Cited by 396Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated ReceptorsEffects and risks of endocrine disrupting chemicals

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Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate

Takacs, Margy L., Abbott, Barbara D.·2007·Toxicological Sciences

DOI 10.1093/toxsci/kfl135

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Abstract

This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) to activate peroxisome proliferator-activated receptors (PPARs), using a transient transfection cell assay. Cos-1 cells were cultured in Dulbecco's Minimal Essential Medium (DMEM) with fetal bovine serum in 96-well plates and transfected with mouse or human PPARalpha, beta/delta, or gamma reporter plasmids. Transfected cells were exposed to PFOA (0.5-100 microM), PFOS (1-250 microM), positive controls (i.e., known agonists and antagonists), and negative controls (i.e., DMEM, 0.1% water, and 0.1% dimethyl sulfoxide). Following treatment for 24 h, activity was measured using the Luciferase reporter assay. In this assay, PFOA had more transactivity than PFOS with both the mouse and human PPAR isoforms. PFOA significantly increased mouse and human PPARalpha and mouse PPARbeta/delta activity relative to vehicle. PFOS significantly increased activation of mouse PPARalpha and PPARbeta/delta isoforms. No significant activation of mouse or human PPARgamma was observed with PFOA or PFOS. The PPARalpha antagonist, MK-886, significantly suppressed PFOA and PFOS activity of mouse and human PPARalpha. The PPARgamma antagonist, GW9662, significantly suppressed PFOA activity on the human isoform. In conclusion, this study characterized the dose response and differential activation of mouse and human PPARalpha, beta/delta, gamma by PFOA and PFOS. While this model allows opportunities to compare potential activation by perfluoroalkyl acids, it only evaluates the interaction and activation of the PPAR reporter constructs and is not necessarily predictive of a toxicological response in vivo.

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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
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Vidal‐Puig, A., Considine, R. V., Jimenez‐Liñan, M., Werman, A., Pories, W. J., Caro, J. F., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119424 · Cited by 785
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2005, Evaluation of the half-life (T1/2) of elimination of perfluorooctanoate (PFOA) from human serum, Toxicologist, 84, 253
1997, Principles of Medical Biology, Molecular and Cellular Endocrinology
U.S. Environmental Protection Agency, 2005, Draft Risk Assessment of Human Health Effects Associated with Exposure to Perfluorooctanoic Acid and its Salts, January, 2005

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PFOA Alters the Expression of Mitochondrial Metabolism Genes in Rats.
Walters, M. W. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
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Salter, D. M. (2015) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-salter-deanna-2015
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Ibrahim, W. N. W., & Norhamidah, W. I. W. (2012) · Figshare
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Ray, J. N. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
探討血清全氟碳化合物與肝功能、甲狀腺功能、血糖調控與心血管疾病危險因子之相關
林建宇 (2011)
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Marques, E. (2020) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-marques-emily-2020
EFFECTS OF PERFLUOROOCTANESULFONATE (PFOS) ON THYROID HORMONE STATUS IN RATS
Chang, S. (2009)
Perfluorooctanesulfonic acid (PFOS) and its salts [MAK Value Documentation, 2011]
Arbeitsstoffe, D. F. S. S. Z. P. G., & Hartwig, A. (2015) · The MAK-Collection for Occupational Health and Safety · doi:10.1002/3527600418.mb176323sale5115
Perfluoroctansulfonsäure und ihre Salze [MAK Value Documentation in German language, 2011]
Arbeitsstoffe, D. F. S. S. Z. P. G., & Hartwig, A. (2012) · The MAK-Collection for Occupational Health and Safety · doi:10.1002/3527600418.mb176323d0051
Metabolic, Neurotoxic and Immunotoxic Effects of Pfaas and Their Mixtures on the Proteome of the Head Kidney and Plasma from Rainbow TroutPreprint
Simmons, D. B. D., Pollard, S., & Silva, A. O. D. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4668629
Associations between perfluoroalkyl substance exposure and lean body mass in US adults: evidence from the NHANES 2015–2018
Song, X.-H., Chen, S., Jiang, F., Jia, Y., Zhu, M., Zhang, C., & Wang, D. (2024) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807039.2024.2395311
PFAS Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen‐ LABS Study
Baumert, B. O., Costello, E. J., Li, Z., Ryder, J. R., Inge, T. H., Jenkins, T. M., Sisley, S. R., Xanthakos, S. A., Walker, D. I., Stratakis, N., et al. (2025) · Obesity · doi:10.1002/oby.70009
Mixtures of p,p′-DDE, PCB153, BDE47, and PFOS Alter Adipocytic Differentiation of 3T3-L1 Cells
Garcia, M., Pearce, J. L., Jacobellis, M. A., Baldwin, W. S., Hunt, K. J., & Bain, L. J. (2025) · Toxics · doi:10.3390/toxics13110975
Additional file 1 of Perfluorinated compounds in adults and their association with fasting glucose and incident diabetes: a prospective cohort study
Chung, S. M., Heo, D.-G., Kim, J.-H., Yoon, J. S., Lee, H. W., Kim, J.-Y., Moon, J. S., & Won, K. C. (2022) · Figshare · doi:10.6084/m9.figshare.21405733
Age disparities in PFAS-associated influenza-like illness among adult females at low exposure levels
Lin, N., Yang, R., Zhang, Y., Yang, Z., Li, N., & Wang, B. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141225 · Cited by 1
Unraveling the PFOS-NSCLC axis: integrated network toxicology, machine learning, and causal inference identify EIF4EBP1 as a key molecular hub
Huang, T., Pang, H., Wang, J., Guo, J., Hu, K., & Zhou, H. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1751125
Exposure to per- and polyfluoroalkyl substance (PFAS) mixtures increases papillary thyroid cancer risk and clinicopathological aggressiveness: Findings from a case-control study and risk assessment
Yu, Y., Wang, Y., Su, X., Wang, Q., Wang, C., Cai, Z., Zhao, Y., Zhang, T., Hu, D., & Liu, Z. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119941
Optimisation d'approches combinées de métabolomique pour l'étude des effets métaboliques hépatiques induits par l'exposition à l'acide perfluorooctanoîque
Villaret, J. (2021) · theses.fr (ABES) · doi:10.70675/88074c0bz45a5z41a8z9728zc0482ec8d2de
Etude de l'impact des perturbateurs endocriniens sur le développement des gonades avec des approches de toxicogénomique et de toxicologie prédictive
Kugathas, I. (2023) · theses.fr (ABES) · doi:10.70675/c44cbf0dz50c5z4d03zafb6z6bf8ffd5c7ca
Elevated serum levels of perfluorophosphonates among elderly residents living near e-waste dismantling areas and their associations with glucose homeostasis
Qin, R., Zhang, B., Chen, Y., Wei, Z., Zhu, H., Sun, H., & Zhang, T. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142317
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Marinello, W. P., & Zylka, M. J. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1814052
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Mylroie, J. E., Gust, K. A., Blanksma, C., Lawrence, A. B., Hoke, A. V., Rosales, I. N. C., Wilbanks, M. S., Steward, C., García‐Reyero, N., Gautam, A., et al. (2026) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgag143
PFAS exposure and implications on human metabolic function based on a cross-sectional study from a southern city, China
Xie, G., Liu, Y., Peng, J., Jiang, Y., Lin, X., Zhuo, L., Song, J., & 张建清 (2026) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2026.06.011
Associations between prenatal per- and polyfluoroalkyl substance exposure and maternal fatty acid homeostasis: Nonmonotonic, compartment-specific patterns in plasma and red blood cells
Liao, C., Zhang, Y., Zeng, Y., Liu, P., Zhong, S., Mu, Y., Wu, Y., Li, T., Zhou, Z., & Zhou, Z. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142843
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Huang, L., Zhou, Y., Xiao, H., Li, Y., Zhou, Z., Xiao, Z., Tong, Y., Hu, K., Wang, S., Shen, M., et al. (2026) · The Innovation Medicine · doi:10.59717/j.xinn-med.2026.100233
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Lenz, B. Q., Ankley, G. T., & Etterson, M. A. (2026) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgag203
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Khan, S., Chen, M., Chen, Z., Liang, Z., Abbas, M., Ahmad, S., Hassan, M. U., Xie, S., & Chen, D. (2026) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2026.110732

Authors: Takacs, M. L., & Abbott, B. D.
Affiliations: Environmental Protection Agency (US)
ORCID: Abbott, Barbara D.
Venue: Toxicological Sciences
Publisher: Oxford University Press (OUP)
Published: 2006-10-17
Volume: 95
Issue: 1
Pages: 108-117
ISSN: 1096-0929 (ISSN-L)
1096-6080
DOI: 10.1093/toxsci/kfl135
OpenAlex: W2120447865
Cited by: 396
References: 53
Citations by year: 2026: 23 · 2025: 29 · 2024: 26 · 2023: 24 · 2022: 24 · 2021: 33 · 2020: 25 · 2019: 15 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 17 · 2014: 20 · 2013: 16 · 2012: 17
FWCI: 13.57
Type: journal article
Language: en
Open access: closed
Locations: Toxicological Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: perfluorooctanoic acid, PFOS, perfluoroalkyl acids, peroxisome proliferator-activated receptors, PPARα, PPARδ, PPARγ, receptor activation, MK-886, GW9662, dose-response relationship, perfluorinated compounds
MeSH terms: Animals, Caprylates, Chlorocebus aethiops, Dose-Response Relationship, Drug, Environmental Pollutants, Fluorocarbons, Humans, Luciferases, Species Specificity, Transfection, Transcriptional Activation, Alkanesulfonic Acids, Genes, Reporter, COS Cells, Peroxisome Proliferator-Activated Receptors, PPAR alpha, PPAR delta, PPAR gamma, PPAR-beta, Mice

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Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate

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