The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Androgens Promote Oocyte Insulin-Like Growth Factor I Expression and Initiation of Follicle Development in the Primate Ovary1
Abstract
In the study reported here, we investigated the effect of androgens on recruitment of resting, primordial follicles into the actively growing pool. Healthy, random-cycling female rhesus monkeys were treated with testosterone, dihydrotestosterone (DHT), or vehicle for 3-10 days, after which ovaries were collected for histological analysis. The first stage of follicle growth is the formation of the primary follicle, consisting of an oocyte surrounded by a single layer of cuboidal granulosa cells. The number of primary follicles was significantly increased over time in testosterone-treated animals. In situ hybridization showed that androgen treatment resulted in an increase to 3-fold in insulin-like growth factor I (IGF-I) and to 5-fold in IGF-I receptor mRNA in primordial follicle oocytes. DHT effects were comparable to those of testosterone, showing that these are androgen receptor-mediated phenomena. These data show that androgens promote initiation of primordial follicle growth and implicate oocyte-derived IGF-I in this activation process.
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In the citing paper
“Several recent publications support a role for androgens in the stimulation of follicular growth in primates through amplification of FSH receptor gene expression (22)(23)(24).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [23]
In the citing paper
“Testosterone was found to augment follicular FSH receptor expression in primates suggesting that follicular growth may be improved by amplification of FSH effects (18 -20).”
From Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders (2002) · cites this paper as [19]
Citations
Cites
Regulation of ovarian follicular development in primates: facts and hypotheses
GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
Kumar, T. R., Wang, Y., Lu, N., & Matzuk, M. M. (1997) · Nature Genetics · doi:10.1038/ng0297-201 · Cited by 1,351
A quantitative and cytological study of germ cells in human ovaries
Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094
Androgens stimulate early stages of follicular growth in the primate ovary
Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2081 · Cited by 712
Self-citationMorphology and Morphogenesis of the Stein-Leventhal Ovary and of So-called “Hyperthecosis”
Hughesdon, P. E. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198202000-00001 · Cited by 429
Weil, S. J., Vendola, K., Zhou, J., Adesanya, O. O., Wang, J., Okafor, J., & Bondy, C. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4917 · Cited by 359
Self-citationInitiation in Vitro of Growth of Bovine Primordial Follicles1
Wandji, S.-A., Sršeň, V., Voss, A. K., Eppig, J. J., & Fortune, J. E. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.5.942 · Cited by 331
Morphometric studies of small follicles in ovaries of women at different ages
Gougeon, A., & Chainy, G. B. N. (1987) · Reproduction · doi:10.1530/jrf.0.0810433 · Cited by 305
Aittomäki, K. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.10.3722 · Cited by 274
Initiation of growth of baboon primordial follicles in vitro
Wandji, S.-A., Srsen, V., Nathanielsz, P. W., Eppig, J. J., & Fortune, J. E. (1997) · Human Reproduction · doi:10.1093/humrep/12.9.1993 · Cited by 243
Research works printed but not linked: 1
- 1991, Ovarian morphology in long-term androgen-treated female to male transsexuals., A human model for the study of polycystic ovarian syndrome? Histopathology, 19, 445
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Sorted by citations
Mitwally, M. F. M., & Casper, R. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01705-2 · Cited by 800
Anti-Mullerian hormone: a new marker for ovarian function
Visser, J. A., de Jong, F. H., Laven, J. S. E., & Themmen, A. P. N. (2005) · Reproduction · doi:10.1530/rep.1.00529 · Cited by 801
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 683
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Dumesic, D. A., Meldrum, D. R., Katz‐Jaffe, M. G., Krisher, R. L., & Schoolcraft, W. B. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.015 · Cited by 638
Androgen and follicle stimulating hormone interactions in primate ovarian follicle development
Weil, S., Vendola, K., Zhou, J., & Bondy, C. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5929 · Cited by 592
Metadata
- Authors
- Vendola, K., Zhou, J., Wang, J., Famuyiwa, O. A., Bievre, M., & Bondy, C. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Bondy, Carolyn A.
- ORCID
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08-01
- Volume
- 61
- Issue
- 2
- Pages
- 353-357
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2122893492
- Cited by
- 324
- References
- 26
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 16 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 19
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- androgens, insulin-like growth factor I, IGF-1 receptor, primordial follicles, folliculogenesis, oocytes, testosterone, dihydrotestosterone, androgen receptor, rhesus monkeys, ovary
- MeSH terms
- Androgens, Animals, Female, Ovarian Follicle, Insulin-Like Growth Factor I, Macaca mulatta, Oocytes, RNA, Messenger, Dihydrotestosterone, Testosterone, Receptor, IGF Type 1
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