The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Dopamine and L‐dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease
Abstract
Protein deposition diseases involve the aggregation of normally soluble proteins, leading to both fibrillar and amorphous deposits. The aggregation of α‐synuclein is associated with Parkinson's disease, and the aggregation of the Aβ peptide is associated with Alzheimer's disease. Here we show that L‐dopa, dopamine, and other catecholamines dissolve fibrils of α‐synuclein and Aβ peptide generated in vitro. The catecholamines also inhibited the fibrillation of these proteins. In addition, intraneuronal α‐synuclein deposits formed in a mouse model were dissolved by incubation of tissue slices with L‐dopa. These catecholamines are susceptible to oxidative breakdown, and we show that oxidation products are more effective than the parent compounds in inhibition. The ability to dissolve fibrils provides a new approach for studying mechanisms and consequences (e.g., the relationship between fibril formation and neurodegeneration) of protein aggregation. It is also likely to help in the development of strategies for the prevention and treatment of protein deposition diseases.
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Cited by
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Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Dominguez, L., Shea, J.-E., Dokholyan, N. V., De Simone, A., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 678
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DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers
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α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis
Mehra, S., Sahay, S., & Maji, S. K. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.03.001 · Cited by 499
Metadata
- Authors
- Li, J., Zhu, M., Manning-Bog, A. B., Di Monte, D. A., & Fink, A. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 18
- Issue
- 9
- Pages
- 962-964
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1968990406
- Cited by
- 258
- References
- 45
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, J., Zhu, M., Manning-Bog, A. B., Di Monte, D. A., & Fink, A. L. (2004). Dopamine and L‐dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease. The FASEB Journal. https://doi.org/10.1096/fj.03-0770fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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