Estrogen‐related receptor‐α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury
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The estrogen‐related receptor‐α (ERRα) regulates mitochondrial biogenesis and glucose and fatty acid oxidation during differentiation in skeletal myocytes. However, whether ERRα controls metabolic remodeling during skeletal muscle regeneration in vivo is unknown. We characterized the time course of skeletal muscle regeneration in wild‐type ( M‐ERRα WT ) and muscle‐specific ERR α –/– ( M‐ERR α –/– ) mice after injury by intramuscular cardiotoxin injection. M‐ERRα –/‐ mice exhibited impaired regeneration characterized by smaller myofibers with increased centrally localized nuclei and reduced mitochondrial density and cytochrome oxidase and citrate synthase activities relative to M‐ERRαWT. Transcript levels of mitochondrial transcription factor A, nuclear respiratory factor‐2α, and peroxisome proliferator‐activated receptor (PPAR)‐γ coactivator (PGC)‐1β, were downregulated in the M‐ERR α –/– muscles at the onset of myogenesis. Furthermore, coincident with delayed myofiber recovery, we observed reduced muscle ATP content (–45% vs. M‐ERRαWT ) and enhanced AMP‐activated protein kinase (AMPK) activation in M‐ERR α –/– muscle. We subsequently demonstrated that pharmacologic postinjury AMPK activation was sufficient to delay muscle regeneration in WT mice. AMPK activation induced ERRα transcript expression in M‐ERRαWT muscle and in C2C12 myotubes through induction of the Esrra promoter, indicating that ERRα may control gene regulation downstream of the AMPK pathway. Collectively, these results suggest that ERRα deficiency during muscle regeneration impairs recovery of mitochondrial energetic capacity and perturbs AMPK activity, resulting in delayed myofiber repair.—LaBarge, S., McDonald, M., Smith‐Powell, L., Auwerx, J., Huss, J. M. Estrogen‐related receptor‐α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury. FASEB J. 28, 1082–1097 (2014). www.fasebj.org
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ERα-null mice have a decreased muscle regenerative capacity following injury, as evidenced by small myofibers and centrally located nuclei.
“ERα-null mice have a decreased muscle regenerative capacity following injury, as evidenced by small myofibers and centrally located nuclei (50).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [50]
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Self-citationEstrogen-related receptor alpha: A novel perspective on skeletal, muscular, and vascular systems
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- Authors
- LaBarge, S., McDonald, M., Smith‐Powell, L., Auwerx, J., & Huss, J. M.
- Affiliations
- Department of Diabetes and Metabolic Diseases Research Duarte California USA
- City Of Hope National Medical Center (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Huss, Janice M.
- ORCID
- Auwerx, Johan
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2013-11-25
- Volume
- 28
- Issue
- 3
- Pages
- 1082-1097
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC3929682
- OpenAlex
- W2105373189
- Cited by
- 74
- References
- 52
- Citations by year
- 2026: 1 · 2025: 13 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 4
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The FASEB Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- U.S. Public Health Service (R01 DK074700)
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health (R01AG043930)
- Beckman Research Institute, City of Hope
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A‐140780)
- National Cancer Institute (P30CA33572)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- estrogen-related receptor alpha, skeletal muscle regeneration, muscle damage, cardiotoxin, AMPK, mitochondrial biogenesis, PGC-1β, TFAM, myogenesis, muscle-specific knockout mice
- MeSH terms
- ERRalpha Estrogen-Related Receptor, Animals, Cell Line, Mitochondria, Muscle, Receptors, Estrogen, Regeneration, Down-Regulation, Mice, Knockout, Muscle, Skeletal, Microscopy, Electron, Transmission, Mice, AMP-Activated Protein Kinases
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