Effects of ionizing radiation on mitochondria

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223 · see citing works

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Rapid evolution of animal mitochondrial DNA

Brown, W. M., George, M., & Wilson, A. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1967 · Cited by 3,439 · see citing works

Untitled work

Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works

Mitochondria: More Than Just a Powerhouse

McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985 · see citing works

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854 · see citing works

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

Holt, I. J., Harding, A. E., & MORGAN-HUGHES, J. A. (1988) · Nature · doi:10.1038/331717a0 · Cited by 1,845 · see citing works

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

Bass, D., Parce, J. W., DeChatelet, L. R., Szejda, P., Seeds, M. C., & Thomas, M. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1910 · Cited by 1,811 · see citing works

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,730 · see citing works

Human Cells Lacking mtDNA: Repopulation with Exogenous Mitochondria by Complementation

King, M. P., & Attardi, G. M. (1989) · Science · doi:10.1126/science.2814477 · Cited by 1,659 · see citing works

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

Azzam, E. I., Jay‐Gerin, J., & Pain, D. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.012 · Cited by 1,611 · see citing works

Reactive Oxygen Species (Ros-Induced) Ros Release

Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412 · see citing works

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90040-d · Cited by 1,386 · see citing works

Mitochondrial ROS-induced ROS release: An update and review

Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.029 · Cited by 1,081 · see citing works

Mitochondria, oxygen free radicals, disease and ageing

Raha, S., & Robinson, B. H. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01674-1 · Cited by 1,066 · see citing works

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

Nagasawa, H., & Little, J. B. (1992) · PubMed · Cited by 1,003 · see citing works

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

Pryor, W. A. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003301 · Cited by 1,000 · see citing works

Mitochondrial Signaling

Butow, R. A., & Avadhani, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00179-0 · Cited by 882 · see citing works

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide

Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., Vásquez-Vivar, J., & Kalyanaraman, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00142-4 · Cited by 803 · see citing works

Detection of a specific mitochondrial DNA deletion in tissues of older humans

Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 785 · see citing works

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology

Spitz, D. R., Azzam, E. I., Jian Li, J., & Gius, D. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031769.14728.bc · Cited by 710 · see citing works

Mitochondrial DNA mutations and human disease

Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.005 · Cited by 676 · see citing works

Mitochondrial DNA mutations in disease and aging

Wallace, D. C. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20586 · Cited by 622 · see citing works

Mitochondrial disease

Schapira, A. H. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68970-8 · Cited by 594 · see citing works

A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescin-diacetate

Rosenkranz, A. R., Schmaldienst, S., Stuhlmeier, K. M., Chen, W., Knapp, W., & Zlabinger, G. J. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90008-h · Cited by 539 · see citing works

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage

Indo, H. P., Davidson, M. M., Yen, H., Suenaga, S., Tomita, K., Nishii, T., Higuchi, M., Koga, Y., Ozawa, T., & Majima, H. J. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.11.026 · Cited by 536 · see citing works

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

Clayton, D. A., Doda, J. N., & Friedberg, E. C. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.7.2777 · Cited by 531 · see citing works

Number matters: control of mammalian mitochondrial DNA copy number

Montier, L., Deng, J., & Bai, Y. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60099-5 · Cited by 513 · see citing works

Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

Leach, J. K., Tuyle, G. V., Lin, P.-S., Schmidt‐Ullrich, R., & Mikkelsen, R. B. (2001) · PubMed · Cited by 511 · see citing works

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

Malik, A. N., & Czajka, A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.10.011 · Cited by 499 · see citing works

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

Narayanan, P. K., Goodwin, E. H., & Lehnert, B. E. (1997) · PubMed · Cited by 454 · see citing works

Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells

Wu, L., Randers-Pehrson, G., Xu, A., Waldren, C. A., Geard, C. R., Yu, Z., & Hei, T. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4959 · Cited by 444 · see citing works

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

Yamamori, T., Yasui, H., Yamazumi, M., Wada, Y., Nakamura, Y., Nakamura, H., & Inanami, O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.033 · Cited by 399 · see citing works

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

Hirose, K., Longo, D. L., Oppenheim, J. J., & Matsushima, K. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.2.8440412 · Cited by 340 · see citing works

The functional organization of mitochondrial genomes in human cells

Iborra, F. J., Kimurâ, H., & Cook, P. R. (2004) · BMC Biology · doi:10.1186/1741-7007-2-9 · Cited by 339 · see citing works

Transcription and replication of mitochondrial DNA

Clayton, D. A. (2000) · Human Reproduction · doi:10.1093/humrep/15.suppl_2.11 · Cited by 318 · see citing works

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

Deshpande, A., Goodwin, E. H., Bailey, S. M., Marrone, B. L., & Lehnert, B. E. (1996) · Radiation Research · doi:10.2307/3578980 · Cited by 291 · see citing works

Nuclear and mitochondrial DNA repair: similar pathways?

Larsen, N. B., Rasmussen, M., & Rasmussen, L. J. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.02.002 · Cited by 289 · see citing works

Oxidative Stress-related Alteration of the Copy Number of Mitochondrial DNA in Human Leukocytes

Liu, C., Tsai, C.-S., Kuo, C., Chen, H., Lii, C., Ma, Y., & Wei, Y. (2003) · Free Radical Research · doi:10.1080/10715760310001621342 · Cited by 285 · see citing works

Why have organelles retained genomes?

Race, H. L., Herrmann, R. G., & Martin, W. F. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01766-7 · Cited by 244 · see citing works

Mitochondrial DNA repair pathways

Croteau, D. L., Stierum, R. H., & Bohr, V. A. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00025-7 · Cited by 240 · see citing works

Mitochondrial DNA Is a Major Cellular Target for a Dihydrodiol-Epoxide Derivative of Benzo[ a ]pyrene

Backer, J. M., & Weinstein, I. B. (1980) · Science · doi:10.1126/science.6770466 · Cited by 233 · see citing works

The oxidation of 2′,7′-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy?

Bonini, M. G., Rota, C., Tomasi, A., & Mason, R. P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.042 · Cited by 223 · see citing works

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction

Chen, Q., Chai, Y.-C., Mazumder, S., Jiang, C., Macklis, R. M., Chisolm, G. M., & Almasan, A. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401148 · Cited by 214 · see citing works

Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

Morgan, W. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206992 · Cited by 209 · see citing works

Mitochondrial Translation and Beyond: Processes Implicated in Combined Oxidative Phosphorylation Deficiencies

Smits, P., Smeitink, J., & van den Heuvel, L. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/737385 · Cited by 202 · see citing works

Radiation response of cell organelles

Somosy, Z. (2000) · Micron · doi:10.1016/s0968-4328(99)00083-9 · Cited by 192 · see citing works

Mutation of Succinate Dehydrogenase Subunit C Results in Increased O2·−, Oxidative Stress, and Genomic Instability

Slane, B. G., Aykin‐Burns, N., Smith, B. J., Kalen, A. L., Goswami, P. C., Domann, F. E., & Spitz, D. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0833 · Cited by 188 · see citing works

Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation

Yoshida, T., Goto, S., Kawakatsu, M., Urata, Y., & Li, T. (2011) · Free Radical Research · doi:10.3109/10715762.2011.645207 · Cited by 185 · see citing works

Cytoplasmic Irradiation Induces Mitochondrial-Dependent 53BP1 Protein Relocalization in Irradiated and Bystander Cells

Tartier, L., Gilchrist, S., Burdak‐Rothkamm, S., Folkard, M., & Prise, K. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0188 · Cited by 183 · see citing works

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review

J.Kim, G., Chandrasekaran, K., & Morgan, W. F. (2006) · Mutagenesis · doi:10.1093/mutage/gel048 · Cited by 181 · see citing works

DNA repair, mitochondria, and neurodegeneration

Weissman, L., de Souza-Pinto, N. C., Stevnsner, T., & Bohr, V. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.061 · Cited by 171 · see citing works

Resistance of Mitochondrial DNA-depleted Cells against Cell Death

Park, S. Y., Chang, I., Kim, J., Kang, S. W., Park, S., Singh, K. K., & Lee, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307677200 · Cited by 170 · see citing works

Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation

Oberley, L. W., Clair, D. K. S., Autor, A. P., & Oberley, T. D. (1987) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(87)90082-8 · Cited by 168 · see citing works

Mitochondrial Function and Nuclear Factor-κB–Mediated Signaling in Radiation-Induced Bystander Effects

Zhou, H., Ivanov, V. N., Lien, Y., Davidson, M. M., & Hei, T. K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5278 · Cited by 167 · see citing works

Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays

Barjaktarović, Ž., Schmaltz, D., Shyla, A., Azimzadeh, O., Schulz, S., Haagen, J., Dörr, W., Sarioglu, H., Schäfer, A., Atkinson, M. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027811 · Cited by 163 · see citing works

Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.

Hickman, A. W., Jaramillo, R. J., Lechner, J. F., & Johnson, N. (1994) · PubMed · Cited by 159 · see citing works

A Role for Mitochondrial Dysfunction in Perpetuating Radiation-Induced Genomic Instability

Kim, G. J., Fiskum, G. M., & Morgan, W. F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3036 · Cited by 158 · see citing works

The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number

Hunter, S. E., Jung, D., Giulio, R. T. D., & Meyer, J. N. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.033 · Cited by 157 · see citing works

Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis

Epperly, M. W., Bray, J. A., Krager, S., Berry, L. M., Gooding, W. E., Engelhardt, J. F., Zwacka, R. M., Travis, E. L., & Greenberger, J. S. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00355-1 · Cited by 153 · see citing works

Simultaneous Detection and Quantification of Mitochondrial DNA Deletion(s), Depletion, and Over-Replication in Patients with Mitochondrial Disease

Bai, R., & Wong, L. C. (2005) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60595-8 · Cited by 152 · see citing works

Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-Induced Cellular Damage

Epperly, M. W., Gretton, J. E., Sikora, C. A., Jefferson, M., Bernarding, M., Nie, S., & Greenberger, J. S. (2003) · Radiation Research · doi:10.1667/rr3081 · Cited by 150 · see citing works

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

Clair, D. K. S., Wan, X. S., Oberley, T. D., Muse, K. E., & Clair, W. H. S. (1992) · Molecular Carcinogenesis · doi:10.1002/mc.2940060404 · Cited by 145 · see citing works

Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma.

Nishikawa, M., Nishiguchi, S., Shiomi, S., Tamori, A., Koh, N., Takeda, T., Kubo, S., Hirohashi, K., Kinoshita, H., Sato, E., et al. (2001) · PubMed · Cited by 138 · see citing works

Accumulation of the common mitochondrial DNA deletion induced by ionizing radiation

Prithivirajsingh, S., Story, M. D., Bergh, S., Geara, F. B., Ang, K. K., Ismail, S. M., Stevens, C. W., Buchholz, T. A., & Brock, W. A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.078 · Cited by 133 · see citing works

Radiation-induced transgenerational alterations in genome stability and DNA damage

Barber, R. C., Hickenbotham, P. T., Hatch, T., Kelly, D., Topchiy, N. M., Almeida, G. M., Jones, G. D. D., Johnson, G. E., Parry, J. M., Rothkamm, K., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209723 · Cited by 133 · see citing works

Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis

Belka, C., Rudner, J., Wesselborg, S., Stępczyńska, A., Marini, P., Lepple-Wienhues, A., Faltin, H., BAMBERG, M., Budach, W., & Schulze‐Osthoff, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203401 · Cited by 131 · see citing works

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

Hori, A., Yoshida, M., Shibata, T., & Ling, F. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn993 · Cited by 129 · see citing works

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

Epperly, M. W., DeFilippi, S. J., Sikora, C. A., Gretton, J. E., Kalend, A. M., & Greenberger, J. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301207 · Cited by 123 · see citing works

The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

Chen, T., He, J., Shen, L., Fang, H., Nie, H., Jin, T., Wei, X., Xin, Y., Jiang, Y., Li, H., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-8 · Cited by 122 · see citing works

Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

Epperly, M. W., Travis, E. L., Sikora, C. A., & Greenberger, J. S. (1999) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.1999.v5.pm10465100 · Cited by 120 · see citing works

Ionizing radiation accelerates Drp1-dependent mitochondrial fission, which involves delayed mitochondrial reactive oxygen species production in normal human fibroblast-like cells

Kobashigawa, S., Suzuki, K., & Yamashita, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.006 · Cited by 118 · see citing works

Irradiation Increases Manganese Superoxide Dismutase mRNA Levels in Human Fibroblasts.

Akashi, M., Hachiya, M., PAQUETTE, R. L., Osawa, Y., Shimizu, S., & Suzuki, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15864 · Cited by 118 · see citing works

Coordinated Behavior of Mitochondria in Both Space and Time: A Reactive Oxygen Species-Activated Wave of Mitochondrial Depolarization

Brady, N. R., Elmore, S. P., van Beek, J. J. H. G. M., Krab, K., Courtoy, P. J., Hue, L., & Westerhoff, H. V. (2004) · Biophysical Journal · doi:10.1529/biophysj.103.035097 · Cited by 118 · see citing works

Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE.

Motoori, S., Majima, H. J., Ebara, M., Kato, H., Hirai, F., Kakinuma, S., Yamaguchi, C., Ozawa, T., NAGANO, T., Tsujii, H., et al. (2001) · PubMed · Cited by 118 · see citing works

Impaired OXPHOS Complex III in Breast Cancer

Owens, K. M., Kulawiec, M., Desouki, M., Vanniarajan, A., & Singh, K. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023846 · Cited by 109 · see citing works

Generation of ρ 0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

Kukat, A., Kukat, C., Brocher, J., Schäfer, I., Krohne, G., Trounce, I. A., Villani, G., & Seibel, P. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn124 · Cited by 109 · see citing works

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

Atkinson, J., Kapralov, A. A., Yanamala, N. V. K., Tyurina, Y. Y., Amoscato, A. A., Pearce, L. L., Peterson, J., Huang, Z., Jiang, J., Samhan-Arias, A. K., et al. (2011) · Nature Communications · doi:10.1038/ncomms1499 · Cited by 106 · see citing works

Effect of DNA damage on PCR amplification efficiency with the relative threshold cycle method

Sikorsky, J. A., Primerano, D. A., Fenger, T. W., & Denvir, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.168 · Cited by 105 · see citing works

Antioxidants Reduce Consequences of Radiation Exposure

Okunieff, P. G., Swarts, S. G., Keng, P., Sun, W., Wang, W., Kim, J., Yang, S., Zhang, H., Liu, C., Williams, J. P., et al. (2008) · Springer eBooks · doi:10.1007/978-0-387-74911-2_20 · Cited by 101 · see citing works

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells

Ogura, A., Oowada, S., Kon, Y., Hirayama, A., Yasui, H., Meike, S., Kobayashi, S., Kuwabara, M., & Inanami, O. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.11.021 · Cited by 101 · see citing works

IRRADIATION OF PARTS OF INDIVIDUAL CELLS. III. EFFECTS OF CHROMOSOMAL AND EXTRACHROMOSOMAL IRRADIATION ON CHROMOSOME MOVEMENTS

Bloom, W., Zirkle, R. E., & Uretz, R. B. (1955) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1955.tb45966.x · Cited by 101 · see citing works

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

Azimzadeh, O., Scherthan, H., Sarioglu, H., Barjaktarović, Ž., Conrad, M., Vogt, A., Calzada‐Wack, J., Neff, F., Aubele, M. M., Buske, C., et al. (2011) · PROTEOMICS · doi:10.1002/pmic.201100178 · Cited by 101 · see citing works

Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

Morales, A., Miranda, M., Sánchez-Reyes, A., Biete, A., & Fernández-Checa, J. C. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00185-0 · Cited by 99 · see citing works

Increased Mitochondrial Mass in Cells with Functionally Compromised Mitochondria after Exposure to both Direct γ Radiation and Bystander Factors

Nugent, S., Mothersill, C. E., Seymour, C. B., McClean, B., Lyng, F. M., & Murphy, J. E. J. (2007) · Radiation Research · doi:10.1667/rr0769.1 · Cited by 98 · see citing works

Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells

HOSOKI, A., YONEKURA, S.-I., ZHAO, Q.-L., WEI, Z.-L., TAKASAKI, I., TABUCHI, Y., WANG, L.-L., HASUIKE, S., NOMURA, T., TACHIBANA, A., et al. (2012) · Journal of Radiation Research · doi:10.1269/jrr.11034 · Cited by 97 · see citing works

Oxygen Stress Induces an Apoptotic Cell Death Associated with Fragmentation of Mitochondrial Genome

Yoneda, M., Katsumata, K., Hayakawa, M., Tanaka, M., & Ozawa, T. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1559 · Cited by 96 · see citing works

Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation

Dayal, D., Martin, S. M., Owens, K. M., Aykin‐Burns, N., Zhu, Y., Amutha, B., Pain, D., Limoli, C. L., Goswami, P. C., Domann, F. E., et al. (2009) · Radiation Research · doi:10.1667/rr1617.1 · Cited by 96 · see citing works

Mitochondrial DNA as a Cancer Biomarker

Jakupciak, J. P., Wang, W., Markowitz, M. E., Ally, D. S., Coble, M. D., Srivastava, S., Maitra, A., Barker, P. E., Sidransky, D., & O’Connell, C. D. (2005) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60553-3 · Cited by 93 · see citing works

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

Aypar, U., Morgan, W. F., & Baulch, J. E. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2010.522686 · Cited by 92 · see citing works

Redox modulation of the DNA damage response

Caputo, F., Vegliante, R., & Ghibelli, L. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.022 · Cited by 91 · see citing works

Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity

Tulard, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00243-0 · Cited by 83 · see citing works

Identification of Respiratory Complexes I and III as Mitochondrial Sites of Damage Following Exposure to Ionizing Radiation and Nitric Oxide

Pearce, L. L., Epperly, M. W., Greenberger, J. S., Pitt, B. R., & Peterson, J. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0338 · Cited by 82 · see citing works

Directly repeated sequences associated with pathogenic mitochondrial DNA deletions.

Johns, D. R., Rutledge, S. L., Stine, O. C., & Hurko, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8059 · Cited by 81 · see citing works

Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells

Murphy, J. E. J., Nugent, S., Seymour, C. B., & Mothersill, C. E. (2005) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2005.04.011 · Cited by 77 · see citing works

Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus

Miyazono, F., Schneider, P. M., Metzger, R., Warnecke‐Eberz, U., Baldus, S. E., Dienes, H. P., Aikou, T., & Hoelscher, A. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205532 · Cited by 77 · see citing works

A Mitochondria-Targeted Triphenylphosphonium-Conjugated Nitroxide Functions as a Radioprotector/Mitigator

Jiang, J., Stoyanovsky, D. A., Belikova, N. A., Tyurina, Y. Y., Zhao, Q., Tungekar, M. A., Kapralova, V. I., Huang, Z., Mintz, A. H., Greenberger, J. S., et al. (2009) · Radiation Research · doi:10.1667/rr1729.1 · Cited by 76 · see citing works

Somatic Mitochondrial DNA Mutations in Human Cancers

Yu, M. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394384-2.00004-8 · Cited by 73 · see citing works

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells

Dayal, D., Martin, S. M., Limoli, C. L., & Spitz, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20071643 · Cited by 70 · see citing works

Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells

Zhao, Q. (1999) · International Journal of Radiation Biology · doi:10.1080/095530099140429 · Cited by 70 · see citing works

Two Strategies for the Development of Mitochondrion-Targeted Small Molecule Radiation Damage Mitigators

Rwigema, J. M., Beck, B., Wang, W., Doemling, A., Epperly, M. W., Shields, D. S., Goff, J. P., Franicola, D., Dixon, T. M., Frantz, M., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.01.059 · Cited by 65 · see citing works

Mitochondria-targeted antioxidant enzyme activity regulates radioresistance in human pancreatic cancer cells

Fisher, C. J., & Goswami, P. C. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.8.6300 · Cited by 64 · see citing works

Irradiation of mitochondria initiates apoptosis in a cell free system

Taneja, N., Tjalkens, R. B., Philbert, M. A., & Rehemtulla, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204054 · Cited by 63 · see citing works

Ionizing Radiation Stimulates Mitochondrial Gene Expression and Activity

Gong, B., Chen, Q., & Almasan, A. (1998) · Radiation Research · doi:10.2307/3579866 · Cited by 63 · see citing works

Radioprotection In Vitro and In Vivo by Minicircle Plasmid Carrying the Human Manganese Superoxide Dismutase Transgene

Zhang, X., Epperly, M. W., Kay, M. A., Chen, Z.-Y., Dixon, T. M., Franicola, D., Greenberger, B. A., Komanduri, P., & Greenberger, J. S. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.141 · Cited by 62 · see citing works

Effects of X-irradiation on mitochondrial DNA damage and its supercoiling formation change

Zhou, X. M., Li, N., Wang, Y., Wang, Y., Zhang, X., & Zhang, H. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.07.005 · Cited by 61 · see citing works

QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology

Meyer, J. N. (2010) · Ecotoxicology · doi:10.1007/s10646-009-0457-4 · Cited by 61 · see citing works

Large deletions in mitochondrial DNA in radiation-associated human thyroid tumors.

Rogounovitch, T., Saenko, V., Shimizu‐Yoshida, Y., Abrosimov, A. Y., Lushnikov, E. F., Roumiantsev, P. O., Ohtsuru, A., Namba, H., Tsyb, A. F., & Yamashita, S. (2002) · PubMed · Cited by 61 · see citing works

Cancer proliferation and therapy: the Warburg effect and quantum metabolism

Demetrius, L., Coy, J. F., & Tuszyński, J. A. (2010) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-7-2 · Cited by 58 · see citing works

Changes in the human mitochondrial genome after treatment of malignant disease

Wardell, T. M., Ferguson, E., Chinnery, P. F., Borthwick, G. M., Taylor, R. W., Jackson, G. H., Craft, A. W., Lightowlers, R. N., Howell, N., & Turnbull, D. M. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00313-5 · Cited by 57 · see citing works

The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation

Guo, Y. P., Cai, Q., Samuels, D. C., Ye, F., Long, J., Li, C.-I., Winther, J. F., Tawn, E. J., Stovall, M. A., Lähteenmäki, P. M., et al. (2012) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2012.02.006 · Cited by 57 · see citing works

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts

Du, C., Gao, Z., Venkatesha, V. A., Kalen, A. L., Chaudhuri, L., Spitz, D. R., Cullen, J. J., Oberley, L. W., & Goswami, P. C. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.20.9648 · Cited by 56 · see citing works

The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.

Rajagopalan, M. S., Gupta, K., Epperly, M. W., Franicola, D., Zhang, X., Wang, H., Zhao, H., Tyurin, V. A., Pierce, J. G., Kagan, V. E., et al. (2009) · PubMed · Cited by 55 · see citing works

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn Vivo

Epperly, M. W., Melendez, J. A., Zhang, X., Nie, S., Pearce, L. L., Peterson, J., Franicola, D., Dixon, T. M., Greenberger, B. A., Komanduri, P., et al. (2009) · Radiation Research · doi:10.1667/rr1424.1 · Cited by 55 · see citing works

Mitochondrial Gene Expression Changes in Normal and Mitochondrial Mutant Cells after Exposure to Ionizing Radiation

Kulkarni, R. M., Marples, B., Balasubramaniam, M., Thomas, R. A., & Tucker, J. D. (2010) · Radiation Research · doi:10.1667/rr1737.1 · Cited by 54 · see citing works

Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE

Indo, H. P., Inanami, O., Koumura, T., Suenaga, S., Yen, H., Kakinuma, S., Matsumoto, K., Nakanishi, I., Clair, W. H. S., Clair, D. K. S., et al. (2012) · Free Radical Research · doi:10.3109/10715762.2012.698012 · Cited by 53 · see citing works

Ionizing radiation-induced micronucleus formation is mediated by reactive oxygen species that are produced in a manner dependent on mitochondria, Nox1, and JNK

Choi, K.-M., Kang, C.-M., Cho, E., Kang, S. M., Lee, S., & Um, H. (2007) · Oncology Reports · doi:10.3892/or.17.5.1183 · Cited by 52 · see citing works

Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation

Wang, L., Kuwahara, Y., Li, L., Baba, T., Shin, R., Ohkubo, Y., Ono, K., & Fukumoto, M. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701370878 · Cited by 50 · see citing works

The increase in mitochondrial DNA copy number in the tissues of gamma-irradiated mice.

Malakhova, L. V., Bezlepkin, V. G., Vn, A., Ushakova, T., Fomenko, L. A., Sirota, N. P., & Gaziev, A. I. (2005) · PubMed · Cited by 49 · see citing works

Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors

Nugent, S., Mothersill, C. E., Seymour, C. B., McClean, B., Lyng, F. M., & Murphy, J. E. J. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2010.486019 · Cited by 49 · see citing works

Normal Human Fibroblasts Exposed to High- or Low-Dose Ionizing Radiation: Differential Effects on Mitochondrial Protein Import and Membrane Potential

Pandey, B. N., Gordon, D. M., Toledo, S. M. D., Pain, D., & Azzam, E. I. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1253 · Cited by 48 · see citing works

Replication-Competent Human Mitochondrial DNA Lacking the Heavy-Strand Promoter Region

Moraes, C. T., Andreetta, F., Bonilla, E., Shanske, S., DiMauro, S., & Schon, E. A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1631 · Cited by 48 · see citing works

A fluorescence-microscopic and flow-cytometric study of HeLa cells with an experimentally induced respiratory deficiency

Skowronek, P., Haferkamp, O., & Rödel, G. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91295-2 · Cited by 47 · see citing works

Mitochondrial DNA Depletion Induces Radioresistance by Suppressing G2Checkpoint Activation in Human Pancreatic Cancer Cells

Cloos, C. R., Daniels, D. H., Kalen, A. L., Matthews, K., Du, J., Goswami, P. C., & Cullen, J. J. (2009) · Radiation Research · doi:10.1667/rr1395.1 · Cited by 47 · see citing works

Selective nicking of mammalian mitochondrial DNA in vivo: Photosensitization by incorporation of 5-bromodeoxyuridine

Lansman, R. A., & Clayton, D. A. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80183-5 · Cited by 45 · see citing works

Consequences of Cytoplasmic Irradiation: Studies from Microbeam

Zhou, H., Hong, M., Chai, Y., & Hei, T. K. (2009) · Journal of Radiation Research · doi:10.1269/jrr.08120s · Cited by 44 · see citing works

Gene-Specific Repair of γ-Ray-Induced DNA Strand Breaks in Colon Cancer Cells: No Coupling to Transcription and No Removal from the Mitochondrial Genome

May, A., & Bohr, V. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2264 · Cited by 43 · see citing works

Analysis of the common deletions in the mitochondrial DNA is a sensitive biomarker detecting direct and non-targeted cellular effects of low dose ionizing radiation

Schilling-Tóth, B. M., Sándor, N., Kis, E., Kadhim, M. A., Sáfrány, G., & Hegyesi, H. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.07.018 · Cited by 42 · see citing works

Induction of a Particular Deletion in Mitochondrial DNA by X Rays Depends on the Inherent Radiosensitivity of the Cells

Kubota, N., Hayashi, J., Inada, T., & Iwamura, Y. (1997) · Radiation Research · doi:10.2307/3579525 · Cited by 41 · see citing works

Mechanism of genotoxicity induced by targeted cytoplasmic irradiation

Hong, M., Xu, A., Zhou, H. W., Wu, L. M., Randers-Pehrson, G., Santella, R. M., Zhang, Y., & Hei, T. K. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605888 · Cited by 41 · see citing works

The Radiation Bystander Effect and its Potential Implications for Human Health

Mancuso, M., Pasquali, E., Giardullo, P., Leonardi, S., Tanori, M., Majo, V. D., Pazzaglia, S., & Saran, A. (2012) · Current Molecular Medicine · doi:10.2174/156652412800620011 · Cited by 40 · see citing works

Replication of Murine Mitochondrial DNA Following Irradiation

Zhang, H., Maguire, D., Swarts, S. G., Sun, W., Yang, S., Wang, W., Liu, C., Zhang, M., Zhang, D., Zhang, L., et al. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-85998-9_7 · Cited by 39 · see citing works

Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays

Willis, J. H., Capaldi, R., Huigsloot, M., Rodenburg, R. J., Smeitink, J. A. M., & Marusich, M. F. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.10.009 · Cited by 39 · see citing works

Detection of Reactive Oxygen Species Induced by Radiation in Cells Using the Dichlorofluorescein Assay

Korystov, Y. N., Shaposhnikova, V. V., Korystova, A. F., & Emel’yanov, M. O. (2007) · Radiation Research · doi:10.1667/rr0925.1 · Cited by 39 · see citing works

The Role of Mitochondria in the Radiation-Induced Bystander Effect in Human Lymphoblastoid Cells

Rajendran, S., Harrison, S. H., Thomas, R. A., & Tucker, J. D. (2010) · Radiation Research · doi:10.1667/rr2296.1 · Cited by 36 · see citing works

Quantification of radiation induced DNA double-strand breaks in human fibroblasts by PFGE: testing the applicability of random breakage models

Pinto, M., Prise, K. M., & Michael, B. D. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000110110941 · Cited by 35 · see citing works

Recovery of Oxidative Phosphorylation in Rat Liver Mitochondria after Whole Body Irradiation

Hall, J. C., Goldstein, A. L., & Sonnenblick, B. P. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81271-6 · Cited by 34 · see citing works

Protein Synthesis and Assembly in Mitochondrial Disorders

Pérez-Martı́nez, X., Funes, S., Camacho‐Villasana, Y., Marjavaara, S. K., Tavares-Carreón, F., & Shingú-Vázquez, M. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608786141124 · Cited by 33 · see citing works

Incorporation of Measurement of DNA Integrity into qPCR Assays

Brisco, M. J., Latham, S., Bartley, P. A., & Morley, A. A. (2010) · BioTechniques · doi:10.2144/000113567 · Cited by 33 · see citing works

A method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin.

Singh, G., Hauswirth, W. W., Ross, W. E., & Neims, A. H. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11455-7 · Cited by 32 · see citing works

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species

Aykin‐Burns, N., Slane, B. G., Liu, A. T. Y., Owens, K. M., O'Malley, M. S., Smith, B. J., Domann, F. E., & Spitz, D. R. (2010) · Radiation Research · doi:10.1667/rr2220.1 · Cited by 32 · see citing works

The developmental changes in mitochondrial DNA content per cell in human cord blood leukocytes during gestation

Pejznochová, M., Tesařová, M., Honzík, T., Hansíková, H., Magner, M., & Zeman, J. (2008) · Physiological Research · doi:10.33549/physiolres.931246 · Cited by 32 · see citing works

Alteration of mtDNA copy number, mitochondrial gene expression and extracellular DNA content in mice after irradiation at lethal dose

Evdokimovsky, E. V., Ushakova, T. E., Kudriavtcev, A. A., & Gaziev, A. I. (2011) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0329-6 · Cited by 28 · see citing works

Proteomic Analysis of Ionizing Radiation-Induced Proteins at the Subcellular Level

Lin, R., Zhao, H., Li, C., Sun, Y., Qian, X., & Wang, S. (2008) · Journal of Proteome Research · doi:10.1021/pr800699w · Cited by 28 · see citing works

Mitochondrial Signal Lacking Manganese Superoxide Dismutase Failed to Prevent Cell Death by Reoxygenation Following Hypoxia in a Human Pancreatic Cancer Cell Line, KP4

Hirai, F., Motoori, S., Kakinuma, S., Tomita, K., Indo, H. P., Kato, H., Yamaguchi, T., Yen, H., Clair, D. K. S., Nagano, T., et al. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604773934288 · Cited by 26 · see citing works

Mitochondrial common deletion mutation and extrinsic skin ageing in German and Japanese women

Kaneko, N., Vierkötter, A., Kraemer, U., Sugiri, D., Matsui, M. S., Yamamoto, A., Krutmann, J., & Morita, A. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01499.x · Cited by 25 · see citing works

Mitochondrial DNA influences radiation sensitivity and induction of apoptosis in human fibroblasts.

Jt, T., Yamazaki, H., Inoue, T., Koizumi, M., Yoshida, K., Ozeki, S., & Inoue, T. (1999) · PubMed · Cited by 25 · see citing works

Predicted ionisation in mitochondria and observed acute changes in the mitochondrial transcriptome after gamma irradiation: A Monte Carlo simulation and quantitative PCR study

Kam, W. W.-Y., McNamara, A. L., Lake, V., Banos, C., Davies, J. B., Kuncic, Z., & Banati, R. B. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.02.005 · Cited by 24 · see citing works

Radiation-induced Damage to Mitochondrial d-β-hydroxybutyrate Dehydrogenase and Lipid Peroxidation

Yukawa, O., Miyahara, M., Shiraishi, N., & Nakazawa, T. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551111 · Cited by 24 · see citing works

Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-κB--STAT3-directed Gene Expression

Ivanov, V., Ghandhi, S., Zhou, H.-N., Huang, S. X., Chai, Y., Amundson, S., & Hei, T. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.03.012 · Cited by 23 · see citing works

Targeted Delivery of Radioprotective Agents to Mitochondria

Zabbarova, I. V., & Kanai, A. (2008) · Molecular Interventions · doi:10.1124/mi.8.6.7 · Cited by 23 · see citing works

Involvement of Mitochondrial DNA Sequence Variations and Respiratory Activity in Late Complications following Radiotherapy

Alsbeih, G., Al-Harbi, N., El-Sebaie, M., Al-Rajhi, N., Al-Hadyan, K., & Abu-Amero, K. K. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0960 · Cited by 22 · see citing works

Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy

Huang, Z., Jiang, J., Belikova, N. A., Stoyanovsky, D. A., Kagan, V. E., & Mintz, A. H. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0387-2 · Cited by 22 · see citing works

Mitochondrial Gene Expression in Directly Irradiated and Nonirradiated Bystander Cells

Chaudhry, M. A., & Omaruddin, R. A. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0940 · Cited by 21 · see citing works

Profiling Mitochondrial Proteins in Radiation-Induced Genome-Unstable Cell Lines with Persistent Oxidative Stress by Mass Spectrometry

Miller, J. H., Jin, S., Morgan, W. F., Yang, A. J., Wan, Y., Aypar, U., Peters, J. S., & Springer, D. L. (2008) · Radiation Research · doi:10.1667/rr1186.1 · Cited by 21 · see citing works

Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy

Wen, Q., Hu, Y., Ji, F., & Qian, G. (2011) · Radiation Oncology · doi:10.1186/1748-717x-6-133 · Cited by 20 · see citing works

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis

Nadanaciva, S., Willis, J. H., Barker‐Haliski, M. L., Gharaibeh, D. N., Capaldi, R., Marusich, M. F., & Will, Y. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.12.002 · Cited by 19 · see citing works

Intrachromosomal Changes and Genomic Instability in Site-Specific Microbeam-Irradiated and Bystander Human-Hamster Hybrid Cells

Hu, B., Grabham, P. W., Nie, J., Balajee, A. S., Zhou, H., Hei, T. K., & Geard, C. R. (2011) · Radiation Research · doi:10.1667/rr2757.1 · Cited by 19 · see citing works

Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α‐particles

Zhang, S., Wen, G., Huang, S. X. L., Wang, J., Tong, J., & Hei, T. K. (2012) · International Journal of Cancer · doi:10.1002/ijc.27656 · Cited by 19 · see citing works

In SilicoNanodosimetry: New Insights into Nontargeted Biological Responses to Radiation

Kuncic, Z., Byrne, H. L., McNamara, A. L., Guatelli, S., Domanova, W., & Incerti, S. (2012) · Computational and Mathematical Methods in Medicine · doi:10.1155/2012/147252 · Cited by 18 · see citing works

[Ionizing radiation can activate the insertion of mitochondrial DNA fragments in the nuclear genome].

Gaziev, A. I., & Go, S. (2008) · PubMed · Cited by 16 · see citing works

Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability

Thomas, S. N., Waters, K. M., Morgan, W. F., Yang, A. J., & Baulch, J. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.025 · Cited by 14 · see citing works

Mitochondrial DNA transcription in mouse liver, skeletal muscle, and brain following lethal X-ray irradiation

Gubina, N., Merekina, O. S., & Ushakova, T. E. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910060131 · Cited by 13 · see citing works

Impact of Mitochondrial DNA on Radiation Sensitivity of Transformed Human Fibroblast Cells: Clonogenic Survival, Micronucleus Formation and Cellular ATP Level

Yoshioka, Y., Yamazaki, H., Yoshida, K., Ozeki, S., Inoue, T., Yoneda, M., & Inoue, T. (2004) · Radiation Research · doi:10.1667/rr3207 · Cited by 12 · see citing works

Role of mitochondrial DNA in radiation exposure.

Yoshida, K., Yamazaki, H., Ozeki, S., Inoue, T., Yoshioka, Y., & Inoue, T. (2000) · PubMed · Cited by 11 · see citing works

Reduction of the number of mutant copies of mitochondrial DNA in tissues of irradiated mice in the postradiation period

Guliaeva, N. A., Abdullaev, S. A., Malakhova, L. V., Antipova, V. N., Bezlepkin, V. G., & Gaziev, A. I. (2009) · Russian Journal of Genetics · doi:10.1134/s1022795409070114 · Cited by 11 · see citing works

Impact of mitochondrial DNA on hypoxic radiation sensitivity in human fibroblast cells and osteosarcoma cell lines

Koizumi, M., Yoneda, M., Inoue, T., Ozeki, S., Isohashi, F., Yoshioka, Y., Yoshida, K., & Yamazaki, H. (2008) · Oncology Reports · doi:10.3892/or.19.6.1545 · Cited by 11 · see citing works

Mitochondrial genotypes and radiation-induced micronucleus formation in human osteosarcoma cells in vitro

Yoshida, K., Yamazaki, H., Ozeki, S., Inoue, T., Yoshioka, Y., Yoneda, M., Fujiwara, Y., & Inoue, T. (2001) · Oncology Reports · doi:10.3892/or.8.3.615 · Cited by 11 · see citing works

Role of Mitochondrial DNA in Cells Exposed to Irradiation: Generation of Reactive Oxygen Species (ROS) is Required for G2 Checkpoint upon Irradiation

Kawamura, S., Takai, D., Watanabe, K., Hayashi, J., Hayakawa, K., & Akashi, M. (2005) · Eisei kagaku · doi:10.1248/jhs.51.385 · Cited by 11 · see citing works

Radiation-induced apoptosis in peritoneal resident macrophages of C3H mice: Selective involvement of superoxide anion, but not other reactive oxygen species

Kubota, Y., Takahashi, S., Sato, H., & Suetomi, K. (2005) · International Journal of Radiation Biology · doi:10.1080/09553000500172145 · Cited by 10 · see citing works

Complements of the house

Schon, E. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22942 · Cited by 7 · see citing works

Effect of ionizing radiation on liver mitochondrial respiratory functions in mice.

Hwang, J., Lin, G. L., Sheu, S. C., & Lin, F. (1999) · PubMed · Cited by 7 · see citing works

Radiobiological effects of solely nuclear and cytoplasmic irradiation with ultraviolet-microbeam in HeLa cells.

Usui, M. (1970) · PubMed · Cited by 3 · see citing works

Mitochondrial genetic apparatus functioning in mice spleen cells under radiation-induced apoptosis

Gubina, N., Evdokimovsky, E. V., & Ushakova, T. E. (2010) · Molecular Biology · doi:10.1134/s0026893310060087 · Cited by 3 · see citing works

Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

Reisz, J. A., Bansal, N., Qian, J. X., Zhao, W., & Furdui, C. M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5489 · Cited by 838 · see citing works

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 579 · see citing works

Pathological effects of ionizing radiation: endothelial activation and dysfunction

Baselet, B., Sonveaux, P., Baatout, S., & Aerts, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2956-z · Cited by 555 · see citing works

Ferroptosis, radiotherapy, and combination therapeutic strategies

Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 518 · see citing works

Cellular Stress Responses in Radiotherapy

Kim, W., Lee, S., Seo, D., Kim, D., Kim, K., Kim, E., Kang, J., Seong, K. M., Youn, H., & Youn, B. (2019) · Cells · doi:10.3390/cells8091105 · Cited by 343 · see citing works

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

Schulz, A., Meyer, F. B., Dubrovska, A., & Borgmann, K. (2019) · Cancers · doi:10.3390/cancers11060862 · Cited by 306 · see citing works

Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer

King, S. N., Dunlap, N., Tennant, P., & Pitts, T. E. (2016) · Dysphagia · doi:10.1007/s00455-016-9710-1 · Cited by 251 · see citing works

Biological effects of radiation on cancer cells

Wang, J., Wang, H., & Qian, H. (2018) · Military Medical Research · doi:10.1186/s40779-018-0167-4 · Cited by 247 · see citing works

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck, D., & Rodriguez‐Lafrasse, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011047 · Cited by 242 · see citing works

Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: The pivotal role of mitochondria

Szumiel, I. (2014) · International Journal of Radiation Biology · doi:10.3109/09553002.2014.934929 · Cited by 234 · see citing works

Targeted iron oxide nanoparticles for the enhancement of radiation therapy

Hauser, A. K., Mitov, M. I., Daley, E. F., McGarry, R. C., Anderson, K. W., & Hilt, J. Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.032 · Cited by 202 · see citing works

The impact of high and low dose ionising radiation on the central nervous system

Betlazar, C., Middleton, R., Banati, R., & Liu, G.-J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.002 · Cited by 126 · see citing works

Effect of ionizing radiation on physiological and molecular processes in plants

Gudkov, S. V., Grinberg, M. A., Sukhov, V., & Vodeneev, V. (2019) · Journal of Environmental Radioactivity · doi:10.1016/j.jenvrad.2019.02.001 · Cited by 179 · see citing works

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Singh, V. K., & Seed, T. M. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1332438 · Cited by 176 · see citing works

Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production

Kawamura, K., Qi, F., & Kobayashi, J. (2018) · Journal of Radiation Research · doi:10.1093/jrr/rrx091 · Cited by 176 · see citing works

Mechanisms of radiation-induced endothelium damage: Emerging models and technologies

Wijerathne, H., Langston, J. C., Yang, Q., Sun, S., Miyamoto, C. T., Kilpatrick, L. E., & Kiani, M. F. (2021) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2021.02.007 · Cited by 175 · see citing works

Molecular targeting of hypoxia in radiotherapy

Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 171 · see citing works

Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

Gawne, P. J., Man, F., Blower, P. J., & de Rosales, R. T. M. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00767 · Cited by 168 · see citing works

Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis

Pouget, J., Georgakilas, A. G., & Ravanat, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7267 · Cited by 160 · see citing works

Ionizing radiation biomarkers in epidemiological studies – An update

Hall, J. A., Jeggo, P. A., West, C., Gomolka, M., Quintens, R., Badie, C., Laurent, O., Aerts, A., Anastasov, N., Azimzadeh, O., et al. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.01.001 · Cited by 151 · see citing works

Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway

Durante, M., & Formenti, S. C. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00192 · Cited by 150 · see citing works

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

Chaiswing, L., Clair, W. H. S., & Clair, D. K. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7485 · Cited by 147 · see citing works

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

Farhood, B., Goradel, N. H., Mortezaee, K., Khanlarkhani, N., Salehi, E., Nashtaei, M. S., Mirtavoos‐Mahyari, H., Motevaseli, E., Shabeeb, D., Musa, A. E., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1934-0 · Cited by 144 · see citing works

Ionizing radiation, antioxidant response and oxidative damage: A meta-analysis

Einor, D., Bonisoli‐Alquati, A., Costantini, D., Mousseau, T. A., & Møller, A. P. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.01.027 · Cited by 138 · see citing works

In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy

Li, Z., Zou, J., & Chen, X. S. (2022) · Advanced Materials · doi:10.1002/adma.202209529 · Cited by 132 · see citing works

Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules

Pannkuk, E. L., Fornace, A. J., & Laiakis, E. C. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2016.1269218 · Cited by 121 · see citing works

Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches

Klein, K., He, K., Younes, A. I. A., Barsoumian, H. B., Chen, D., Ozgen, T., Mosaffa, S., Patel, R. R., Gu, M., Novaes, J. A. M. D. O., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573326 · Cited by 120 · see citing works

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Hughes, A. M., & Hu, N. (2023) · Cancers · doi:10.3390/cancers15164091 · Cited by 115 · see citing works

Effects of ionizing radiation on the mammalian brain

Hladik, D., & Tapio, S. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.08.003 · Cited by 109 · see citing works

Protection against Radiotherapy-Induced Toxicity

Hall, S., Rudrawar, S., Zunk, M., Bernaitis, N., Arora, D. S., McDermott, C., & Anoopkumar‐Dukie, S. (2016) · Antioxidants · doi:10.3390/antiox5030022 · Cited by 104 · see citing works

Subcellular Targeting of Theranostic Radionuclides

Bavelaar, B. M., Lee, B. Q., Gill, M. R., Falzone, N., & Vallis, K. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00996 · Cited by 101 · see citing works

Direct 1O2 optical excitation: A tool for redox biology

Blázquez‐Castro, A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.011 · Cited by 98 · see citing works

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

Martinez, R. M., Pinho-Ribeiro, F. A., Steffen, V. S., Silva, T. C. C., Caviglione, C. V., Bottura, C., Fonseca, M. J. V., Vicentini, F. T. M. C., Vignoli, J. A., Baracat, M. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146296 · Cited by 96 · see citing works

Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns

Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95 · see citing works

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells

Rodrigues-Moreira, S., Moreno, S. G., Ghinatti, G., Lewandowski, D., Hoffschir, F., Ferri, F., Gallouët, A.-S., Gay, D. L., Motohashi, H., Yamamoto, M. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.013 · Cited by 94 · see citing works

Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles

Ariyoshi, K., Miura, T., Kasai, K., Fujishima, Y., Nakata, A., & Yoshida, M. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-45669-z · Cited by 91 · see citing works

Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response

McCann, E., O'Sullivan, J. N., & Marcone, S. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100905 · Cited by 89 · see citing works

Effects of Gamma Radiation on Crop Production

Ali, H., Ghori, Z., Sheikh, S., & Gul, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-23162-4_2 · Cited by 84 · see citing works

Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation

Holmila, R. J., Vance, S. A., King, S. B., Tsang, A. W., Singh, R. N., & Furdui, C. M. (2019) · Antioxidants · doi:10.3390/antiox8110552 · Cited by 82 · see citing works

Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway

Constanzo, J., Faget, J., Ursino, C., Badie, C., & Pouget, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680503 · Cited by 82 · see citing works

Targeting of cellular redox metabolism for mitigation of radiation injury

Farhood, B., Ashrafizadeh, M., Khodamoradi, E., Hoseini‐Ghahfarokhi, M., Afrashi, S., Musa, A. E., & Najafi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117570 · Cited by 78 · see citing works

Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells

Cao, X., Wen, P., Fu, Y., Gao, Y., Qi, X., Chen, B., Tao, Y., Wu, L., Xu, A., Lü, H., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.06.002 · Cited by 76 · see citing works

A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death

Saini, S., & Gurung, P. (2024) · Immunological Reviews · doi:10.1111/imr.13409 · Cited by 76 · see citing works

Repair characteristics and time-dependent effects in Saccharomyces cerevisiae cells after X-ray irradiation

Guo, X., Zhang, M., Liu, R., Gao, Y., Yang, Y., Li, W., & Lü, D. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2566-9 · Cited by 71 · see citing works

Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat cerebellum

Zhou, K., Boström, M., Ek, C. J., Li, T., Xie, C., Xu, Y., Sun, Y., Blomgren, K., & Zhu, C. (2017) · Scientific Reports · doi:10.1038/srep46181 · Cited by 68 · see citing works

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Wang, Q., Xie, C., Xi, S.-J., Qian, F., Peng, X., Huang, J., & Tang, F.-R. (2020) · Molecules · doi:10.3390/molecules25235719 · Cited by 71 · see citing works

Ionizing radiation and heart risks

Bhattacharya, S., & Asaithamby, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.045 · Cited by 67 · see citing works

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

Liu, Y., Yan, J., Sun, C., Guo, L., Li, S., Zhang, L., Di, C., Gan, L., Wang, Y., Zhou, R., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.012 · Cited by 68 · see citing works

Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury

Gorbunov, N. V., & Kiang, J. G. (2021) · Radiation Research · doi:10.1667/rade-20-00147.1 · Cited by 69 · see citing works

Reactive Oxygen Species: Angels and Demons in the Life of a Neuron

Biswas, K., Alexander, K. D., & Francis, M. M. (2022) · NeuroSci · doi:10.3390/neurosci3010011 · Cited by 69 · see citing works

Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma

Cruz‐Gregorio, A., Martínez-Ramírez, I., Pedraza‐Chaverrí, J., & Lizano, M. (2019) · Cancers · doi:10.3390/cancers11020182 · Cited by 66 · see citing works

Age-related effects of X-ray irradiation on mouse hippocampus

Casciati, A., Dobos, K., Antonelli, F., Benedek, A., Kempf, S. J., Bellés, M., Balogh, A., Tanori, M., Heredia, L., Atkinson, M. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8575 · Cited by 66 · see citing works

The Protective Roles of ROS‐Mediated Mitophagy on 125I Seeds Radiation Induced Cell Death in HCT116 Cells

Hu, L., Wang, H., Huang, L., Zhao, Y. L., & Wang, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9460462 · Cited by 66 · see citing works

Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential

Walsh, D. W. M., Siebenwirth, C., Greubel, C., Ilicic, K., Reindl, J., Girst, S., Muggiolu, G., Simon, M., Barberet, P., Seznec, H., et al. (2017) · Scientific Reports · doi:10.1038/srep46684 · Cited by 66 · see citing works

Fasting, Fats, and Physics: Combining Ketogenic and Radiation Therapy against Cancer

Klement, R. J. (2017) · Complementary Medicine Research · doi:10.1159/000484045 · Cited by 65 · see citing works

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

Rong, R., Xia, X., Peng, H., Li, H., You, M., Liang, Z., Yao, F., Yao, X., Xiong, K., Huang, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02922-y · Cited by 64 · see citing works

Mitochondrial Signaling Pathways Associated with DNA Damage Responses

Shimura, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076128 · Cited by 65 · see citing works

Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

Nosrati, H., Ghaffarlou, M., Salehiabar, M., Mousazadeh, N., Abhari, F., Barsbay, M., Ertas, Y. N., Rashidzadeh, H., Mohammadi, A., Nasehi, L., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213090 · Cited by 60 · see citing works

The role of radiation induced oxidative stress as a regulator of radio-adaptive responses

Sisakht, M., Darabian, M., Mahmoodzadeh, A., Bazı, A., Shafiee, S. M., Mokarram, P., & Khoshdel, Z. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721597 · Cited by 60 · see citing works

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Boyd, A., Byrne, S., Middleton, R. J., Banati, R. B., & Liu, G. J. (2021) · Cells · doi:10.3390/cells10092381 · Cited by 62 · see citing works

Crosstalk between autophagy and intracellular radiation response (Review)

Hu, L., Wang, H., Huang, L., Zhao, Y. L., & Wang, J. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3719 · Cited by 59 · see citing works

Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells

Shimura, T., Kobayashi, J., Komatsu, K., & Kunugita, N. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1156276 · Cited by 55 · see citing works

FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge

Borghini, A., Labate, L. U., Piccinini, S., Panaino, C. M. V., Andreassi, M. G., & Gizzi, L. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052546 · Cited by 55 · see citing works

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nakajima, T. (2015) · Medical Science Monitor · doi:10.12659/msm.893234 · Cited by 55 · see citing works

Antioxidant marine algae phlorotannins and radioprotection: A review of experimental evidence

Shin, T., Ahn, M., Hyun, J. W., Kim, S. H., & Moon, C. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.03.008 · Cited by 55 · see citing works

Targeting mitochondria in cancer cells using gold nanoparticle‐enhanced radiotherapy: A Monte Carlo study

Kirkby, C., & Ghasroddashti, E. (2015) · Medical Physics · doi:10.1118/1.4906192 · Cited by 55 · see citing works

Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol

McNamara, A. L., Kam, W. W.-Y., Scales, N., McMahon, S. J., Bennett, J. W., Byrne, H. L., Schuemann, J., Paganetti, H., Banati, R. B., & Kuncic, Z. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/16/5993 · Cited by 54 · see citing works

The influence of ketogenic therapy on the 5 R’s of radiobiology

Klement, R. J. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1380330 · Cited by 54 · see citing works

Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects

Duarte, G. T., Volkova, P., Pérez, F. F., & Horemans, N. (2023) · Plants · doi:10.3390/plants12051178 · Cited by 53 · see citing works

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism

Eshraghi, R. S., Deth, R. C., Mittal, R., Aranke, M., Kay, S.-I. S., Moshiree, B., & Eshraghi, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00256 · Cited by 55 · see citing works

MitoQ ameliorates testicular damage induced by gamma irradiation in rats: Modulation of mitochondrial apoptosis and steroidogenesis

Ibrahim, A. A., Karam, H. M., Shaaban, E. A., Safar, M. M., & El-Yamany, M. F. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116655 · Cited by 51 · see citing works

Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development

Song, Y., Xie, L., Lee, Y., Brede, D. A., Lyne, F. M., Kassaye, Y. A., Thaulow, J., Caldwell, G. S., Salbu, B., & Tollefsen, K. E. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135912 · Cited by 51 · see citing works

Radiation-induced liver disease: beyond DNA damage

Zhou, Y. J., Tang, Y., Liu, S. J., Zeng, P. H., Qu, L., Jing, Q., & Yin, W. J. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2131163 · Cited by 50 · see citing works

Enhanced cytotoxic and genotoxic effects of gadolinium-doped ZnO nanoparticles on irradiated lung cancer cells at megavoltage radiation energies

Zangeneh, M., Nedaei, H. A., Mozdarani, H., Mahmoudzadeh, A., & Salimi, M. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109739 · Cited by 49 · see citing works

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

McNamara, A. L., Ramos‐Méndez, J., Perl, J., Held, K. D., Dominguez, N., Moreno, E., Henthorn, N. T., Kirkby, K. J., Meylan, S., Villagrasa, C., et al. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aad8eb · Cited by 48 · see citing works

The effect of radiation dose on mouse skeletal muscle remodeling

Hardee, J. P., Puppa, M., Fix, D. K., Gao, S., Hetzler, K. L., Bateman, T. A., & Carson, J. A. (2014) · Radiology and Oncology · doi:10.2478/raon-2014-0025 · Cited by 47 · see citing works

Mild mitochondrial uncoupling protects from ionizing radiation induced cell death by attenuating oxidative stress and mitochondrial damage

Rai, Y., Anita, A., Kumari, N., Singh, S., Kalra, N., Soni, R., & Bhatt, A. N. (2020) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2020.148325 · Cited by 47 · see citing works

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy

Chen, L., Liao, F., Jiang, Z., Zhang, C., Wang, Z., Luo, P., Jiang, Q., Wu, J., Wang, Q., Luo, M., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15149 · Cited by 45 · see citing works

Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent

Kesäniemi, J., Jernfors, T., Lavrinienko, A., Kivisaari, K., Kiljunen, M., Mappes, T., & Watts, P. C. (2019) · Molecular Ecology · doi:10.1111/mec.15241 · Cited by 44 · see citing works

Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

Hoque, S., Dhar, R., Kar, R., Mukherjee, S., Mukherjee, D., Mukerjee, N., Nag, S., Tomar, N., & Mallik, S. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2157875 · Cited by 43 · see citing works

In vivo assessment of reactive oxygen species production and oxidative stress effects induced by chronic exposure to gamma radiation in Caenorhabditis elegans

Maremonti, E., Eide, D. M., Rossbach, L. M., Lind, O. C., Salbu, B., & Brede, D. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.037 · Cited by 43 · see citing works

Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1

Shimura, T., & Kunugita, N. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1170271 · Cited by 42 · see citing works

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Bhattacharya, S., & Asaithamby, A. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.05.22 · Cited by 42 · see citing works

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Gomes, T., Song, Y., Brede, D. A., Xie, L., Gützkow, K. B., Salbu, B., & Tollefsen, K. E. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.02.039 · Cited by 42 · see citing works

NOBF4-Functionalized Au–Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation

Klein, S., Harreiß, C., Menter, C., Hümmer, J., Distel, L. V., Meyer, K., Hock, R., & Kryschi, C. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b03660 · Cited by 42 · see citing works

Early Changes in Rat Heart After High‐Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation

Cha, M., Seo, J., Kim, H. J., Kim, M. H., Yoon, H.-S., Jo, S. W., Oh, S., & Chang, J. H. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019072 · Cited by 42 · see citing works

Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons

Chien, L., Chen, W.-K., Liu, S.-T., Chang, C., Kao, M., Chen, K., Chiu, S.-C., Hsu, M.-L., Hsiang, I.-C., Chen, Y.-J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5790 · Cited by 41 · see citing works

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

Stoyanovsky, D. A., Jiang, J., Murphy, M. P., Epperly, M. W., Zhang, X., Li, S., Greenberger, J. S., Kagan, V. E., & Bayır, H. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml5003635 · Cited by 41 · see citing works

The Molecular Effects of Ionizing Radiations on Brain Cells: Radiation Necrosis vs. Tumor Recurrence

Cuccurullo, V., Stasio, G. D. D., Cascini, G. L., Gatta, G., & Bianco, C. (2019) · Diagnostics · doi:10.3390/diagnostics9040127 · Cited by 40 · see citing works

ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer

Foglietta, F., Serpe, L., & Canaparo, R. (2023) · Discover Nano · doi:10.1186/s11671-023-03939-w · Cited by 41 · see citing works

5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells

Ueta, K., Yamamoto, J., Tanaka, T., Nakano, Y., Kitagawa, T., & Nishizawa, S. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2841 · Cited by 39 · see citing works

Ameliorative effect of selenium nanoparticles and fish oil on cisplatin and gamma irradiation-induced nephrotoxicity in male albino rats

Saif‐Elnasr, M., Abdel-Aziz, N., & El-Batal, A. I. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1497050 · Cited by 39 · see citing works

Flavonoids sensitize tumor cells to radiation: molecular mechanisms and relevance to cancer radiotherapy

Tiwari, P., & Mishra, K. P. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1694193 · Cited by 39 · see citing works

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Baulch, J. E. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1549757 · Cited by 37 · see citing works

Mechanisms of vascular dysfunction evoked by ionizing radiation and possible targets for its pharmacological correction

Soloviev, A. I., & Kizub, I. V. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.019 · Cited by 36 · see citing works

Metabolic Reprogramming: A Friend or Foe to Cancer Therapy?

McCann, C. K., & Kerr, E. M. (2021) · Cancers · doi:10.3390/cancers13133351 · Cited by 35 · see citing works

Mechanisms of Energy Metabolism in Skeletal Muscle Mitochondria Following Radiation Exposure

Kim, E. J., Lee, M. Y., Kim, D. Y., Kim, K. I., & Yi, J. Y. (2019) · Cells · doi:10.3390/cells8090950 · Cited by 35 · see citing works

Radiotherapy Induces Intestinal Barrier Dysfunction by Inhibiting Autophagy

Qu, W., Zhang, L., & Ao, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c00706 · Cited by 35 · see citing works

Mitochondrial Translocator Protein (TSPO) Expression in the Brain After Whole Body Gamma Irradiation

Betlazar, C., Middleton, R. J., Howell, N. R., Storer, B., Davis, E., Davies, J. B., Banati, R. B., & Liu, G.-J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.715444 · Cited by 35 · see citing works

Necrostatin-1 rescues mice from lethal irradiation

Huang, Z., Epperly, M. W., Watkins, S. C., Greenberger, J. S., Kagan, V. E., & Bayır, H. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.014 · Cited by 35 · see citing works

Mitochondria: The Target of Ionizing Radiation Damage

Lian-chen, T., Yuan, Y., & Xu-Hong, D. (2025) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.16476/j.pibb.2024.0394

Mitochondria as extranuclear targets of ionizing radiation

Tong, J. (2015) · Zhonghua fangshe yixue yu fanghu zazhi · doi:10.3760/cma.j.issn.0254-5098.2015.01.001

Пути сохранения целостности митохондриальной ДНК и функций митохондрий в клетках, подвергшихся воздействию ионизирующей радиации

Gaziev, A. I. (2013) · Радиационная биология Радиоэкология · doi:10.7868/s0869803113020045 · Cited by 15 · see citing works

Track-structure simulations of energy deposition patterns to mitochondria and damage to their DNA

Friedland, W., Schmitt, E., Kundrát, P., Baiocco, G., & Ottolenghi, A. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1450532 · Cited by 18 · see citing works

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Rong, J., Yu, Q., Huang, G., Wang, Y., & Zhang, N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1660330 · Cited by 25 · see citing works