The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
Abstract
Apoptosis is activated during the early phase of reperfusion after liver ischemia and after liver transplantation in animals. However, the molecular basis of ischemia‐induced cell death remains poorly understood. In this study we show that hepatocytes from ischemic liver lobes undergo apoptosis after reperfusion. In vivo pretreatment of rats with a specific inhibitor of caspases abrogates the apoptotic response in ischemic liver lobes. Inhibition of apoptosis can be accounted for by total inhibition of caspase activation as assessed in an enzymatic assay and by specific affinity labeling. Treatment with a caspase inhibitor fully protects rats from death induced by ischemia/ reperfusion. These findings indicate that liver injury after ischemia/reperfusion can be prevented by inhibition of caspases. Thus, caspase inhibitors may have important therapeutic implications in liver ischemic diseases and after liver transplantation.—Cursio, R., Gugenheim, J., RicciJ, E., Crenesse, D., Rostagno, P., Maulon, L., Saint‐Paul, M.‐C., Ferrua, B., Auberger, P. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J. 13, 253–261 (1999)
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Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881
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Cited by
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1015 · Cited by 984
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
Jaeschke, H. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00342.2002 · Cited by 852
From bench to clinic with apoptosis-based therapeutic agents
Nicholson, D. W. (2000) · Nature · doi:10.1038/35037747 · Cited by 687
Prevention of lymphocyte cell death in sepsis improves survival in mice
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Chang, K. C., Cobb, J. P., Buchman, T. G., Korsmeyer, S. J., & Karl, I. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14541 · Cited by 454
Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection
TEOH, N. C., & FARRELL, G. C. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03056.x · Cited by 441
Metadata
- Authors
- CURSIO, R., GUGENHEIM, J., RICCI, J. E., CRENESSE, D., ROSTAGNO, P., MAULON, L., SAINT-PAUL, M.-C., FERRUA, B., & AUBERGER, P.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-02
- Volume
- 13
- Issue
- 2
- Pages
- 253-261
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1583862506
- Cited by
- 220
- References
- 4
- FWCI
- 22.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CURSIO, R., GUGENHEIM, J., RICCI, J. E., CRENESSE, D., ROSTAGNO, P., MAULON, L., SAINT-PAUL, M.-C., FERRUA, B., & AUBERGER, P. (1999). A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. The FASEB Journal. https://doi.org/10.1096/fasebj.13.2.253
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
