrogens in chow can enhance sex differences in the brain and in behavior [51,52,53,54,55].”
BackgroundPhytoestrogens and Health Effects
Lavier, M.-C. C., & Bennetau‐Pelissero, C. (2023) · Nutrients · doi:10.3390/nu15020317 · Cited by 168 · see citing works
Genistein treatment protects mice from ionizing radiation injury
Landauer, M. R., Srinivasan, V., & Seed, T. M. (2003) · Journal of Applied Toxicology · doi:10.1002/jat.904 · Cited by 154 · see citing works
Rough-and-Tumble Play and the Development of the Social Brain
Pellis, S. M., Himmler, B. T., Himmler, S. M., & Pellis, V. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804036-2.00012-1 · Cited by 150 · see citing works
Linford, N. J., & Dorsa, D. M. (2002) · Steroids · doi:10.1016/s0039-128x(02)00062-4 · Cited by 129 · see citing works
Behavioral changes in fish exposed to phytoestrogens
Clotfelter, E. D., & Rodriguez, A. C. (2006) · Environmental Pollution · doi:10.1016/j.envpol.2006.02.007 · Cited by 128 · see citing works
Owens, J. W., & Ashby, J. (2002) · Critical Reviews in Toxicology · doi:10.1080/20024091064291 · Cited by 124 · see citing works
Robertson, K. M.-P., O’Donnell, L., Simpson, E. R., & Jones, M. E. E. (2002) · Endocrinology · doi:10.1210/endo.143.8.8957 · Cited by 118 · see citing works
Lamartiniere, C. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/65.2.228 · Cited by 117 · see citing works
Wisniewski, A., Cernetich, A., Gearhart, J., & Klein, S. (2005) · Physiology and Behavior · doi:10.1016/j.physbeh.2004.12.008 · Cited by 103 · see citing works
Dietary genistein suppresses chemically induced prostate cancer in Lobund–Wistar rats
Wang, J., Eltoum, I.-E. A., & Lamartiniere, C. A. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00811-4 · Cited by 97 · see citing works
Timing of Exposure and Mammary Cancer Risk
Lamartiniere, C. A. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1015722507237 · Cited by 91 · see citing works
NTP‐CERHR expert panel report on the developmental toxicity of soy infant formula
McCarver, G., Bhatia, J. J. S., Chambers, C., Clarke, R. C., Etzel, R. A., Foster, W. G., Hoyer, P. B., Leeder, J. S., Peters, J. M., Rissman, E. F., et al. (2011) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20314 · Cited by 90 · see citing works
You, L. (2002) · Toxicological Sciences · doi:10.1093/toxsci/66.1.91 · Cited by 88 · see citing works
NTP‐CERHR expert panel report on the reproductive and developmental toxicity of genistein
Rozman, K. K., Bhatia, J. J. S., Calafat, A. M., Chambers, C., Culty, M., Etzel, R. A., Flaws, J. A., Hansen, D. K., Hoyer, P. B., Jeffery, E. H., et al. (2006) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20087 · Cited by 85 · see citing works
Emergence and Persistence of Hantaviruses
Klein, S. L., & Calisher, C. H. (2007) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-70962-6_10 · Cited by 83 · see citing works
Reproductive safety studies with genistein in rats
McClain, R. M., Wolz, E., Davidovich, A., Edwards, J. A., & Bausch, J. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.01.009 · Cited by 81 · see citing works
Padilla‐Banks, E., Jefferson, W. N., & Newbold, R. R. (2006) · Endocrinology · doi:10.1210/en.2006-0389 · Cited by 76 · see citing works
Guo, T. L., White, K. L., Brown, R. D., Delclos, K. B., Newbold, R. R., Weis, C. C., Germolec, D. R., & McCay, J. A. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9418 · Cited by 72 · see citing works
Zhao, R., Zhou, Y.-C., Ni, Y., Lu, L. Z., Tao, Z. R., Chen, W. H., & Chen, J. (2005) · British Poultry Science · doi:10.1080/00071660500064808 · Cited by 70 · see citing works
Boudalia, S., Bergès, R., Chabanet, C., Folia, M., Decocq, L., Pasquis, B., Abdennebi‐Najar, L., & Lavier, M.-C. C. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.11.002 · Cited by 67 · see citing works
Silver Nanoparticles Decrease Body Weight and Locomotor Activity in Adult Male Rats
Zhang, Y., Ferguson, S. A., Watanabe, F., Jones, Y., Xu, Y., Biris, A. S., Hussain, S. M., & Ali, S. F. (2013) · Small · doi:10.1002/smll.201201548 · Cited by 66 · see citing works
Early Exposure to Genistein Exerts Long-Lasting Effects on the Endocrine and Immune Systems in Rats
Klein, S. L., Wisniewski, A. B., Marson, A. L., Glass, G. E., & Gearhart, J. P. (2002) · Molecular Medicine · doi:10.1007/bf03402038 · Cited by 63 · see citing works
Pharmacologic, but Not Dietary, Genistein Supports Endometriosis in a Rat Model
Cotroneo, M. S. (2001) · Toxicological Sciences · doi:10.1093/toxsci/61.1.68 · Cited by 59 · see citing works
Colbert, N. K. W., Pelletier, N. C., Cote, J. M., Concannon, J. B., Jurdak, N. A., Minott, S. B., & Markowski, V. P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7509 · Cited by 60 · see citing works
Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities
Galluzzo, P., & Marino, M. (2006) · Genes & Nutrition · doi:10.1007/bf02829966 · Cited by 59 · see citing works
Transplacental transfer of the phytoestrogen daidzein in DA/Han rats
Degen, G. H., Janning, P., Diel, P. R., Michna, H., & Bolt, H. M. (2002) · Archives of Toxicology · doi:10.1007/s00204-001-0305-7 · Cited by 56 · see citing works
Ronis, M. J. J., Little, J. M., Barone, G. W., Chen, G., Radominska-p, A., & Badger, T. M. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.348 · Cited by 56 · see citing works
Sex steroid receptor regulation by genistein in the prepubertal rat uterus
Cotroneo, M. S., Wang, J., Eltoum, I. A., & Lamartiniere, C. A. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00405-6 · Cited by 56 · see citing works
Doerge, D. R., Twaddle, N. C., Churchwell, M. I., Newbold, R. R., & Delclos, K. B. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.09.007 · Cited by 54 · see citing works
Soy-Based Infant Formula: Are Phyto-Oestrogens Still in Doubt?
Testa, I., Salvatori, C., Cara, G. D., Latini, A., Frati, F., Troiani, S., Principi, N., & Esposito, S. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00110 · Cited by 52 · see citing works
Zhao, R., Wang, Y., Zhou, Y., Ni, Y., Lu, L., Großmann, R., & Chen, J. (2004) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2004.06.004 · Cited by 51 · see citing works
Ferguson, S. A., Flynn, K., Delclos, K. B., & Newbold, R. R. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(00)00071-4 · Cited by 51 · see citing works
Self-citationKang, K., Che, J. H., & Lee, Y. S. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00091-6 · Cited by 47 · see citing works
The Effects of the Soy Isoflavone Genistein on the Reproductive Development of Striped Bass
Pollack, S. J., Ottinger, M. A., Sullivan, C. V., & Woods, L. C. (2003) · North American Journal of Aquaculture · doi:10.1577/c02-041 · Cited by 45 · see citing works
Dietary Diethylstilbestrol but Not Genistein Adversely Affects Rat Testicular Development
Fritz, W. A., Cotroneo, M. S., Wang, J., Eltoum, I.-E. A., & Lamartiniere, C. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2287 · Cited by 38 · see citing works
Scallet, A. C. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh297 · Cited by 35 · see citing works
Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H. O., & Scholz, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.124 · Cited by 34 · see citing works
Ferguson, S. A., Law, C. D., & Kissling, G. E. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu077 · Cited by 32 · see citing works
“, 2000, 2001), saccharin solution intake (Ferguson and Boctor, 2010; Flynn et al., 2000), and sodium solution intake (Ferguson et al.”
BackgroundScallet, A. C. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg029 · Cited by 32 · see citing works
Behavioral responses of rats exposed to long-term dietary vinclozolin
Flynn, K. M., Delclos, K. B., Newbold, R. R., & Ferguson, S. A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0008893 · Cited by 33 · see citing works
Self-citationFerguson, S. A., Flynn, K., Delclos, K. B., Newbold, R. R., & Gough, B. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(01)00193-3 · Cited by 31 · see citing works
Self-citationGender-Based Differences in Rats after Chronic Dietary Exposure to Genistein
Slikker, W., Scallet, A. C., Doerge, D. R., & Ferguson, S. A. (2001) · International Journal of Toxicology · doi:10.1080/109158101317097764 · Cited by 31 · see citing works
Lv, Z., Fan, H., Zhang, B., Ning, C., Xing, K., & Guo, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201701457r · Cited by 30 · see citing works
Rochester, J. R., & Millam, J. R. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.06.017 · Cited by 30 · see citing works
Impact of Environmental Endocrine Disruptors on Sexual Differentiation in Birds and Mammals
Ottinger, M. A., & Saal, F. S. V. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50070-6 · Cited by 30 · see citing works
Genistein Alters Growth but Is Not Toxic to the Rat Prostate
Fritz, W. A., Eltoum, I.-E. A., Cotroneo, M. S., & Lamartiniere, C. A. (2002) · Journal of Nutrition · doi:10.1093/jn/131.10.3007 · Cited by 29 · see citing works
Ferguson, S. A., Delclos, K. B., Newbold, R. R., & Flynn, K. (2003) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(03)00015-1 · Cited by 27 · see citing works
Self-citationDifferential effect of pure isoflavones and soymilk on estrogen receptor activity in mice
Rando, G., Ramachandran, B., Rebecchi, M., Ciana, P., & Maggi, A. C. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.022 · Cited by 26 · see citing works
Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene.
Kudwa, A. E., Boon, W. C., Simpson, E. R., Handa, R. J., & Rissman, E. F. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.356 · Cited by 26 · see citing works
Takagi, H., Shibutani, M., Lee, K., Lee, H. C., Nishihara, M., Uneyama, C., Takigami, S., Mitsumori, K., & Hirose, M. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.03.002 · Cited by 25 · see citing works
Oral treatment with ACCUTANE® does not increase measures of anhedonia or depression in rats
Ferguson, S. A., Cisneros, F. J., Hanig, J. P., & Berry, K. J. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.003 · Cited by 25 · see citing works
Estrogen receptor expression in the prostate of rats treated with dietary genistein
Dalu, A., Blaydes, B. S., Bryant, C. W., Latendresse, J. R., Weis, C. C., & Delclos, K. B. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00346-x · Cited by 25 · see citing works
Proteomic Discovery of Genistein Action in the Rat Mammary Gland
Wang, J., Betancourt, A. M., Mobley, J. A., & Lamartiniere, C. A. (2011) · Journal of Proteome Research · doi:10.1021/pr100974w · Cited by 24 · see citing works
Effects of dietary phytoestrogen exposure during perinatal period
Becker, L. A., Kunkel, A. J., Brown, M. R., Ball, E. E., & Williams, M. T. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.05.007 · Cited by 21 · see citing works
Blake, B. E., & McCoy, K. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.021 · Cited by 20 · see citing works
Licorice Extract Does Not Impair the Male Reproductive Function of Rats
Shin, S., Jang, J. Y., Choi, B.-I., Baek, I., Yon, J., Hwang, B. Y., Park, D., Jeon, J. H., Nam, S.-Y., Yun, Y. W., et al. (2008) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.57.11 · Cited by 20 · see citing works
Concerns for the use of soy-based formulas in infant nutrition
Leung, A., Otley, A. R., & Canadian Paediatric Society (2009) · Paediatrics & Child Health · doi:10.1093/pch/14.2.109 · Cited by 20 · see citing works
Guo, T. L., Chi, R. P., Germolec, D. R., & White, K. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2449 · Cited by 19 · see citing works
Tousen, Y., Umeki, M., Nakashima, Y., Ishimi, Y., & Ikegami, S. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.174 · Cited by 17 · see citing works
Lembè, D. M., Gasco, M., Rubio, J., Yucra, S., Sock, E. T. N., & Gonzales, G. F. (2011) · Andrologia · doi:10.1111/j.1439-0272.2009.01035.x · Cited by 16 · see citing works
Isoflavones and their effects on the onset of puberty in male Wistar rats
Caceres, S., Peña, L., Moyano, G., Martinez-Fernandez, L., Monsalve, B., Illera, M. J., Millan, P., Illera, J. C., & Silvan, G. (2015) · Andrologia · doi:10.1111/and.12394 · Cited by 15 · see citing works
Ferguson, S. A., Delclos, K. B., Newbold, R. R., & Flynn, K. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.01.009 · Cited by 15 · see citing works
Self-citationFlynn, K. M., Delclos, K. B., Newbold, R. R., & Ferguson, S. A. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.03.009 · Cited by 14 · see citing works
Self-citationA Delayed Nonlinear PBPK Model for Genistein Dosimetry in Rats
Zager, M. G., Schlosser, P. M., & Tran, H. T. (2006) · Bulletin of Mathematical Biology · doi:10.1007/s11538-006-9068-x · Cited by 14 · see citing works
Chen, Y., Li, T., Ji, H., Wang, X., Sun, X., Miao, M., Wang, Y., Wu, Q., Liang, H., & Yuan, W. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115752 · Cited by 13 · see citing works
Khezri, S., Alihemmati, A., & Abedelahi, A. (2021) · JBRA · doi:10.5935/1518-0557.20210089 · Cited by 11 · see citing works
Boyle, C., Moizer, K., Barlow, T., Jeffrey, B., & Paul, S. M. N. (2003) · Elsevier eBooks · doi:10.1533/9781855736986.1.65 · Cited by 11 · see citing works
Ikegami, S., Tousen, Y., Ishimi, Y., Umegaki, K., & Nakashima, Y. (2006) · Eisei kagaku · doi:10.1248/jhs.52.558 · Cited by 10 · see citing works
Perinatal xenohormone exposure impacts sweet preference and submandibular development in male rats
Kouidhi, W., Bergès, R., Tiffon, C., Desmetz, C., May, M. E., Auger, J., & Lavier, M.-C. C. (2013) · Oral Diseases · doi:10.1111/odi.12078 · Cited by 9 · see citing works
Early endocrine disruptors exposure acts on 3T3-L1 differentiation and endocrine activity
Boudalia, S., Belloir, C., Miller, M.-L., & Lavier, M.-C. C. (2017) · Bioimpacts · doi:10.15171/bi.2017.11 · Cited by 8 · see citing works
Yousofi, M. ́., Saberivand, A., Becker, L. A., & Karimi, I. (2011) · Developmental Psychobiology · doi:10.1002/dev.20534 · Cited by 7 · see citing works
In vivo dynamics of estrogen receptor activity: The ERE-Luc model
Maggi, A. C., & Villa, A. M. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.007 · Cited by 6 · see citing works
Effects of Transmaternal Exposure to Genistein in Hatano High- and Low-Avoidance Rats
Ohta, R., Shirota, M., Kanazawa, Y., SHINDO, T., Furuya, M., Seki, T., Ono, H., Kojima, K., Asai, S., Watanabe, G., et al. (2009) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.58.471 · Cited by 6 · see citing works
Chen, Y., Liang, H., Ji, H., Sun, X., He, G., Wang, Y., Dai, W., Miao, M., & Yuan, W. (2022) · Human Reproduction · doi:10.1093/humrep/deac234 · Cited by 5 · see citing works
Che, J., Kwon, E., Kim, S.-H., You, J.-R., Kim, B.-H., Lee, S. J., Chung, J. H., & Kang, B.-C. (2010) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2010.11.001 · Cited by 4 · see citing works
A chain reaction approach to modelling gene pathways.
Cheng, G. C., Chen, D., Chen, J. J., Soong, S.-J., Lamartiniere, C. A., & Barnes, S. (2012) · PubMed · Cited by 3 · see citing works
Effects of a soybean milk product on feto-neonatal development in rats
An, E. S., Park, D., Ban, Y.-H., Jieun, C., Seo, D. W., Yoon, B., Shon, M. Y., Choi, E., & Kim, Y.-B. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.31.20170067 · Cited by 3 · see citing works
Kimura, N., Kimura, T., & Totsukawa, K. (2008) · Journal of Mammalian Ova Research · doi:10.1274/0916-7625-25.4.272 · Cited by 2 · see citing works
Genistein: Programming Against Breast Cancer
Lamartiniere, C. A., Jenkins, S. B., & Wang, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-27135-4_2 · Cited by 2 · see citing works
Tousen, Y., Umeki, M., Ishimi, Y., & Ikegami, S. (2006) · The Japanese Journal of Nutrition and Dietetics · doi:10.5264/eiyogakuzashi.64.161 · Cited by 2 · see citing works
Assessing the intake of phytoestrogens: isoflavones
Lorenzetti, S., & Branca, F. (2003) · Elsevier eBooks · doi:10.1533/9781855736986.2.189 · Cited by 1 · see citing works
Public Health Implications of Dietary Phytoestrogens
a, R. N., Jefferson, W. N., Padilla‐Banks, E., Bullock, B. C., Delclos, B., Badger, T. M., Ronis, M. J. J., Hakkak, R., Korourian, S., a, O. R., et al. (2002) · AOCS Publishing eBooks · doi:10.1201/9781439822197.ch12 · Cited by 1 · see citing works
Azios, N. G. (2006) · Texas ScholarWorks (Texas Digital Library)
The role of the sex steroids in regulation of physical activity levels in mice
Bowen, R. S., & NC DOCKS at The University of North Carolina at Charlotte (2010) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)
Phytoestrogens: Health benefits and possible adverse effect
Nashar, M. A. (2015) · Varna Medical Forum · doi:10.14748/vmf.v4i2.1280
Modeling the Distribution and Metabolism of the Phytoestrogen Genistein in Rats
Zager, M. G. (2003) · NCSU Libraries Repository (North Carolina State University Libraries)
TOXICOKINETICS A ND M ETABOLISM
Degen, G. H., Janning, P., Diel, P. R., & Michna, H. (2002)
Leung, A., Otley, A. R., de pédiatrie, S. C., & de gastroentérologie, C. D. N. E. (2009) · Paediatrics & Child Health · doi:10.1093/pch/14.2.114
Windiani, I. G. A. T., Indradjaja, A., Adnyana, I. G. A. N. S., & Soetjiningsih, I. (2019) · American Journal of Pediatrics · doi:10.11648/j.ajp.20190504.31
- Authors
- Flynn, K. M.
- Affiliations
- National Center for Toxicological Research (US)
- Corresponding author
- Flynn, K. M.
- ORCID
- Flynn, K. M.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-06-01
- Volume
- 55
- Issue
- 2
- Pages
- 311-319
- ISSN
- 1096-0929 (ISSN-L)
- OpenAlex
- W2135029034
- Cited by
- 92
- References
- 36
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- genistein, phytoestrogens, isoflavones, soybean, early life exposure, prenatal exposure, sexually dimorphic behavior, play behavior, wheel running, saccharin consumption, salt intake, offspring body weight, maternal weight, litter sex ratio, gestational nutrition
- MeSH terms
- Animals, Animals, Newborn, Body Weight, Eating, Endocrine System Diseases, Feeding Behavior, Female, Growth Inhibitors, Male, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Sexual Behavior, Animal, Sex Characteristics, Rats, Sprague-Dawley, Maternal Exposure, Genistein, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review