Cited by 347Adipokines, Inflammation, and Metabolic DiseasesNF-κB Signaling PathwaysDiet, Metabolism, and Disease

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JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni, Karin, Michael·2010·The FASEB Journal

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Abstract

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low‐grade inflammation thought to contribute to several metabolic disorders' including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. The precise mechanisms of these linkages are still being investigated. However, as we discuss here, JNK1 and IKKβ are activated by almost all forms of metabolic stress that have been implicated in insulin resistance or islet dysfunction. Furthermore, both JNK1 and IKKβ are critically involved in the promotion of diet‐induced obesity, metabolic inflammation, insulin resistance, and β‐cell dysfunction. Understanding the molecular mechanisms by which JNK1 and IKKβ mediate obesity‐induced metabolic stress is likely to be of importance for the development of new treatments for a variety of obesity‐associated diseases.—Solinas, G., Karin, M. JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction. FASEB J . 24, 2596–2611 (2010). www.fasebj.org

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Authors: Solinas, G., & Karin, M.
Affiliations: University of Fribourg (CH)
University of California San Diego (US)
Corresponding author: Solinas, Giovanni
ORCID: Solinas, Giovanni
Karin, Michael
Venue: The FASEB Journal
Publisher: Wiley
Published: 2010-04-06
Volume: 24
Issue: 8
Pages: 2596-2611
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.09-151340
OpenAlex: W2127873334
Cited by: 347
References: 179
Citations by year: 2026: 8 · 2025: 12 · 2024: 13 · 2023: 15 · 2022: 18 · 2021: 20 · 2020: 15 · 2019: 28 · 2018: 28 · 2017: 27 · 2016: 29 · 2015: 31 · 2014: 23 · 2013: 32 · 2012: 28
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
reroDoc Digital Library (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF31003A‐118172)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: JNK1, IKKβ, obesity, metabolic inflammation, insulin resistance, beta-cell dysfunction, pancreatic islets, glucose homeostasis, metabolic stress, diet-induced obesity, low-grade inflammation
MeSH terms: Humans, Inflammation, Metabolic Diseases, Obesity, Mitogen-Activated Protein Kinase 8, I-kappa B Kinase

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JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

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