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Cited by 158Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis

Taleb, Soraya, Lacasa, Danièle, Bastard, Jean‐Philippe, Poitou, Christine, Cancello, Raffaella, Pelloux, Veronique, Viguerie, Nathalie, Benis, Arriel, Zucker, Jean‐Daniel, Bouillot, Jean‐Luc, Coussieu, Christiane, Basdevant, Arnaud, Langin, Dominique, Clement, Karine·2005·The FASEB Journal
DOI 10.1096/fj.05-3673fje
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Abstract

The molecular mechanisms by which obesity increases the risk of cardiovascular diseases are poorly understood. The purpose of this study was to identify candidate biomarkers overexpressed in adipose tissue of obese subjects that could link expanded fat mass to atherosclerosis. We compared gene expression profile in subcutaneous adipose tissue (scWAT) of 28 obese and 11 lean subjects using microarray technology. This analysis identified 240 genes significantly overexpressed in scWAT of obese subjects. The genes were then ranked according to the correlation between gene expression and body mass index (BMI). In this list, the elastolytic cysteine protease cathepsin S was among the highly correlated genes. RT‐PCR and Western blotting confirmed the increase in cathepsin S mRNA ( P =0.006) and protein ( P <0.05) in obese scWAT. The circulating concentrations of cathepsin S were also significantly higher in obese than in nonobese subjects ( P <0.0001). Both cathepsin S mRNA in scWAT and circulating levels were positively correlated with BMI, body fat, and plasma triglyceride levels. In addition, we show that the proinflammatory factors, lipopolysaccharide, interleukin‐lβ, and tumor necrosis factor‐α increase cathepsin S secretion in human scWAT explants. This study identifies cathepsin S as a novel marker of adiposity. Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis.

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Crossref · 10.1096/fj.05-3673fje

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  1. 10.1177/107155760000700309 · DOI

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Metadata

Authors
Taleb, S., Lacasa, D., Bastard, J., Poitou, C., Cancello, R., Pelloux, V., Viguerie, N., Benis, A., Zucker, J., Bouillot, J., Coussieu, C., Basdevant, A., Langin, D., & Clement, K.
Affiliations
  • Inserm (FR)
  • INSERM “Avenir” Team and CHRU Pitié Salpétrière Hôtel‐Dieu Nutrition Department Centre de Recherche en Nutrition Humaine F‐75004 Paris
  • Hôtel-Dieu de Paris (FR)
  • Pitié-Salpêtrière Hospital (FR)
ORCID
Venue
The FASEB Journal
Publisher
Wiley
Published
2005-06-28
Volume
19
Issue
11
Pages
1540-1542
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.05-3673fje
OpenAlex
W2165745035
Cited by
158
References
42
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 13
FWCI
8.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The FASEB Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
Institut National de la Santé et de la Recherche Médicale
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
cathepsin S, adiposity biomarkers, obesity, atherosclerosis, subcutaneous adipose tissue, gene expression profiling, body mass index, cysteine protease, inflammation, lipopolysaccharide, IL-1β, TNF-α, plasma triglycerides, cardiovascular risk
MeSH terms
Adipose Tissue, Cathepsins, Female, Humans, Muscle, Smooth, Vascular, Obesity, RNA, Messenger, Biomarkers, Extracellular Matrix Proteins, Adipocytes, Gene Expression Profiling, Adiposity, Atherosclerosis

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