Poly(ADP-Ribose) Polymerase-1 Inhibition by Arsenite Promotes the Survival of Cells With Unrepaired DNA Lesions Induced by UV Exposure
Open accessAbstract
Human arsenic exposure is associated with increased risk of skin cancer, and arsenite greatly enhances ultraviolet (UV)-induced skin tumors in a mouse model of carcinogenesis. Inhibition of DNA repair is one proposed mechanism for the observed cocarcinogenicity. We have previously demonstrated that low concentrations of arsenite inhibit poly(ADP-ribose) polymerase (PARP)-1, thus interfering with DNA repair process triggered by UV radiation. Because overactivation of PARP-1 often leads to apoptotic cell death, and unrepaired DNA lesions promote genomic instability and carcinogenesis, we hypothesized that inhibition of PARP-1 by arsenic may promote the survival of potentially "initiated carcinogenic cells," i.e., cells with unrepaired DNA lesions. In the present study, we tested this hypothesis on UV-challenged HaCat cells. Cells were pretreated with 2μM arsenite for 24 h before UV exposure. Outcome parameters included apoptotic death rate, PARP-1 activation, apoptotic molecules, and retention of DNA lesions. UV exposure induced PARP-1 activation and associated poly(ADP-ribose) production, apoptosis-inducing factor release, cytochrome C release, and caspases activation, which led to apoptotic death in HaCat cells. Pretreatment with 2μM arsenite significantly inhibited UV-induced cell death as well as the associated molecular events. Notably, knockdown of PARP-1 with small interfering RNA completely abolished the antagonism of arsenite. Furthermore, arsenite pretreatment led to long-term retention of UV-induced cyclobutane pyrimidine dimers. Together, these results suggest that low concentration of arsenite reduces UV-induced apoptosis via inhibiting PARP-1, thus promoting the survival of cells with unrepaired DNA lesions, which may be an important mechanism underlying arsenic cocarcinogenic action.
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PARP activation is crucial for damage signaling, and cell death occurs only after achieving a particular threshold.
“However, PARP activation is crucial for damage signaling and only after achieving a particular threshold does cell death occur.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [68]
Inhibition of PARP-1 with PARP inhibiting agents may promote cell survival in response to UV radiation, but cells most probably accommodate unrepaired DNA lesions contributing to UV-induced carcinogenesis.
“Inhibition of PARP-1 with PARP inhibiting agents (such as low concentration of arsenite) may promote cell survival in response to UV radiation, but the cells most probably accommodate unrepaired DNA lesions contributing to UV-induced carcinogenesis [68].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [68]
UV radiation produces significant DNA damage that leads to excessive PARP-1 activation and cell death.
“UV radiation produces significant DNA damage that leads to excessive PARP-1 activation and cell death.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [68]
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Cites
Poly(ADP-ribose): novel functions for an old molecule
Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,917 · see citing works
PARP inhibition: PARP1 and beyond
Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., & Poirier, G. G. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2812 · Cited by 1,298 · see citing works
Petrusevski, B., Sharma, S. K., Shordt, K., Schippers, J. C., & van Wijk, C. (2009) · Cited by 1,273 · see citing works
Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms
Beyersmann, D., & Hartwig, A. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0313-y · Cited by 1,209 · see citing works
Toxicological profile for arsenic
Chou, C.-H. S. J. (.-H. S. J. )., & Harper, C. (2007) · doi:10.15620/cdc:11481 · Cited by 1,175 · see citing works
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
Chaitanya, G. V., Alexander, J. S., & Babu, P. P. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-31 · Cited by 929 · see citing works
Role of oxidative stress and DNA damage in human carcinogenesis
Kryston, T. B., Georgiev, A. B., Pissis, P., & Georgakilas, A. G. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.016 · Cited by 927 · see citing works
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606528103 · Cited by 718 · see citing works
Poly(ADP-ribose) (PAR) polymer is a death signal
Andrabi, S. A., Kim, N. S., Yu, S.-W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606526103 · Cited by 644 · see citing works
Lange, S. S., Takata, K.-I., & Wood, R. D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2998 · Cited by 615 · see citing works
Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis
Ziech, D., Franco, R., Pappa, A., & Panayiotidis, M. I. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.015 · Cited by 568 · see citing works
Role of AIF in caspase-dependent and caspase-independent cell death
Cregan, S. P., Dawson, V. L., & Slack, R. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207517 · Cited by 520 · see citing works
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
Wang, Y., Dawson, V. L., & Dawson, T. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.020 · Cited by 405 · see citing works
Arsenic carcinogenesis in the skin
Yu, H.-S., Liao, W.-T., & Chai, C.-Y. (2006) · Journal of Biomedical Science · doi:10.1007/s11373-006-9092-8 · Cited by 318 · see citing works
Molecular mechanisms of arsenic carcinogenesis
Huang, C., Ke, Q., Costa, M., & Shi, X. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007261.04684.78 · Cited by 288 · see citing works
Oxidative stress and apoptosis in metal ion-induced carcinogenesis
Shi, H., Hudson, L. G., & Liu, K. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.012 · Cited by 270 · see citing works
Self-citationEvidence that arsenite acts as a cocarcinogen in skin cancer
Rossman, T. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.10.016 · Cited by 249 · see citing works
Rossman, T. G., Uddin, A., Burns, F. J., & Bosland, M. C. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9277 · Cited by 224 · see citing works
Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis
Witkiewicz-Kucharczyk, A., & Bal, W. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.10.018 · Cited by 215 · see citing works
Kitchin, K. T., & Conolly, R. B. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900343d · Cited by 202 · see citing works
Poly ADP-ribose polymerase-1: An international molecule of mystery
Woodhouse, B. C., & Dianov, G. L. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.009 · Cited by 179 · see citing works
Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs
Zhou, X., Sun, X., Cooper, K. L., Wang, F., Liu, K. J., & Hudson, L. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232926 · Cited by 177 · see citing works
Self-citationPoly(ADP-ribose) makes a date with death
Heeres, J. T., & Hergenrother, P. J. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.08.038 · Cited by 158 · see citing works
Lung Cancer in a U.S. Population with Low to Moderate Arsenic Exposure
Heck, J. E., Andrew, A. S., Onega, T., Rigas, J. R., Jackson, B. P., Karagas, M. R., & Duell, E. J. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900566 · Cited by 158 · see citing works
Modulation of DNA repair processes by arsenic and selenium compounds
Hartwig, A., Blessing, H., Schwerdtle, T., & Walter, I. (2003) · Toxicology · doi:10.1016/j.tox.2003.08.004 · Cited by 150 · see citing works
Ding, W. Q., Liu, W., Cooper, K. L., Qin, X.-J., Bergo, P. L. D. S., Hudson, L. G., & Liu, K. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805566200 · Cited by 148 · see citing works
Self-citationCoordination of Altered DNA Repair and Damage Pathways in Arsenite-Exposed Keratinocytes
Hamadeh, H. K. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.2.306 · Cited by 136 · see citing works
The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives
Gagné, J., Hendzel, M. J., Droit, A., & Poirier, G. G. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.02.013 · Cited by 122 · see citing works
Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci<sup>†</sup>
De Gruijl, F. R., & Rebel, H. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00275.x · Cited by 120 · see citing works
Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity
Maier, A., Schumann, B. L., Chang, X., Talaska, G., & Puga, A. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00057-8 · Cited by 120 · see citing works
Burns, F. J., Uddin, A. N., Wu, F., Nádas, A., & Rossman, T. G. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6655 · Cited by 114 · see citing works
Insights into the carcinogenic mode of action of arsenic
Kligerman, A. D., & Tennant, A. H. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.006 · Cited by 107 · see citing works
Opening the doors to cytochrome c: Changes in mitochondrial shape and apoptosis
Scorrano, L. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.04.016 · Cited by 94 · see citing works
Ultraviolet Radiation and Cutaneous Carcinogenesis
Molho‐Pessach, V., & Lotem, M. (2007) · Current Problems in Dermatology · doi:10.1159/000106407 · Cited by 92 · see citing works
Pi, J., He, Y., Bortner, C. D., Huang, J.-L., Liu, J., Zhou, T., Qu, W., North, S. L., Kasprzak, K. S., Diwan, B. A., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.20990 · Cited by 79 · see citing works
Qin, X.-J., Hudson, L. G., Liu, W., Timmins, G. S., & Liu, K. J. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.05.019 · Cited by 69 · see citing works
Self-citationDual Actions Involved in Arsenite-Induced Oxidative DNA Damage
Qin, X.-J., Hudson, L. G., Liu, W., Ding, W., Cooper, K. L., & Liu, K. J. (2008) · Chemical Research in Toxicology · doi:10.1021/tx8001548 · Cited by 57 · see citing works
Self-citationThe molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival
Paul, O. H. (2009) · Frontiers in bioscience · doi:10.2741/3232 · Cited by 53 · see citing works
Siegel, C., & McCullough, L. D. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02229.x · Cited by 50 · see citing works
Durham, T. R., & Snow, E. T. (2006) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7378-4_5 · Cited by 42 · see citing works
Ding, W., Hudson, L. G., Sun, X. H., Feng, C., & Liu, K. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.022 · Cited by 38 · see citing works
Self-citationSchalau, J. (2005) · UA Campus Repository (The University of Arizona) · Cited by 30 · see citing works
Wu, F. C., Burns, F. J., Zhang, R., Uddin, A., & Rossman, T. G. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7846 · Cited by 25 · see citing works
Stevenson, R. L. (2013) · Cited by 25 · see citing works
Chen, P., Lan, C.-C. E., Chiou, M.-H., Hsieh, M.-C., & Chen, G. (2005) · Chemical Research in Toxicology · doi:10.1021/tx049834b · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Andrabi, S. A., Kim, N. S., Yu, S. W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., et al . (2006). Poly(ADPribose) (PAR) polymer is a death signal. Proc. Natl. Acad. Sci. U.S.A. 103, 18308-18313.
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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works
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Cohen, S. M., Arnold, L. L., Beck, B. D., Lewis, A. S., & Eldan, M. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.827152 · Cited by 170 · see citing works
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Morales, M. E., Derbes, R. S., Ade, C. M., Ortego, J. C., Stark, J. M., Deininger, P. L., & Roy‐Engel, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151367 · Cited by 163 · see citing works
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Tam, L. M., Price, N. E., & Wang, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00464 · Cited by 153 · see citing works
Molecular features in arsenic-induced lung tumors
Hubaux, R., Becker‐Santos, D. D., Enfield, K. S. S., Rowbotham, D. A., Lam, S. C., Lam, W. L., & Martínez, V. D. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-20 · Cited by 144 · see citing works
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Bhattacharjee, P., Banerjee, M., & Giri, A. K. (2013) · Environment International · doi:10.1016/j.envint.2012.12.004 · Cited by 132 · see citing works
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Bernstein, C., Anil, R., Nfonsam, V. N., & Bernstei, H. (2013) · InTech eBooks · doi:10.5772/53919 · Cited by 94 · see citing works
Zhao, Y., Pan, R., Li, S., Luo, Y., Yan, F., Yin, J., Qi, Z., Yan, Y., Ji, X., & Liu, K. J. (2014) · Stroke · doi:10.1161/strokeaha.113.004296 · Cited by 70 · see citing works
Self-citationEbert, F., Leffers, L., Weber, T., Berndt, S., Mangerich, A., Beneke, S., Bürkle, A., & Schwerdtle, T. (2013) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2013.06.004 · Cited by 54 · see citing works
Zhang, F., Paramasivam, M., Cai, Q., Dai, X., Wang, P., Lin, K., Song, J., Seidman, M. M., & Wang, Y. (2014) · Journal of the American Chemical Society · doi:10.1021/ja507863d · Cited by 53 · see citing works
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Soza‐Ried, C., Bustamante, E. I., Caglevic, C., Rolfo, C. D., Sirera, R., & Marsiglia, H. R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.01.012 · Cited by 51 · see citing works
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Pines, A., Mullenders, L. H. F., van Attikum, H., & Luijsterburg, M. S. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.03.002 · Cited by 48 · see citing works
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Self-citationMonomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells
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Self-citationWilson, J., Zuniga, M. C., Yazzie, F., & Stearns, D. M. (2014) · Journal of Applied Toxicology · doi:10.1002/jat.3015 · Cited by 20 · see citing works
Xu, H., Lauer, F. T., Liu, K. J., Hudson, L. G., & Burchiel, S. W. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw151 · Cited by 20 · see citing works
Self-citationWang, L., Hitron, J. A., Wise, J. T. F., Son, Y., Roy, R. V., Kim, D., Dai, J., Pratheeshkumar, P., Zhang, Z., Xu, M., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.019 · Cited by 16 · see citing works
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Burchiel, S. W., Lauer, F. T., Factor-Litvak, P. R., Liu, X., Islam, T., Eunus, M., Horayara, M. A., Islam, M. T., Rahman, M., Ahmed, A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234965 · Cited by 13 · see citing works
Luo, Q., Li, Y., Lai, Y., & Zhang, Z. (2015) · The Journal of Toxicological Sciences · doi:10.2131/jts.40.349 · Cited by 13 · see citing works
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Ezeh, P. C., Lauer, F. T., Liu, K. J., Hudson, L. G., & Burchiel, S. W. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0279-6 · Cited by 11 · see citing works
Self-citationChakrabarty, N. (2015) · CRC Press eBooks · doi:10.1201/b18734 · Cited by 11 · see citing works
Xu, H., Medina, S., Lauer, F. T., Douillet, C., Liu, K. J., Hudson, L. G., Stýblo, M., Aleksunes, L. M., & Burchiel, S. W. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx075 · Cited by 11 · see citing works
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- Authors
- Qin, X.-J., Liu, W., Li, Y.-N., Sun, X., Hai, C.-X., Hudson, L. G., & Liu, K. J.
- Affiliations
- University of New Mexico (US)
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-02
- Volume
- 127
- Issue
- 1
- Pages
- 120-129
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- PMC
- PMC3327874
- OpenAlex
- W2122671671
- Cited by
- 43
- References
- 45
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 1
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA118100)
- National Institute of Environmental Health Sciences (R01ES15826-03S1, R01ES015826, R01ES012938, R01ES021100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Keywords
- arsenite, PARP1, PARP1 inhibition, ultraviolet radiation, DNA repair, DNA damage, apoptosis, cyclobutane pyrimidine dimers, skin cancer, HaCaT keratinocytes, cytochrome c release, caspase activation
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase-1, Cell Line, Transformed, Cell Survival, DNA Damage, DNA Repair, Dose-Response Relationship, Drug, Enzyme Inhibitors, Humans, Radiation Effects, Ultraviolet Rays, Keratinocytes, Apoptosis, Arsenites, Gene Silencing, Gene Knockdown Techniques, Caspase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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