The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
DNA precursor metabolism and genomic stability
Abstract
Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely regulated, and imbalances in the four dNTP pools have genotoxic consequences. Replication errors leading to mutations can occur, for example, if one dNTP in excess drives formation of a non‐Watson‐Crick base pair or if it forces replicative DNA chain elongation past a mismatch before DNA polymerase can correct the error by 3′ exonuclease proofreading. This review focuses on developments since 1994, when the field was last reviewed comprehensively. Emphasis is placed on the following topics: 1 ) novel aspects of dNTP pool regulation, 2 ) dNTP pool asymmetries as mutagenic determinants, 3 ) dNTP metabolism and hypermutagenesis of retroviral genomes, 4 ) dNTP metabolism and mutagenesis in the mitochondrial genome, 5 ) chemical modification of nucleotides as a premutagenic event, 6 ) relationships between dNTP metabolism, genome stability, aging, and cancer.—Mathews, C. K. DNA precursor metabolism and genomic stability. FASEB J. 20, 1300–1314 (2006)
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Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375
Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
Liu, Y.-C., Li, F., Handler, J., Huang, C. R. L., Xiang, Y., Neretti, N., Sedivy, J. M., Zeller, K. I., & Dang, C. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002722 · Cited by 317
Nucleotide metabolism, oncogene-induced senescence and cancer
Aird, K. M., & Zhang, R. (2015) · Cancer Letters · doi:10.1016/j.canlet.2014.01.017 · Cited by 166
Gaglio, D., Soldati, C., Vanoni, M., Alberghina, L., & Chiaradonna, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004715 · Cited by 164
DNA replication fidelity and cancer
Preston, B. D., Albertson, T. M., & Herr, A. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.009 · Cited by 160
Metadata
- Authors
- Mathews, C. K.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-07
- Volume
- 20
- Issue
- 9
- Pages
- 1300-1314
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1968291566
- Cited by
- 311
- References
- 105
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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