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Pericyte physiology
Abstract
Endothelial cells are the primary physical barrier between blood and tissue in microvessels. The other capillary and post‐capillary venule wall cell is the pericyte. The literature on the biology of endothelium is appreciable but less is known about pericytes. Pericytes are morphologically, biochemically, and physiologically heterogeneous. Some of pericyte functional characteristics observed in vivo and in vitro are that they: regulate endothelial proliferation and differentiation; contract in manners that either exacerbate or stem endothelial cell functional inflammatory leakage; function as a progenitor cell; synthesize and secrete a wide variety of vasoactive autoregulating agonists; synthesize and release structural constituents of the basement membrane and extracellular matrix. Pericytes are also involved in specific microvascular diseases. This review focuses principally on nonmesangial pericytes and specific activities such as the posttranslational, short‐term responses that affect microvascular perfusion and permeability, and on pericyte‐endothelial cell interaction.—Shepro, D., Morel, N. M. L. Pericyte physiology. FASEB J. 7: 1031‐1038; 1993.
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Citations
Cited by
Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Pericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128
Endothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048
Metadata
- Authors
- Shepro, D., & Morel, N. M. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1993-08
- Volume
- 7
- Issue
- 11
- Pages
- 1031-1038
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W4235369040
- Cited by
- 635
- References
- 0
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shepro, D., & Morel, N. M. L. (1993). Pericyte physiology. The FASEB Journal. https://doi.org/10.1096/fasebj.7.11.8370472
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