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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals

Walker, Glenda A., Lithgow, Gordon J.·2003·Aging Cell
DOI 10.1046/j.1474-9728.2003.00045.x
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Abstract

Summary: Insulin‐like signalling is a key determinate of lifespan in diverse species including mammals but the mechanism by which this pathway influences the rate of aging is unknown. In the roundworm Caenorhabditis elegans, mutations in the insulin‐like signalling pathway extend adult lifespan and are associated with up‐regulation of stress response genes including those for heat shock proteins (HSPs). We tested the hypothesis that the C. elegans insulin‐like signalling pathway determines longevity through modulating HSP levels. We introduced extra copies of the gene encoding HSP‐16 and this conferred stress resistance and longevity both in a wildtype and a long‐lived mutant strain. The DAF‐16 transcription factor is essential for maximal hsp‐16 expression and for lifespan extension conferred by hsp‐16. This demonstrates that lifespan is determined in part by insulin‐like regulation of molecular chaperones.

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  • Transgenic worms and flies overexpressing chaperones are long-lived.

    “In particular, transgenic worms and flies overexpressing chaperones are long-lived (Morrow et al., 2004; Walker and Lithgow, 2003).”

    From The Hallmarks of Aging (2013) · cites this paper as Walker and Lithgow, 2003

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Metadata

Authors
Walker, G. A., & Lithgow, G. J.
Venue
Aging Cell
Publisher
Wiley
Published
2003-03-26
Volume
2
Issue
2
Pages
131-139
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1046/j.1474-9728.2003.00045.x
Cited by
273
References
3
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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