The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1
Abstract
One of the most promising applications of microarrays is the study of changes in gene expression associated with the growth and development of mammalian tissues. The testis provides an excellent model to determine the ability of microarrays to effectively characterize the changes in gene expression as an organ develops from birth to adulthood. To this end, a developmental testis gene expression time course profiling the expression patterns of approximately 36 000 transcripts on the Affymetrix MGU74v2 GeneChip platform at 11 distinct time points was created to gain a greater understanding of the molecular changes necessary for and elicited by the development of the testis. Additionally, gene expression profiles of isolated testicular cell types were created that can aid in the further characterization of the specific functional actions of each cell type in the testis. Statistical analysis of the data revealed 11 252 transcripts (9846 unique) expressed differentially in a significant manner. Subsequent cluster analysis produced five distinct expressional patterns within the time course. These patterns of expression are present at distinct chronological periods during testis development and often share similarities with cell-specific expression profiles. Analysis of cell-specific expression patterns produced unique and characteristic groups of transcripts that provide greater insight into the activities, biological and chronological, of testicular cell types during the progression of spermatogenesis. Further analysis of this time course can provide a distinct and more definitive view into the genes implicated, known and unknown, in the maturation, maintenance, and function of the testis and the integrated process of spermatogenesis.
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Cites
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Cited by
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
Self-citationCellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis
Soumillon, M., Necsulea, A., Weier, M., Brawand, D., Zhang, X., Gu, H., Barthès, P., Kokkinaki, M., Nef, S., Gnirke, A., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.031 · Cited by 607
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The Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
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Metadata
- Authors
- Shima, J. E., McLean, D. J., McCarrey, J. R., & Griswold, M. D.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 71
- Issue
- 1
- Pages
- 319-330
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2133948311
- Cited by
- 488
- References
- 66
- FWCI
- 33.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shima, J. E., McLean, D. J., McCarrey, J. R., & Griswold, M. D. (2004). The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.103.026880
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