Cited by 144Wound Healing and TreatmentsLiver physiology and pathologyBurn Injury Management and Outcomes

Tumor Necrosis Factor and Wound Healing

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MOONEY, DAVID P., OʼREILLY, MICHAEL, GAMELLI, RICHARD L.·1990·Annals of Surgery

Abstract

Tumor necrosis factor alpha (TNF), 1 to 500 ng in saline (PBS) or collagen, was applied to the wounds of normal and Adriamycin-impaired mice and wound disruption strength (WDS) and histology were examined. Also wounded mice were administered TNF 25 to 75 micrograms/kg IP daily and WDS was determined. Wound histology was examined 6 months after wounding and local TNF application. Local TNF 5 to 500 ng in PBS did not significantly affect WDS. Local TNF 5 to 50 ng in collagen increased WDS 33% to 65% in Adriamycin-impaired animals (p = 0.05 to p less than 0.02). Local TNF 50 to 500 ng in collagen increased WDS 23% to 49% in normal animals (p = 0.08 to p less than 0.01). Adriamycin-impaired animals demonstrated improved wound histology with local TNF in collagen. Systemic TNF did not significantly affect WDS. Local TNF in collagen did not induce histologic pathology at 6 months. TNF may modulate macrophage function and local TNF in collagen can improve WDS in normal and Adriamycin-impaired animals.

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Crossref · 10.1097/00000658-199002000-00002

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  • There are contradictory reports on the effects of locally applied TNFα on granulation tissue formation in skin wound healing, indicating there is no consensus on the effects of local TNFα application.

    “There are contradictory reports on the effects of locally applied TNFα on granulation tissue formation in skin wound healing,59,64,65 indicating there is no consensus on the effects of local TNFα application.”

    From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [64]

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Authors
MOONEY, D. P., OʼREILLY, M., & GAMELLI, R. L.
Affiliations
University of Vermont (US)
Venue
Annals of Surgery
Published
1990-02
Volume
211
Issue
2
Pages
124-129
ISSN
0003-4932 (ISSN-L)
OpenAlex
W1978738930
Cited by
144
References
20
Citations by year
2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
8.54
Type
journal article
Language
en
Open access
Locations
  • Annals of Surgery (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
Keywords
TNF-α, wound healing, adriamycin nephropathy, macrophage function, collagen matrix, wound histology
MeSH terms
Administration, Topical, Animals, Collagen, Doxorubicin, Granulation Tissue, Male, Mice, Inbred Strains, Random Allocation, Skin, Sodium Chloride, Tumor Necrosis Factor-alpha, Wound Healing, Mice

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