CoChat
Sign Up
Cited by 288

The DOI matches its Crossref record.

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

Morrow, Geneviève, Samson, Mélanie, Michaud, Sébastien, M. Tanguay, Robert·2004·The FASEB Journal
DOI 10.1096/fj.03-0860fje
Open this paper in CoChat — free account

Abstract

Heat shock proteins (Hsp) are involved in protein folding, transport and stress resistance. Studies reporting an increased mRNA level of hsp genes in aged Drosophila suggest that expression of Hsp might be beneficial in preventing damages induced by aging. Because oxidative damage is often observed in aged organisms and mitochondria are sensitive to reactive oxygen species, we tested the hypothesis that increased levels of a small Hsp localized in mitochondria, Hsp22 of Drosophila melanogaster , could protect mitochondrial proteins and influence the aging process. We demonstrate that a ubiquitous or a targeted expression of Hsp22 within motorneurons increases the mean life span by more than 30%. Hsp22 shows beneficial effects on early‐aging events since the premortality phase displays the same increase as the mean lifespan. Moreover, flies expressing Hsp22 in their motorneurons maintain their locomotor activity longer as assessed by a negative geotaxis assay. The motorneurons‐targeted expression of Hsp22 also significantly increases flies’ resistance to oxidative injuries induced by paraquat (up to 35%) and thermal stress (39% at 30°C and 23% at 37°C). These observations establish Hsp22 as a key player in cell‐protection mechanisms against oxidative injuries and aging in Drosophila and corroborate the pivotal role of mitochondria in the process of aging.

Overview

Integrity signals

Registry

Crossref · 10.1096/fj.03-0860fje

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Transgenic worms and flies overexpressing chaperones are long-lived.

    “In particular, transgenic worms and flies overexpressing chaperones are long-lived (Morrow et al., 2004; Walker and Lithgow, 2003).”

    From The Hallmarks of Aging (2013) · cites this paper as Morrow et al., 2004

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 44

  1. 10.1038/534 · DOI
  2. 10.1126/science.290.5499.2137 · DOI
  3. Vettraino J., 2001, Direct selection for paraquat resistance in Drosophila results in a different extended longevity phenotype, J. Gerontol., 56, B415, 10.1093/gerona/56.10.B415 · DOI
  4. Chavous D. A., 2001, Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase, Proc. Natl. Acad. Sci. USA., 98, 14,814, 10.1073/pnas.251446498 · DOI
  5. 10.1016/S0960-9822(01)00203-2 · DOI
  6. Moskovitz J., 2001, Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals, Proc. Natl. Acad. Sci. USA., 98, 12,920, 10.1073/pnas.231472998 · DOI
  7. 10.1073/pnas.032671199 · DOI
  8. 10.1016/S0891-5849(02)00856-0 · DOI
  9. 10.1007/PL00013199 · DOI
  10. 10.1016/S0047-6374(98)00034-7 · DOI
  11. 10.1016/S0047-6374(00)00217-7 · DOI
  12. 10.1016/S0531-5565(01)00229-7 · DOI
  13. 10.1073/pnas.022631999 · DOI
  14. 10.1126/science.1057987 · DOI
  15. 10.1073/pnas.92.16.7540 · DOI · Paper page
  16. 10.1093/gerona/56.7.B281 · DOI
  17. 10.1006/cbir.2001.0789 · DOI
  18. 10.1093/gerona/52A.1.B48 · DOI
  19. Rattan S. I., 1998, Repeated mild heat shock delays aging in cultured human skin fibroblasts, Biochem. Mol. Biol. Int., 45, 753
  20. 10.1016/S0531-5565(00)00263-1 · DOI
  21. 10.1016/S0531-5565(01)00161-9 · DOI
  22. 10.1023/A:1011561107055 · DOI
  23. Wheeler J. C., 1995, Muscle‐specific expression of Drosophila hsp70 in response to aging and oxidative stress, Proc. Natl. Acad. Sci. USA., 92, 408
  24. 10.1002/eji.1830231049 · DOI
  25. 10.1093/gerona/55.11.B552 · DOI
  26. 10.1093/emboj/16.2.221 · DOI
  27. 10.1083/jcb.109.1.7 · DOI
  28. 10.1016/S0006-291X(05)80963-5 · DOI
  29. 10.1111/j.1432-1033.1993.tb18032.x · DOI
  30. 10.1038/35023595 · DOI
  31. 10.1073/pnas.92.15.7036 · DOI
  32. Rørth P. A., 1996, A modular misexpression screen in Drosophila detecting tissue‐specific phenotypes, Proc. Natl. Acad. Sci. USA., 93, 418
  33. Leal S. M., 2002, Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster, Neurobiol., 50, 245, 10.1002/neu.10030 · DOI
  34. 10.1139/g96-094 · DOI
  35. Morrow G., 2000, The small heat shock protein Hsp22 of Drosophila melanogaster is a mitochondrial protein displaying oligomeric organization, J. Biol. Chem., 275, 204
  36. 10.1242/dev.118.2.401 · DOI
  37. 10.1126/science.282.5390.943 · DOI
  38. 10.1016/S0047-6374(01)00245-7 · DOI
  39. 10.1023/A:1011517325711 · DOI
  40. 10.1023/A:1013270512172 · DOI
  41. Garigan D., 2002, Genetic analysis of tissue aging in Caehorhabditis elegans: A role for heat‐shock factor and bacterial proliferation, Genetics, 161, 1101, 10.1093/genetics/161.3.1101 · DOI · Paper page
  42. 10.1046/j.1474-9728.2003.00045.x · DOI · Paper page
  43. 10.1126/science.1083614 · DOI · Paper page
  44. 10.1016/S0047-6374(02)00168-9 · DOI

Cited by

Sorted by citations

Metadata

Authors
Morrow, G., Samson, M., Michaud, S., & M. Tanguay, R.
Affiliations
Laboratory of Cell & Developmental Genetics, CREFSIP and Dept Medicine, Pav. Marchand UniversitéLaval Ste‐Foy Québec Canada G1K 7P4
Venue
The FASEB Journal
Publisher
Wiley
Published
2004-01-20
Volume
18
Issue
3
Pages
598-599
ISSN
  • 0892-6638
  • 1530-6860
DOI
10.1096/fj.03-0860fje
Cited by
288
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Canadian Institutes of Health Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review