Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis

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Cathepsin cysteine proteases in cardiovascular disease

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Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus

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T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

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Cathepsin S: therapeutic, diagnostic, and prognostic potential

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Cathepsin K inhibitors for osteoporosis and potential off-target effects

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Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue

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The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction

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Biochemical properties and regulation of cathepsin K activity

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Potential Contribution of Adipose Tissue to Elevated Serum Cystatin C in Human Obesity

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Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids

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Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential

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Cathepsin S Promotes Human Preadipocyte Differentiation: Possible Involvement of Fibronectin Degradation

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Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

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The Problem of Wound Healing in Diabetes—From Molecular Pathways to the Design of an Animal Model

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Cathepsins and cystatin C in atherosclerosis and obesity

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Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity

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Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases

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Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet

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The usefulness of circulating adipokine levels for the assessment of obesity-related health problems

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Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity

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Kininogens: More than cysteine protease inhibitors and kinin precursors

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Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications

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Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation

Naour, N., Rouault, C., Fellahi, S., Lavoie, M.-È., Poitou, C., Kéophiphath, M., Eberlé, D., Shoelson, S. E., Rizkalla, S. W., Bastard, J., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1894 · Cited by 102

Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?

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Regulation of inflammation-related genes in human adipose tissue

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Mast Cell Tryptase Deficiency Attenuates Mouse Abdominal Aortic Aneurysm Formation

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Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction

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Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

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Pathophysiology of osteoporosis

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Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice

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Association between serum cathepsin S and mortality in older adults.

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Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity

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Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

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Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse

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Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non–fat cells, not by the adipocytes

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Upregulation of cathepsin S in psoriatic keratinocytes

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Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D)

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Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women

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Differential Estimation of CKD Using Creatinine- Versus Cystatin C–Based Estimating Equations by Category of Body Mass Index

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Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

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The S2 subsites of cathepsins K and L and their contribution to collagen degradation

Lecaille, F., Chowdhury, S. F., Purisima, E. O., Brömme, D., & Lalmanach, G. (2007) · Protein Science · doi:10.1110/ps.062666607 · Cited by 61

Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases

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High levels of cathepsin D and cystatin B are associated with increased risk of coronary events

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Cathepsin K Null Mice Show Reduced Adiposity during the Rapid Accumulation of Fat Stores

Funicello, M., Novelli, M., Ragni, M., Vottari, T., Cocuzza, C., López‐Soriano, J., Chiellini, C., Boschi, F., Marzola, P., Masiello, P., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000683 · Cited by 56

Emerging role of cathepsin S in obesity and its associated diseases

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Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men

Shea, J. L., French, C. R., Bishop, J., Martin, G., Roebothan, B., Pace, D., Fitzpatrick, D., & Sun, G. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.25970 · Cited by 54

A strategy to search for common obesity and type 2 diabetes genes

Elbers, C. C., Onland‐Moret, N. C., Franke, L., Niehoff, A. G., van der Schouw, Y. T., & Wijmenga, C. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.003 · Cited by 51

Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer

Liu, W., Liu, D., Cheng, K., Liu, Y., Xing, S., Chi, P., Liu, X., Xue, N., Lai, Y., Guo, L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8582 · Cited by 49

Elastase and Tryptase Govern TNFα-Mediated Production of Active Chemerin by Adipocytes

Parlee, S. D., McNeil, J. O., Muruganandan, S., Sinal, C. J., & Goralski, K. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051072 · Cited by 44

Angiogenesis in Adipose Tissue

Bråkenhielm, E., & Cao, Y. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-245-8_5 · Cited by 45

Serum Cathepsin S Is Associated With Decreased Insulin Sensitivity and the Development of Type 2 Diabetes in a Community-Based Cohort of Elderly Men

Jobs, E. N., Risérus, U., Ingelsson, E., Sundström, J., Jobs, M., Nerpin, E., Iggman, D., Basu, S., Larsson, A. O., Lind, L., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0494 · Cited by 43

Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery

Liu, Y., Jin, J., Chen, Y., Chen, C., Chen, Z., & Xu, L. (2020) · Adipocyte · doi:10.1080/21623945.2020.1795434 · Cited by 42

Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.

Jobs, E., Risérus, U., Ingelsson, E., Helmersson, J., Nerpin, E., Jobs, M., Sundström, J., Lind, L., Larsson, A., Basu, S., et al. (2010) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-0328 · Cited by 43

Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture

Rauner, M., Föger‐Samwald, U., Kurz, M., Brünner-Kubath, C., Schamall, D., Kapfenberger, A., Varga, P., Kudlacek, S., Wutzl, A., Höger, H., et al. (2014) · Bone · doi:10.1016/j.bone.2014.04.022 · Cited by 40

Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)

Wojczynski, M. K., Parnell, L. D., Pollin, T. I., Lai, C., Feitosa, M. F., O’Connell, J. R., Wood, A. C., Gibson, Q., Aslibekyan, S. W., Ryan, K. A., et al. (2015) · Metabolism · doi:10.1016/j.metabol.2015.07.001 · Cited by 39

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., Yanai, T., et al. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00199 · Cited by 36

DNA microarrays to define and search for genes associated with obesity

Kim, Y., & Park, T. (2009) · Biotechnology Journal · doi:10.1002/biot.200900228 · Cited by 36

A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss ,

Roumans, N. J. T., Vink, R., Fazelzadeh, P., van Baak, M. A., & Mariman, E. C. M. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.148874 · Cited by 36

Inflammation, adipokines et obésité

Clément, K., & Vignes, S. (2009) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2009.03.363 · Cited by 40

Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease

Ye, Z., Wang, S., Yang, Z., He, M., Zhang, S., Zhang, W., Wen, J., Li, Q., Huang, Y., Wang, X., et al. (2014) · Molecular Biology Reports · doi:10.1007/s11033-013-2977-5 · Cited by 35

F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes

Kaartinen, M. T., Arora, M., Heinonen, S., Hang, A., Barry, A., Lundbom, J., Hakkarainen, A., Lundholm, N., Rissanen, A., Kaprio, J. A., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00722-0 · Cited by 33

Cathepsin S inhibition lowers blood glucose levels in mice

Lafarge, J.-C., Pini, M., Pelloux, V., Orasanu, G., Hartmann, G. R., Venteclef, N., Sulpice, T., Shi, G., Clément, K., & Guerre-Millo, M. (2014) · Diabetologia · doi:10.1007/s00125-014-3280-2 · Cited by 34

Discovery of Novel Cathepsin S Inhibitors by Pharmacophore-Based Virtual High-Throughput Screening

Markt, P., McGoohan, C., Walker, B., Kirchmair, J., Feldmann, C., Martino, G. D., Spitzer, G. M., Distinto, S., Schuster, D., Wolber, G., et al. (2008) · Journal of Chemical Information and Modeling · doi:10.1021/ci800101j · Cited by 30

Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma

Paraoan, L. (2009) · Frontiers in bioscience · doi:10.2741/3393 · Cited by 29

Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure

Marmarinos, A., Garoufi, A., Panagoulia, A., Dimou, S., Drakatos, A., Paraskakis, I., & Gourgiotis, D. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.10.012 · Cited by 28

Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs

Fontanesi, L., Speroni, C., Buttazzoni, L., Scotti, E., Costa, L. N., Davoli, R., & Russo, V. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.01.023 · Cited by 28

Importance of adipokines in glucose homeostasis

Blüher, M. (2013) · Diabetes Management · doi:10.2217/dmt.13.35 · Cited by 26

The Emerging Relevance of the Cysteine Protease Cathepsin S in Disease

Small, D. M., Burden, R. E., & Scott, C. J. (2011) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-011-9095-5 · Cited by 25

Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice

Poussin, C., Hall, D., Minehira, K., Galzin, A., Tarussio, D., & Thorens, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003385 · Cited by 24

Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Takayama, F., Zhang, X., Hayashi, Y., Wu, Z., & Nakanishi, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.061 · Cited by 22

Cysteinyl Cathepsins: Multifunctional Enzymes in Cardiovascular Disease

Li, X., Liu, Z., Cheng, Z., & Cheng, X. W. (2012) · Chonnam Medical Journal · doi:10.4068/cmj.2012.48.2.77 · Cited by 21

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis

Sage, J., de Quéral, D., Noblesse, E., Kurfürst, R., Schnebert, S., Perrier, É., Nizard, C., Lalmanach, G., & Lecaille, F. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.07.002 · Cited by 20

Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People

Lu, Z., Meng, L., Sun, Z., Shi, X., Shao, W., Zheng, Y., Yao, X., & Song, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.620740 · Cited by 20

Influence of SNPs in nutrient-sensitive candidate genes and gene–diet interactions on blood lipids: the DiOGenes study

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Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice

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