Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulation by striatal target cells
Abstract
Dopamine (DA) is a key regulator of circuits controlling movement and motivation. A subset of midbrain DA neurons has been shown to express the vesicular glutamate transporter (VGLUT)2, underlying their capacity for glutamate release. Glutamate release is found mainly by DA neurons of the ventral tegmental area (VTA) and can be detected at terminals contacting ventral, but not dorsal, striatal neurons, suggesting the possibility that target-derived signals regulate the neurotransmitter phenotype of DA neurons. Whether glutamate can be released from the same terminals that release DA or from a special subset of axon terminals is unclear. Here, we provide in vitro and in vivo data supporting the hypothesis that DA and glutamate-releasing terminals in mice are mostly segregated and that striatal neurons regulate the cophenotype of midbrain DA neurons and the segregation of release sites. Our work unveils a fundamental feature of dual neurotransmission and plasticity of the DA system.-Fortin, G. M., Ducrot, C., Giguère, N., Kouwenhoven, W. M., Bourque, M.-J., Pacelli, C., Varaschin, R. K., Brill, M., Singh, S., Wiseman, P. W., Trudeau, L.-E. Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulation by striatal target cells.
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A recent study suggested that striatal neuron contact may regulate Vglut2 expression in DA neurons.
“Supporting the possibility of extrinsically driven refinement of gene expression, a recent study suggested that contact with striatal neurons could modulate the expression of Vglut2 in DA neurons [42].”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [42]
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Srinivasan, S., Pifl, C., & Steinkellner, T. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70299 · Cited by 1 · see citing works
Membrane and nuclear initiated estrogenic regulation of homeostasis
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- Authors
- Fortin, G. M., Ducrot, C., Giguère, N., Kouwenhoven, W. M., Bourque, M.-J., Pacelli, C., Varaschin, R. K., Brill, M., Singh, S., Wiseman, P. W., & Trudeau, L.-É.
- Affiliations
- Université de Montréal (CA)
- McGill University (CA)
- Corresponding author
- Trudeau, Louis-Éric
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-07-16
- Volume
- 33
- Issue
- 1
- Pages
- 400-417
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2883419158
- Cited by
- 45
- References
- 54
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-106556)
- Fondation Brain Canada
- Parkinson Society Canada
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopaminergic neurons, glutamate release, vesicular glutamate transporter 2, ventral tegmental area, striatum, midbrain dopamine system, synaptic plasticity
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Male, Synaptic Transmission, Ventral Tegmental Area, Mice, Knockout, Glutamic Acid, Vesicular Glutamate Transport Protein 2, Mice, Dopaminergic Neurons
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