The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
Abstract
The molecular mechanisms by which obesity increases the risk of cardiovascular diseases are poorly understood. The purpose of this study was to identify candidate biomarkers overexpressed in adipose tissue of obese subjects that could link expanded fat mass to atherosclerosis. We compared gene expression profile in subcutaneous adipose tissue (scWAT) of 28 obese and 11 lean subjects using microarray technology. This analysis identified 240 genes significantly overexpressed in scWAT of obese subjects. The genes were then ranked according to the correlation between gene expression and body mass index (BMI). In this list, the elastolytic cysteine protease cathepsin S was among the highly correlated genes. RT‐PCR and Western blotting confirmed the increase in cathepsin S mRNA ( P =0.006) and protein ( P <0.05) in obese scWAT. The circulating concentrations of cathepsin S were also significantly higher in obese than in nonobese subjects ( P <0.0001). Both cathepsin S mRNA in scWAT and circulating levels were positively correlated with BMI, body fat, and plasma triglyceride levels. In addition, we show that the proinflammatory factors, lipopolysaccharide, interleukin‐lβ, and tumor necrosis factor‐α increase cathepsin S secretion in human scWAT explants. This study identifies cathepsin S as a novel marker of adiposity. Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among the genes showing the strongest association with the BMI were cathepsin S (CTSS), involved in the degradation of several components of the extracellular matrix [19], lymphocyte cytosolic protein 2 (LCP2) and CD247 (CD247), both related to T cell development and activation, as well as the hypoxia-inducible factor 1 (HIF1A).”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [19]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931 · cited 1×
“Insulin sensitivity was evaluated using QUICKI index (20).”
MethodHotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Obesity, Metabolic Syndrome, and Cardiovascular Disease
Grundy, S. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0372 · Cited by 1,395
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304
Meier, U., & Gressner, A. M. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.032482 · Cited by 1,048
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY
Chapman, H. A., Riese, R. J., & Shi, G. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.63 · Cited by 793
Research works printed but not linked: 1
- 10.1177/107155760000700309 · DOI
Cited by
Sorted by citations
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 702
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471
Self-citationChemerin: at the crossroads of inflammation and obesity
Ernst, M. C., & Sinal, C. J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.001 · Cited by 431
Cathepsin cysteine proteases in cardiovascular disease
Lutgens, S. P. M., Cleutjens, K. B. J. M., Daemen, M. J. A. P., & Heeneman, S. (2007) · The FASEB Journal · doi:10.1096/fj.06-7924com · Cited by 351
Rodríguez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 287
Metadata
- Authors
- Taleb, S., Lacasa, D., Bastard, J., Poitou, C., Cancello, R., Pelloux, V., Viguerie, N., Benis, A., Zucker, J., Bouillot, J., Coussieu, C., Basdevant, A., Langin, D., & Clement, K.
- Affiliations
- Inserm (FR)
- INSERM “Avenir” Team and CHRU Pitié Salpétrière Hôtel‐Dieu Nutrition Department Centre de Recherche en Nutrition Humaine F‐75004 Paris
- Hôtel-Dieu de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2005-06-28
- Volume
- 19
- Issue
- 11
- Pages
- 1540-1542
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2165745035
- Cited by
- 158
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 13
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- cathepsin S, adiposity biomarkers, obesity, atherosclerosis, subcutaneous adipose tissue, gene expression profiling, body mass index, cysteine protease, inflammation, lipopolysaccharide, IL-1β, TNF-α, plasma triglycerides, cardiovascular risk
- MeSH terms
- Adipose Tissue, Cathepsins, Female, Humans, Muscle, Smooth, Vascular, Obesity, RNA, Messenger, Biomarkers, Extracellular Matrix Proteins, Adipocytes, Gene Expression Profiling, Adiposity, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
