Autophagy Is a Cell Self-Protective Mechanism Against Arsenic-Induced Cell Transformation

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Reactive Oxygen Species

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Autophagy suppresses tumor progression by limiting chromosomal instabilityPreprint

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Autophagy is a protective mechanism in normal cartilage, and its aging‐related loss is linked with cell death and osteoarthritis

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Tumor measurement in the nude mouse

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Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

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Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

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Role of autophagy in suppression of inflammation and cancer

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The multiple roles of autophagy in cancer

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Molecular mechanisms of arsenic carcinogenesis

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Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

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Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

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Chapter 1 Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3

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Is mitochondrial generation of reactive oxygen species a trigger for autophagy?

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Mitochondrial ROS generation for regulation of autophagic pathways in cancer

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The paradox of autophagy and its implication in cancer etiology and therapy

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Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation

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Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine

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Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation

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What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy?

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NADPH Oxidase Activation Is Required in Reactive Oxygen Species Generation and Cell Transformation Induced by Hexavalent Chromium

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A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

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A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase

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Arsenic Induced Mitochondrial DNA Damage and Altered Mitochondrial Oxidative Function: Implications for Genotoxic Mechanisms in Mammalian Cells

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Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide

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Ethanol promotes endoplasmic reticulum stress‐induced neuronal death: Involvement of oxidative stress

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Endogenous IL-12 triggers an antiangiogenic program in melanoma cells

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Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation

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Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1

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Why Sick Cells Produce Tumors: The Protective Role of Autophagy

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Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells

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Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes

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Comparison of Gene Expression Profiles in Chromate Transformed BEAS-2B Cells

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Macroautophagy and its role in nutrient homeostasis

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Synergistic Effect of Cyclin D1 and c-Myc Leads to More Aggressive and Invasive Mammary Tumors in Severe Combined Immunodeficient Mice

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Autophagy process is associated with anti-neoplastic function

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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

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Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals

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Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane

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Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis

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Toxic Metals and Autophagy

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Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway

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Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress

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Role of Nrf2 and Autophagy in Acute Lung Injury

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Role of mitochondria ROS and DNA damage in arsenic induced carcinogenesis

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Culture conditions profoundly impact phenotype in BEAS‐2B, a human pulmonary epithelial model

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Autophagy Inhibition by Sustained Overproduction of IL6 Contributes to Arsenic Carcinogenesis

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Dual Roles of Oxidative Stress in Metal Carcinogenesis

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Arsenic exposure induces the Warburg effect in cultured human cells

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NRF2 signalling pathway: New insights and progress in the field of wound healing

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Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression

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Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations

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Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics

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Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract

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The protective effect of autophagy on mouse spermatocyte derived cells exposure to 1800MHz radiofrequency electromagnetic radiation

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Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism

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Progress and Prospects of Reactive Oxygen Species in Metal Carcinogenesis

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Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability

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Sodium arsenite induces ROS-dependent autophagic cell death in pancreatic β-cells

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Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective

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From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect inCaenorhabditis elegans

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Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

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The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway

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Highly Stable Iron Carbonyl Complex Delivery Nanosystem for Improving Cancer Therapy

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A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis

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PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling

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M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells

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Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cells

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Evaluation of tumorigenic potential of CeO2 and Fe2O3 engineered nanoparticles by a human cell in vitro screening model

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The mechanistic role of chemically diverse metal ions in the induction of autophagy

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Oxidative stress-induced autophagy: Role in pulmonary toxicity

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Activation of Autophagy Rescues Amiodarone-Induced Apoptosis of Lung Epithelial Cells and Pulmonary Toxicity in Rats

Lee, K.-Y., Oh, S., Choi, Y., Oh, S., Yang, Y., Yang, M., Lee, K., & Lee, B. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft168 · Cited by 30 · see citing works

Melatonin improves arsenic-induced hypertension through the inactivation of the Sirt1/autophagy pathway in rat

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A comprehensive review of metal-induced cellular transformation studies

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Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line

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The p-eIF2α/ATF4 pathway links endoplasmic reticulum stress to autophagy following the production of reactive oxygen species in mouse spermatocyte-derived cells exposed to dibutyl phthalate

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Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes

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Premature senescence is regulated by crosstalk among TFEB, the autophagy lysosomal pathway and ROS derived from damaged mitochondria in NaAsO2-exposed auditory cells

Suzuki, Y., Hayashi, K., Goto, F., Nomura, Y., Fujimoto, C., & Makishima, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02139-4 · Cited by 25 · see citing works

Autophagy as the effector and player in DNA damage response of cells to genotoxicants

Zhang, S.-M., Shang, Z., & Zhou, P. (2015) · Toxicology Research · doi:10.1039/c5tx00043b · Cited by 23 · see citing works

Autophagy upregulation as a possible mechanism of arsenic induced diabetes

Zeinvand‐Lorestani, M., Kalantari‬, H., Khodayar, M. J., Teimoori, A., Saki, N., Ahangarpour, A., Rahim, F., & Alboghobeish, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-30439-0 · Cited by 25 · see citing works

Arsenite-Induced Pseudo-Hypoxia Results in Loss of Anchorage-Dependent Growth in BEAS-2B Pulmonary Epithelial Cells

Zhao, F. L., Malm, S. W., Hinchman, A., Cherrington, N. J., Beeks, C. G., & Klimecki, W. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114549 · Cited by 25 · see citing works

Recent insights into autophagy and metals/nanoparticles exposure

Li, Q., Feng, Y., Wang, R., Liu, R., Ba, Y., & Huang, H. (2023) · Toxicological Research · doi:10.1007/s43188-023-00184-2 · Cited by 25 · see citing works

Co-exposure to arsenic and fluoride to explore the interactive effect on oxidative stress and autophagy in myocardial tissue and cell

Tian, X., Wang, M., Ying, X., Dong, N., Li, M., Feng, J. Q., Zhao, Y., Zhao, Q., Tian, F., Li, B., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114647 · Cited by 24 · see citing works

Autophagy in arsenic carcinogenesis

Qi, Y., Li, H., Zhang, M., Zhang, T., Frank, J. A., & Chen, G. (2014) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2014.01.004 · Cited by 24 · see citing works

Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes

Chen, D., Stueckle, T. A., Luanpitpong, S., Rojanasakul, Y., Lu, Y., & Wang, L. (2015) · Nanoscale Research Letters · doi:10.1186/s11671-014-0707-0 · Cited by 24 · see citing works

Natural β-carboline alkaloids regulate the PI3K/Akt/mTOR pathway and induce autophagy in insect Sf9 cells

Cui, G., Shu, B., Sethuraman, V., Yuan, H., Yi, X., & Zhong, G. (2018) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2018.12.005 · Cited by 22 · see citing works

Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs

Zhao, Y., Su, X., Gao, Y., Yin, H., Wang, L., Qiao, R., & Wang, S. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22334 · Cited by 21 · see citing works

The impact of oil spill to lung health—Insights from an RNA-seq study of human airway epithelial cells

Liu, Y., Roy‐Engel, A. M., Baddoo, M., Flemington, E. K., Wang, G., & Wang, H. (2015) · Gene · doi:10.1016/j.gene.2015.12.016 · Cited by 20 · see citing works

A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis

Shukla, V., Chandrasekaran, B., Tyagi, A., Navin, A. K., Saran, U., Adam, R. M., & Damodaran, C. (2022) · Cells · doi:10.3390/cells11152435 · Cited by 20 · see citing works

Dysregulation of autophagy-related lncRNAs in peripheral blood of coronary artery disease patients

Ebadi, N., Ghafouri‐Fard, S., Taheri, M. N., Arsang‐Jang, S., Parsa, S. A., & Omrani, M. D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172852 · Cited by 19 · see citing works

ATF3 inhibits arsenic-induced malignant transformation of human bronchial epithelial cells by attenuating inflammation

Shi, Q., Hu, B., Yang, C., Deng, S., Cheng, X., Wu, J., & Qi, N. (2021) · Toxicology · doi:10.1016/j.tox.2021.152890 · Cited by 17 · see citing works

Graphene oxide antagonizes the toxic response to arsenic via activation of protective autophagy and suppression of the arsenic-binding protein LEC-1 in Caenorhabditis elegans

Dai, H., Liu, Y., Wang, J., Nie, Y., Sun, Y., Wang, M., Wang, D., Yang, Z. C., Cheng, L., Wang, J., et al. (2018) · Environmental Science Nano · doi:10.1039/c8en00244d · Cited by 17 · see citing works

Arsenic Compromises Both p97 and Proteasome Functions

Tillotson, J., Zerio, C. J., Harder, B. G., Ambrose, A. J., Jung, K. S., Kang, M., Zhang, D. D., & Chapman, E. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00158 · Cited by 17 · see citing works

Carbon Nanotubes Induce Apoptosis Resistance of Human Lung Epithelial Cells Through FLICE-Inhibitory Protein

Pongrakhananon, V., Luanpitpong, S., Stueckle, T. A., Wang, L., Nimmannit, U., & Rojanasakul, Y. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu251 · Cited by 15 · see citing works

Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway

Wu, L., Wang, Z., Li, X., He, X., Han, Y., Chen, Y., Liu, L., Fu, L., & Zhang, T. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.06.006 · Cited by 15 · see citing works

The role of autophagy in metal-induced urogenital carcinogenesis

Saran, U., Tyagi, A., Chandrasekaran, B., Ankem, M. K., & Damodaran, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.022 · Cited by 15 · see citing works

Long term exposure to environmental concentrations of diesel exhaust particles does not impact the phenotype of human bronchial epithelial cells

Savary, C. C., Bellamri, N., Morzadec, C., Langouët, S., Lecureur, V., & Vernhet, L. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.06.014 · Cited by 13 · see citing works

Iron Oxide Nanoparticle-Induced Neoplastic-Like Cell Transformation in Vitro Is Reduced with a Protective Amorphous Silica Coating

Kornberg, T. G., Stueckle, T. A., Coyle, J. P., Derk, R. C., Demokritou, P., Rojanasakul, Y., & Rojanasakul, L. W. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00118 · Cited by 12 · see citing works

Graphene oxide regulates endoplasmic reticulum stress: autophagic pathways in nasopharyngeal carcinoma cells.

Xiao, H., Yang, X., Luo, L.-H., & Zong, N. (2018) · Europe PMC (PubMed Central) · Cited by 11 · see citing works

GJA1 reverses arsenic-induced EMT via modulating MAPK/ERK signaling pathway

Wu, L., Wang, Z., He, X., Jiang, Y., Pan, R., Chen, S., Chen, Y., Han, Y., Yu, H., & Zhang, T. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116138 · Cited by 11 · see citing works

AMPKα is active in autophagy of endothelial cells in arsenic-induced vascular endothelial dysfunction by regulating mTORC1/p70S6K/ULK1

Xu, Z., Liu, Q., Li, J., Wang, J., Yang, Z., Wang, J., Gao, L., Cheng, J., He, J., Dong, Y., et al. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110832 · Cited by 10 · see citing works

Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells

Tu, W., Liu, Y., Xie, C., & Zhou, X. M. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3555 · Cited by 10 · see citing works

Crosstalk between autophagy and apoptosis induced by camphor in Schizosaccharomyces pombe

Ağuş, H. H., Yilmaz, S., & Şengöz, C. O. (2019) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1908-11 · Cited by 9 · see citing works

The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis

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Arsenic-induced suppression of kidney cell proliferation and the transcriptional coregulator MAML1

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Alterations of miRNAs and Their Potential Roles in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells

Gu, S., Sun, D., Li, X., & Zhang, Z. (2017) · Genes · doi:10.3390/genes8100254 · Cited by 9 · see citing works

Autophagy in Toxicology: Defense against Xenobiotics

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Beneficial and detrimental effects of antioxidants in cancer

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Sodium arsenite-induced cytotoxicity is regulated by BNIP3L/Nix-mediated endoplasmic reticulum stress responses and CCPG1-mediated endoplasmic reticulum-phagy

Kim, S. H., & Oh, S. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104111 · Cited by 6 · see citing works

STAT3in arsenic lung carcinogenicity

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Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells

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Transformed ALDH2−/− hepatocytes by ethanol could serve as a useful tool for studying alcoholic hepatocarcinogenesis

Zhang, X., Meng, F.-G., Wang, Y., Liu, S.-X., & Zeng, T. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110366 · Cited by 4 · see citing works

Metals and Autophagy in Neurotoxicity

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Constructing interactive networks of functional genes and metabolites to uncover the cellular events related to colorectal cancer cell migration induced by arsenite

Zhang, R., Sun, J., Tu, L., Lu, W., Li, Y., Luan, T., & Chen, B. (2023) · Environment International · doi:10.1016/j.envint.2023.107860 · Cited by 3 · see citing works

Advances in molecular mechanisms of heavy metal induced cell malignant transformation

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Culture of Continuous Cell Lines

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Role of Autophagy in Cancer Development via Mitochondrial Reactive Oxygen Species

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Arsenite-induced cytotoxicity is regulated by poly-ADP ribose polymerase 1 activation and parthanatos in p53-deficient H1299 cells: The roles of autophagy and p53

So, K.-Y., & Oh, S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.018 · Cited by 1 · see citing works

Paradigms in Heavy Metal Induced Autophagy: A Toxicological Approach

Bhattacharya, S., Bose, M., & Munshi, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00136-4 · Cited by 1 · see citing works

Designing novel Au(III) complexes based on the structure of diazepam: Achieving a multiaction mechanism against glioma

Li, Y., Liu, H., Fang, R., Jin, J., Yang, F., Chen, J., & Zhang, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117171 · Cited by 1 · see citing works

Cadmium-induced Autophagy and Autophagic Contribution to Cell Death in Cadmium-treated Mesangial Cells

Ahmadi, B. (2016) · TSpace (University of Toronto)

ARSENIC INDUCED PSEUDOHYPOXIA IN MALIGNANT TRANSFORMATION: THE ROLE OF HIF-1A MEDIATED METABOLISM DISTURBANCE

Zhao, F. L. (2014) · UA Campus Repository (The University of Arizona)

Critical Physicochemical Properties for Nanoparticle Toxicity: Impact of Surface Coating and Size on Particle-Induced Cell Transformation and Inflammatory Response

Kornberg, T. G. (2019) · doi:10.33915/etd.7430

Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells

Zhang, Z., Pratheeshkumar, P., Budhraja, A., Son, Y., Kim, D., & Shi, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.010 · Cited by 69 · see citing works

Autophagy in arsenic carcinogenesis

Qi, Y., Li, H., Zhang, M., Zhang, T., Frank, J. A., & Chen, G. (2014) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2014.01.004 · Cited by 24 · see citing works

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

Wu, X., Sun, R. B., Wang, H., Yang, B., Wang, F., Xu, H., Chen, S., Zhao, R., Pi, J., & Xu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1038932 · Cited by 45 · see citing works

Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway

Wu, L., Wang, Z., Li, X., He, X., Han, Y., Chen, Y., Liu, L., Fu, L., & Zhang, T. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.06.006 · Cited by 15 · see citing works

P12-03 Rethinking human testicular organoid formation: the missing toxicological model for the human testis?

Silva, S. M., Richer, G., Goossens, E., & Baert, Y. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.07.482