The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Lactate fuels the human brain during exercise.
Abstract
The human brain releases a small amount of lactate at rest, and even an increase in arterial blood lactate during anesthesia does not provoke a net cerebral lactate uptake. However, during cerebral activation associated with exercise involving a marked increase in plasma lactate, the brain takes up lactate in proportion to the arterial concentration. Cerebral lactate uptake, together with glucose uptake, is larger than the uptake accounted for by the concomitant O 2 uptake, as reflected by the decrease in cerebral metabolic ratio (CMR) [the cerebral molar uptake ratio O 2 /(glucose+½ lactate)] from a resting value of 6 to <2. The CMR also decreases when plasma lactate is not increased, as during prolonged exercise, cerebral activation associated with mental activity, or exposure to a stressful situation. The CMR decrease is prevented with combined β 1 ‐ and β 2 ‐adrenergic receptor blockade but not with β 1 ‐adrenergic blockade alone. Also, CMR decreases in response to epinephrine, suggesting that a β 2 ‐adrenergic receptor mechanism enhances glucose and perhaps lactate transport across the blood‐brain barrier. The pattern of CMR decrease under various forms of brain activation suggests that lactate may partially replace glucose as a substrate for oxidation. Thus, the notion of the human brain as an obligatory glucose consumer is not without exceptions.—Quistorff, B., Secher, N. H., and Van Lieshout, J. J. Lactate fuels the human brain during exercise. FASEB J. 22, 3443–3449 (2008)
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“peripheral blood lactate (e.g., from muscles) can cross the blood–brain barrier and provides energy to the brain”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Quistorff et al., 2008
Citations
Cites
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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
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Supply and demand in cerebral energy metabolism: the role of nutrient transporters
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Cardiac output during submaximal and maximal work
Åstrand, P.-O., Cuddy, T. E., Saltin, B., & Stenberg, J. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.2.268 · Cited by 722 · cited 1×
“In contrast, skeletal muscles tolerate O2 desaturation down to 10% (7).”
BackgroundEffect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis
Greenhaff, P. L., Bodin, K., Soderlund, K., & Hultman, E. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.5.e725 · Cited by 531
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Diet, muscle glycogen, and endurance performance
Karlsson, J., & Saltin, B. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.2.203 · Cited by 440
Intra- and extra-cellular lactate shuttles.
Brooks, G. A. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200004000-00011 · Cited by 391
Syncope, cerebral perfusion, and oxygenation
Van Lieshout, J. J., Wieling, W., Karemaker, J. M., & Secher, N. H. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00260.2002 · Cited by 365
Self-citationCerebral blood flow and metabolism during exercise: implications for fatigue
Secher, N. H., Seifert, T., & Van Lieshout, J. J. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00853.2007 · Cited by 344
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The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
“, 1981, 1988), brain (Glenn et al., 2015b; Quistorff et al., 2008; van Hall et al., 2009), liver and kidneys (Bergman et al.”
BackgroundInfluentialRegulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 1,005
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 911
Lactate as a fulcrum of metabolism
Brooks, G. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101454 · Cited by 724
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571
“We observed an accumulation of cellular and extracellular brain lactate during artificially increased blood lactate levels, which indicate a net uptake under these conditions and is in agreement with findings in humans (Boumezbeur et al., 2010; Quistorff et al., 2008; Rasmussen et al., 2011).”
Result
Metadata
- Authors
- Quistorff, B., Secher, N. H., & Van Lieshout, J. J.
- Affiliations
- University of Copenhagen (DK)
- Department of Internal Medicine, Medium Care Unit University of Amsterdam Amsterdam The Netherlands
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2008-07-24
- Volume
- 22
- Issue
- 10
- Pages
- 3443-3449
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2141894573
- Cited by
- 262
- References
- 54
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 15 · 2023: 23 · 2022: 14 · 2021: 14 · 2020: 12 · 2019: 14 · 2018: 10 · 2017: 13 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 15
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- brain energy metabolism, physical activity, glucose oxidation, beta-adrenergic receptors, epinephrine, blood-brain barrier transport, brain glucose metabolism
- MeSH terms
- Anaerobiosis, Brain, Glucose, Humans, Oxygen, Exercise, Lactic Acid
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