Vasopressin: Sexual dimorphism in secretion, cardiovascular actions and hypertension
Abstract
We have investigated the issue of sexual dimorphism in the secretion of vasopressin, its pressor action, and the development of deoxycorticosterone (DOC)-salt hypertension. In normal human subjects on controlled salt intake, the basal secretion of vasopressin, indicated by plasma vasopressin levels and urinary excretion of vasopressin, was higher in men than in women and in blacks than in whites. Basal vasopressin secretion also was higher in male than in female rats. This effect was not associated with a difference in the metabolic clearance of the hormone. The sex-related difference in vasopressin release in rats was abolished by gonadectomy and restored by treatment of males with testosterone and females with ovarian hormones. The pressor responsiveness to vasopressin was higher in male than in randomly cycling female rats. Finally, DOC-salt hypertension, which is dependent on vasopressin, developed more rapidly in male than in female rats. Although there was no sex-related difference in the extent to which plasma vasopressin levels were elevated, pressor responsiveness to vasopressin was greater and baroreflex sensitivity was attenuated to a lesser extent in hypertensive males than in hypertensive females. Thus, it seems likely that gonadal hormones play a significant role in cardiovascular regulation.
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Sex differences in VP neurons and plasma VP concentrations have also been found in humans.
“Sex differences in VP neurons and plasma VP concentrations have also been found in humans”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Share et al., 1988
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- Authors
- Share, L., Crofton, J. T., & Ouchi, Y.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Share, Leonard
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 295
- Issue
- 4
- Pages
- 314-319
- ISSN
- 0002-9629 (ISSN-L)
- OpenAlex
- W1990459648
- Cited by
- 62
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 19209, HL12990)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- vasopressin, sexual dimorphism, sex differences, deoxycorticosterone-salt hypertension, pressor responsiveness, baroreflex sensitivity, gonadal hormones, testosterone, ovarian hormones, gonadectomy, plasma vasopressin levels, cardiovascular regulation, racial differences
- MeSH terms
- Animals, Blood Pressure, Desoxycorticosterone, Estrus, Female, Humans, Hypertension, Male, Orchiectomy, Ovariectomy, Rats, Inbred Strains, Sex Characteristics, Vasopressins, Black People, White People, Rats
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