Karin, Michael

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 10,755

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 4,766

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 3,638

Nuclear factor-κB in cancer development and progression

Karin, M. (2006) · Nature

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 3,519

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 3,359

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 3,188

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 2,961

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,709

NF-κB, inflammation, immunity and cancer: coming of age

Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,679

The two NF-κB activation pathways and their role in innate and adaptive immunity

Bonizzi, G., & Karin, M. (2004) · Trends in Immunology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 2,535

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,433

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,390

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 2,155

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 2,125

Inflammation and Colon Cancer

Terzić, J., Grivennikov, S., Karin, E., & Karin, M. (2010) · Gastroenterology

Inflammatory mediators and NSAID effectsImmune cells in cancer

Cited by 1,974

Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007) · Science

Liver physiology and pathologyImmune cells in cancer

Cited by 1,955

A cytokine-mediated link between innate immunity, inflammation, and cancer

Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation

Immune cells in cancerCytokine Signaling Pathways and Interactions

Cited by 1,940

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 1,937

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 1,886

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science

Adipokines, Inflammation, and Metabolic DiseasesNF-κB Signaling Pathways

Cited by 1,884

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 1,792

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesNF-κB Signaling Pathways

Cited by 1,773

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 1,764