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Cited by 235Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchBiomedical and Chemical Research

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Positron Emission Tomography Study of Regional Cerebral Metabolism in Humans during Isoflurane Anesthesia

Alkire, Michael T. MD, Haier, Richard J. PhD, Shah, Nitin K. MD, Anderson, Cynthia T. MD·1997·Anesthesiology
DOI 10.1097/00000542-199703000-00006
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Abstract

Background: Although the anesthetic effects of the intravenous anesthetic agent propofol have been studied in the living human brain using brain imaging technology, the nature of the anesthetic state evident in the human brain during inhalational anesthesia remains unknown. To examine this issue, the authors studied the effects of isoflurane anesthesia on human cerebral glucose metabolism using positron emission tomography (PET). Methods: Five volunteers each underwent two PET scans; one scan assessed awake-baseline metabolism and the other scan assessed metabolism during isoflurane anesthesia titrated to the point of unresponsiveness (means +/- SD; expired = 0.5 +/- 0.1%). Scans were obtained with a GE2048 scanner (4.5-mm resolution-FWHM) using the 18fluorodeoxyglucose technique. Results: Awake whole-brain glucose metabolism averaged 6.9 +/- 1.5 mg.100 g-1.min-1 (means +/- SD). Isoflurane reduced whole-brain metabolism 46 +/- 11% to 3.6 +/- 0.3 mg.100 g-1.min-1 (P < or = 0.005). Regional metabolism decreased fairly uniformly throughout the brain, and no evidence of any regional metabolic increases were found in any brain region for any participant. A region-of-interest analysis showed that the pattern of regional metabolism evident during isoflurane anesthesia was not significantly different from that seen when participants were awake. Conclusion: These data clarify that the anesthetic state evident in the living human brain during unresponsiveness induced with isoflurane is associated with a global, fairly uniform, whole-brain glucose metabolic reduction of 46 +/- 11%.

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Metadata

Authors
Alkire, M. T. M., Haier, R. J. P., Shah, N. K. M., & Anderson, C. T. M.
Affiliations
University of California, Irvine Medical Center (US)
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-03-01
Volume
86
Issue
3
Pages
549-557
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/00000542-199703000-00006
OpenAlex
W2035252578
Cited by
235
References
22
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 6 · 2018: 18 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 14
FWCI
7.93
Type
journal article
Language
en
Open access
closed
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
  • Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords
isoflurane, inhalational anesthesia, brain glucose metabolism, regional brain metabolism, unresponsiveness, 18F-FDG PET
MeSH terms
Adult, Anesthesia, Inhalation, Brain, Consciousness, Depression, Chemical, Glucose, Humans, Isoflurane, Male, Tomography, Emission-Computed, Anesthetics, Inhalation

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