Cited by 92Phytoestrogen effects and researchEffects and risks of endocrine disrupting chemicalsEstrogen and related hormone effects

Effects of genistein exposure on sexually dimorphic behaviors in rats.

Flynn, K. M.·2000·Toxicological Sciences

Abstract

The phytoestrogen genistein, the principal isoflavone in soybeans, has adverse effects on animal reproduction. As adult physiology and behavior are sensitive to perturbation by developmental estrogens, exposure to genistein during development may produce behavioral alterations as well. Pregnant rats were fed soy-free diets containing 0, 25, 250, or 1250 ppm genistein (approximately 0, 2, 20, or 100 mg/kg/day) beginning on gestational day 7, and offspring continued on these diets through postnatal day (PND) 77. Male and female offspring were assessed for levels of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. Consumption of the salt solution was affected by genistein, with animals in the 1250-ppm group drinking significantly more than controls; consumption of plain water was unaffected. Genistein treatment also significantly affected play behavior; although no treated group was significantly different from controls, and the effect was not sexually dimorphic. Running wheel activity and saccharin solution consumption showed significant sex differences, but no effects of genistein treatment. Gestational duration, total and live pups per litter, and total and live litter sex ratios were not significantly affected by genistein. However, average weight per live pup at birth and offspring body weights from PND 42-77 were significantly decreased in the 1250-ppm group. Body…

Integrity signals

Registry

Crossref · 10.1093/toxsci/55.2.311

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Flynn, K. M.
Affiliations
National Center for Toxicological Research (US)
Corresponding author
Flynn, K. M.
Venue
Toxicological Sciences
Published
2000-06-01
Volume
55
Issue
2
Pages
311-319
ISSN
1096-0929 (ISSN-L)
OpenAlex
W2135029034
Cited by
92
References
36
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
7.06
Type
journal article
Language
en
Open access
closed
Locations
  • Toxicological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
genistein, phytoestrogens, isoflavones, soybean, early life exposure, prenatal exposure, sexually dimorphic behavior, play behavior, wheel running, saccharin consumption, salt intake, offspring body weight, maternal weight, litter sex ratio, gestational nutrition
MeSH terms
Animals, Animals, Newborn, Body Weight, Eating, Endocrine System Diseases, Feeding Behavior, Female, Growth Inhibitors, Male, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Sexual Behavior, Animal, Sex Characteristics, Rats, Sprague-Dawley, Maternal Exposure, Genistein, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review