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From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

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Nicotinamide riboside alleviates brain dysfunction induced by chronic cerebral hypoperfusion via protecting mitochondria

Wang, L., Peng, T., Deng, J., Gao, W., Wang, H., Luo, O. J., Huang, L., & Chen, G. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116272 · Cited by 19 · see citing works

Altered expression of clock and clock‐controlled genes in a hSOD1‐linked amyotrophic lateral sclerosis mouse model

Killoy, K. M., Pehar, M., Harlan, B. A., & Vargas, M. R. (2021) · The FASEB Journal · doi:10.1096/fj.202000386rr · Cited by 17 · see citing works

The many faces of SIRT6 in the retina and retinal pigment epithelium

Cheng, J., Keuthan, C. J., & Esumi, N. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1244765 · Cited by 14 · see citing works

NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons

Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2022) · The FASEB Journal · doi:10.1096/fj.202101275r · Cited by 12 · see citing works

Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders

Bresque, M., Esteve, D., Pehar, M., & Vargas, M. R. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0241 · Cited by 12 · see citing works

NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality

Tarot, P., Lasbleiz, C., & Liévens, J.-C. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385283 · Cited by 9 · see citing works

Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS

Lundt, S., & Ding, S. (2024) · Cells · doi:10.3390/cells13171509 · Cited by 9 · see citing works

The identification of new roles for nicotinamide mononucleotide after spinal cord injury in mice: an RNA-seq and global gene expression study

Zhang, C., Li, Y., Bai, F., Talifu, Z., Ke, H., Xu, X. P., Li, Z., Liu, W., Pan, Y., Gao, F., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1323566 · Cited by 5 · see citing works

Early nuclear phenotypes and reactive transformation in human iPSC ‐derived astrocytes from ALS patients with SOD1 mutations

Soubannier, V., Chaineau, M., Gursu, L., Lépine, S., Kalaydjian, D., Sirois, J., Haghi, G., Rouleau, G. A., Durcan, T. M., & Stifani, S. (2024) · Glia · doi:10.1002/glia.24598 · Cited by 4 · see citing works

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Bresque, M., Esteve, D., Balmer, G., Hamilton, H., Stephany, J. S., Pehar, M., & Vargas, M. R. (2025) · Glia · doi:10.1002/glia.70023 · Cited by 3 · see citing works

Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) as neuroinflammatory biomarkers in Amyotrophic Lateral Sclerosis (ALS) progression

Santos, K. D. F., Azevedo, R. M., da Costa, C. C. P., da Cruz, P. B. D., Reis, A. A. D. S., & Santos, R. D. S. (2022) · Research, Society and Development · doi:10.33448/rsd-v11i5.28073 · Cited by 3 · see citing works

Exploring epigenetic modifications as potential biomarkers and therapeutic targets in amyotrophic lateral sclerosis

Hou, X., Jiang, J., & Deng, M. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13028-w · Cited by 2 · see citing works

Vitagenes in avian biology: protective functions of sirtuins

Surai, P. F., Kochish, I. I., & Fisinin, V. I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00019-7 · Cited by 1 · see citing works

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutationsPreprint

Soubannier, V., Chaineau, M., Gursu, L., Lépine, S., Kalaydjian, D., Haghi, G., Rouleau, G. A., Durcan, T. M., & Stifani, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.05.561079 · Cited by 1 · see citing works

Mitochondria and Neurodegenerative Diseases

Johri, A., & Chandra, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11474-6

Chapter 8: Sirtuins in avian biology

Surai, P. F. (2020) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-906-0_8

Neuroprotection and neuroenhancement

Gillmann, K., & Goldberg, J. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88442-6.00014-5

Impact of the NAD+ salvage pathway on the motor system and bioenergetics

Lundt, S. (2023) · doi:10.32469/10355/96990

Enhancing NAD+ salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant superoxide dismutase 1 (SOD1)

Harlan, B. A., Pehar, M., Sharma, D. R., Beeson, G., Beeson, C. C., & Vargas, M. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698779 · Cited by 94 · see citing works

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479 · see citing works

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice

Obrador, E., Palmer, R. S., Marchio, P., López‐Blanch, R., Jihad-Jebbar, A., Rivera, P., Vallés, S. L., Banacloche, S., Alcácer, J., Colomer, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02188-7 · Cited by 46 · see citing works

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

Cassina, P., Cassina, A., Pehar, M., Castellanos, R., Gandelman, M., de León, A., Robinson, K. M., Mason, R. P., Beckman, J. S., Barbeito, L., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5308-07.2008 · Cited by 310 · see citing works

Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1G93A Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

Pehar, M., Beeson, G. C., Beeson, C. C., Johnson, J. A., & Vargas, M. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103438 · Cited by 44 · see citing works