Muscle as a “Mediator” of Systemic Metabolism
Open accessAbstract
Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The quality of muscle mass is an important predictor of mortality.
“Consistently, the metabolic adaptations occurring in skeletal muscles are assumed to work as a disease modifier and the quality of muscle mass is an important predictor of mortality1.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [1]
Skeletal muscle is the protein reservoir of the body and is fundamental for glucose, amino acid, and lipid homeostasis.
“Being the most abundant tissue (40–50% of the total mass in healthy-weight individual) and the protein reservoir in the human body, skeletal muscles not only control locomotion but they are fundamental for breathing, eating, energy expenditure, as well as for glucose, amino acids, and lipids homeostasis and for maintaining a high quality of life1.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Self-citationThyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421 · see citing works
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 2× · see citing works
“It functions in tissues with high oxidative capacity to regulate myofiber switching, mitochondrial biogenesis, and expression of fatty acid oxidation enzymes (Figure 1B) (reviewed in Chan and Arany, 2014; Finck and Kelly, 2006; Lin et al., 2005).”
BackgroundExercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works
PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,845 · see citing works
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J. A., & Olson, E. N. (2007) · Science · doi:10.1126/science.1139089 · Cited by 1,648 · see citing works
Self-citationPGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works
Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156 · see citing works
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works
Cardiac Metabolism in Heart Failure
Doenst, T., Nguyễn, T. D., & Abel, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300376 · Cited by 1,104 · see citing works
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works
Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973 · see citing works
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887 · see citing works
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 799 · see citing works
Self-citationInterleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
Muñoz‐Cánoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013) · The FEBS Journal · doi:10.1111/febs.12338 · Cited by 774 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765 · see citing works
Thyroid Hormone Action in the Heart
Kahaly, G. J., & DILLMANN, W. H. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0033 · Cited by 710 · see citing works
Metabolic Regulation of Epigenetics
Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699 · see citing works
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · see citing works
Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works
Metabolic Gene Expression in Fetal and Failing Human Heart
Razeghi, P., Young, M. E., Alcorn, J. L., Moravec, C. S., Frazier, O. H., & Taegtmeyer, H. (2001) · Circulation · doi:10.1161/hc4901.100526 · Cited by 616 · see citing works
Activation of PPARγ Coactivator-1 Through Transcription Factor Docking
Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 596 · see citing works
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 584 · see citing works
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.
Fondell, J. D., Ge, H., & Roeder, R. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8329 · Cited by 578 · see citing works
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 558 · see citing works
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works
Willis, L. H., Slentz, C. A., Bateman, L. A., Shields, A. T., Piner, L. W., Bales, C. W., Houmard, J. A., & Kraus, W. E. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01370.2011 · Cited by 496 · see citing works
Muscle-specific Pparg deletion causes insulin resistance
Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G. K., Olson, P., Wilkes, J. J., Evans, R. M., & Olefsky, J. M. (2003) · Nature Medicine · doi:10.1038/nm956 · Cited by 492 · see citing works
Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works
Nuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works
Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass
Gallagher, D., Belmonte, D., Deurenberg, P., Wang, Z., Krasnow, N., Pi-Sunyer, F. X., & Heymsfield, S. B. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e249 · Cited by 470 · see citing works
Adaptation and Maladaptation of the Heart in Diabetes: Part II
Young, M. E., McNulty, P. H., & Taegtmeyer, H. (2002) · Circulation · doi:10.1161/01.cir.0000012467.61045.87 · Cited by 465 · see citing works
Cheng, L., Ding, G., Qin, Q., Huang, Y., Lewis, W., He, N., Evans, R. M., Schneider, M. D., Brako, F. A., Xiao, Y., et al. (2004) · Nature Medicine · doi:10.1038/nm1116 · Cited by 453 · see citing works
Spector, K. S. (1998) · Clinical Cardiology · doi:10.1002/clc.4960211205 · Cited by 442 · see citing works
Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418 · see citing works
Self-citationNorris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17305 · Cited by 417 · see citing works
Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410 · see citing works
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Yang, F., Vought, B. W., Satterlee, J. S., Walker, A. K., Jim Sun, Z.-Y., Watts, J. L., DeBeaumont, R., Mako Saito, R., Hyberts, S. G., Yang, S., et al. (2006) · Nature · doi:10.1038/nature04942 · Cited by 405 · see citing works
Thyroid hormones and skeletal muscle—new insights and potential implications
Salvatore, D., Simonides, W. S., Dentice, M., Zavacki, A. M., & Larsen, P. R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.238 · Cited by 389 · see citing works
A mediator required for activation of RNA polymerase II transcription in vitro
Flanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., & Kornberg, R. D. (1991) · Nature · doi:10.1038/350436a0 · Cited by 386 · cited 1× · see citing works
“First discovered in yeast as an essential regulator of activatorinduced transcription (Flanagan et al., 1991), the Mediator complex has been isolated from mammalian cells in active and inactive forms.”
BackgroundKajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., Limana, F., Nadal‐Ginard, B., Leri, A., & Anversa, P. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1414 · Cited by 384 · see citing works
Schuler, M. J., Ali, F., Chambon, C., Duteil, D., Bornert, J., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., & METZGER, D. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.003 · Cited by 368 · see citing works
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Grueter, C. E., van Rooij, E., Johnson, B. A., DeLeon, S. M., Sutherland, L. B., Qi, X., Gautron, L., Elmquist, J. K., Bassel‐Duby, R., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.03.029 · Cited by 365 · see citing works
Self-citationThe Mediator complex and transcription regulation
Poss, Z. C., Ebmeier, C. C., & Taatjes, D. J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.840259 · Cited by 364 · see citing works
Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781930 · Cited by 362 · cited 1× · see citing works
“Insulin resistance, a hallmark of metabolic syndrome and diabetes, correlates with a higher composition of fast-twitch myofibers (Simoneau et al., 1995).”
BackgroundCardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Son, N.-H., Park, T., Yamashita, H., Yokoyama, M., Huggins, L. A., Okajima, K., Homma, S., Szabolcs, M. J., Huang, L., & Goldberg, I. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30335 · Cited by 335 · see citing works
The human Mediator complex: a versatile, genome-wide regulator of transcription
Taatjes, D. J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.02.004 · Cited by 327 · see citing works
ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart
Alaynick, W. A., Kondo, R. P., Xie, W., He, W., Dufour, C. R., Downes, M., Jonker, J. W., Giles, W. R., Naviaux, R. K., Giguère, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.007 · Cited by 311 · see citing works
Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease
Pearen, M. A., & Muscat, G. E. O. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0015 · Cited by 308 · see citing works
Hamby, R. I. (1974) · JAMA · doi:10.1001/jama.1974.03230510023016 · Cited by 305 · see citing works
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development · doi:10.1101/gad.214023.113 · Cited by 297 · see citing works
Nuclear Receptors and Their Selective Pharmacologic Modulators
Burris, T. P., Solt, L. A., Wang, Y., Crumbley, C., Banerjee, S., Griffett, K., Lundåsen, T., Hughes, T., & Kojetin, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006833 · Cited by 285 · see citing works
Exercise for the management of type 2 diabetes: a review of the evidence
Zanuso, S., Jiménez, A., Pugliese, G., Corigliano, G., & Balducci, S. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0126-3 · Cited by 283 · see citing works
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
Burkart, E. M., Sambandam, N., Han, X., Gross, R. W., COURTOIS, M. R., Gierasch, C. M., Shoghi, K. I., Welch, M. J., & Kelly, D. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32578 · Cited by 279 · see citing works
Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
Taatjes, D. J., Näär, A. M., Andel, F., Nogales, E., & Tjian, R. (2002) · Science · doi:10.1126/science.1065249 · Cited by 277 · see citing works
The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?
Pedersen, B. K., Steensberg, A., Fischer, C. P., Keller, C., Keller, P., Plomgaard, P., Petersen, E. W., & Febbraio, M. A. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004338 · Cited by 273 · see citing works
Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270 · see citing works
Huss, J. M., Imahashi, K., Dufour, C. R., Weinheimer, C. J., COURTOIS, M. R., Kovács, A., Giguère, V., Murphy, E., & Kelly, D. P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.005 · Cited by 264 · see citing works
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258 · see citing works
MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease
Olson, E. N. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009008 · Cited by 253 · see citing works
Self-citationERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · cited 2× · see citing works
“Mouse gene deletion studies have revealed a role for ERRa in regulation of cardiac energy metabolism and adaptation to pressure overload (Huss et al., 2007; Huss and Kelly, 2004; Villena and Kralli, 2008).”
BackgroundModulation of transcription factor function by O-GlcNAc modification
Özcan, S., Andrali, S. S., & Cantrell, J. E. L. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.02.005 · Cited by 250 · see citing works
Wallberg, A. E., Yamamura, S., Malik, S., Spiegelman, B. M., & Roeder, R. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00391-5 · Cited by 247 · see citing works
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
Madrazo, J., & Kelly, D. P. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.021 · Cited by 242 · see citing works
Muoio, D. M., Way, J. M., Tanner, C. J., Winegar, D. A., Kliewer, S. A., Houmard, J. A., Kraus, W. E., & Dohm, G. L. (2002) · Diabetes · doi:10.2337/diabetes.51.4.901 · Cited by 226 · see citing works
Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1
Zhao, X., Feng, D., Wang, Q., Abdulla, A., Xie, X.-J., Zhou, J., Sun, Y., Yang, E. S. T., Liu, L., Vaitheesvaran, B., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61462 · Cited by 214 · see citing works
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
Gan, Z., Rumsey, J. W., Hazen, B. C., Lai, L., Leone, T. C., Vega, R. B., Xie, H., Conley, K. E., Auwerx, J. H., Smith, S. R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67652 · Cited by 198 · see citing works
Self-citationExercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ
Narkar, V. A., Fan, W., Downes, M., Yu, R. T., Jonker, J. W., Alaynick, W. A., Banayo, E., Karunasiri, M. S., Lorca, S., & Evans, R. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.019 · Cited by 185 · see citing works
Regulation of triglyceride metabolism by Angiopoietin-like proteins
Mattijssen, F., & Kersten, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.010 · Cited by 180 · see citing works
Physiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161 · see citing works
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77
Chao, L. C., Wroblewski, K., Zhang, Z., Pei, L., Vergnes, L., Ilkayeva, O. R., Ding, S. Y., Reue, K., Watt, M. J., Newgard, C. B., et al. (2009) · Diabetes · doi:10.2337/db09-0763 · Cited by 154 · cited 1× · see citing works
“Nur77 knockout mice develop skeletal muscle insulin resistance in response to a high-fat diet (Chao et al., 2009), whereas overexpression of Nur77 in muscle increases oxidative metabolism (Chao et al., 2012).”
Myostatin: A novel insight into its role in metabolism, signal pathways, and expression regulation
Huang, Z., Chen, X., & Chen, D. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.003 · Cited by 149 · see citing works
Cdk8 Is Essential for Preimplantation Mouse Development
Westerling, T., Kuuluvainen, E., & Mäkelä, T. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01302-06 · Cited by 141 · see citing works
MicroRNA 146 (Mir146) Modulates Spermatogonial Differentiation by Retinoic Acid in Mice1
Huszar, J. M., & Payne, C. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.103747 · Cited by 140 · see citing works
Diabetic cardiomyopathy: mechanisms and therapeutic targets
Battiprolu, P. K., Gillette, T. G., Wang, Z. V., Lavandero, S., & Hill, J. A. (2010) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2010.08.001 · Cited by 139 · see citing works
Zhu, Y., Qi, C., Jia, Y., Nye, J. S., Rao, M. S., & Reddy, J. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000121200 · Cited by 131 · see citing works
The many roles of PGC-1α in muscle — recent developments
Chan, M. C., & Arany, Z. P. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.006 · Cited by 125 · see citing works
MiR‐205 silences MED1 in hypoxic primary human trophoblasts
Mouillet, J., Chu, T., Nelson, D. M., Mishima, T., & Sadovsky, Y. (2010) · The FASEB Journal · doi:10.1096/fj.09-149724 · Cited by 125 · see citing works
Ito, M., Okano, H. J., Darnell, R. B., & Roeder, R. G. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf348 · Cited by 122 · see citing works
Metabolic benefits of resistance training and fast glycolytic skeletal muscle
LeBrasseur, N. K., Walsh, K. X., & Arany, Z. P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2010 · Cited by 119 · see citing works
Amin, R., Mathews, S. T., Camp, H. S., Ding, L., & Leff, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2009 · Cited by 118 · see citing works
Cardiokines: recent progress in elucidating the cardiac secretome
Shimano, M., Ouchi, N., & Walsh, K. (2012) · Circulation · doi:10.1161/circulationaha.112.150656 · Cited by 116 · see citing works
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart
Doroudgar, S., & Glembotski, C. C. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.12.003 · Cited by 116 · see citing works
Davis, M. A., Larimore, E. A., Fissel, B. M., Swanger, J., Taatjes, D. J., & Clurman, B. E. (2013) · Genes & Development · doi:10.1101/gad.207720.112 · Cited by 112 · see citing works
Transcriptional Coregulators: Fine-Tuning Metabolism
Mouchiroud, L., Eichner, L. J., Shaw, R. J., & Auwerx, J. H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.027 · Cited by 111 · see citing works
Jia, Y., Qi, C., Kashireddy, P. V., Surapureddi, S., Zhu, Y., Rao, M. S., Roith, D. L., Chambon, P., Gonzalez, F. J., & Reddy, J. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402391200 · Cited by 111 · see citing works
Involvement of Mediator complex in malignancy
Schiano, C., Casamassimi, A., Rienzo, M., de Nigris, F., Sommese, L., & Claudio Napoli, A. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.001 · Cited by 102 · see citing works
Mediator-dependent nuclear receptor function
Chen, W., & Roeder, R. G. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.026 · Cited by 100 · see citing works
Flamant, F., & Gauthier, K. C. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.06.003 · Cited by 98 · see citing works
Hamby, R. I., Zoneraich, S., & Sherman, L. (1974) · PubMed · Cited by 98 · see citing works
Spaeth, J. M., Kim, N. H., & Boyer, T. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.024 · Cited by 94 · see citing works
Distinct functions for RIP140 in development, inflammation, and metabolism
Nautiyal, J., Christian, M., & Parker, M. G. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.001 · Cited by 94 · see citing works
Baskin, K. K., Grueter, C. E., Kusminski, C. M., Holland, W. L., Bookout, A. L., Satapati, S., Kong, Y. M., Burgess, S. C., Malloy, C. R., Scherer, P. E., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404218 · Cited by 90 · see citing works
Self-citationYu, F., Göthe, S., Wikström, L., Forrest, D., Vennström, B., & Larsson, L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.6.r1545 · Cited by 89 · see citing works
Hulf, T., Sibbritt, T., Wiklund, E. D., Patterson, K., Song, J. Z., Stirzaker, C., Qu, W., Nair, S. S., Horvath, L. G., Armstrong, N. J., et al. (2012) · Oncogene · doi:10.1038/onc.2012.300 · Cited by 88 · see citing works
Complexity in Transcription Control at the Activation Domain–Mediator Interface
Balamotis, M. A., Pennella, M. A., Stevens, J. L., Wasylyk, B., Belmont, A. S., & Berk, A. J. (2009) · Science Signaling · doi:10.1126/scisignal.1164302 · Cited by 84 · see citing works
Hong, S., Haldin, C. E., Lawson, N. D., Weinstein, B. M., Dawid, I. B., & Hukriede, N. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509457102 · Cited by 81 · see citing works
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
Chao, L. C., Wroblewski, K., Ilkayeva, O., Stevens, R. D., Bain, J. R., Meyer, G. A., Schenk, S., Martinez, L., Vergnes, L., Narkar, V. A., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m029355 · Cited by 81 · see citing works
Chen, W., Zhang, X., Birsoy, K., & Roeder, R. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005626107 · Cited by 76 · see citing works
LaBarge, S., McDonald, M., Smith‐Powell, L., Auwerx, J., & Huss, J. M. (2014) · The FASEB Journal · doi:10.1096/fj.13-229211 · Cited by 74 · see citing works
Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
Brahma, M. K., Adam, R. C., Pollak, N. M., Jaeger, D., Zierler, K. A., Poecher, N., Schreiber, R., Romauch, M., Moustafa, T., Eder, S., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044784 · Cited by 70 · see citing works
Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity
Chu, Y., Rosso, L. A. G., Huang, P., Wang, Z., Xu, Y., Xiao, Y., Bao, M., Yan, J., Song, H., & Wang, G. (2014) · Cell Research · doi:10.1038/cr.2014.120 · Cited by 69 · see citing works
Acetylation and nuclear receptor action
Wang, C., Tian, L., Popov, V. M., & Pestell, R. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.003 · Cited by 67 · see citing works
Belakavadi, M., & Fondell, J. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01541-09 · Cited by 65 · see citing works
Krebs, P., Fan, W., Chen, Y., Tobita, K., Downes, M., Wood, M. R., Sun, L., Li, X., Xia, Y., Ding, N., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117835108 · Cited by 64 · see citing works
The road to nuclear receptors of thyroid hormone
Tata, J. R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.02.017 · Cited by 61 · see citing works
Belakavadi, M., Pandey, P. K., Vijayvargia, R., & Fondell, J. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02191-07 · Cited by 61 · see citing works
Lee, J.-H., Bassel‐Duby, R., & Olson, E. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409427111 · Cited by 59 · see citing works
Self-citationThe roles of Mediator complex in cardiovascular diseases
Schiano, C., Casamassimi, A., Vietri, M. T., Rienzo, M., & Claudio Napoli, A. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.012 · Cited by 57 · see citing works
Weigert, C., Lehmann, R., Hartwig, S., & Lehr, S. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300094 · Cited by 57 · see citing works
Road to exercise mimetics: targeting nuclear receptors in skeletal muscle
Fan, W., Atkins, A. R., Yu, R. T., Downes, M., & Evans, R. M. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0258 · Cited by 55 · see citing works
The Mediator complex in thyroid hormone receptor action
Fondell, J. D. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.02.012 · Cited by 55 · see citing works
Unraveling framework of the ancestral Mediator complex in human diseases
Claudio Napoli, A., Sessa, M., Infante, T., & Casamassimi, A. (2011) · Biochimie · doi:10.1016/j.biochi.2011.09.016 · Cited by 52 · see citing works
Cardiac Dysfunction Caused by Myocardium-Specific Expression of a Mutant Thyroid Hormone Receptor
Pazos-Moura, C. C., Abel, E. D., Boers, M.-E., de Moura, E. G., Hampton, T., Wang, J., Morgan, J. P., & Wondisford, F. E. (2000) · Circulation Research · doi:10.1161/01.res.86.6.700 · Cited by 46 · see citing works
Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy
Magida, J. A., & Leinwand, L. A. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302852 · Cited by 44 · see citing works
Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions*
Miller, C., Matic, I., Maier, K., Schwalb, B., Roether, S., Sträßer, K., Tresch, A., Mann, M., & Cramer, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.430140 · Cited by 42 · see citing works
Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor
Kim, G. H., Oh, G., Yoon, J. H., Lee, G. G., Lee, K.-U., & Kim, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73615 · Cited by 35 · see citing works
The heart‐liver metabolic axis: defective communication exacerbates disease
Baskin, K. K., Bookout, A. L., & Olson, E. N. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303800 · Cited by 30 · see citing works
Self-citationMicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31
Jiang, C., Chen, H., SHAO, L., & Wang, Q. (2014) · Oncology Reports · doi:10.3892/or.2014.3274 · Cited by 22 · see citing works
Mediator Complex Dependent Regulation of Cardiac Development and Disease
Grueter, C. E. (2013) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2013.05.002 · Cited by 20 · see citing works
Cardiac glucose utilization in mice with mutated α- and β-thyroid hormone receptors
Esaki, T., Suzuki, H., Cook, M., Shimoji, K., Cheng, S.-Y., Sokoloff, L., & Nunez, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00078.2004 · Cited by 18 · see citing works
The Mediator Complex and Lipid Metabolism.
Zhang, Y., Xiaoli, Zhao, X., & Yang, F. (2013) · PubMed · Cited by 14 · see citing works
Hyyti, O. M., Olson, A. K., Ge, M. J., Ning, X.-H., Buroker, N. E., Chung, Y., Jue, T., & Portman, M. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90329.2008 · Cited by 14 · see citing works
Large-Scale Identification of MicroRNA Targets in Murine Dgcr8-Deficient Embryonic Stem Cell Lines
Davis, M. P. A., Abreu‐Goodger, C., van Dongen, S., Lu, D., Tate, P. H., Bartoniček, N., Kutter, C., Liu, P., Skarnes, W. C., Enright, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041762 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 139 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940 · see citing works
Tezze, C., Romanello, V., Desbats, M. A., Fadini, G. P., Albiero, M., Favaro, G., Ciciliot, S., Soriano, M. E., Morbidoni, V., Cerqua, C., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.021 · Cited by 568 · see citing works
“This is an emerging concept that considers the metabolic adaptations occurring in skeletal muscles as disease modifier/controller (Baskin et al., 2015) and explains why physical activity elicits several beneficial effects in many different diseases.”
InfluentialEffects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 477 · see citing works
Self-citationCsapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 435 · see citing works
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 429 · see citing works
Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis
Sato, S., Basse, A. L., Schönke, M., Chen, S., Samad, M., Altıntaş, A., Laker, R. C., Dalbram, E., Barrès, R., Baldi, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.013 · Cited by 298 · see citing works
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
Karsenty, G., & Olson, E. N. (2016) · Cell · doi:10.1016/j.cell.2016.02.043 · Cited by 274 · see citing works
Self-citationFibroblast growth factor 21 controls mitophagy and muscle mass
Oost, L. J., Kustermann, M., Armani, A., Blaauw, B., & Romanello, V. (2019) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12409 · Cited by 231 · see citing works
Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice
Benoit, B., Meugnier, E., Castelli, M., Chanon, S., Vieille-Marchiset, A., Durand, C., Bendridi, N., Pesenti, S., Monternier, P.-A., Durieux, A.-C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4363 · Cited by 225 · see citing works
Khodabukus, A., Madden, L. R., Prabhu, N. K., Koves, T. R., Jackman, C. P., Muoio, D. M., & Bursac, N. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.058 · Cited by 227 · see citing works
Role of microRNAs in obesity and obesity-related diseases
Iacomino, G., & Siani, A. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0577-z · Cited by 225 · see citing works
Signaling Pathways That Control Muscle Mass
Vainshtein, A., & Sandri, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134759 · Cited by 214 · see citing works
Physiological and Molecular Dissection of Daily Variance in Exercise Capacity
Ezagouri, S., Zwighaft, Z., Sobel, J., Baillieul, S., Doutreleau, S., Ladeuix, B., Golik, M., Vergès, S., & Asher, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.012 · Cited by 173 · see citing works
Gut microbiota–bile acid–skeletal muscle axis
Mancin, L., Wu, G. D., & Paoli, A. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.10.003 · Cited by 176 · see citing works
Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
Wan, M., Gray-Gaillard, E. F., & Elisseeff, J. H. (2021) · Bone Research · doi:10.1038/s41413-021-00164-y · Cited by 150 · see citing works
Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity
Fu, T., Xu, Z., Liu, L., Guo, Q., Wu, H., Liang, X., Zhou, D., Xiao, L., Liu, L., Liu, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.127 · Cited by 145 · see citing works
Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling
Wang, T., Xu, Y., Yuan, Y., Xu, P., Zhang, C., Li, F., Wang, L., Yin, C., Zhang, L., Cai, X., et al. (2019) · EMBO Reports · doi:10.15252/embr.201947892 · Cited by 139 · see citing works
Regulation and functional role of the electron transport chain supercomplexes
Cogliati, S., Cabrera-Alarcón, J. L., & Enrı́quez, J. A. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210460 · Cited by 124 · see citing works
Molecular bases of the crosstalk between bone and muscle
Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 116 · see citing works
The Vitamin D/Vitamin D receptor (VDR) axis in muscle atrophy and sarcopenia
Bollen, S. E., Bass, J. J., Fujita, S., Wilkinson, D. J., Hewison, M., & Atherton, P. J. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110355 · Cited by 116 · see citing works
Stage-specific effects of Notch activation during skeletal myogenesis
Bi, P., Yue, F., Sato, Y., Wirbisky, S. E., Liu, W., Shan, T., Wen, Y., Zhou, D., Freeman, J. L., & Kuang, S. (2016) · eLife · doi:10.7554/elife.17355 · Cited by 102 · see citing works
Carson, J. A., Hardee, J. P., & VanderVeen, B. N. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.11.005 · Cited by 104 · see citing works
Lei, Y., Gan, M., Qiu, Y., Chen, Q., Wang, X., Liao, T., Zhao, M., Chen, L., Zhang, S., Zhao, Y., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00572-y · Cited by 100 · see citing works
Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila
Zhao, X. L., & Karpac, J. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.004 · Cited by 98 · see citing works
The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia
Romanello, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010091 · Cited by 101 · see citing works
Gonzalez, A. M., Hoffman, J. R., Stout, J. R., Fukuda, D. H., & Willoughby, D. S. (2015) · Sports Medicine · doi:10.1007/s40279-015-0450-4 · Cited by 94 · see citing works
Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology
Manickam, R., & Wahli, W. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.010 · Cited by 98 · see citing works
Rocchi, A., Milioto, C., Parodi, S., Armirotti, A., Borgia, D., Pellegrini, M., Urciuolo, A., Molon, S., Morbidoni, V., Marabita, M., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1550-4 · Cited by 87 · see citing works
Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.02.010 · Cited by 85 · see citing works
Xu, Z., Fu, T., Guo, Q., Zhou, D., Sun, W., Zhou, Z., Chen, X., Zhang, J., Liu, L., Xiao, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28557-5 · Cited by 82 · see citing works
Armutçu, F. (2019) · Inflammation Research · doi:10.1007/s00011-019-01271-7 · Cited by 80 · see citing works
Ren, J., & Xiao, H. (2023) · Life · doi:10.3390/life13071505 · Cited by 96 · see citing works
Yan, Y., Li, M., Lin, J., Ji, Y., Wang, K., Yan, D., Shen, Y., Wang, W., Huang, Z., Jiang, H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.947387 · Cited by 81 · see citing works
McNally, B. D., Ashley, D. F., Hänschke, L., Daou, H. N., Watt, N. T., Murfitt, S. A., MacCannell, A. D. V., Whitehead, A., Bowen, T. S., Sanders, F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29363-9 · Cited by 75 · see citing works
Decoding the transcriptome of denervated muscle at single‐nucleus resolution
Lin, H., Ma, X., Sun, Y., Peng, H., Wang, Y., Thomas, S. S., & Hu, Z. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13023 · Cited by 69 · see citing works
Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy
Amor, F., Hong, A. V., Corre, G., Sanson, M., Suel, L., Blaie, S., Servais, L., Voït, T., Richard, I., & Israeli, D. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12708 · Cited by 67 · see citing works
Zhang, H., Wang, B., Wang, X., Huang, C., Xu, S., Wang, J., Huang, T., Xiao, W., Tian, X., Lan, X., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13381 · Cited by 64 · see citing works
Tumor-derived MMPs regulate cachexia in a Drosophila cancer model
Lodge, W., Zavortink, M., Golenkina, S., Froldi, F., Dark, C., Cheung, S., Parker, B. L., Blazev, R., Bakopoulos, D., Christie, E. L., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.08.008 · Cited by 63 · see citing works
Frampton, J., Murphy, K. G., Frost, G. S., & Chambers, E. S. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12820 · Cited by 62 · see citing works
Endocardium Contributes to Cardiac Fat
Zhang, H., Pu, W., Liu, Q., He, L., Huang, X., Tian, X., Zhang, L., Nie, Y., Hu, S., Lui, K. O., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.307202 · Cited by 61 · see citing works
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging
Jing, Y., Zuo, Y., Yu, Y., Sun, L., Yu, Z., Ma, S., Zhao, Q., Sun, G., Hu, H., Li, J., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac061 · Cited by 57 · see citing works
Intertwined Relationship of Mitochondrial Metabolism, Gut Microbiome and Exercise Potential
Imdad, S., Lim, W., Kim, J., & Kang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052679 · Cited by 57 · see citing works
Skeletal Muscle and Bone – Emerging Targets of Fibroblast Growth Factor-21
Sun, H., Sherrier, M. C., & Li, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.625287 · Cited by 54 · see citing works
Müller, J. N., Lanferdini, F. J., Karam, J. Y. P., & Fontana, H. D. B. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0413 · Cited by 53 · see citing works
Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
Vanhoutte, D., Schips, T. G., Minerath, R. A., Huo, J., Kavuri, N. S. S., Prasad, V., Lin, S.-C., Bround, M. J., Sargent, M. A., Adams, C. M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114149 · Cited by 52 · see citing works
Che, H., Gao, Y., Xu, Y., Xu, H., Eils, R., & Tian, M. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02329-1 · Cited by 55 · see citing works
Nutrients against Glucocorticoid-Induced Muscle Atrophy
Lee, M., Jeong, H. H., Kim, M., Ryu, H., Baek, J.-W., & Lee, B. (2022) · Foods · doi:10.3390/foods11050687 · Cited by 52 · see citing works
Welch, A. A., Hayhoe, R. P. G., & Cameron, D. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119001150 · Cited by 52 · see citing works
Ru, Q., Li, Y., Zhang, F., Chen, L., Wu, Y., Min, J., & Wang, F. (2025) · Bone Research · doi:10.1038/s41413-024-00398-6 · Cited by 57 · see citing works
Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways
Wang, P., Kang, S. Y., Kim, S. J., Park, Y., & Jung, H. W. (2022) · Nutrients · doi:10.3390/nu14091859 · Cited by 49 · see citing works
Wang, Y., Yung, P. S., Lü, G., Liu, Y., Ding, C., Mao, C., Li, Z. A., & Tuan, R. S. (2024) · Advanced Materials · doi:10.1002/adma.202401334 · Cited by 49 · see citing works
Qi, Z., Liu, W., & Lu, J. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.05.010 · Cited by 47 · see citing works
Macrophage Involvement in Aging-Associated Skeletal Muscle Regeneration
Cui, C., Ferrucci, L., & Gorospe, M. (2023) · Cells · doi:10.3390/cells12091214 · Cited by 47 · see citing works
Bone and Joint‐on‐Chip Platforms: Construction Strategies and Applications
Du, C., Liu, J., Liu, S., Xiao, P., Chen, Z., Chen, H., Huang, W., & Lei, Y. (2024) · Small Methods · doi:10.1002/smtd.202400436 · Cited by 47 · see citing works
Zhao, X. L., & Karpac, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.003 · Cited by 43 · see citing works
Daytime-restricted feeding enhances running endurance without prior exercise in mice
Xin, H., Huang, R., Zhou, M., Chen, J., Zhang, J., Zhou, T., Ji, S., Liu, X., Tian, H., Lam, S. M., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00826-7 · Cited by 44 · see citing works
A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1‐mediated oxidative stress
Villivalam, S. D., Ebert, S. M., Lim, H., Kim, J., You, D., Jung, B. C., Palacios, H. H., Tcheau, T., Adams, C. M., & Kang, S. (2021) · The EMBO Journal · doi:10.15252/embj.2020106491 · Cited by 45 · see citing works
The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases
Han, X., Goh, K. Y., Lee, W. X., Choy, S. M., & Tang, H.-W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010297 · Cited by 46 · see citing works
Walter, L. M., Deguise, M., Meijboom, K. E., Betts, C., Ahlskog, N., van Westering, T. L. E., Hazell, G., McFall, E. R., Kordala, A. J., Hammond, S. M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.04.024 · Cited by 43 · see citing works
Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice
Zhang, W., Yang, D. L., Yuan, Y., Liu, C., Chen, H., Zhang, Y., Wang, Q., Petersen, R. B., Huang, K., & Zheng, L. (2020) · Diabetes · doi:10.2337/db20-0437 · Cited by 43 · see citing works
Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
de Souza, R. W. A., Gallo, D. J., Lee, G. R., Katsuyama, E., Schaufler, A., Weber, J., Csizmadia, E., Tsokos, G. C., Koch, L. G., Britton, S. L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109018 · Cited by 42 · see citing works
Wang, Y., Luo, D., Liu, J., Song, Y., Jiang, B., & Jiang, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286745 · Cited by 40 · see citing works
Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle
Lofaro, F. D., Cisterna, B., Lacavalla, M. A., Boschi, F., Malatesta, M., Quaglino, D., Zancanaro, C., & Boraldi, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910564 · Cited by 40 · see citing works
Reljic, D., Dieterich, W., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2022) · Nutrients · doi:10.3390/nu14101996 · Cited by 40 · see citing works
Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass
Shirakawa, J., Jesus, D. F. D., & Kulkarni, R. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.13 · Cited by 39 · see citing works
Badu-Mensah, A., Guo, X., McAleer, C. W., Rumsey, J. W., & Hickman, J. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70510-3 · Cited by 39 · see citing works
Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate
Chen, J., Li, Z., Zhang, Y., Zhang, X., Zhang, S., Liu, Z., Yuan, H., Pang, X., Liu, Y., Tao, W., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00826-2 · Cited by 38 · see citing works
Comparative efficacy of seven exercise interventions for symptoms of depression in college students
Guo, S., Liu, F., Shen, J., Wei, M., & Yang, Y. (2020) · Medicine · doi:10.1097/md.0000000000023058 · Cited by 37 · see citing works
Pierobon, E. S., Moletta, L., Zampieri, S., Sartori, R., Brazzale, A. R., Zanchettin, G., Serafini, S., Capovilla, G., Valmasoni, M., Merigliano, S., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143033 · Cited by 37 · see citing works
Nutrient sensing and utilization: getting to the heart of metabolic flexibility
Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H.-Y., & Szweda, L. I. (2016) · Biochimie · doi:10.1016/j.biochi.2015.10.013 · Cited by 36 · see citing works
Postoperative muscle loss, protein intake, physical activity and outcome associations
Hogenbirk, R. N. M., van der Plas, W. Y., Hentzen, J. E. K. R., van Wijk, L., Wijma, A. G., Buis, C. I., Viddeleer, A. R., de Bock, G. H., van der Schans, C. P., van Dam, G. M., et al. (2022) · British journal of surgery · doi:10.1093/bjs/znac384 · Cited by 36 · see citing works
Spitler, K. M., Ponce, J., Oudit, G. Y., Hall, D. D., & Grueter, C. E. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00728.2016 · Cited by 36 · see citing works
Collins, B. C., & Kardon, G. (2021) · Development · doi:10.1242/dev.199861 · Cited by 34 · see citing works
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
Lu, W., Xiao, W., Xie, W., Fu, X., Pan, L., Jin, H., Yu, Y., Zhang, Y., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.735374 · Cited by 33 · see citing works
Zhan, G., Huang, N., Li, S., Hua, D., Zhang, J., Fang, X., Yang, N., Luo, A., & Yang, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5041-2 · Cited by 32 · see citing works
Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?
Gerosa, L., Malvandi, A. M., Malavolta, M., Provinciali, M., & Lombardi, G. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101943 · Cited by 32 · see citing works
Sex‐specific, reciprocal regulation of ERα and miR‐22 controls muscle lipid metabolism in male mice
Schweisgut, J., Schutt, C., Wüst, S., Wietelmann, A., Ghesquière, B., Carmeliet, P., Dröse, S., Korach, K. S., Braun, T. W., & Boettger, T. (2017) · The EMBO Journal · doi:10.15252/embj.201695988 · Cited by 32 · see citing works
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
Swalsingh, G., Pani, P., & Bal, N. C. (2022) · Clinical Science · doi:10.1042/cs20220636 · Cited by 31 · see citing works
Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases
Zhang, Y., & Li, H. (2017) · Physiology · doi:10.1152/physiol.00038.2016 · Cited by 31 · see citing works
Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle
Lettieri‐Barbato, D., Minopoli, G., Caggiano, R., Izzo, R., Santillo, M., Aquilano, K., & Faraonio, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207780 · Cited by 28 · see citing works
Ferroptosis and Its Potential Role in the Physiopathology of Skeletal Muscle Atrophy
Sun, C., Xiao, J.-L., Sun, C., & Tang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212463 · Cited by 30 · see citing works
GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
Biagetti, B., & Simó, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010415 · Cited by 29 · see citing works
Reljic, D., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2021) · Nutrients · doi:10.3390/nu13051640 · Cited by 28 · see citing works
Exercise as a therapy for cancer-induced muscle wasting
Halle, J. L., Counts, B. R., & Carson, J. A. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.11.004 · Cited by 27 · see citing works
Dalske, K. A., Raymond‐Pope, C. J., McFaline‐Figueroa, J., Basten, A. M., Call, J. A., & Greising, S. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253629 · Cited by 27 · see citing works
Li, Y., Zhang, Y., Hu, Q., Egranov, S. D., Xing, Z., Zhang, Z., Liang, K., Ye, Y., Pan, Y., Chatterjee, S. S., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00937-4 · Cited by 27 · see citing works
Palmdelphin promotes myoblast differentiation and muscle regeneration
Nie, Y., Chen, H., Guo, C., Yuan, Z., Zhou, X., Zhang, Y., Zhang, X., Mo, D., & Chen, Y. (2017) · Scientific Reports · doi:10.1038/srep41608 · Cited by 27 · see citing works
Role of Actin-Binding Proteins in Skeletal Myogenesis
Nguyen, M. T., Dash, R., Jeong, K., & Lee, W. (2023) · Cells · doi:10.3390/cells12212523 · Cited by 26 · see citing works
Kang, B., & Chiang, B. (2021) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2021.08.004 · Cited by 26 · see citing works
Barbe, M. F., Massicotte, V. S., Assari, S., Monroy, M. A., Frara, N. A., Harris, M. Y., Amin, M., King, T. E., Cruz, G. E., & Popoff, S. N. (2018) · Bone · doi:10.1016/j.bone.2018.02.014 · Cited by 26 · see citing works
Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism
Passini, F. S., Bornstein, B., Rubin, S., Kuperman, Y., Krief, S., Masschelein, E., Mehlman, T., Brandis, A. S., Addadi, Y., Shalom, S. H.-O., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2024.12.016 · Cited by 25 · see citing works
Probiotics and muscle health: the impact of Lactobacillus on sarcopenia through the gut-muscle axis
Zhu, J., Peng, F., Yang, H., Luo, J., Zhang, L., Chen, X., Liao, H., Lei, H., Liu, S., Yang, T., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1559119 · Cited by 26 · see citing works
Monnerat, G., Sanchez, C. A., dos Santos, C. G. M., Paulucio, D., Velasque, R., Evaristo, G. P. C., Evaristo, J. A. M., Nogueira, F. C. S., Domont, G. B., Serrato, M., et al. (2020) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2019-0267 · Cited by 26 · see citing works
Effects of Aging on Collagen in the Skeletal Muscle of Mice
Kanazawa, Y., Miyachi, R., Higuchi, T., & Sato, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713121 · Cited by 25 · see citing works
Cikes, D., Leutner, M., Cronin, S. J. F., Novatchkova, M., Pfleger, L., Klepochová, R., Lair, B., Lac, M., Bergoglio, C., Viguerie, N., et al. (2024) · Nature Aging · doi:10.1038/s43587-023-00551-6 · Cited by 28 · see citing works
Effects of Functional Electrical Stimulation Lower Extremity Training in Myotonic Dystrophy Type I
Cudia, P., Weis, L., Baba, A., Kiper, P., Marcante, A., Rossi, S., Angelini, C. I., & Piccione, F. (2016) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000497 · Cited by 24 · see citing works
Metabolism and Skeletal Muscle Homeostasis in Lung Disease
Ceco, E., Weinberg, S. E., Chandel, N. S., & Sznajder, J. I. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0355tr · Cited by 24 · see citing works
Xiang, C., Zhang, Y., Chen, Q., Sun, A., Peng, Y., Zhang, G., Zhou, D., Xie, Y., Hou, X., Zheng, F., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16698 · Cited by 23 · see citing works
Kim, Y. J., Kim, H. J., Lee, S. G., Kim, D. H., Jang, S., Go, H. S., Lee, W. J., & Seong, J. K. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155178 · Cited by 23 · see citing works
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
Hu, X., Sun, M., Chen, Q., Zhao, Y., Liang, N., Wang, S., Yin, P., Yang, Y., Lam, S. M., Zhang, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43402-z · Cited by 24 · see citing works
- Authors
- Baskin, K. K., Winders, B. R., & Olson, E. N.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Olson, Eric N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 21
- Issue
- 2
- Pages
- 237-248
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4398026
- OpenAlex
- W2052045659
- Cited by
- 333
- References
- 139
- Citations by year
- 2026: 38 · 2025: 38 · 2024: 47 · 2023: 41 · 2022: 42 · 2021: 43 · 2020: 25 · 2019: 17 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 7
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01hl100401-07)
- National Heart, Lung, and Blood Institute (R01HL111665, R01HL077439, HL- 111665, U01-HL-100401, R01HL053351, R01HL093039, HL077439, HL093039)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK099653, R01DK099653)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- Mediator complex, skeletal muscle, myocardium, muscle metabolism, transcriptional regulation, tissue-specific gene regulation, physical activity, metabolic plasticity
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Humans, Muscles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
