Insulin/IGF-like signalling, the central nervous system and aging

Broughton, Susan; Partridge, Linda

doi:10.1042/bj20082102

Cited by 228Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology ResearchMetabolism, Diabetes, and Cancer

Insulin/IGF-like signalling, the central nervous system and aging

Broughton, Susan, Partridge, Linda·2009·Biochemical Journal

DOI 10.1042/bj20082102

Open this paper in CoChat — free account

Abstract

Enormous strides in understanding aging have come from the discovery that mutations in single genes can extend healthy life-span in laboratory model organisms such as the yeast Saccharomyces, the fruit fly Drosophila melanogaster, the nematode worm Caenorhabditis elegans and the mouse. IIS [insulin/IGF (insulin-like growth factor)-like signalling] stands out as an important, evolutionarily conserved pathway involved in the determination of lifespan. The pathway has diverse functions in multicellular organisms, and mutations in IIS can affect growth, development, metabolic homoeostasis, fecundity and stress resistance, as well as lifespan. The pleiotropic nature of the pathway and the often negative effects of its disruption mean that the extent, tissue and timing of IIS manipulations are determinants of a positive effect on lifespan. One tissue of particular importance for lifespan extension in diverse organisms is the CNS (central nervous system). Although lowered IIS in the CNS can extend lifespan, IIS is also widely recognized as being neuroprotective and important for growth and survival of neurons. In the present review, we discuss our current understanding of the role of the nervous system in extension of lifespan by altered IIS, and the role of IIS in determination of neuronal function during aging. The nervous system can play both endocrine and cell-autonomous roles in extension of lifespan by IIS, and the effects of IIS on lifespan and neuronal function can be uncoupled to some extent. Tissue-specific manipulation of IIS and the cellular defence mechanisms that it regulates will better define the ways in which IIS affects neuronal and whole-organism function during aging.

Integrity signals

Registry

Crossref · 10.1042/bj20082102

Cites

156 of 156 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reduced signalling through the insulin/IGF-1 signalling (IIS) pathway is a strongly conserved mechanism of lifespan extension in worms, flies and mammals.
“Reduced signalling through the insulin/IGF-1 signalling (IIS) pathway is a strongly conserved mechanism of lifespan extension in worms, flies and mammals (reviewed in ref. 61).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [61]
Insulin and IGF-1 can also promote learning and memory in humans and animal models.
“Insulin and IGF-1 can also promote learning and memory in humans and animal models (61,68).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [61]
CNS insulin signaling is important for many aspects of neuronal survival and function.
“it is now clear that CNS insulin signaling is important for many aspects of neuronal survival and function (Broughton and Partridge, 2009; de la Monte and Wands, 2005; Reagan, 2007; Zhao and Alkon, 2001; Zhao et al., 2004).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Broughton and Partridge, 2009
The decrease in Igf1 may not affect microglial survival because the IGF1 receptor is found largely on neurons, but it could contribute to neurodegeneration.
“While this may not affect microglial survival as the IGF1 receptor is found largely on neurons, it could contribute to neurodegeneration, being an important factor in neuronal survival and lifespan across many species (67).”
From Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [67]

1 retracted

RETRACTED: Hippocampus of Ames dwarf mice is resistant to β‐amyloid‐induced tau hyperphosphorylation and changes in apoptosis‐regulatory protein levels
Schrag, M., Sharma, S., Brown‐Borg, H. M., & Ghribi, O. (2007) · Hippocampus · doi:10.1002/hipo.20387 · Cited by 34 · see citing works
Retracted
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
Autophagy as a regulated pathway of cellular degradation.
Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436 · see citing works
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924 · see citing works
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513 · see citing works
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works
Self-citation
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
Frye, R. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3000 · Cited by 1,409 · see citing works
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,348 · see citing works
The Endocrine Regulation of Aging by Insulin-like Signals
Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327 · see citing works
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans
Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255 · see citing works
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works
Dwarf mice and the ageing process
Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064 · see citing works
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060 · see citing works
Influence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057 · see citing works
Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
Pap, M., & Cooper, G. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.19929 · Cited by 1,046 · see citing works
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
Kulik, G., Klippel, A., & Weber, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1595 · Cited by 1,033 · see citing works
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.
Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,011 · see citing works
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 954 · see citing works
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S.-J., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 918 · see citing works
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891 · see citing works
Inducible gene targeting in mice using the Cre/lox system.
Sauer, B. (1998) · Methods · doi:10.1006/meth.1998.0593 · Cited by 858 · see citing works
Opposing activities protect against age-onset proteotoxicity
Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., & Dillin, A. (2006) · Science · doi:10.1126/science.1124646 · Cited by 843 · see citing works
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822 · see citing works
Self-citation
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820 · see citing works
Nutrient-Dependent Expression of Insulin-like Peptides from Neuroendocrine Cells in the CNS Contributes to Growth Regulation in Drosophila
Ikeya, T., Galic, M., Belawat, P., Nairz, K., & Hafen, E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01043-6 · Cited by 765 · see citing works
Insulin signaling in health and disease
White, M. F. (2003) · Science · doi:10.1126/science.1092952 · Cited by 733 · see citing works
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716 · see citing works
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 705 · see citing works
Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681 · see citing works
Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 675 · see citing works
Rapamycin alleviates toxicity of different aggregate-prone proteins
Berger, Z., Ravikumar, B., Menzies, F. M., Oroz, L. G., Underwood, B. R., Pangalos, M. N., Schmitt, I., Wullner, U., Evert, B. O., O'Kane, C. J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi458 · Cited by 657 · see citing works
Two neurons mediate diet-restriction-induced longevity in C. elegans
Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643 · see citing works
Regulation of DAF-2 receptor signaling by human insulin and ins-1 , a member of the unusually large and diverse C. elegans insulin gene familyPreprint
Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 639 · see citing works
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin‐Villemant, C., Antoniewski, C., Carré, C., Noselli, S., & Léopold, P. (2005) · Science · doi:10.1126/science.1119432 · Cited by 620 · see citing works
Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1
Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
Garsin, D. A., Villanueva, J. M., Begun, J., Kim, D. H., Sifri, C. D., Calderwood, S. B., Ruvkun, G., & Ausubel, F. M. (2003) · Science · doi:10.1126/science.1080147 · Cited by 610 · see citing works
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577 · see citing works
Self-citation
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease
de la Monte, S. M., & Wands, J. R. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7106 · Cited by 552 · see citing works
JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling
Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works
Self-citation
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans
Arantes-Oliveira, N., Apfeld, J., Dillin, A. G., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1065768 · Cited by 530 · see citing works
Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works
Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510 · see citing works
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J., & Kapahi, P. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00266.x · Cited by 491 · see citing works
Hormonal pleiotropy and the juvenile hormone regulation ofDrosophila development and life history
Flatt, T., Tu, M., & Tatar, M. (2005) · BioEssays · doi:10.1002/bies.20290 · Cited by 476 · see citing works
Timing Requirements for Insulin/IGF-1 Signaling in C. elegans
Dillin, A., Crawford, D. K., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1074240 · Cited by 467 · see citing works
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
Klass, M. R. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90082-9 · Cited by 449 · see citing works
Insulin signaling in the central nervous system: Learning to survive
van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444 · see citing works
Sex and Death: What Is the Connection?
Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 443 · see citing works
Self-citation
Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
Chiu, S.-L., Chen, C.-M., & Cline, H. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.014 · Cited by 425 · see citing works
JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila
Wang, M. C., Bohmann, D., & Jasper, H. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00323-x · Cited by 422 · see citing works
Extending the Lifespan of Long-Lived Mice
Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S. (2001) · Nature · doi:10.1038/35106646 · Cited by 422 · see citing works
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors
Libert, S., Zwiener, J., Chu, X., VanVoorhies, W., Roman, G., & Pletcher, S. D. (2007) · Science · doi:10.1126/science.1136610 · Cited by 410 · see citing works
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster
Roman, G., Endo, K., Zong, L., & Davis, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303998 · Cited by 406 · see citing works
Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance
McElwee, J. J., Schuster, E. F., Blanc, E., Thomas, J. H., & Gems, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406207200 · Cited by 402 · see citing works
The life of a cell: apoptosis regulation by the PI3K/PKB pathway
Duronio, V. (2008) · Biochemical Journal · doi:10.1042/bj20081056 · Cited by 392 · see citing works
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388 · see citing works
Control of Growth by the Somatropic Axis: Growth Hormone and the Insulin-Like Growth Factors Have Related and Independent Roles
Butler, A. A., & Roith, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.141 · Cited by 387 · see citing works
Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span
Apfeld, J., & Kenyon, C. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81751-1 · Cited by 380 · see citing works
A-to-I Pre-mRNA Editing in Drosophila Is Primarily Involved in Adult Nervous System Function and Integrity
Palladino, M. J., Keegan, L. P., O’Connell, M. A., & Reenan, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00049-0 · Cited by 379 · see citing works
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathwayPreprint
Li, W., Kennedy, S. G., & Ruvkun, G. (2003) · Genes & Development · doi:10.1101/gad.1066503 · Cited by 368 · see citing works
Common pathological processes in Alzheimer disease and type 2 diabetes: A review
Li, L., & Hölscher, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.001 · Cited by 367 · see citing works
The interaction between FOXO and SIRT1: tipping the balance towards survival
Giannakou, M. E., & Partridge, L. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.006 · Cited by 354 · see citing works
Self-citation
Drosophila Short Neuropeptide F Regulates Food Intake and Body Size
Lee, K., You, K., Choo, J., Han, Y., & Yu, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407842200 · Cited by 348 · see citing works
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331 · see citing works
Signaling by insulin-like growth factor 1 in brain
Bondy, C. A., & Cheng, C. M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.042 · Cited by 323 · see citing works
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
Morrow, G., Samson, M., Michaud, S., & Tanguay, R. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0860fje · Cited by 317 · see citing works
Insulin-Like Signaling, Nutrient Homeostasis, and Life Span
Taguchi, A., & White, M. F. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100533 · Cited by 309 · see citing works
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals
Walker, G. A., & Lithgow, G. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00045.x · Cited by 303 · see citing works
Insulin promotes rapid delivery of N -methyl- d - aspartate receptors to the cell surface by exocytosis
Skeberdis, V. A., Lan, J.-Y., Zheng, X., Zukin, R. S., & Bennett, M. V. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634698 · Cited by 303 · see citing works
Demography of longevity: past, present, and future trends
Wilmoth, J. R. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00194-7 · Cited by 302 · see citing works
Drosophila germ-line modulation of insulin signaling and lifespan
Flatt, T., Min, K., D’Alterio, C., Villa-Cuesta, E., Cumbers, J. R., Lehmann, R., Jones, D. L., & Tatar, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709128105 · Cited by 297 · see citing works
Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models
Berryman, D. E., Christiansen, J. S., Johannsson, G., Thorner, M. O., & Kopchick, J. J. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.05.005 · Cited by 288 · see citing works
To die or not to die: how does p53 decide?
Slee, E. A., O’Connor, D. J., & Lü, X. (2004) · Oncogene · doi:10.1038/sj.onc.1207516 · Cited by 278 · see citing works
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works
Steroid Control of Longevity in Drosophila melanogaster
Simon, A. F., Shih, C., Mack, A., & Benzer, S. (2003) · Science · doi:10.1126/science.1080539 · Cited by 265 · see citing works
The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
Carro, E., & Torres‐Alemán, I. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.050 · Cited by 262 · see citing works
Untitled work
(2006) · doi:10.1016/j.tem.2006.01.005 · Cited by 256 · see citing works
Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster
Tu, M., Yin, C., & Tatar, M. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.02.009 · Cited by 244 · see citing works
Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53
Yamaguchi, A., Tamatani, M., Matsuzaki, H., Namikawa, K., Kiyama, H., Vitek, M. P., Mitsuda, N., & Tohyama, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008552200 · Cited by 242 · see citing works
Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth
Pinkston, J. M., Garigan, D., Hansen, M., & Kenyon, C. (2006) · Science · doi:10.1126/science.1121908 · Cited by 242 · see citing works
The role of insulin receptor substrate 2 in hypothalamic and β cell function
Choudhury, A. I., Heffron, H., Smith, M. A., Al‐Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24445 · Cited by 241 · see citing works
Genetic mouse models of extended lifespan
Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 236 · see citing works
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
Lee, K., Kwon, O., Lee, J. H., Kwon, K., Min, K., Jung, S., Kim, A., You, K., Tatar, M., & Yu, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1710 · Cited by 230 · see citing works
Insulin receptor signaling in long-term memory consolidation following spatial learningPreprint
Dou, J., Chen, M., Dufour, F., Alkon, D. L., & Zhao, W. (2005) · Learning & Memory · doi:10.1101/lm.88005 · Cited by 217 · see citing works
Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects
Jl, T., Piriz, J., Llorens-Martı́n, M., Fernandez, A. M., Bolós, M., LeRoith, D., Núñez, Á., & Torres‐Alemán, I. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002076 · Cited by 210 · see citing works
Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
Benyoucef, S., Surinya, K. H., Hadaschik, D., & Siddle, K. (2007) · Biochemical Journal · doi:10.1042/bj20061709 · Cited by 203 · see citing works
Evolutionary conservation of regulated longevity assurance mechanisms
McElwee, J. J., Schuster, E. F., Blanc, E., Piper, M. D. W., Thomas, J. H., Patel, D. S., Selman, C., Withers, D. J., Thornton, J. M., Partridge, L., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-7-r132 · Cited by 201 · see citing works
Self-citation
SIRT1 and endocrine signaling
Yang, T., Fu, M., Pestell, R. G., & Sauve, A. A. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.04.002 · Cited by 181 · see citing works
Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
Sun, L. Y., Al-Regaiey, K., Masternak, M. M., Wang, J., & Bartke, A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.010 · Cited by 167 · see citing works
Endocrine regulation of aging and reproduction in Drosophila
Toivonen, J. M., & Partridge, L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.005 · Cited by 158 · see citing works
Self-citation
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
Pinkston-Gosse, J., & Kenyon, C. J. (2007) · Nature Genetics · doi:10.1038/ng.2007.1 · Cited by 154 · see citing works
Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
Piper, M. D. W., Selman, C., McElwee, J. J., & Partridge, L. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01906.x · Cited by 154 · see citing works
Self-citation
daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation
Henderson, S. T., Bonafè, M., & Johnson, T. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.444 · Cited by 154 · see citing works
Evidence That Ames Dwarf Mice Age Differently from Their Normal Siblings in Behavioral and Learning and Memory Parameters
Kinney, B. A., Meliska, C. J., Steger, R. W., & Bartke, A. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1654 · Cited by 152 · see citing works
Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
Kinney, B. A., Coschigano, K. T., Kopchick, J. J., Steger, R. W., & Bartke, A. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00423-1 · Cited by 148 · see citing works
Axons Guided by Insulin Receptor in Drosophila Visual System
Song, J., Wu, L., Chen, Z., Kohanski, R. A., & Pick, L. (2003) · Science · doi:10.1126/science.1081203 · Cited by 146 · see citing works
Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants
Tu, M., Yin, C., & Tatar, M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00016.x · Cited by 145 · see citing works
The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer
Ryan, P. D., & Goss, P. E. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0199 · Cited by 145 · see citing works
Premature aging in mice activates a systemic metabolic response involving autophagy induction
Mariño, G., Ugalde, A. P., Salvador-Montoliu, N., Varela, I., Quirós, P. M., Cadiñanos, J., van der Pluijm, I., Freije, J. M. P., & López-Otı́n, C. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn120 · Cited by 143 · see citing works
Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?
Gems, D., & McElwee, J. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.001 · Cited by 141 · see citing works
Age of ovary determines remaining life expectancy in old ovariectomized mice
Cargill, S. L., Carey, J. R., Müller, H., & Anderson, G. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00049.x · Cited by 138 · see citing works
Insulin-Like Growth Factor-I Overexpression Attenuates Cerebellar Apoptosis by Altering the Expression of Bcl Family Proteins in a Developmentally Specific Manner
Chrysis, D., Calikoglu, A. S., Ye, P., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01481.2001 · Cited by 137 · see citing works
Alterations in xenobiotic metabolism in the long‐lived Little mice
Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00300.x · Cited by 134 · see citing works
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
Ghazi, A., Henis-Korenblit, S., & Kenyon, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700638104 · Cited by 134 · see citing works
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
Bauer, J. H., Poon, P. C., Glatt-Deeley, H. R., Abrams, J., & Helfand, S. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.051 · Cited by 121 · see citing works
Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans
Murakami, H., Bessinger, K., Hellmann, J. L., & Murakami, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3600-04.2005 · Cited by 114 · see citing works
Dynamics of the action of dFOXO on adult mortality in Drosophila
Giannakou, M. E., Goss, M. W., Jacobson, J., Vinti, G., Leevers, S. J., & Partridge, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00290.x · Cited by 107 · see citing works
Self-citation
Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction
Libert, S., Chao, Y., Zwiener, J., & Pletcher, S. D. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.06.353 · Cited by 106 · see citing works
Serum Growth Factors and Neuroprotective Surveillance
Torres‐Alemán, I. (2000) · Molecular Neurobiology · doi:10.1385/mn:21:3:153 · Cited by 104 · see citing works
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body sizePreprint
Kaplan, D. D., Zimmermann, G., Suyama, K. L., Meyer, T., & Scott, M. P. (2008) · Genes & Development · doi:10.1101/gad.1670508 · Cited by 104 · see citing works
Origin of Insulin Receptor-Like Tyrosine Kinases in Marine Sponges
Skorokhod, A. A., Gamulin, V., Gundacker, D., Kavsan, V. M., Müller, I. M., & Müller, W. E. G. (1999) · Biological Bulletin · doi:10.2307/1542615 · Cited by 96 · see citing works
Forkhead transcription factors and ageing
Partridge, L., & Brüning, J. C. (2008) · Oncogene · doi:10.1038/onc.2008.28 · Cited by 95 · see citing works
Self-citation
The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
Wang, S., Tulina, N. M., Carlin, D. L., & Rulifson, E. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707465104 · Cited by 90 · see citing works
Dopamine and senescence in Drosophila melanogaster☆
Neckameyer, W. S., Woodrome, S., Holt, B., et al. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00109-8 · Cited by 83 · see citing works
Glucose regulation and oxidative stress in healthy centenarians
Barbieri, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00153-5 · Cited by 83 · see citing works
Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
Puglielli, L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.010 · Cited by 80 · see citing works
Role of serum insulin-like growth factor I in mammalian brain aging
Trejo, J. L., Carro, E., Lopez‐Lopez, C., & Torres‐Alemán, I. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.010 · Cited by 75 · see citing works
Insulin/IGF signalling in neurogenesis
Bateman, J. E., & McNeill, H. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6036-4 · Cited by 67 · see citing works
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling
Bauer, J. H., Chang, C.-Y., Morris, S. N. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706121104 · Cited by 67 · see citing works
IGF-1 signaling and aging
Holzenberger, M., Kappeler, L., & Filho, C. D. D. M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.017 · Cited by 61 · see citing works
SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
Tang, B. L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.001 · Cited by 56 · see citing works
The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila
Liao, P., Lin, H., Yuh, C., Yu, L., & Wang, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.161 · Cited by 54 · see citing works
Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"
Selman, C., Lingard, S. J., Gems, D., Partridge, L., & Withers, D. J. (2008) · Science · doi:10.1126/science.1152366 · Cited by 50 · see citing works
Self-citation
Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population
Aimaretti, G., Boschetti, M., Corneli, G., Gasco, V., Valle, D. D. L. N. M., Borsotti, M., Rossi, A., Barreca, A., Fazzuoli, L., Ferone, D., et al. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346389 · Cited by 49 · see citing works
Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
Iser, W. B., Gami, M. S., & Wolkow, C. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.467 · Cited by 48 · see citing works
The effect of serotonin on in vitro insulin secretion and biosynthesis in mice
Gagliardino, J. J., Nierle, C., & Pfeiffer, E. F. (1974) · Diabetologia · doi:10.1007/bf01221630 · Cited by 46 · see citing works
Melatonin and serotonin regulate the release of insulin-like growth factor-I, oxytocin and progesterone by cultured human granulosa cells
Schaeffer, H.-J., & Sirotkin, A. V. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211736 · Cited by 46 · see citing works
Distinct genetic influences on locomotor senescence in Drosophila revealed by a series of metrical analyses
Martin, I., & Grotewiel, M. S. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.052 · Cited by 41 · see citing works
Caenorhabditis elegans as a model system to study aging of learning and memory
Murakami, S. (2007) · Molecular Neurobiology · doi:10.1007/bf02700625 · Cited by 40 · see citing works
Autophagy in neuronal cell loss: a road to death
Takács‐Vellai, K., Bayci, A., & Vellai, T. (2006) · BioEssays · doi:10.1002/bies.20489 · Cited by 37 · see citing works
Can flies shed light on our own age-related memory impairment?
Horiuchi, J., & Saitoe, M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.10.001 · Cited by 27 · see citing works
Role of Insulin Metabolism Disturbances in the Development of Alzheimer Disease: Mini Review
Sabayan, B., Foroughinia, F., Mowla, A., & Borhani‐Haghighi, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507312623 · Cited by 25 · see citing works
Drosophila Atg7: Required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis
Juhász, G., & Neufeld, T. P. (2008) · Autophagy · doi:10.4161/auto.5572 · Cited by 23 · see citing works
The Ongoing Saga of Sirtuins and Aging
Kaeberlein, M. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.004 · Cited by 22 · see citing works
The double-edged effect of insulin on the neuronal cell death associated with hypoglycemia on the hippocampal slice culture.
Tanaka, Y., Takata, T., Satomi, T., et al. (2008) · PubMed · doi:10.24546/81000766 · Cited by 11 · see citing works

Flagged first, then by citations

Sorted by citations

Ageing as a Risk Factor for Disease
Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831 · see citing works
Self-citation
Neural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works
Autophagy as a promoter of longevity: insights from model organisms
Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain
Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works
Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
Toth, M. L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1494-11.2012 · Cited by 205 · see citing works
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
Liu, W., Taso, O., Wang, R., Bayram, S., Graham, A. C., Garcia-Reitboeck, P., Mallach, A., Andrews, W. D., Piers, T. M., Botia, J. A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa209 · Cited by 214 · see citing works
“While this may not affect microglial survival as the IGF1 receptor is found largely on neurons, it could contribute to neurodegeneration, being an important factor in neuronal survival and lifespan across many species (Broughton and Partridge 2009).”
Background
Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176 · see citing works
Aging and reprogramming: a two-way street
Mahmoudi, S., & Brunet, A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.004 · Cited by 171 · see citing works
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective
Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166 · see citing works
The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009
Payton, A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9116-z · Cited by 95 · see citing works
Protein homeostasis and aging: Role of ubiquitin protein ligases
Jana, N. R. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.009 · Cited by 67 · see citing works
ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans
Thyagarajan, B., Blaszczak, A. G., Chandler, K. J., Watts, J. L., Johnson, W. E., & Graves, B. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001125 · Cited by 51 · see citing works
The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain
Soeda, Y., Tsuneki, H., Muranaka, H., Mori, N., Hosoh, S., Ichihara, Y., Kagawa, S., Wang, X., Toyooka, N., Takamura, Y., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0163 · Cited by 38 · see citing works

Working with Worms: Caenorhabditis elegans as a Model Organism
Meneely, P., Dahlberg, C. L., & Rose, J. K. (2019) · Current Protocols Essential Laboratory Techniques · doi:10.1002/cpet.35 · Cited by 117 · see citing works
Why do more scientists use Caenorhabditis elegans as a model organism to study human system?
Nilwarangkoon, S. (2008) · Journal of Medicine and Health Sciences · doi:10.14456/jmhs.2008.4
The intertwining between lead and ethanol in the model organism Caenorhabditis elegans
Albrecht, P. A., Fernandez-Hubeid, L. E., Deza-Ponzio, R., et al. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.991787 · Cited by 4 · see citing works
Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals
Ayuda‐Durán, B., González‐Manzano, S., Paramás, A. M. G., & Santos‐Buelga, C. (2020) · Molecules · doi:10.3390/molecules25143194 · Cited by 70 · see citing works
Deceptively simple but simply deceptive – Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects
Gruber, J., Ng, L. F., Poovathingal, S. K., & Halliwell, B. B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.051 · Cited by 111 · see citing works

Authors: Broughton, S., & Partridge, L.
Affiliations: Max Planck Society (DE)
University College London (GB)
ORCID: Broughton, Susan
Partridge, Linda
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 2009-01-28
Volume: 418
Issue: 1
Pages: 1-12
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj20082102
OpenAlex: W2063014525
Cited by: 228
References: 156
Citations by year: 2026: 2 · 2025: 3 · 2024: 9 · 2023: 1 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 15 · 2015: 18 · 2014: 20 · 2013: 25 · 2012: 20
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Journal (publishedVersion)
PubMed (publishedVersion)
Lancaster EPrints (Lancaster University) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: U.S. Public Health Service (066750/A/01/Z)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: aging, lifespan extension, central nervous system, neuroprotection, neuronal function, hormonal regulation, stress tolerance, metabolic homeostasis, growth and development
MeSH terms: Aging, Animals, Central Nervous System, Humans, Insulin, Models, Biological, Somatomedins, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin/IGF-like signalling, the central nervous system and aging

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks