Cited by 159Cytokine Signaling Pathways and InteractionsRegulation of Appetite and ObesityTryptophan and brain disorders

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Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.

Schöbitz, Bernd, Pezeshki, Gita, Pohl, Thomas, Hemmann, Ulrike, Heinrich, Peter C., Holsboer, Florian, Reul, Johannes M. H. M.·1995·The FASEB Journal

DOI 10.1096/fasebj.9.8.7768358

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Abstract

The pleiotropic cytokine interleukin-6 (IL-6) controls both the peripheral and central components of the acute-phase response. These activities are mediated via the IL-6 membrane receptor, but probably also via agonistic soluble IL-6 receptors (sIL-6Rs). In the present study we conducted dose-response experiments with rats that were intracerebroventricularly i.c.v.) injected with recombinant human IL-6 and sIL-6R and determined body temperature, locomotor activity, food intake, and water consumption using radiotelemetry and continuous recordings of feeding and drinking. IL-6 injected i.c.v. at 1, 10, and 100 ng increased body temperature and decreased locomotor activity and food intake, but it did not affect water consumption. When 10 ng sIL-6R, which lacked detectable biological activity, was injected i.c.v. 1 h before 1 ng IL-6, the central effects of IL-6 were enhanced and prolonged, and this was not due to endotoxin contamination of the recombinant proteins. Our data suggest that IL-6 plays an important role in the regulation of body temperature, general activity, and food intake in sick animals. Moreover, we have shown for the first time that it is possible to potentiate the effects of a mediator in vivo by administration of the corresponding receptor, which is a novel pharmacological tool for increasing receptor capacity.

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Authors: Schöbitz, B., Pezeshki, G., Pohl, T., Hemmann, U., Heinrich, P. C., Holsboer, F., & Reul, J. M. H. M.
Affiliations: Max Planck Society (DE)
RWTH Aachen University (DE)
Corresponding author: Reul, Johannes M. H. M.
ORCID: Reul, Johannes M. H. M.
Venue: The FASEB Journal
Publisher: Wiley
Published: 1995-05
Volume: 9
Issue: 8
Pages: 659-664
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fasebj.9.8.7768358
OpenAlex: W2132562760
Cited by: 159
References: 22
Citations by year: 2026: 2 · 2025: 2 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 3 · 2012: 4
FWCI: 4.84
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (publishedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: interleukin-6, soluble IL-6 receptor, acute phase response, thermoregulation, locomotor activity, dietary intake, water intake, intracerebroventricular administration, receptor potentiation, cytokine receptor signaling
MeSH terms: Animals, Body Temperature, Drug Synergism, Eating, Fever, Humans, Injections, Intraventricular, Locomotion, Male, Recombinant Proteins, Solubility, Interleukin-6, Rats, Wistar, Receptors, Interleukin, Receptors, Interleukin-6, Rats

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Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.

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