A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, Alan J.; Cavanagh, Julie; Tournier, Cathy; Yasuda, Jun; Davis, Roger J.

doi:10.1126/science.281.5383.1671

Cited by 652Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysProtein Tyrosine Phosphatases

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, Alan J., Cavanagh, Julie, Tournier, Cathy, Yasuda, Jun, Davis, Roger J.·1998·Science

DOI 10.1126/science.281.5383.1671

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Abstract

The c-Jun NH 2 -terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

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JIP was originally identified as a putative scaffold that binds components of the JNK signaling pathway.
“The JNK-interacting protein (JIP) was originally identified as a putative scaffold that binds components of the JNK signaling pathway (Whitmarsh et al., 1998).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Whitmarsh et al., 1998
JIP1 is a scaffolding protein that assembles components of the JNK cascade and regulates JNK signaling.
“JNK-interacting protein-1 (JIP1) was identified as a scaffolding protein of the JNK module in yeast two-hybrid analysis, enhancing the correspondent signaling through the pathway (Whitmarsh et al , 1998).”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Whitmarsh et al , 1998
JIP-1, JIP-2, and JIP-3 are scaffolding proteins for the JNK signaling pathway.
“Three proteins were found, the c-jun NH2-terminal kinase (JNK)–interacting proteins (JIPs) JIP-1, JIP-2, and JIP-3, which are scaffolding proteins for the JNK signaling pathway.”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Whitmarsh et al. 1998

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Authors: Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Davis, Roger J.
ORCID: Whitmarsh, Alan J.
Cavanagh, Julie
Tournier, Cathy
Yasuda, Jun
Davis, Roger J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-09-11
Volume: 281
Issue: 5383
Pages: 1671-1674
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5383.1671
OpenAlex: W1967218150
Cited by: 652
References: 25
Citations by year: 2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 17 · 2012: 10
FWCI: 25.47
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: scaffold proteins, c-Jun NH2-terminal kinase, JNK activation, MAPK signaling, mixed lineage kinase, MKK7, MAP kinase kinase kinase, stress signaling, protein-protein interaction
MeSH terms: Mitogen-Activated Protein Kinase Kinase Kinase 11, Animals, Carrier Proteins, Cell Line, Chlorocebus aethiops, Enzyme Activation, Interleukin-1, Molecular Sequence Data, Protein Kinases, Recombinant Fusion Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinases, COS Cells, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Kinase Kinases, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 7

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A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

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