Superoxide Dismutases in the Lung and Human Lung Diseases
Abstract
The lungs are directly exposed to higher oxygen concentrations than most other tissues. Increased oxidative stress is a significant part of the pathogenesis of obstructive lung diseases such as asthma and chronic obstructive pulmonary disease, parenchymal lung diseases (e.g., idiopathic pulmonary fibrosis and lung granulomatous diseases), and lung malignancies. Lung tissue is protected against these oxidants by a variety of antioxidant mechanisms among which the superoxide dismutases (SODs) are the only ones converting superoxide radicals to hydrogen peroxide. There are three SODs: cytosolic copper–zinc, mitochondrial manganese, and extracellular SODs. These enzymes have specific distributions and functions. Their importance in protecting lung tissue has been confirmed in transgenic and knockout animal studies. Relatively few studies have been conducted on these enzymes in the normal human lung or in human lung diseases. Most human studies suggest that there is induction of manganese SOD and, possibly, extracellular SOD during inflammatory, but not fibrotic, phases of parenchymal lung diseases and that both copper–zinc SOD and manganese SOD may be downregulated in asthmatic airways. Many previous antioxidant therapies have been disappointing, but newly characterized SOD mimetics are being shown to protect against oxidant-related lung disorders in animal models.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Manganese and copper are involved in antioxidant mechanisms through their structural role within SOD and other enzymes protecting cells from oxidative stress.
“Manganese and copper are further trace elements involved in antioxidant mechanisms through their structural role within SOD and other crucial enzymes useful for protecting cells from OS [447,448,449].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [448]
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,997 · see citing works
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works
Jobe, A. H., & Bancalari, E. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2011060 · Cited by 4,817 · see citing works
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196 · see citing works
Reactive oxygen species in cell signaling
Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works
Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works
Tobacco Smoke Carcinogens and Lung Cancer
Hecht, S. S. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.14.1194 · Cited by 1,976 · see citing works
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works
Free-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications
CHURCH, D. F., & PRYOR, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,442 · see citing works
Idiopathic Pulmonary Fibrosis: Clinical Relevance of Pathologic Classification
KATZENSTEIN, A.-L. A., & MYERS, J. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707039 · Cited by 1,261 · see citing works
Reversible Inactivation of the Tumor Suppressor PTEN by H2O2
Lee, S.-R., Yang, K., Kwon, J., Lee, C., Jeong, W., & Rhee, S. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111899200 · Cited by 1,061 · see citing works
Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works
Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future
Gutteridge, J. M. C., & Halliwell, B. B. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06182.x · Cited by 1,002 · see citing works
Gross, T. J., & Hunninghake, G. W. (2001) · New England Journal of Medicine · doi:10.1056/nejmra003200 · Cited by 970 · see citing works
Mitochondrial Superoxide Dismutase
Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43735-6 · Cited by 960 · see citing works
Oxidative stress and regulation of glutathione in lung inflammation
Rahman, I., & MacNee, W. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.016003534.x · Cited by 923 · see citing works
Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism
Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914 · see citing works
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913 · see citing works
Exhaled Markers of Pulmonary Disease
Kharitonov, S. A., & Barnes, P. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2009041 · Cited by 837 · see citing works
Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802 · see citing works
Normal alveolar epithelial lining fluid contains high levels of glutathione
Cantin, A. M., North, S. L., Hubbard, R. C., & Crystal, R. G. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.1.152 · Cited by 797 · see citing works
Human copper-containing superoxide dismutase of high molecular weight.
Marklund, S. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7634 · Cited by 749 · see citing works
The multifaceted roles of nitric oxide in cancer
Wink, D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.711 · Cited by 682 · see citing works
Crapo, J. D., Barry, B. E., Foscue, H. A., & Shelburne, J. D. (1980) · PubMed · doi:10.1164/arrd.1980.122.1.123 · Cited by 669 · see citing works
Self-citationManna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563 · see citing works
Interstitial Lung Disease: A Quantitative Study Using the Adaptive Multiple Feature Method
Uppaluri, R., Hoffman, E. A., Milan Sonka, A., Hunninghake, G. W., & McLennan, G. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.2.9707145 · Cited by 562 · see citing works
Cellular and Structural Bases of Chronic Obstructive Pulmonary Disease
Saetta, M. P., Turato, G., Maestrelli, P., Mapp, C. E., & Fabbri, L. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.6.2009116 · Cited by 551 · see citing works
Allometric Relationships of Cell Numbers and Size in the Mammalian Lung
Stone, K. C., Mercer, R. R., Gehr, P., Stockstill, B. L., & Crapo, J. D. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.2.235 · Cited by 550 · see citing works
Self-citationMarklund, S. L. (1984) · Biochemical Journal · doi:10.1042/bj2220649 · Cited by 518 · see citing works
MacMillan-Crow, L. A., Crow, J. P., & Thompson, J. A. (1998) · Biochemistry · doi:10.1021/bi971894b · Cited by 508 · see citing works
Mossman, B. T., & Gee, J. B. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906293202604 · Cited by 504 · see citing works
Antioxidant Function of Thioredoxin and Glutaredoxin Systems
Holmgren, A. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.4-811 · Cited by 504 · see citing works
Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.
Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., & Chang, L. Y. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10405 · Cited by 503 · see citing works
Self-citationNitric oxide and asthmatic inflammation
Barnes, P. J., & Liew, F. Y. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80128-6 · Cited by 502 · see citing works
Shimoda‐Matsubayashi, S., Matsumine, H., Kobayashi, T., Nakagawa-Hattori, Y., Shimizu, Y., & Mizuno, Y. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1394 · Cited by 498 · see citing works
Cell and tissue responses to oxidative damage.
Janssen-Heininger, Y. M. W., Houten, B. V., Borm, P. J. A., & Mossman, B. T. (1993) · PubMed · Cited by 488 · see citing works
Kokoszka, J. E., Coskun, P. E., Esposito, L., & Wallace, D. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051627098 · Cited by 488 · see citing works
Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.
Carlsson, L. M. S., Jonsson, J., Edlund, H., & Marklund, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6264 · Cited by 487 · see citing works
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D. A., Coskun, P. E., Mirra, S. S., Crapo, J. D., & Wallace, D. C. (1998) · Nature Genetics · doi:10.1038/ng0298-159 · Cited by 487 · see citing works
Self-citationTurrens, J. F., Crapo, J. D., & Freeman, B. Α. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111210 · Cited by 485 · see citing works
Self-citationChurch, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S., & Trent, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3113 · Cited by 474 · see citing works
Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse.
Szapiel, S. V., Elson, N., Fulmer, J. D., et al. (1979) · PubMed · doi:10.1164/arrd.1979.120.4.893 · Cited by 466 · see citing works
Superoxide dismutase and pulmonary oxygen toxicity
Crapo, J., & Tierney, D. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.226.6.1401 · Cited by 461 · see citing works
Self-citationCigarette smoke radicals and the role of free radicals in chemical carcinogenicity.
PRYOR, W. A. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s4875 · Cited by 458 · see citing works
Williams, M. D., Remmen, H. V., Conrad, C. C., Huang, T., Epstein, C. J., & Richardson, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28510 · Cited by 453 · see citing works
The effect of hyperoxia on superoxide production by lung submitochondrial particles
Turrens, J. F., Freeman, B. Α., Levitt, J. G., & Crapo, J. D. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90518-5 · Cited by 448 · see citing works
Self-citationThe insulin receptor: structure, function, and signaling
Lee, J., & Pilch, P. F. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.2.c319 · Cited by 446 · see citing works
The role of the redox protein thioredoxin in cell growth and cancer
Powis, G., Mustacich, D. J., & Coon, A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00313-0 · Cited by 443 · see citing works
Yamakura, F., Taka, H., Fujimura, T., & Murayama, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14085 · Cited by 442 · see citing works
Extracellular superoxide dismutase in human tissues and human cell lines.
Marklund, S. L. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111550 · Cited by 431 · see citing works
The role of free radicals in asbestos-induced diseases
Kamp, D. W., Graceffa, P., Pryor, W. A., & Weitzman, S. A. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90117-y · Cited by 428 · see citing works
Oxidative stress in allergic respiratory diseases
Bowler, R. P., & Crapo, J. D. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.126780 · Cited by 425 · see citing works
Self-citationThe role of O2.− in the production of HO.: in vitro and in vivo
Liochev, S. I., & Fridovich, I. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90239-9 · Cited by 423 · see citing works
Beckman, J. S., Minor, R. L., White, C. W., Repine, J. E., Rosen, G. M., & Freeman, B. Α. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68727-7 · Cited by 417 · see citing works
Morphologic Changes in Pulmonary Oxygen Toxicity
Crapo, J. D. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003445 · Cited by 405 · see citing works
Self-citationDifferential regulation of antioxidant enzymes in response to oxidants.
Shull, S., Heintz, N. H., Periasamy, M., Manohar, M., Janssen, Y. M., Marsh, J. P., & Mossman, B. T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54242-3 · Cited by 403 · see citing works
Visner, G. A., Dougall, W. C., Wilson, J. M., Burr, I. A., & Nick, H. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39880-1 · Cited by 376 · see citing works
Manganese superoxide dismutase in disease
MacMillan-Crow, L. A., & Cruthirds, D. L. (2001) · Free Radical Research · doi:10.1080/10715760100300281 · Cited by 371 · see citing works
Primary Pulmonary Hypertension
Archer, S. L., & Rich, S. (2000) · Circulation · doi:10.1161/01.cir.102.22.2781 · Cited by 353 · see citing works
Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.
Cantin, A. M., North, S. L., Fells, G. A., Hubbard, R. C., & Crystal, R. G. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113005 · Cited by 351 · see citing works
Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways
Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A., & Shirato, K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908132 · Cited by 347 · see citing works
Do Nitroxide Antioxidants Act as Scavengers of O2−˙ or as SOD Mimics?
Krishna, M. C., Russo, A., Mitchell, J. B., Goldstein, S., Dafni, H., & Samuni, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26026 · Cited by 342 · see citing works
Khalil, N. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00259-2 · Cited by 341 · see citing works
Hirose, K., Longo, D. L., Oppenheim, J. J., & Matsushima, K. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.2.8440412 · Cited by 340 · see citing works
Baker, K. L., Marcus, C. B., Huffman, K. D., Kruk, H., Malfroy, B., & Doctrow, S. R. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37225-8 · Cited by 334 · see citing works
Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase
Ho, Y.-S., Gargano, M. D., Cao, J., Bronson, R. T., Heimler, I., & Hutz, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7765 · Cited by 333 · see citing works
Wispé, J. R., Warner, B. B., Clark, J. C., Dey, C. R., Neuman, J. T., Glasser, S. W., Crapo, J. D., Chang, L. Y., & Whitsett, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35927-1 · Cited by 314 · see citing works
Self-citationOxidative Stress, Human Genetic Variation, and Disease
Forsberg, L. M., Fairé, U. D., & Morgenstern, R. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2295 · Cited by 310 · see citing works
Antioxidant responses to oxidant-mediated lung diseases
COMHAIR, S. A. A., & ERZURUM, S. C. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00491.2001 · Cited by 307 · see citing works
Amstad, P., Peskin, A. V., Shah, G. M., Mirault, M. E., Moret, R., Zbinden, I., & Cerutti, P. (1991) · Biochemistry · doi:10.1021/bi00102a024 · Cited by 302 · see citing works
Exhaled Ethane, a Marker of Lipid Peroxidation, is Elevated in Chronic Obstructive Pulmonary Disease
Paredi, P., Kharitonov, S. A., LEAK, D., Ward, S. P., CRAMER, D., & Barnes, P. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9909025 · Cited by 298 · see citing works
Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells
Inoue, N., Ramasamy, S., Fukai, T., Nerem, R. M., & Harrison, D. G. (1996) · Circulation Research · doi:10.1161/01.res.79.1.32 · Cited by 297 · see citing works
Folz, R. J., Abushamaa, A. M., & Suliman, H. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3816 · Cited by 289 · see citing works
Day, B. J., Fridovich, I., & Crapo, J. D. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0341 · Cited by 285 · see citing works
Self-citationDifferential expression of manganese superoxide dismutase and catalase in lung cancer.
Ho, J., Zheng, X. F. S., COMHAIR, S. A. A., Farver, C. F., & ERZURUM, S. C. (2001) · PubMed · Cited by 278 · see citing works
Melov, S., Doctrow, S. R., Schneider, J. A., Haberson, J., Patel, M., Coskun, P. E., Huffman, K. D., Wallace, D. C., & Malfroy, B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08348.2001 · Cited by 277 · see citing works
Role of Antioxidant Enzymes on Ionizing Radiation Resistance
Sun, J., Chen, Y., Li, M., et al. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00291-8 · Cited by 273 · see citing works
Rong, Y., Doctrow, S. R., Tocco, G., & Baudry, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9897 · Cited by 264 · see citing works
Saleh, D. M., Barnes, P. J., & Giaid, A. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.5.9154889 · Cited by 264 · see citing works
Increased Nitrotyrosine in Exhaled Breath Condensate of Patients with Asthma
Hanazawa, T., Kharitonov, S. A., & Barnes, P. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9912064 · Cited by 257 · see citing works
Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability.
Oury, T. D., Day, B. J., & Crapo, J. D. (1996) · PubMed · Cited by 256 · see citing works
Self-citationCombined Use of Exhaled Hydrogen Peroxide and Nitric Oxide in Monitoring Asthma
Horváth, I., Donnelly, L., KISS, A., Kharitonov, S. A., Lim, S., Chung, K. F., & Barnes, P. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.4.9710091 · Cited by 251 · see citing works
Molecular immunocytochemistry of the CuZn superoxide dismutase in rat hepatocytes.
Chang, L. Y., Slot, J. W., Geuze, H. J., & Crapo, J. D. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2169 · Cited by 248 · see citing works
Self-citationLi, J. J., Oberley, L. W., Clair, D. K. S., Ridnour, L. A., & Oberley, T. D. (1995) · PubMed · Cited by 248 · see citing works
Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.
Oury, T. D., Ho, Y.-S., Piantadosi, C. A., & Crapo, J. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9715 · Cited by 238 · see citing works
Self-citationExtracellular superoxide dismutase in vessels and airways of humans and baboons
Oury, T. D., Day, B. J., & Crapo, J. D. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02222-8 · Cited by 234 · see citing works
Self-citationMechanisms of peroxynitrite-induced injury to pulmonary surfactants
Haddad, I. Y., Ischiropoulos, H., Holm, B. A., et al. (1993) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1993.265.6.l555 · Cited by 233 · see citing works
de Haan, J. B., Cristiano, F., Iannello, R. C., Bladier, C., Kelner, M. J., & Kola, I. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.2.283 · Cited by 233 · see citing works
Knockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis
Remmen, H. V., Williams, M. D., Guo, Z., Estlack, L. E., Yang, H. C., Carlson, E. J., Epstein, C. J., Huang, T., & Richardson, A. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1422 · Cited by 230 · see citing works
On signal sequence polymorphisms and diseases of distribution.
Rosenblum, J. S., Gilula, N. B., & Lerner, R. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4471 · Cited by 228 · see citing works
KANEKO, F. T., ARROLIGA, A. C., DWEIK, R. A., COMHAIR, S. A., LASKOWSKI, D., OPPEDISANO, R., THOMASSEN, M. J., & ERZURUM, S. C. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.3.9802066 · Cited by 228 · see citing works
MacMillan-Crow, L. A., & Thompson, J. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1202 · Cited by 227 · see citing works
Sandström, J., Nilsson, P., Karlsson, K., & Marklund, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32289-5 · Cited by 220 · see citing works
Szabó, C., Day, B. J., & Salzman, A. L. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00087-7 · Cited by 219 · see citing works
Apoptosis: molecular aspects of cell death and disease.
Granville, D. J., Carthy, C. M., Hunt, D. W. C., et al. (1998) · PubMed · Cited by 217 · see citing works
Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung
Kimball, R., Reddy, K. V., Peirce, T. H., et al. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.5.1425 · Cited by 215 · see citing works
Generation and disposal of reactive oxygen metabolites in the lung.
Kinnula, V., Jd, C., & Raivio, K. O. (1995) · PubMed · Cited by 214 · see citing works
Self-citationMolecular Structure and Organization of the Human Manganese Superoxide Dismutase Gene
Wan, X. S., Devalaraja, M. N., & Clair, D. K. S. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.1127 · Cited by 213 · see citing works
Increased Nitrosothiols in Exhaled Breath Condensate in Inflammatory Airway Diseases
Corradi, M., Montuschi, P., Donnelly, L., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.2001108 · Cited by 212 · see citing works
Cu,Zn superoxide dismutase is a peroxisomal enzyme in human fibroblasts and hepatoma cells.
Keller, G. A., Warner, T. G., Steimer, K. S., & Hallewell, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7381 · Cited by 211 · see citing works
Salen-Manganese Complexes Are Superoxide Dismutase-Mimics
Baudry, M., Etienne, S., Bruce‐Keller, A. J., Palucki, M., Jacobsen, E., & Malfroy, B. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1509 · Cited by 207 · see citing works
Immunocytochemical localization of extracellular superoxide dismutase in human lung.
Oury, T. D., Chang, L. Y., Marklund, S. L., Day, B. J., & Crapo, J. D. (1994) · PubMed · Cited by 202 · see citing works
Self-citationAβ-peptides enhance vasoconstriction in cerebral circulation
Niwa, K., Porter, V. A., Kazama, K., Cornfield, D., Carlson, G. A., & Iadecola, C. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2417 · Cited by 202 · see citing works
Oberley, T. D. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64857-2 · Cited by 201 · see citing works
Day, B. J., Shawen, S., Liochev, S. I., & Jd, C. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12174-5 · Cited by 196 · see citing works
Synthesis and processing of the precursor for human mangano-superoxide dismutase
Wispé, J. R., Clark, J. C., Burhans, M. S., Kropp, K. E., Korfhagen, T. R., & Whitsett, J. A. (1989) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(89)90058-7 · Cited by 196 · see citing works
Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response
COMHAIR, S. A. A., Bhathena, P. R., Dweik, R. A., Kavuru, M. S., & ERZURUM, S. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)04736-4 · Cited by 193 · see citing works
Jw, S., Geuze, H. J., Freeman, B. A., & Jd, C. (1986) · PubMed · Cited by 192 · see citing works
Developmental aspects of experimental pulmonary oxygen toxicity
Frank, L. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90062-8 · Cited by 191 · see citing works
Niwa, K., Carlson, G. A., & Iadecola, C. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00005 · Cited by 191 · see citing works
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Soini, Y., Kahlos, K., Näpänkangas, U., Kaarteenaho–Wiik, R., Säily, M., Koistinen, P., Pääakkö, P., Holmgren, A., & Kinnula, V. L. (2001) · PubMed · Cited by 188 · see citing works
Self-citationOxygen Toxicity: Comparison of Lung Biochemical Responses in Neonatal and Adult Rats
Yam, J., Frank, L., & Roberts, R. J. (1978) · Pediatric Research · doi:10.1203/00006450-197802000-00010 · Cited by 186 · see citing works
Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis
Borok, Z. (1991) · The Lancet · doi:10.1016/0140-6736(91)90350-x · Cited by 184 · see citing works
Folz, R. J., & Crapo, J. D. (1994) · Genomics · doi:10.1006/geno.1994.1357 · Cited by 182 · see citing works
Self-citationInterstitial Pneumonitis Associated with Bleomycin Therapy
Luna, M. A., BEDROSSIAN, C. W. M., Lichticer, B., et al. (1972) · American Journal of Clinical Pathology · doi:10.1093/ajcp/58.5.501 · Cited by 178 · see citing works
Redox regulation of manganese superoxide dismutase
Warner, B. B., Stuart, L., Gebb, S. A., & Wispé, J. R. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.271.1.l150 · Cited by 178 · see citing works
Jung, C., Rong, Y., Doctrow, S. R., Baudry, M., Malfroy, B., & Xu, Z. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01784-0 · Cited by 177 · see citing works
Zhao, Y., Xue, Y., Oberley, T. D., Kiningham, K. K., Lin, S., Yen, H., Majima, H. J., Hines, J., & Clair, D. K. S. (2001) · PubMed · Cited by 176 · see citing works
The Nature of Antioxidant Defense Mechanisms: A Lesson from Transgenic Studies
Ho, Y., Magnenat, J.-L., Gargano, M. D., & Cao, J. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s51219 · Cited by 171 · see citing works
Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD
Wong, G. H. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00029-4 · Cited by 171 · see citing works
A family of novel peroxidases, peroxiredoxins
Rhee, S. G., Kang, S. W., Netto, L. E. S., Seo, M. S., & Stadtman, E. R. (1999) · BioFactors · doi:10.1002/biof.5520100218 · Cited by 170 · see citing works
Frank, L., & Sosenko, I. R. S. (1991) · Pediatric Research · doi:10.1203/00006450-199103000-00014 · Cited by 170 · see citing works
Adhesion at a granular surface
Zhou, J., Rar, A., Otte, D., & Barnard, J. A. (2000) · Journal of Applied Physics · doi:10.1063/1.1303764 · Cited by 169 · see citing works
Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts
Huang, T., Yasunami, M., Carlson, E. J., Gillespie, A. M., Reaume, A. G., Hoffman, E. K., Chan, P. H., Scott, R. W., & Epstein, C. J. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0237 · Cited by 168 · see citing works
Das, K. C., Lewis-Molock, Y., & White, C. W. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.269.5.l588 · Cited by 168 · see citing works
Cellular Mechanisms of Resistance to Chronic Oxidative Stress
Sagara, Y., Dargusch, R., Chambers, D. J., Davis, J. B., Schubert, D. A., & Maher, P. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00457-7 · Cited by 163 · see citing works
Mossman, B. T., Marsh, J. P., Sesko, A., Hill, S., Shatos, M. A., Doherty, J., Petruska, J., Adler, K. B., Hemenway, D., Mickey, R., et al. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.5_pt_1.1266 · Cited by 163 · see citing works
Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression.
Clerch, L. B., & Massaro, D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116228 · Cited by 159 · see citing works
Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica.
Janssen-Heininger, Y. M. W., Marsh, J. P., Absher, M. P., Hemenway, D. R., Vacek, P. M., Leslie, K. O., Borm, P. J. A., & Mossman, B. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50063-1 · Cited by 157 · see citing works
Hohmeier, H. E., Thigpen, A. E., Tran, V. V., Davis, R. J., & Newgard, C. B. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1489 · Cited by 155 · see citing works
Yan, T., Oberley, L. W., Zhong, W., & Clair, D. K. S. (1996) · PubMed · Cited by 154 · see citing works
Folz, R. J., Guan, J., Seldin, M. F., Oury, T. D., Enghild, J. J., & Crapo, J. D. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.4.2826 · Cited by 153 · see citing works
Self-citationAttenuation of Bleomycin-Induced Pulmonary Fibrosis by a Catalytic Antioxidant Metalloporphyrin
Oury, T. D., Thakker, K. D., Ménache, M. G., et al. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.2.4235 · Cited by 152 · see citing works
Carnemolla, B., Neri, D., Castellani, P., Leprini, A., Neri, G., Pini, A., Winter, G. P., & Zardi, L. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19961104)68:3 · Cited by 147 · see citing works
Elevation of Manganese Superoxide Dismutase Gene Expression by Thioredoxin
Das, K. C., Lewis-Molock, Y., & White, C. W. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.6.2809 · Cited by 145 · see citing works
Clair, D. K. S., Wan, X. S., Oberley, T. D., Muse, K. E., & Clair, W. H. S. (1992) · Molecular Carcinogenesis · doi:10.1002/mc.2940060404 · Cited by 145 · see citing works
Ho, Y., & Crapo, J. D. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81136-0 · Cited by 143 · see citing works
Self-citationRole of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis
Bowler, R. P., Nicks, M., Warnick, K., et al. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00058.2001 · Cited by 142 · see citing works
Padmanabhan, R., Gudapaty, R., Liener, I. E., et al. (1985) · PubMed · doi:10.1164/arrd.1985.132.1.164 · Cited by 140 · see citing works
Raeve, H. R. D., Thunnissen, E., Kaneko, F. T., Guo, F. H., Lewis, M., Kavuru, M. S., Secic, M., Thomassen, M. J., & ERZURUM, S. C. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.1.l148 · Cited by 139 · see citing works
Harris, C., Derbin, K. S., Hunte, B., Krauss, M. R., Chen, K., Smith, D. M., & Epstein, L. B. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.149 · Cited by 138 · see citing works
Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase.
Safford, S. E., Oberley, T. D., Urano, M., & Clair, D. K. S. (1994) · PubMed · Cited by 138 · see citing works
Tissue distribution of immunoreactive mouse extracellular superoxide dismutase
Ookawara, T., Imazeki, N., Matsubara, O., Kizaki, T., Oh‐ishi, S., Nakao, C., Sato, Y., & Ohno, H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.3.c840 · Cited by 138 · see citing works
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
Zhang, Y., Zhao, W., Zhang, H. J., Domann, F. E., & Oberley, L. W. (2002) · PubMed · Cited by 137 · see citing works
White, C. W., Avraham, K. B., Shanley, P. F., & Groner, Y. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115249 · Cited by 137 · see citing works
Gonzalez, P. K., Zhuang, J. C., Doctrow, S. R., Malfroy, B., Benson, P. F., Menconi, M. J., & Fink, M. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12131-9 · Cited by 136 · see citing works
Pani, G., Bedogni, B., Anzevino, R., Colavitti, R., Palazzotti, B., Borrello, S., & Galeotti, T. (2000) · PubMed · Cited by 134 · see citing works
Oxygen Radical Production by Alveolar Inflammatory Cells in Idiopathic Pulmonary Fibrosis
Strausz, J., Müller–Quernheim, J., Steppling, H., et al. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.124 · Cited by 133 · see citing works
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403
Salvemini, D., Mazzon, E., Dugo, L., Riley, D. P., Serraino, I., Caputi, A. P., & Cuzzocrea, S. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703841 · Cited by 133 · see citing works
Expression and Developmental Profile of Antioxidant Enzymes in Human Lung and Liver
Asikainen, T. M., Raivio, K. O., Saksela, M., & Kinnula, V. L. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.6.3248 · Cited by 132 · see citing works
Self-citationBellocq, A., Azoulay, É., Marullo, S., Flahault, A., Fouqueray, B. L., Philippe, C., Cadranel, J. L., & Baud, L. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.1.3379 · Cited by 132 · see citing works
Ho, Y., Vincent, R., Dey, M. S., Slot, J. W., & Crapo, J. D. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.4.2959 · Cited by 132 · see citing works
Self-citationBinding of human extracellular superoxide dismutase C to sulphated glycosaminoglycans
Karlsson, K., Lindahl, U., & Marklund, S. L. (1988) · Biochemical Journal · doi:10.1042/bj2560029 · Cited by 132 · see citing works
Thiol modulation of TNF? and IL-1 induced MnSOD gene expression and activation of NF-?B
Das, K. C., Lewis-Molock, Y., & White, C. W. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf00929502 · Cited by 129 · see citing works
Zwacka, R. M., Dudus, L., Epperly, M. W., Greenberger, J. S., & Engelhardt, J. F. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.9-1381 · Cited by 127 · see citing works
Bt, M., Jp, M., & Shatos, M. A. (1986) · PubMed · Cited by 127 · see citing works
Antioxidant enzyme expression in rat lungs during hyperoxia
Ho, Y., Dey, M. S., & Crapo, J. D. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.270.5.l810 · Cited by 126 · see citing works
Self-citationManganese Superoxide Dismutase Alanine-to-Valine Polymorphism at Codon 16 and Lung Cancer Risk
Wang, L. I., Miller, D. P., Sai, Y., Liu, G., Su, L., Wain, J. C., Lynch, T. J., & Christiani, D. C. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.23.1818 · Cited by 125 · see citing works
Wang, Y. Z., & Wong, Y. C. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980515)35:3 · Cited by 123 · see citing works
Chuang, Y.-Y. E., Chen, Y., Gadisetti, Chandramouli, V. R., Cook, J. A., Coffin, D., Tsai, M., DeGraff, W., Yan, H., Zhao, S., et al. (2002) · PubMed · Cited by 121 · see citing works
A Catalytic Antioxidant Attenuates Alveolar Structural Remodeling in Bronchopulmonary Dysplasia
Chang, L.-Y., Subramaniam, M., Yoder, B. A., Day, B. J., Ellison, M. C., Sunday, M. E., & Crapo, J. D. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200203-232oc · Cited by 120 · see citing works
Self-citationCyclin D1 protein expression and gene polymorphism in colorectal cancer
McKay, J., Douglas, J. J., Ross, V. G., Curran, S., Murray, G. I., Cassidy, J., & Initiative, O. B. O. T. A. C. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001001)88:1 · Cited by 120 · see citing works
Motoori, S., Majima, H. J., Ebara, M., Kato, H., Hirai, F., Kakinuma, S., Yamaguchi, C., Ozawa, T., NAGANO, T., Tsujii, H., et al. (2001) · PubMed · Cited by 118 · see citing works
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis
Bálint, B., Kharitonov, S. A., Hanazawa, T., et al. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00072501 · Cited by 118 · see citing works
Kiningham, K. K., Yong, X. U., Daosukho, C., POPOVA, B., & Clair, D. K. S. (2000) · Biochemical Journal · doi:10.1042/bj3530147 · Cited by 114 · see citing works
Expression of antioxidant enzymes in human inflammatory cells
Pietarinen-Runtti, P., Lakari, E., Raivio, K. O., & Kinnula, V. L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.1.c118 · Cited by 113 · see citing works
Self-citationOury, T. D., Crapo, J. D., Valnickova, Z., & Enghild, J. J. (1996) · Biochemical Journal · doi:10.1042/bj3170051 · Cited by 111 · see citing works
Self-citationSmith, K. R., Uyeminami, D. L., Kodavanti, U. P., Crapo, J. D., Chang, L., & Pinkerton, K. E. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01003-1 · Cited by 110 · see citing works
Self-citationCell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis
Kinnula, V. L. (2002) · Thorax · doi:10.1136/thorax.57.2.157 · Cited by 110 · see citing works
Self-citationAntioxidant gene expression in rat lung after exposure to cigarette smoke.
Gilks, C. B., Price, K., Wright, J. R., & Churg, A. (1998) · Europe PMC (PubMed Central) · Cited by 108 · see citing works
Strålin, P., & Marklund, S. L. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00427-x · Cited by 105 · see citing works
Distribution of Lung Cell Numbers and Volumes between Alveolar and Nonalveolar Tissue
Stone, K. C., Mercer, R. R., Freeman, B. Α., et al. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.454 · Cited by 104 · see citing works
Depletion of pulmonary EC-SOD after exposure to hyperoxia
Oury, T. D., Schaefer, L. M., Fattman, C. L., et al. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00011.2002 · Cited by 104 · see citing works
Increased Oxygen Species Generation in Blood Monocytes of Asthmatic Patients
Vachier, I., Damon, M., Doucen, C. L., et al. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1161 · Cited by 103 · see citing works
Polyethylene glycol-attached antioxidant enzymes decrease pulmonary oxygen toxicity in rats
White, C. W., Jackson, J. H., Abuchowski, A., Kazo, G. M., Mimmack, R. F., Berger, E. M., Freeman, B. Α., McCord, J. M., & Repine, J. E. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.2.584 · Cited by 103 · see citing works
Zhang, H. J., Yan, T., Oberley, T. D., & Oberley, L. W. (1999) · PubMed · Cited by 102 · see citing works
Copin, J., Gasche, Y., & Chan, P. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00280-x · Cited by 102 · see citing works
Adachi, T., Ohta, H., Yamada, H., et al. (1992) · Clinica Chimica Acta · doi:10.1016/0009-8981(92)90176-q · Cited by 102 · see citing works
Enghild, J. J., Thøgersen, I. B., Oury, T. D., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14818 · Cited by 102 · see citing works
Kinnula, V., Yankaskas, J. R., Chang, L., Virtanen, I., Linnala, A., Kang, B. H., & Crapo, J. D. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.5.7946385 · Cited by 101 · see citing works
Self-citationAntioxidant Enzyme Activity in Alveolar Type II Cells after Exposure of Rats to Hyperoxia
Freeman, B. Α., Mason, R. J., Williams, M. C., et al. (1986) · Experimental Lung Research · doi:10.3109/01902148609061493 · Cited by 96 · see citing works
Extracellular Superoxide Dismutase Protects Lung Development in Hyperoxia-exposed Newborn Mice
Ahmed, M. N., Suliman, H. B., Folz, R. J., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200202-108oc · Cited by 92 · see citing works
Modulation of oxidant lung injury by using liposome-entrapped superoxide dismutase and catalase.
Freeman, B. Α., Turrens, J. F., Mirza, Z., et al. (1985) · PubMed · Cited by 91 · see citing works
Pong, K., Doctrow, S. R., Huffman, K. D., Adinolfi, C. A., & Baudry, M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7747 · Cited by 91 · see citing works
Structural and biochemical adaptive changes in rat lungs after exposure to hypoxia.
Sjostrom, K., & Jd, C. (1983) · PubMed · Cited by 91 · see citing works
Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic
Chang, L., & Crapo, J. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00919-x · Cited by 88 · see citing works
Self-citationGhio, A. J., Suliman, H. B., Carter, J. D., Abushamaa, A. M., & Folz, R. J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00409.2001 · Cited by 86 · see citing works
A Metalloporphyrin Superoxide Dismutase Mimetic Protects against Paraquat-Induced Lung Injuryin Vivo
Day, B. J., & Crapo, J. D. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0201 · Cited by 85 · see citing works
Self-citationThe superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse
Malassagne, B., Ferret, P., Hammoud, R., Tulliez, M., Bedda, S., Trebeden‐Negre, H., Jaffray, P., Calmus, Y., Weill, B. J., & Batteux, F. (2001) · Gastroenterology · doi:10.1053/gast.2001.29590 · Cited by 84 · see citing works
Interstitial lung disease induced by exogenous agents: factors governing susceptibility
Nemery, B., Bast, A., Behr, J., Borm, P. J. A., Bourke, S., Camus, P., Vuyst, P. D., Jansen, H. M., Kinnula, V., Lison, D., et al. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.18s320030 · Cited by 84 · see citing works
Self-citationRat lung antioxidant enzymes: differences in perinatal gene expression and regulation
Clerch, L. B., & Massaro, D. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.4.l466 · Cited by 84 · see citing works
Janssen-Heininger, Y. M. W., Marsh, J. P., Driscoll, K. E., Borm, P. J. A., Oberdörster, G., & Mossman, B. T. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90032-9 · Cited by 83 · see citing works
Liposome-mediated augmentation of catalase in alveolar type II cells protects against H2O2 injury
Buckley, B. J., Tanswell, A. K., & Freeman, B. Α. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.1.359 · Cited by 83 · see citing works
Hass, M. A., & Massaro, D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)35421-3 · Cited by 81 · see citing works
Tracheal insufflation of tumor necrosis factor protects rats against oxygen toxicity
Tsan, M., White, J. E., Santana, T. A., et al. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.3.1211 · Cited by 80 · see citing works
Response of Human Endothelial Cell Antioxidant Enzymes to Hyperoxia
Jornot, L., & Junod, A. F. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.1.107 · Cited by 78 · see citing works
ERZURUM, S. C., Danel, C. J., Gillissen, A., Chu, C. S., Trapnell, B. C., & Crystal, R. G. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1256 · Cited by 78 · see citing works
Coursin, D. B., Cihla, H. P., Sempf, J. M., Oberley, T. D., & Oberley, L. W. (1996) · PubMed · Cited by 77 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897 · see citing works
Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms
McGuinness, A., & Sapey, E. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6020021 · Cited by 243 · see citing works
Koli, K., Myllärniemi, M., Keski-Oja, J., & Kinnula, V. L. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1914 · Cited by 168 · see citing works
Self-citationShvedova, A. A., Kisin, E. R., Murray, A. R., Gorelik, O., Arepalli, S., Castranova, V., Young, S.-H., Gao, F., Tyurina, Y. Y., Oury, T. D., et al. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.03.018 · Cited by 163 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Li, N., & Nel, A. E. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.88 · Cited by 130 · see citing works
Pharmacological antioxidant strategies as therapeutic interventions for COPD
Rahman, I. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.004 · Cited by 117 · see citing works
Reactive Oxygen Species a Double-Edged Sword for Mesothelioma
Benedetti, S., Nuvoli, B., Catalani, S., & Galati, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4253 · Cited by 97 · see citing works
Starr, M. E., Ueda, J., Yamamoto, S., Evers, B. M., & Saito, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.013 · Cited by 86 · see citing works
Xu, K., Liu, X., & Tang, B. (2007) · ChemBioChem · doi:10.1002/cbic.200600392 · Cited by 71 · see citing works
Chan, J. K., Charrier, J. G., Kodani, S. D., Vogel, C. F., Kado, S. Y., Anderson, D. S., Anastasio, C., & Van Winkle, L. S. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-34 · Cited by 69 · see citing works
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice
Park, J.-R., Lee, H., Kim, S.-I., & Yang, S.-R. (2016) · Oncotarget · doi:10.18632/oncotarget.11168 · Cited by 60 · see citing works
Twidwell, J., & Levine, L. (2016) · International Journal of Impotence Research · doi:10.1038/ijir.2015.22 · Cited by 51 · see citing works
Puig, Á., Rancan, L., Paredes, S. D., Carrasco, A., Escames, G., Vara, E., & Tresguerres, J. A. F. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.021 · Cited by 37 · see citing works
Mineral Micronutrients in Asthma
Zajac, D. (2021) · Nutrients · doi:10.3390/nu13114001 · Cited by 33 · see citing works
- Authors
- Kinnula, V. L., & Crapo, J. D.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Crapo, James D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06
- Volume
- 167
- Issue
- 12
- Pages
- 1600-1619
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1983754228
- Cited by
- 620
- References
- 313
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 14 · 2023: 21 · 2022: 25 · 2021: 24 · 2020: 25 · 2019: 23 · 2018: 28 · 2017: 31 · 2016: 25 · 2015: 21 · 2014: 31 · 2013: 26 · 2012: 37
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL031992, K30 HL40111, U01 HL 63397, P01-HL 31992, U01HL063397)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- superoxide dismutase, copper-zinc superoxide dismutase, manganese superoxide dismutase, extracellular superoxide dismutase, oxidative stress, lung disease, asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, lung cancer, antioxidant defense, superoxide dismutase mimetic, antioxidant therapy
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Drug Evaluation, Preclinical, Free Radicals, Humans, Inflammation, Lung, Lung Diseases, Lung Neoplasms, Polymorphism, Genetic, Superoxide Dismutase, Genetic Therapy, Down-Regulation, Free Radical Scavengers, Reactive Oxygen Species, Lung Diseases, Interstitial, Oxidative Stress, Pulmonary Disease, Chronic Obstructive, Biomimetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review