Regulation of metabolism by the innate immune system

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Abdominal obesity and metabolic syndrome

Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works

Alternative activation of macrophages: mechanism and functions

Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · see citing works

PPARγ signaling and metabolism: the good, the bad and the future

Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works

NF-κB, Inflammation, and Metabolic Disease

Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773 · see citing works

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596 · see citing works

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551 · see citing works

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,380 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299 · see citing works

Adipose tissue browning and metabolic health

Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

Type 2 innate lymphoid cells control eosinophil homeostasis

Nussbaum, J. C., Dyken, S. J. V., von Moltke, J., Cheng, L. E., Mohapatra, A., Molofsky, A. B., Thornton, E. E., Krummel, M. F., Chawla, A., Liang, H.-E., et al. (2013) · Nature · doi:10.1038/nature12526 · Cited by 1,069 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

Lumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes · doi:10.2337/db06-1076 · Cited by 1,016 · see citing works

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., et al. (2015) · Nature · doi:10.1038/nature14115 · Cited by 968 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · see citing works

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

Molofsky, A. B., Nussbaum, J. C., Liang, H.-E., Dyken, S. J. V., Cheng, L. E., Mohapatra, A., Chawla, A., & Locksley, R. M. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121964 · Cited by 879 · see citing works

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., & Chawla, A. (2014) · Cell · doi:10.1016/j.cell.2014.03.066 · Cited by 869 · see citing works

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Brennan, P. J., Brigl, M., & Brenner, M. B. (2013) · Nature reviews. Immunology · doi:10.1038/nri3369 · Cited by 839 · see citing works

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

Amar, J., Chabo, C., Waget, A., Klopp, P., Vachoux, C., Bermúdez‐Humarán, L. G., Smirnova, N. F., Bergé, M., Sulpice, T., Lahtinen, S. J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100159 · Cited by 835 · see citing works

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes &amp; Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

Kratz, M., Coats, B. R., Hisert, K. B., Hagman, D. K., Mutskov, V. J., Peris, E., Schoenfelt, K. Q., Kuzma, J. N., Larson, I. A., Billing, P. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.010 · Cited by 821 · see citing works

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.015 · Cited by 804 · see citing works

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796 · see citing works

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Ehses, J. A., Perren, A. A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Guéripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., et al. (2007) · Diabetes · doi:10.2337/db06-1650 · Cited by 783 · see citing works

Macrophages, Immunity, and Metabolic Disease

McNelis, J., & Olefsky, J. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.010 · Cited by 728 · see citing works

Inflammasome is a central player in the induction of obesity and insulin resistance

Stienstra, R., van Diepen, J. A., Tack, C. J., Zaki, M. H., van de Veerdonk, F. L., Perera, D., Neale, G. A., Hooiveld, G. J., Hijmans, A., Vroegrijk, I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100255108 · Cited by 727 · see citing works

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., & Davis, R. J. (2012) · Science · doi:10.1126/science.1227568 · Cited by 635 · see citing works

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 625 · see citing works

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., & Davis, R. J. (2008) · Science · doi:10.1126/science.1160794 · Cited by 604 · see citing works

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., et al. (2011) · Diabetes · doi:10.2337/db11-0194 · Cited by 566 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

Kim, H.-J., Higashimori, T., Park, S.-Y., Choi, H., Dong, J., Kim, Y.-J., Noh, H.-L., Cho, Y.-R., Cline, G., Kim, Y.-B., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1060 · Cited by 534 · see citing works

Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes

Ruan, H., Hacohen, N., Golub, T. R., Parijs, L. V., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1319 · Cited by 531 · see citing works

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

Xu, X., Grijalva, A., Skowronski, A., van Eijk, M., Serlie, M. J., & Ferrante, A. W. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.001 · Cited by 523 · see citing works

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Huang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520 · see citing works

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

Eguchi, K., Manabe, I., Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.023 · Cited by 520 · see citing works

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

Lynch, L., Nowak, M. A., Varghese, B., Clark, J., Hogan, A. E., Toxavidis, V., Balk, S. P., O'Shea, D. B., O’Farrelly, C., & Exley, M. A. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.016 · Cited by 516 · see citing works

JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513 · see citing works

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

Wang, X., Ota, N., Manzanillo, P. S., Kates, L., Zavala‐Solorio, J., Eidenschenk, C., Zhang, J., Lesch, J., Lee, W. P., Ross, J., et al. (2014) · Nature · doi:10.1038/nature13564 · Cited by 503 · see citing works

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works

Immune Regulation of Metabolic Homeostasis in Health and Disease

Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 498 · see citing works

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

Heilbronn, L. K., & Campbell, L. V. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784246153 · Cited by 496 · see citing works

Adaptive immunity in obesity and insulin resistance

Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486 · see citing works

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Wensveen, F. M., Jelenčić, V., Marinović, S., Šestan, M., Wensveen, T. T., Theurich, S., Glasner, A., Mendrila, D., Štimac, D., Wunderlich, F. T., et al. (2015) · Nature Immunology · doi:10.1038/ni.3120 · Cited by 478 · see citing works

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

Zigmond, E., Samia-Grinberg, S., Pasmanik‐Chor, M., Brazowski, E., Shibolet, O., Halpern, Z., & Varol, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400574 · Cited by 477 · see citing works

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

Shoelson, S. E., Lee, J., & Yuan, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802501 · Cited by 474 · see citing works

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31561 · Cited by 459 · see citing works

MicroRNA regulatory networks in human adipose tissue and obesity

Arner, P., & Kulyté, A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.25 · Cited by 456 · see citing works

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

Tornatore, L., Thotakura, A. K., Bennett, J., Moretti, M., & Franzoso, G. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.001 · Cited by 448 · see citing works

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Reilly, S. M., Chiang, S.-H., Decker, S. J., Chang, L. C., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J. C., White, N. M. A., Hochberg, I., et al. (2013) · Nature Medicine · doi:10.1038/nm.3082 · Cited by 434 · see citing works

Immunological Goings-on in Visceral Adipose Tissue

Mathis, D. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.008 · Cited by 433 · see citing works

Ceramides as modulators of cellular and whole-body metabolism

Bikman, B. T., & Summers, S. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57144 · Cited by 425 · see citing works

Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

Solomon, D. H. (2011) · JAMA · doi:10.1001/jama.2011.878 · Cited by 394 · see citing works

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Oh, D. Y., Walenta, E., Akiyama, T. E., Lagakos, W., Lackey, D. E., Pessentheiner, A. R., Šášik, R., Hah, N., Chi, T. J., Cox, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3614 · Cited by 391 · see citing works

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

Jourdan, T., Godlewski, G., Cinar, R., Bertola, A., Szanda, G., Liu, J., Tam, J., Han, T., Mukhopadhyay, B., Skarulis, M. C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3265 · Cited by 388 · see citing works

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

Lynch, L., Michelet, X., Zhang, S., Brennan, P. J., Moseman, E. A., Lester, C., Besra, G. S., Vomhof‐DeKrey, E. E., Tighe, M., Koay, H., et al. (2014) · Nature Immunology · doi:10.1038/ni.3047 · Cited by 387 · see citing works

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

Stephens, J. M., & Pekala, P. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54714-1 · Cited by 370 · see citing works

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J., & Olefsky, J. M. (2011) · Diabetes · doi:10.2337/db11-0860 · Cited by 365 · see citing works

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 363 · see citing works

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359 · see citing works

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

Hui, X. H., Gu, P., Zhang, J., Nie, T., Pan, Y., Wu, D., Feng, T., Zhong, C., Wang, Y., Lam, K. S. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.004 · Cited by 349 · see citing works

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, G., & Karin, M. (2010) · The FASEB Journal · doi:10.1096/fj.09-151340 · Cited by 347 · see citing works

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

Böni‐Schnetzler, M., Boller, S., Debray, S., Bouzakri, K., Meier, D. T., Prazak, R., Kerr-Conte, J. A., Pattou, F. N., Ehses, J. A., Schuit, F. C., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0543 · Cited by 344 · see citing works

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

Chiang, S.-H., Bazuine, M., Lumeng, C. N.-K., Geletka, L. M., Mowers, J. C., White, N. M. A., Ma, J.-T., Zhou, J., Qi, N., Westcott, D. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.046 · Cited by 344 · see citing works

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

Caesar, R., Reigstad, C. S., Bäckhed, H. K., Reinhardt, C., Ketonen, M., Östergren‐Lundén, G., Cani, P. D., & Bäckhed, F. (2012) · Gut · doi:10.1136/gutjnl-2011-301689 · Cited by 330 · see citing works

IL-5 and eosinophilia

Takatsu, K., & Nakajima, H. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.04.001 · Cited by 323 · see citing works

Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 323 · see citing works

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

Stanley, T. L., Zanni, M. V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., Khor, V. K., Ahima, R. S., & Grinspoon, S. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1170 · Cited by 321 · see citing works

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

Obstfeld, A. E., Sugaru, E., Thearle, M. S., Francisco, A.-M., Gayet, C., Ginsberg, H. N., Ables, E. V., & Ferrante, A. W. (2010) · Diabetes · doi:10.2337/db09-1403 · Cited by 314 · see citing works

NLRP3 at the interface of metabolism and inflammation

Haneklaus, M., & O'Neill, L. A. J. (2015) · Immunological Reviews · doi:10.1111/imr.12285 · Cited by 294 · see citing works

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

Cavelti‐Weder, C., Babians-Brunner, A., Keller, C., Stahel, M., Kurz-Levin, M. M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, T. R., Dinarello, C. A., & Donath, M. Y. (2012) · Diabetes Care · doi:10.2337/dc11-2219 · Cited by 294 · see citing works

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 289 · see citing works

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

Finucane, O. M., Lyons, C. L., Murphy, A. M., Reynolds, C. M., Klinger, R. W., Healy, N. P., Cooke, A. A., Coll, R. C., McAllan, L., Nilaweera, K. N., et al. (2015) · Diabetes · doi:10.2337/db14-1098 · Cited by 281 · see citing works

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

Schubert, K. M., Scheid, M. P., & Duronio, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13330 · Cited by 277 · see citing works

Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

Chen, Q., Wang, H., Liu, Y., Song, Y., Lai, L., Han, Q., Cao, X., & Wang, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042971 · Cited by 271 · see citing works

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Hasnain, S. Z., Borg, D. J., Harcourt, B. E., Tong, H., Sheng, Y., Ng, C. P., Das, I., Wang, R., Chen, A. C. –., Loudovaris, T., et al. (2014) · Nature Medicine · doi:10.1038/nm.3705 · Cited by 263 · see citing works

Kupffer cell activation is a causal factor for hepatic insulin resistance

Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 258 · see citing works

Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity

Lynch, L., O'Shea, D. B., Winter, D. C., Geoghegan, J., Doherty, D. G., & O’Farrelly, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939349 · Cited by 258 · see citing works

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

Kim, J. I., Huh, J. Y., Sohn, J. H., Choe, S. S., Lee, Y. S., Lim, C. Y., Jo, A., Park, S. B., Han, W., & Kim, J. B. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01321-14 · Cited by 258 · see citing works

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B., White, D. A., Murphy, A. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.006 · Cited by 257 · see citing works

Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302

Werner, E. D., Lee, J., Hansen, L., Yuan, M., & Shoelson, S. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405203200 · Cited by 252 · see citing works

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

Inouye, K. E., Shi, H., Howard, J. K., Daly, C. H., Lord, G. M., Rollins, B. J., & Flier, J. S. (2007) · Diabetes · doi:10.2337/db07-0425 · Cited by 252 · see citing works

Ontogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages

Dey, A., Allen, J. N., & Hankey, G. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00683 · Cited by 245 · see citing works

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18917 · Cited by 244 · see citing works

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

Li, P., Lu, M. M., Nguyen, M. T., Bae, E. J., Chapman, J., Feng, D., Hawkins, M. A., Pessin, J. E., Sears, D. D., Nguyen, A.-K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100263 · Cited by 240 · see citing works

Islet-associated macrophages in type 2 diabetes

Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Diabetologia · doi:10.1007/s00125-009-1410-z · Cited by 240 · see citing works

Increase in intranuclear nuclear factor κB and decrease in inhibitor κB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect

Aljada, A., Mohanty, P., Ghanim, H., Abdo, T., Tripathy, D., Chaudhuri, A., & Dandona, P. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.682 · Cited by 239 · see citing works

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

Hams, E., Locksley, R. M., McKenzie, A. N. J., & Fallon, P. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301176 · Cited by 232 · see citing works

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229 · see citing works

Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity

Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K. S. L., Gao, B., Lee, C., Kersten, S., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350066 · Cited by 221 · see citing works

Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention

Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 215 · see citing works

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 213 · see citing works

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418917 · Cited by 212 · see citing works

Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors

Teixeira, T. F. S., Souza, N. C., Chiarello, P. G., Franceschini, S. C. C., Bressan, J., Ferreira, C. L. D. L. F., & Pelúzio, M. D. C. G. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.02.009 · Cited by 200 · see citing works

Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans

Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, T. E., Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. G., & Klip, A. (2013) · Obesity · doi:10.1002/oby.20615 · Cited by 199 · see citing works

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

Sauter, N. S., Schulthess, F. T., Galasso, R., Castellani, L. W., & Maedler, K. (2008) · Endocrinology · doi:10.1210/en.2007-1059 · Cited by 198 · see citing works

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

O’Rourke, R. W., Metcalf, M. D., White, A. E., Madala, A., Winters, B. R., Maizlin, I. I., Jobe, B. A., Roberts, C. T., Slifka, M. K., & Marks, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.133 · Cited by 196 · see citing works

Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C. M., Ozir‐Fazalalikhan, A., Berbée, J. F. P., van Dijk, K. W., van Harmelen, V., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-266239 · Cited by 192 · see citing works

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

Wu, L., Parekh, V. V., Gabriel, C. L., Bracy, D. P., Marks–Shulman, P. A., Tamboli, R. A., Kim, S., Mendez-Fernandez, Y., Besra, G. S., Lomenick, J. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200498109 · Cited by 191 · see citing works

Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

Divoux, A., Moutel, S., Poitou, C., Lacasa, D., Veyrie, N., Aissat, A., Arock, M., Guerre-Millo, M., & Clément, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1532 · Cited by 187 · see citing works

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes

Sloan‐Lancaster, J., Abu-Raddad, E., Polzer, J. P., Miller, J. W., Scherer, J. C., Gaetano, A. D., Berg, J. K., & Landschulz, W. H. (2013) · Diabetes Care · doi:10.2337/dc12-1835 · Cited by 185 · see citing works

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

Spencer, M. L., Finlin, B. S., Ünal, R., Zhu, B., Morris, A. J., Shipp, L. R., Lee, J. D., Walton, R. G., Adu, A. K., Erfani, R. A., et al. (2013) · Diabetes · doi:10.2337/db12-1042 · Cited by 181 · see citing works

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

Spite, M. R., Hellmann, J. L., Tang, Y., Mathis, S., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 177 · see citing works

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A. R., Chi, T. J., et al. (2015) · Diabetes · doi:10.2337/db14-1238 · Cited by 175 · see citing works

Activation of leukocytes by postprandial lipemia in healthy volunteers

van Oostrom, A. J. H. H. M., Rabelink, T. J., Verseijden, C., Sijmonsma, T., Plokker, H. W. M., de Jaegere, P. P. T., & Cabezas, M. C. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.07.004 · Cited by 172 · see citing works

Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome

Tousoulis, D., Plastiras, A., Siasos, G., Oikonomou, E. K., Verveniotis, A., Kokkou, E., Maniatis, K., Gouliopoulos, N., Miliou, A., Paraskevopoulos, T., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.014 · Cited by 169 · see citing works

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150 · see citing works

High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability

Johnson, A. M. F., Costanzo, A. E., Gareau, M. G., Armando, A. M., Quehenberger, O., Jameson, J., & Olefsky, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122195 · Cited by 150 · see citing works

Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

Kirk, E. A., Sagawa, Z. K., McDonald, T. O., O'Brien, K. D., & Heinecke, J. W. (2008) · Diabetes · doi:10.2337/db07-1061 · Cited by 149 · see citing works

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Mowers, J. C., Uhm, M., Reilly, S. M., Simon, J., Leto, D. E., Chiang, S.-H., Chang, L. C., & Saltiel, A. R. (2013) · eLife · doi:10.7554/elife.01119 · Cited by 149 · see citing works

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

Shimizu, I., Yoshida, Y., Moriya, J., Nojima, A., Uemura, A., Kobayashi, Y., & Minamino, T. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.001 · Cited by 136 · see citing works

A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells

Huh, J. Y., Kim, J. I., Park, Y. J., Hwang, I., Lee, Y. S., Sohn, J. H., Lee, S. K., Alfadda, A. A., Kim, S. S., Choi, S. H., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-12 · Cited by 130 · see citing works

A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance

Goldfine, A. B., Conlin, P. R., Halperin, F., Koška, J., Permana, P. A., Schwenke, D. C., Shoelson, S. E., & Reaven, P. D. (2013) · Diabetologia · doi:10.1007/s00125-012-2819-3 · Cited by 128 · see citing works

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

Patsouris, D., Cao, J.-J., Vial, G., Bravard, A., Lefai, E., Durand, A., Durand, C., Chauvin, M.-A., Laugerette, F., Debard, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110653 · Cited by 122 · see citing works

TNFα-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors

Liu, S., Yang, Y., & Wu, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.131 · Cited by 120 · see citing works

Adipose tissue‐resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

Cipolletta, D. (2014) · Immunology · doi:10.1111/imm.12262 · Cited by 118 · see citing works

Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity

Mantell, B. S., Stefanović-Račić, M., Yang, X., Dedousis, N., SIPULA, I. J., & O'Doherty, R. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019831 · Cited by 118 · see citing works

The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

Koenen, T. B., Stienstra, R., van Tits, L. J., Joosten, L. A. B., van Velzen, J. F., Hijmans, A., Pol, J. A., van der Vliet, J. A., Netea, M. G., Tack, C. J., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1480 · Cited by 115 · see citing works

Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration

Eguchi, A., Mulya, A., Lazić, M., Radhakrishnan, D., Berk, M. P., Povero, D., Górnicka, A., & Feldstein, A. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123110 · Cited by 112 · see citing works

A high-fat meal is accompanied by increased plasma interleukin-6 concentrations

Lundman, P., Boquist, S., Samnegård, A., Bennermo, M. B., Held, C., Ericsson, C.-G., Silveira, A. M. V., Hamsten, A., & Tornvall, P. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.11.009 · Cited by 108 · see citing works

Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial

Hensen, J., Howard, C. P., Walter, V., & Thuren, T. Y. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.07.003 · Cited by 107 · see citing works

Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes

Fink, L. N., Oberbach, A., Costford, S. R., Chan, K. L., Sams, A. G., Blüher, M., & Klip, A. (2013) · Diabetologia · doi:10.1007/s00125-013-2897-x · Cited by 107 · see citing works

Chronic TNF-α Neutralization Does Not Improve Insulin Resistance or Endothelial Function in “Healthy” Men with Metabolic Syndrome

Wascher, T. C., Lindeman, J. H. N., Sourij, H., Kooistra, T., Pacini, G., & Roden, M. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00221 · Cited by 105 · see citing works

microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome

Ge, Q., Brichard, S. M., Yi, X., & Li, Q. (2014) · Journal of Immunology Research · doi:10.1155/2014/987285 · Cited by 103 · see citing works

Reduced Adipose Tissue Macrophage Content Is Associated With Improved Insulin Sensitivity in Thiazolidinedione-Treated Diabetic Humans

Koppaka, S., Kehlenbrink, S., Carey, M., Li, W., Sánchez, E., Lee, D.-E., Lee, H., Chen, J., Carrasco, E., Kishore, P., et al. (2013) · Diabetes · doi:10.2337/db12-0868 · Cited by 93 · see citing works

Impact of CD1d Deficiency on Metabolism

Kotas, M. E., Lee, H., Gillum, M. P., Annicelli, C., Guigni, B. A., Shulman, G. I., & Medzhitov, R. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025478 · Cited by 84 · see citing works

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

Reilly, S. M., Ahmadian, M., Zamarron, B. F., Chang, L. C., Uhm, M., Poirier, B., Peng, X., Krause, D., Korytnaya, E., Neidert, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7047 · Cited by 84 · see citing works

Glucocorticoids and Thiazolidinediones Interfere with Adipocyte-mediated Macrophage Chemotaxis and Recruitment

Patsouris, D., Neels, J. G., Fan, W., Li, P., Nguyen, M. T., & Olefsky, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041665 · Cited by 83 · see citing works

Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

Westwell-Roper, C. Y., Nąckiewicz, D., Dan, M., & Ehses, J. A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.4 · Cited by 73 · see citing works

Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway

Chen, Y., Sun, L., Wang, B., et al. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1530 · Cited by 71 · see citing works

Adipose invariant natural killer T cells

Lynch, L. (2014) · Immunology · doi:10.1111/imm.12269 · Cited by 70 · see citing works

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats

Holmes, A. G., Mesa, J. L., Neill, B., Chung, J. Z. Y., Carey, A. L., Steinberg, G. R., Kemp, B. E., Southgate, R. J., Lancaster, G. I., Bruce, C. R., et al. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0113 · Cited by 70 · see citing works

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

Yin, J.-J., Wang, Y., Gu, L., Fan, N., Ma, Y., & Peng, Y. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2085 · Cited by 67 · see citing works

Activated Kupffer cells inhibit insulin sensitivity in obese mice

Tencerová, M., Aouadi, M., Vangala, P., Nicoloro, S. M. C., Yawe, J. C., Cohen, J. L., Shen, Y., Garcia‐Menendez, L., Pedersen, D. J., Gallagher-Dorval, K. A., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-270496 · Cited by 65 · see citing works

Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance

Revelo, X. S., Tsai, S. J., Lei, H., Luck, H., Ghazarian, M., Tsui, H., Shi, S. Y., Schroer, S. A., Luk, C. T., Lin, G. H. Y., et al. (2014) · Diabetes · doi:10.2337/db13-1524 · Cited by 65 · see citing works

Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission

Arora, T., Velagapudi, V., Pournaras, D. J., Welbourn, R., le Roux, C. W., Orešič, M., & Bäckhed, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126401 · Cited by 63 · see citing works

Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity

O’Rourke, R. W., Meyer, K. A., Neeley, C. K., Gaston, G. D., Sekhri, P., Szumowski, M., Zamarron, B. F., Lumeng, C. N.-K., & Marks, D. L. (2014) · Obesity · doi:10.1002/oby.20823 · Cited by 62 · see citing works

Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance

Gutierrez, D. A., Muralidhar, S., Feyerabend, T. B., Herzig, S., & Rodewald, H.-R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.013 · Cited by 61 · see citing works

Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation

Pardo, V., González‐Rodríguez, Á., Guijas, C., Balsinde, J., & Valverde, Á. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.649483 · Cited by 60 · see citing works

Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects

Sauter, N. S., Thienel, C., Plutino, Y., Kampe, K., Dror, E., Traub, S., Timper, K., Bédat, B., Pattou, F. N., Kerr-Conte, J. A., et al. (2014) · Diabetes · doi:10.2337/db14-1282 · Cited by 59 · see citing works

Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes

Morris, D. L. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1393 · Cited by 56 · see citing works

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Pillon, N. J., Arane, K., Bilan, P. J., Chiu, T. T., & Klip, A. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-30 · Cited by 53 · see citing works

High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKα/β phosphorylation and decreases PI-3 kinase activity in muscle

Yaspelkis, B. B., Kvasha, I. A., & Figueroa, T. Y. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00117.2009 · Cited by 47 · see citing works

CCR2 antagonism in patients with type 2 diabetes mellitus: a randomized, placebo‐controlled study

Prospero, N. A. D., Artis, E., Andrade‐Gordon, P., Johnson, D. L., Vaccaro, N. M., Xi, L., & Rothenberg, P. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12309 · Cited by 45 · see citing works

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

Boon, M. R., Bakker, L. E. H., Haks, M. C., Quinten, E., Schaart, G., van Beek, L., Wang, Y., van Schinkel, L. D., van Harmelen, V., Meinders, A. E., et al. (2014) · Clinical Science · doi:10.1042/cs20140179 · Cited by 45 · see citing works

Salicylates Increase Insulin Secretion in Healthy Obese Subjects

Fernández‐Real, J. M., López‐Bermejo, A., Ropero, A. B., Piquer, S., Nadal, Á., Bassols, J., Casamitjana, R., Gomis, R., Arnáiz, E., Pérez, I., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1212 · Cited by 37 · see citing works

Insulin Sensitizing and Anti-Inflammatory Effects of Thiazolidinediones Are Heightened in Obese Patients

Esterson, Y. B., Zhang, K., Koppaka, S., Kehlenbrink, S., Kishore, P., Raghavan, P., Maginley, S. R., Carey, M., & Hawkins, M. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0000000000000017 · Cited by 34 · see citing works

Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells

Poletto, A. C., Furuya, D. T., David-Silva, A., Silva, P. E., Santos, C. L., Corrêa‐Giannella, M. L., Passarelli, M., & Machado, U. F. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.001 · Cited by 34 · see citing works

The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes

Barzilay, J. I., Jablonski, K. A., Fonseca, V. A., Shoelson, S. E., Goldfine, A. B., Strauch, C., & Monnier, V. M. (2013) · Diabetes Care · doi:10.2337/dc13-1527 · Cited by 34 · see citing works

Orally-Administered Chemokine Receptor CCR2 Antagonist CCX140-B in Type 2 Diabetes: A Pilot Double-Blind, Randomized Clinical Trial

Markolf Hanefeld, E. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000225 · Cited by 27 · see citing works

Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle

Zolotnik, I. A., Figueroa, T. Y., & Yaspelkis, B. B. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.038 · Cited by 26 · see citing works

Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice

van Diepen, J. A., Wong, M. C., Guigas, B., Bos, J. E., Stienstra, R., Hodson, L., Shoelson, S. E., Berbée, J. F. P., Rensen, P. C. N., Romijn, J. A., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m010405 · Cited by 26 · see citing works

Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function

Raghavan, R., Laight, D. W., & Cummings, M. H. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12310 · Cited by 25 · see citing works

Lack of Invariant Natural Killer T Cells Affects Lipid Metabolism in Adipose Tissue of Diet-Induced Obese Mice

Strodthoff, D., Lundberg, A. M., Agardh, H. E., Ketelhuth, D. F. J., Paulsson‐Berne, G., Arner, P., Hansson, G. K., & Gerdes, N. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301105 · Cited by 25 · see citing works

The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men

Xiao, C., Giacca, A., & Lewis, G. F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00313.2009 · Cited by 24 · see citing works

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

Goldfine, A. B., Fonseca, V. A., Jablonski, K. A., Pyle, L. L., Staten, M. A., Shoelson, S. E., & for the TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team* (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-6-201003160-00004 · Cited by 18 · see citing works

Macrophage plasticity, polarization, and function in health and disease

Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212 · see citing works

Inflammation in obesity, diabetes, and related disorders

Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works

Adapting to obesity with adipose tissue inflammation

Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204 · see citing works

Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.035 · Cited by 1,191 · see citing works

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Chávez-Talavera, O., Tailleux, A., Lefebvre, P., & Staels, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.055 · Cited by 970 · see citing works

Western Diet and the Immune System: An Inflammatory Connection

Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907 · see citing works

Phagocytosis: An Immunobiologic Process

Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902 · see citing works

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works

Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1161521 · Cited by 799 · see citing works

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews · doi:10.1152/physrev.00019.2016 · Cited by 696 · see citing works

Skeletal muscle inflammation and insulin resistance in obesity

Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695 · see citing works

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686 · see citing works

Targeting adipose tissue in the treatment of obesity-associated diabetes

Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review

Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint

Wischhusen, J., Melero, I., & Fridman, W. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00951 · Cited by 506 · see citing works

Insulin resistance causes inflammation in adipose tissue

Shimobayashi, M., Albert, V., Woelnerhanssen, B., Frei, I. C., Weissenberger, D., Meyer-Gerspach, A. C., Clement, N., Moes, S., Colombi, M., Meier, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96139 · Cited by 480 · see citing works

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462 · see citing works

Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences

Hong, S.-H., & Choi, K. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020494 · Cited by 390 · see citing works

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

Quail, D. F., Olson, O. C., Bhardwaj, P., Walsh, L. A., Akkari, L., Quick, M. L., Chen, I.-C., Wendel, N., Ben-Chetrit, N., Walker, J., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3578 · Cited by 277 · see citing works

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

Hirsova, P., Ibrabim, S. H., Gores, G. J., & Malhi, H. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066357 · Cited by 270 · see citing works

Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice

Lee, H., Lee, Y., Kim, J., An, J., Lee, S., Kong, H., Song, Y., Lee, C.-K., & Kim, K. (2018) · Gut Microbes · doi:10.1080/19490976.2017.1405209 · Cited by 203 · see citing works

Toward an understanding of how immune cells control brown and beige adipobiology

Villarroya, F., Cereijo, R., Villarroya, J., Gavaldà-Navarro, A., & Giralt, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.006 · Cited by 198 · see citing works

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188 · see citing works

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

Giladi, A., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2017.11.011 · Cited by 168 · see citing works

The SGLT2 Inhibitor Empagliflozin Ameliorates the Inflammatory Profile in Type 2 Diabetic Patients and Promotes an Antioxidant Response in Leukocytes

Iannantuoni, F., M. de Marañon, A., Diaz-Morales, N., Falcon, R., Bañuls, C., Abad-Jimenez, Z., Victor, V. M., Hernandez-Mijares, A., & Rovira-Llopis, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111814 · Cited by 166 · see citing works

Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health

Bansal, A., Henao-Mejia, J., & Simmons, R. A. (2018) · Endocrinology · doi:10.1210/en.2017-00882 · Cited by 152 · see citing works

Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study

Honka, M.-J., Latva-Rasku, A., Bucci, M., Virtanen, K. A., Hannukainen, J. C., Kalliokoski, K. K., & Nuutila, P. (2018) · European Journal of Endocrinology · doi:10.1530/eje-17-0882 · Cited by 140 · see citing works

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation

Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.005 · Cited by 130 · see citing works

Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning

Okla, M., Zaher, W., Alfayez, M., & Chung, S. (2018) · Inflammation · doi:10.1007/s10753-017-0718-y · Cited by 96 · see citing works

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0501-z · Cited by 72 · see citing works

Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice

Warfel, J. D., Bermudez, E. M., Mendoza, T. M., Ghosh, S., Zhang, J., Elks, C. M., Mynatt, R., & Vandanmagsar, B. (2016) · Scientific Reports · doi:10.1038/srep37941 · Cited by 50 · see citing works

Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial

Markova, M., Koelman, L., Hornemann, S., Pivovarova, O., Sucher, S., Machann, J., Rudovich, N., Thomann, R., Schneeweiss, R., Rohn, S., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.03.019 · Cited by 47 · see citing works

Endocrine, Genetic, and Microbiome Nexus of Obesity and Potential Role of Postbiotics: A Narrative Review

Wu, W., Chen, Z., Han, J., Qian, L., Wang, W., Lei, J., & Wang, H. (2023) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-023-01593-w · Cited by 18 · see citing works

Serum Amyloid P and a Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin Ligand Inhibit High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice

Pilling, D., Cox, N., Thomson, M. A., Karhadkar, T. R., & Gomer, R. H. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.08.005 · Cited by 17 · see citing works

New targets to alleviate skeletal muscle inflammation: Role of microRNAs regulated by adiponectin

Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2017) · Scientific Reports · doi:10.1038/srep43437 · Cited by 18 · see citing works

Preferential recognition of advanced glycation end products by serum antibodies and low-grade systemic inflammation in diabetes mellitus and its complications

Raghav, A., Ahmad, J., & Alam, K. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.033 · Cited by 15 · see citing works

Childhood poverty, immune cell aging, and African Americans' insulin resistance: A prospective study

Barton, A. W., Yu, T., Gong, Q., Miller, G. E., Chen, E., & Brody, G. H. (2022) · Child Development · doi:10.1111/cdev.13795 · Cited by 8 · see citing works

MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines

Ma, J., Zhao, W., Pei, X., et al. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03797-3 · Cited by 3 · see citing works

Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner

Zhao, J., Hu, Y., Huang, C., et al. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.002 · Cited by 21 · see citing works

Effects of Proinflammatory Cytokines in the Heart

Zhang, C. (2004) · Life Science Research

Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p′-DDT in macrophages

Kim, J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.001 · Cited by 45 · see citing works

Proinflammatory Cytokines Mediate GPCR Dysfunction

Mohan, M. L., Vasudevan, N. T., & Prasad, S. V. N. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000456 · Cited by 21 · see citing works