An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775 · see citing works

Why do we age?

Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461 · see citing works

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90290-2 · Cited by 938 · see citing works

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Y.-J., Seroude, L., & Benzer, S. (1998) · Science · doi:10.1126/science.282.5390.943 · Cited by 804 · see citing works

Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster

Pletcher, S. D., Macdonald, S. J., Marguerie, R., Certa, U., Stearns, S. C., Goldstein, D. B., & Partridge, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00808-4 · Cited by 568 · see citing works

Resveratrol: from grapevines to mammalian biology

Pervaiz, S. (2003) · The FASEB Journal · doi:10.1096/fj.03-0168rev · Cited by 518 · see citing works

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506 · see citing works

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- l -carnitine and/or R -α-lipoic acid

Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504 · see citing works

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467 · see citing works

P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster

Roman, G., Endo, K., Zong, L., & Davis, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303998 · Cited by 406 · see citing works

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

Sun, J., Folk, D. G., Bradley, T. J., & Tower, J. (2002) · Genetics · doi:10.1093/genetics/161.2.661 · Cited by 381 · see citing works

Chaperoning extended life

Tatar, M., Khazaeli, A. A., & Curtsinger, J. W. (1997) · Nature · doi:10.1038/36237 · Cited by 332 · see citing works

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

Morrow, G., Samson, M., Michaud, S., & Tanguay, R. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0860fje · Cited by 317 · see citing works

Feeding acetyl- l -carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

Hagen, T. M., Liu, J., Lykkesfeldt, J., Wehr, C. M., Ingersoll, R. T., Vinarsky, V., Bartholomew, J. C., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261708898 · Cited by 313 · see citing works

Life extension in Drosophila by feeding a drug

Kang, H.-L., Benzer, S., & Min, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022631999 · Cited by 294 · see citing works

( R )‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

Hagen, T. M., Ingersoll, R. T., Lykkesfeldt, J., Liu, J., Wehr, C. M., Vinarsky, V., Bartholomew, J. C., & Ames, B. N. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.411 · Cited by 291 · see citing works

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

Rogina, B., Helfand, S. L., & Frankel, S. A. (2002) · Science · doi:10.1126/science.1078986 · Cited by 276 · see citing works

Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae

Kim, S., Benguría, A., Lai, C.-Y., & Jazwinski, S. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3125 · Cited by 212 · see citing works

Effect of Dietary Restriction on the Age-Dependent Changes in the Expression of Antioxidant Enzymes in Rat Liver

Rao, G., Xia, E., Nadakavukaren, M. J., & Richardson, A. G. (1990) · Journal of Nutrition · doi:10.1093/jn/120.6.602 · Cited by 206 · see citing works

Subfield History: Caloric Restriction, Slowing Aging, and Extending Life

Masoro, E. J. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.8.re2 · Cited by 149 · see citing works

The effects of reproduction on longevity and fertility in male Drosophila melanogaster

Prowse, N., & Partridge, L. (1997) · Journal of Insect Physiology · doi:10.1016/s0022-1910(97)00014-0 · Cited by 129 · see citing works

Spatio‐temporal analysis of gene expression during aging in Drosophila melanogaster

Seroude, L., Brummel, T., Kapahi, P., & Benzer, S. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00007.x · Cited by 128 · see citing works

Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster.

Helfand, S. L., Blake, K. J., Rogina, B., Stracks, M. D., Centurion, A., & Naprta, B. (1995) · Genetics · doi:10.1093/genetics/140.2.549 · Cited by 62 · see citing works

Drosophila drop-dead mutations accelerate the time course of age-related markers

Rogina, B., Benzer, S., & Helfand, S. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6303 · Cited by 57 · see citing works

Regulation of gene expression is linked to life span in adult Drosophila.

Rogina, B., & Helfand, S. L. (1995) · Genetics · doi:10.1093/genetics/141.3.1043 · Cited by 48 · see citing works

From genes to aging in Drosophila.

Helfand, S., & Rogina, B. (2003) · Advances in Genetics · doi:10.1016/s0065-2660(03)01002-2 · Cited by 39 · see citing works

Regulation of gene expression is preserved in aging Drosophila melanogaster

Rogina, B., Vaupel, J. W., Partridge, L., & Helfand, S. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70184-8 · Cited by 34 · see citing works

Long-lived lines of Caenorhabditis elegans can be used to establish predictive biomarkers of aging

Johnson, T. E., Conley, W. L., & Keller, M. L. (1988) · Experimental Gerontology · doi:10.1016/0531-5565(88)90031-9 · Cited by 23 · see citing works

Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms

Rogina, B., & Helfand, S. L. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00033-6 · Cited by 18 · see citing works

[Reactive changes in circulating neutrophilic granulocytes in physiologic and complicated gestational process].

Sb, K. (2003) · PubMed · Cited by 1 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834 · see citing works

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345 · see citing works

Of mice and men: the benefits of caloric restriction, exercise, and mimetics

Mercken, E. M., Carboneau, B. A., Krzysik-Walker, S. M., & de Cabo, R. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.005 · Cited by 318 · see citing works

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

Bao, J., & Sack, M. N. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0402-y · Cited by 67 · see citing works

Resveratrol Attenuates Denervation-Induced Muscle Atrophy Due to the Blockade of Atrogin-1 and p62 Accumulation

Asami, Y., Aizawa, M., Kinoshita, M., Ishikawa, J., & Sakuma, K. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.22723 · Cited by 33 · see citing works

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons

Morton, D. J., Jalloh, B., Kim, L., Kremsky, I., Nair, R. J., Nguyen, K. B., Rounds, J. C., Sterrett, M. C., Brown, B., Le, T., et al. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1008901 · Cited by 24 · see citing works

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9939-8 · Cited by 11 · see citing works

Drosophilids with darker cuticle have higher body temperature under light

Freoa, L., Chevin, L., Christol, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-30652-6 · Cited by 14 · see citing works

Drosophilid cuticle pigmentation impacts body temperaturePreprint

Freoa, L., Chevin, L., Christol, P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.03.518031 · Cited by 1 · see citing works

Drosophila melanogaster: A Model Organism to Understand Biological Activities of Nanoparticles

Patra, B., Ghosh, P., & Das, S. P. (2020) · Springer eBooks · doi:10.1007/978-981-15-1702-0_10 · Cited by 3 · see citing works

Analysis of Drosophila melanogaster Lifespan

Landis, G. N., Doherty, D. V., & Tower, J. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0592-9_4 · Cited by 33 · see citing works

The art and design of genetic screens: Drosophila melanogaster

St Johnston, D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg751 · Cited by 644 · see citing works