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Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation
Abstract
Interleukin‐1 (IL‐1) and tumor necrosis factor (TNF) selectively induce mitochondrial manganese superoxide dismutase (MnSOD) production in various cell types. We have evaluated the capacity of tumor cells that overexpress MnSOD to recover from the cytostatic and cytotoxic effects of cytokines (IL‐1 and TNF), chemotherapeutic agents, and ionizing irradiation. Clones of human melanoma cell line, A375, which overex‐pressed MnSOD after sense MnSOD cDNA transfection, showed increased recovery from treatment with cytostatic and cytotoxic doses of IL‐1 α and TNF α , whereas clones of A375 cells that were transfected with anti‐sense MnSOD cDNA recovered less well than normal cells from IL‐1 α and TNF α. In addition, Chinese hamster ovary (CHO) cells transfected with sense MnSOD cDNA showed increased survival after treatment with doxorubicin, mitomycin C, and gamma (7) radiation in vitro. It is hypothesized that mitochondrial MnSOD, by scavenging oxygen radicals induced by cytokines, some cytotoxic drugs, and ionizing radiation, is protective and promotes the survival of cells from the lethal effects of these treatments.— Hirose, K., Longo, D. L., Oppenheim, J. J., and Matsushima, K. Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation. FASEB J. 7: 361‐368; 1993.
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Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892
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Superoxide Dismutases in the Lung and Human Lung Diseases
Kinnula, V. L., & Crapo, J. D. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1479so · Cited by 620
Effects of ionizing radiation on mitochondria
Kam, W. W.-Y., & Banati, R. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.024 · Cited by 386
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Oxidative stress and antioxidants in the pathophysiology of malignant melanoma
Obrador, E., Liu-Smith, F., Dellinger, R. W., Salvador, R., Meyskens, F. L., & Estrela, J. M. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0327 · Cited by 119
Bedogni, B., Pani, G., Colavitti, R., Riccio, A., Borrello, S., Murphy, M., Smith, R., Eboli, M. L., & Galeotti, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301089200 · Cited by 124
Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies
Pizzimenti, S., Ribero, S., Cucci, M. A., Grattarola, M., Monge, C., Dianzani, C., Barrera, G., & Muzio, G. (2021) · Antioxidants · doi:10.3390/antiox10121942 · Cited by 79
WANG, J., & LÜ, Y.-Y. (2009) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.2009.04.0014 · Cited by 33
Metadata
- Authors
- Hirose, K., Longo, D. L., Oppenheim, J. J., & Matsushima, K.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1993-02
- Volume
- 7
- Issue
- 2
- Pages
- 361-368
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2162695832
- Cited by
- 340
- References
- 1
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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