The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
A Suppression of Gonadotropin Secretion by Cortisol in Castrated Male Rhesus Monkeys (Macaca Mulatta) Mediated by the Interruption of Hypothalamic Gonadotropin-Releasing Hormone Release1
Abstract
Four orchidectomized rhesus monkeys (3-3.5 yr of age) were treated for 62 days with daily i.m. injections of hydrocortisone acetate (HCA) at a dose of 10-20 mg/(kg BW X day), and blood samples were obtained daily or every other day before, during, and after treatment. Hydrocortisone acetate injections resulted in a progressive rise in mean plasma cortisol from basal concentrations of 17-35 micrograms/100 ml prior to initiation of steroid treatment to approximately 150 micrograms/100 ml 5 wk later. When serum cortisol concentrations reached 100 micrograms/100 ml, 3-4 wk after the initiation of HCA treatment, circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) began to decline, reaching nondetectable concentrations 35 days later. Withdrawal of HCA resulted in a return in plasma cortisol concentrations to pretreatment control levels, which was associated with a complete restoration of gonadotropin secretion. In 2 animals, administration of an intermittent i.v. infusion of gonadotropin-releasing hormone (GnRH) (0.1 micrograms/min for 3 min once every hour), which appears to stimulate the gonadotropes in a physiologic manner, reversed the cortisol-induced inhibition of gonadotropin secretion, restoring circulating LH and FSH concentrations to within 80-100% of control. These results suggest that, in the rhesus monkey, the major site of the inhibitory action of cortisol on gonadotropin release resides at a suprapituitary level and is mediated by interruption of hypothalamic GnRH release.
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“In vertebrate models, stress-induced glucocorticoids repress the HPG axis by inhibiting GnRH neurons or stimulating neurons releasing gonadotropin-inhibitory hormone (GnIH) [89–91].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [90]
In the citing paper
“Cortisol has been shown to inhibit gonadotropin secretion directly in vitro [20] and indirectly in vivo, as determined by the ability of i.v.GnRH to restore normal gonadotropin secretion in hypogonadotropic, hydrocortisone-treated animals [21].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [21]
In the citing paper
“This finding suggests that cortisol acts directly on the hypothalamus to suppress GnRH secretion and is in agreement with other reports suggesting a suprapituitary site of action for cortisol [21].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [21]
Citations
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Arita, K., Hirano, H., Unoue, S., Fujio, S., Habu, M., Tominaga, A., Sakoguchi, T., & Kurisu, K. (2009) · Japanese Journal of Neurosurgery · doi:10.7887/jcns.18.347
Acute Stress Response in Women with Recurrent Miscarriage and Infertility
Bhandari, S. (2018) · Nepalese Medical Journal · doi:10.3126/nmj.v1i1.20393
Jayamurali, D., & Govindarajulu, S. N. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i8.26635
Camacho, M. B. (2018) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Hypothalamic Disorders During Ovulation, Pregnancy, and Lactation
Papadakis, G. E., Xu, C., & Pitteloud, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00016-7
Yu, B. P., Darves-Bornoz, A. L., Brannigan, R. E., & Halpern, J. A. (2020) · F&S Reports · doi:10.1016/j.xfre.2020.09.014
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Mecanismos del estrés y efectos sobre la reproducción animal
Góngora-Orjuela, A., & Cardoso, J. L. C. (2002) · Revista de la Facultad de Medicina Veterinaria y de Zootecnia
Efecto del estrés crónico en la espermatogénesis de la rata macho
Rojas, A. L. J. (2011) · doi:10.24275/uami.f7623c76z
Sohi, M. T., Cali, M. G., Forster, J. E., Kiseljak‐Vassiliades, K., & Wierman, M. E. (2023) · PM&R · doi:10.1002/pmrj.13001
Noise-induced hormonal & morphological malformations in breeding pigeons
Amjad, R., Ruby, T., Talib, S., Zahra, S., Liaquat, M. T., & Batool, A. (2023) · Brazilian Journal of Biology · doi:10.1590/1519-6984.271945
Roles of nutrition in minimizing stress-related infertility: a narrative review
Sharma, L., & Sharma, D. (2024) · Exploration of Foods and Foodomics · doi:10.37349/eff.2024.00031
The Hypothalamus-Pituitary in Males in Health and Disease
Winters, S. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_7
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Bonomi, M., Vezzoli, V., Goggi, G., & Cariboni, A. M. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_1-2
Metadata
- Authors
- Dubey, A. K., & Plant, T. M.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Plant, T. M.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-09-01
- Volume
- 33
- Issue
- 2
- Pages
- 423-431
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2133777142
- Cited by
- 217
- References
- 33
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 3
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 08610, HD 16851)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- cortisol, gonadotropin secretion, hypothalamic-pituitary-gonadal axis, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, hydrocortisone acetate, orchiectomy, rhesus monkeys
- MeSH terms
- Animals, Follicle Stimulating Hormone, Hydrocortisone, Hypothalamus, Luteinizing Hormone, Macaca mulatta, Male, Orchiectomy, Pituitary Gland, Anterior, Pituitary Hormone-Releasing Hormones
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