The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of matrix metalloproteinase expression in tumor invasion
Abstract
Degradation of basement membranes and stromal extracellular matrix (ECM) is crucial for invasion and metastasis of malignant cells. Degradation of ECM is initiated by proteinases secreted by different cell types participating in tumor cell invasion, and increased expression or activity of every known class of proteinases (metallo‐, serine‐, aspartic‐, and cysteine) has been linked to malignancy and invasion of tumor cells. Studies performed over the last decade have revealed that matrix metalloproteinases (MMPs) play a crucial role in tumor invasion. Expression of MMP genes is transcriptionally regulated by a variety of extracellular factors including cytokines, growth factors, and cell contact to ECM. This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the role of mitogen‐activated protein kinases and AP‐1 and ETS transcription factors in the regulation of MMP gene expression during invasion process.—Westermarck, J., Kähäri, V.‐M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 13, 781–792 (1999)
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Cites
A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652 · cited 1×
“Recent identification of specific adapter proteins that physically connect kinases of MAPK cascades suggests the existence of highly specific MAPK cascades that are activated in specific situations (90, 91).”
BackgroundCui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
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Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441
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Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004
Metadata
- Authors
- Westermarck, J., & Kähäri, V.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-05
- Volume
- 13
- Issue
- 8
- Pages
- 781-792
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1800142641
- Cited by
- 1,494
- References
- 2
- FWCI
- 23.76
- Type
- journal article
- Language
- en
- Open access
- closed
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