Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults
Open accessAbstract
Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight older individuals that successfully completed 26 weeks of resveratrol intake (200 mg/d) were pairwise matched to 23 participants that received placebo (total n = 46, 18 females, 50-75 years). Before and after the intervention/control period, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity (FC) of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were assayed. We observed a significant effect of resveratrol on retention of words over 30 min compared with placebo (p = 0.038). In addition, resveratrol led to significant increases in hippocampal FC, decreases in glycated hemoglobin (HbA1c) and body fat, and increases in leptin compared with placebo (all p < 0.05). Increases in FC between the left posterior hippocampus and the medial prefrontal cortex correlated with increases in retention scores and with decreases in HbA1c (all p < 0.05). This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults. Our findings offer the basis for novel strategies to maintain brain health during aging.
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The intake of polyphenols in the elderly has been associated with improved cognitive abilities.
“Moreover, the intake of polyphenols in the elderly has been associated with improved cognitive abilities [83, 84].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [84]
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- Authors
- Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A.
- Affiliations
- NeuroCure Cluster of Excellence (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-06-04
- Volume
- 34
- Issue
- 23
- Pages
- 7862-7870
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6608268
- OpenAlex
- W2160427616
- Cited by
- 455
- References
- 56
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 33 · 2023: 33 · 2022: 36 · 2021: 43 · 2020: 50 · 2019: 35 · 2018: 43 · 2017: 47 · 2016: 37 · 2015: 41 · 2014: 7 · 2012: 1
- FWCI
- 22.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- resveratrol, memory performance, hippocampal functional connectivity, glucose metabolism, older adults, brain aging, dietary supplementation, HbA1c, leptin, fat mass, medial prefrontal cortex, vocabulary retention
- MeSH terms
- Resveratrol, Aged, Aged, 80 and over, Antioxidants, Blood Glucose, Cognition, Fasting, Female, Follow-Up Studies, Glycated Hemoglobin, Hippocampus, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Quercetin, Stilbenes, Case-Control Studies, Leptin
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