The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Diseases of liporegulation: new perspective on obesity and related disorders
Abstract
Obesity‐related diseases now threaten to reach epidemic proportions in the United States. Here we review in a rodent model of genetic obesity, the fa/fa Zucker diabetic fatty (ZDF) rat, the mechanisms involved in the most common complications of diet‐induced human obesity, i.e., noninsulin‐dependent diabetes mellitus, and myocardial dysfunction. In ZDF rats, hyperphagia leads to hyperinsulinemia, which up‐regulates transcription factors that stimulate lipogene‐sis. This causes ectopic deposition of triacylglycerol in nonadipocytes, providing fatty acid (FA) substrate for damaging pathways of nonoxidative metabolism, such as ceramide synthesis. In β cells and myocardium, the resulting functional impairment and apoptosis cause diabetes and cardiomyopathy. Interventions that lower ectopic lipid accumulation or block nonoxidative metabolism of FA and ceramide formation completely prevent these complications. Given the evidence for a similar etiology for the complications of human obesity, it would be appropriate to develop strategies to avert the predicted epidemic of lipotoxic disorders.—Unger, R. H., Orci, L. Diseases of lipid overflow: new perspective on obesity and related disorders. FASEB J. 15, 312‐321 (2001)
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Cites
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Self-citationFatty acid-induced β cell apoptosis: A link between obesity and diabetes
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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292
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Western Diet and the Immune System: An Inflammatory Connection
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Self-citationRegulation of lipid stores and metabolism by lipophagy
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Metadata
- Authors
- UNGER, R. H., & ORCI, L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-02
- Volume
- 15
- Issue
- 2
- Pages
- 312-321
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2105532009
- Cited by
- 430
- References
- 14
- FWCI
- 15.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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