The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Moderate consumption of Cabernet Sauvignon attenuates A� neuropathology in a mouse model of Alzheimer's disease
Abstract
Recent studies suggest that moderate red wine consumption reduces the incidence of Alzheimer's disease (AD) clinical dementia. Using Tg2576 mice, which model AD‐type amyloid beta‐protein (Aβ) neuropathology, we tested whether moderate consumption of the red wine Cabernet Sauvignon modulates AD‐type neuropathology and cognitive deterioration. The wine used in the study was generated using Cabernet Sauvignon grapes from Fresno, California, and was delivered to Tg2576 in a final concentration of ~6% ethanol. We found that Cabernet Sauvignon significantly attenuated AD‐type deterioration of spatial memory function and Aβ neuropathology in Tg2576 mice relative to control Tg2576 mice that were treated with either a comparable amount of ethanol or water alone. Chemical analysis showed the Cabernet Sauvignon used in this study contains a very low content of resveratrol (0.2 mg/L), 10‐fold lower than the minimal effective concentration shown to promote Aβ clearance in vitro . Our studies suggest Cabernet Sauvignon exerts a beneficial effect by promoting nonamyloidogenic processing of amyloid precursor protein, which ultimately prevents the generation of Aβ peptides. This study supports epidemiological evidence indicating that moderate wine consumption, within the range recommended by the FDA dietary guidelines of one drink per day for women and two for men, may help reduce the relative risk for AD clinical dementia.—Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Meenakshisundaram, T., Percival, S. S., Talcott, S. T., Pasinetti, G. M. Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse model of Alzheimer's disease. FASEB J. 20, 2313–2320 (2006)
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Cites
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Animal models of Alzheimer's disease and frontotemporal dementia
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Anstey, K. J., Mack, H. A., & Cherbuin, N. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181a2fd07 · Cited by 452
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Sabogal-Guáqueta, A. M., Muñoz-Manco, J. I., Ramírez-Pineda, J. R., Lamprea-Rodriguez, M., Osorio, E., & Cardona-Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 447
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Metadata
- Authors
- Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Thiyagarajan, M., Percival, S. S., Talcott, S. T., & Maria Pasinetti, G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-11
- Volume
- 20
- Issue
- 13
- Pages
- 2313-2320
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1996583908
- Cited by
- 298
- References
- 33
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
